Jerry Avorn has some sobering news. Drawing on more than twenty-five years of patient care, teaching, and research at Harvard Medical School, he shares his firsthand experience of the wide gap in our knowledge of the effectiveness of one medication as compared to another. In Powerful Medicines, he reminds us that every pill we take represents a delicate compromise between the promise of healing, the risk of side effects, and an increasingly daunting price. The stakes on each front grow higher every year as new drugs with impressive power, worrisome side effects, and troubling costs are introduced.This is a comprehensive behind-the-scenes look at issues that affect everyone: our shortage of data comparing the worth of similar drugs for the same condition; alarming lapses in the detection of lethal side effects; the underuse of life-saving medications; lavish marketing campaigns that influence what doctors prescribe; and the resulting upward spiral of costs that places vital drugs beyond the reach of many Americans.In this engagingly written book, Dr. Avorn asks questions that will interest every consumer: How can a product judged safe by the Food and Drug Administration turn out to have unexpectedly lethal side effects? Why has the nation’s drug bill been growing at nearly 20 percent per year? How can physicians and patients pick the best medication in its class? How do doctors actually make their prescribing decisions, and why do those decisions sometimes go wrong? Why do so many Americans suffer preventable illnesses and deaths that proper drug use could have averted? How can the nation gain control over its escalating drug budget without resorting to rationing or draconian governmental controls?Using clinical case histories taken from his own work as a practitioner, researcher, and advocate, Dr. Avorn demonstrates the impressive power of the well-conceived prescription as well as the debacles that can result when medications are misused. He describes an innovative program that employs the pharmaceutical industry’s own marketing techniques to reduce use of some of the most overprescribed and overpriced products. Powerful Medicines offers timely and practical advice on how the nation can improve its drug-approval process, and how patients can work with doctors to make sure their prescriptions are safe, effective, and as affordable as possible. This is a passionate and provocative call for action as well as a compelling work of clear-headed science.From the Hardcover edition.

     Mike Weiss spent nearly two years with Ferrari-Carano, a California winemaker founded in Sonoma County just over twenty years ago by Don Carano, a casino and hotel mogul from Reno. The narrative in A Very Good Year follows Ferrari-Carano’s Fume Blanc from barren vines in November to its first sampling by a customer at the Four Seasons in New York, and, over the course of the book, Weiss presents his unique insight into the making and marketing of wine today. BACKCOVER: “Superb. . . . Weiss tells a great story.” —THE NEW YORK TIMES “Finally, a wine book that explains all the ingredients. . . . You will marvel at the richness of what Mike Weiss . . . was able to capture and convey within this delicious book.” —LOS ANGELES TIMES “Compelling . . . A Very Good Year is both entertaining and comprehensive.” —THE BOSTON GLOBE “A sweeping book about tourism, globalism, environmental sustainability, immigration, and glamour. . . . The bottle of Fume Blanc . . . is like a Pandora’s box. Open it up and out spill all the vanity, marketing savvy, self-mythologizing, acres of land, buckets of money, precise science, alchemical blending, and feudal working conditions that make up the California dream known as the wine industry.” —SAN FRANCISCO CHRONICLE

    Take your playing to the stratosphere with the most advanced lead book by this proven heavy metal author. Speed Mechanics is the ultimate technique book for developing the kind of speed and precision in today's explosive playing styles. Learn the fastest ways to achieve speed and control, secrets to make your practice time really count, and how to open your ears and make your musical ideas more solid and tangible. Packed with over 200 vicious exercises including Troy's scorching version of "Flight of the Bumblebee." Music and examples demonstrated on CD. 89-minute audio.

    Connect Public Speaking provides students a wealth of resources to prepare and plan speeches, while LearnSmart--McGraw-Hill's proven adaptive learning system--guides them toward mastery of key course concepts. Additionally, Connect's highly flexible speech capture tool saves instructors valuable time in managing assignments and evaluating student speeches. Taking a practical, accessible, and non-intimidating approach to public speaking, Public Speaking for College & Career presents numerous stories, examples, activities, and concrete techniques to show students how to achieve clarity and confidence during the speeches they must give in college, in their careers, and in their communities.

    Inspired by Mamma's simple, old-fashoined home cooking, the beloved movie and television star shares a scrumptious collection of treasured family recipes -- all topped with the zest of his humor and warmth. Dom regales us with colorful anecdotes about growing up in Bensonhurst, an Italian section of Brooklyn...the kitchen that was the center of his universe...and what it was like having a lively, loving mother who would cook a five-course meal for you at the drop of a fork.

    Designed in an easy-to-follow format, this chunky compilation presents all of the classic pastries in the simplest possible way, along with a collection of recipes.

    But he didn t break - instead he made himself redundant and took off to France with girlfriend Rose to pursue his dream of brewing beer. Settled in a dilapidated house in the Loire they are beset by calamities (mainly of Tommy s making), mad neighbours and an unexpected pregnancy. Not to mention, Burt the Satanic dog who truly has it in for his master. Featuring colourful characters, a stunning location a collection of beer recipes, this is an irresistible feast of humour and heart.

    Written with characteristic warmth, vigor, and wit, this fascinating account brings to life the infectious enthusiasms, fervent battles, and bountiful friendships of a truly American original. "A warm, discursive, and salty document." - New Yorker

    First there were the rats in the pantry, then the floods, then the fires, then the visiting cougar. Life in Bull Canyon was daunting and dangerous. Often Lin wondered just what in the world they were doing so far from their customary home on the open seas. Bull Canyon joins the canon of great tales of homesteading, told in the warm, funny, and insightful voice of a true storyteller.

    Each photo captures the way you see the knot as you make it. And when two or more ropes are involved, they are color coded to help you clearly tell them apart.Filled with more than 600 photographs, this convenient, compact guide also includes a section on decorative knots, a cross-reference list of the many applications of knots, and a detailed glossary.

    The 378 dramatic photographs capture cloud types, precipitation, storms, twisters, and optical phenomena such as the Northern Lights. Essays with accompanying maps and illustrations discuss the earth's atmosphere, weather systems, cloud formation, and development of tornadoes and many other weather events.

    Reptiles & Amphibians features: ¸ Background information on evolution, anatomy, physiology, habitats, and life cycles of a range of reptile and amphibian families. ¸ A detailed look at how reptiles and amphibians survive-how they eat, move around, defend themselves, and combat temperature extremes. ¸ Examinations of metamorphosis, growth and longevity, and vocalization techniques. ¸ Practical advice on how to responsibly study reptiles and amphibians in the wild or care for them as pets. ¸ An identification guide to more than 160 of the most fascinating herpetological species from around the world, organized by environment. ¸ More than 300 full-color photos and illustrations.

    Turn to the corresponding page to discover its country of origin, common uses, and season of harvest.This practical guide includes more than 200 full-color photographs of the world's most popular fruits and vegetables, cross-referenced to in-depth descriptions and selection tips. Step-by-step preparation directions tell you whether the item must be peeled, washed, trimmed, or blanched. Grocery shopping--and dinner--will never be the same again!

    It was a bitter pill. After working on their own in Vietnam for more than two years, the Brigade LRRPs were ordered to join forces with the division once again.But even as these formidable hunters and killers were themselves swallowed up by the Screaming Eagles' Division LRPs to eventually become F Co., 58th Infantry, they continued the deadly, daring LRRP tradition. From saturation patrols along the Laotian border to near-suicide missions and compromised positions in the always dangerous A Shau valley, the F/58th unflinchingly faced death every day and became one of the most highly decorated companies in the history of the 101st.

    Based on the natural way a mother dog trains her puppies, Benjamin's training method is humane, effective and all natural. Now we've put a bright new cover on a timeless classic.