But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    As sociologist and network science pioneer Duncan Watts explains in this provocative book, the explanations that we give for the outcomes that we observe in life—explanation that seem obvious once we know the answer—are less useful than they seem.Drawing on the latest scientific research, along with a wealth of historical and contemporary examples, Watts shows how common sense reasoning and history conspire to mislead us into believing that we understand more about the world of human behavior than we do; and in turn, why attempts to predict, manage, or manipulate social and economic systems so often go awry.It seems obvious, for example, that people respond to incentives; yet policy makers and managers alike frequently fail to anticipate how people will respond to the incentives they create. Social trends often seem to have been driven by certain influential people; yet marketers have been unable to identify these “influencers” in advance. And although successful products or companies always seem in retrospect to have succeeded because of their unique qualities, predicting the qualities of the next hit product or hot company is notoriously difficult even for experienced professionals.Only by understanding how and when common sense fails, Watts argues, can we improve how we plan for the future, as well as understand the present—an argument that has important implications in politics, business, and marketing, as well as in science and everyday life.

    Mass starvation, long predicted for the fast-growing population, was about to become a reality. A call went out to the world’s scientists to find a solution. This is the story of the two enormously gifted, fatally flawed men who found it: the brilliant, self-important Fritz Haber and the reclusive, alcoholic Carl Bosch. Together they discovered a way to make bread out of air, built city-sized factories, controlled world markets, and saved millions of lives. Their invention continues to feed us today; without it, more than two billion people would starve.But their epochal triumph came at a price we are still paying. The Haber-Bosch process was also used to make the gunpowder and high explosives that killed millions during the two world wars. Both men were vilified during their lives; both, disillusioned and disgraced, died tragically. Today we face the other un­intended consequences of their discovery—massive nitrogen pollution and a growing pandemic of obesity.The Alchemy of Air is the extraordinary, previously untold story of two master scientists who saved the world only to lose everything and of the unforseen results of a discovery that continues to shape our lives in the most fundamental and dramatic of ways.

    Twenty years on, Hancock returns with the sequel to his seminal work filled with completely new, scientific and archaeological evidence, which has only recently come to light...Near the end of the last Ice Age 12,800 years ago, a giant comet that had entered the solar system from deep space thousands of years earlier, broke into multiple fragments. Some of these struck the Earth causing a global cataclysm on a scale unseen since the extinction of the dinosaurs. At least eight of the fragments hit the North American ice cap, while further fragments hit the northern European ice cap. The impacts, from comet fragments a mile wide approaching at more than 60,000 miles an hour, generated huge amounts of heat which instantly liquidized millions of square kilometers of ice, destabilizing the Earth's crust and causing the global Deluge that is remembered in myths all around the world. A second series of impacts, equally devastating, causing further cataclysmic flooding, occurred 11,600 years ago, the exact date that Plato gives for the destruction and submergence of Atlantis.The evidence revealed in this book shows beyond reasonable doubt that an advanced civilization that flourished during the Ice Age was destroyed in the global cataclysms between 12,800 and 11,600 years ago. But there were survivors - known to later cultures by names such as 'the Sages', 'the Magicians', 'the Shining Ones', and 'the Mystery Teachers of Heaven'. They travelled the world in their great ships doing all in their power to keep the spark of civilization burning. They settled at key locations - Gobekli Tepe in Turkey, Baalbek in the Lebanon, Giza in Egypt, ancient Sumer, Mexico, Peru and across the Pacific where a huge pyramid has recently been discovered in Indonesia. Everywhere they went these 'Magicians of the Gods' brought with them the memory of a time when mankind had fallen out of harmony with the universe and paid a heavy price. A memory and a warning to the future...For the comet that wrought such destruction between 12,800 and 11,600 years may not be done with us yet. Astronomers believe that a 20-mile wide 'dark' fragment of the original giant comet remains hidden within its debris stream and threatens the Earth. An astronomical message encoded at Gobekli Tepe, and in the Sphinx and the pyramids of Egypt,warns that the 'Great Return' will occur in our time...

    Where would we be without bike helmets, baggies, toothbrushes, and pacemakers? But a century into our love affair with plastic, we’re starting to realize it’s not such a healthy relationship. Plastics draw on dwindling fossil fuels, leach harmful chemicals, litter landscapes, and destroy marine life. As journalist Susan Freinkel points out in this engaging and eye-opening book, we’re nearing a crisis point. We’ve produced as much plastic in the past decade as we did in the entire twentieth century. We’re drowning in the stuff, and we need to start making some hard choices. Freinkel gives us the tools we need with a blend of lively anecdotes and analysis. She combs through scientific studies and economic data, reporting from China and across the United States to assess the real impact of plastic on our lives. She tells her story through eight familiar plastic objects: comb, chair, Frisbee, IV bag, disposable lighter, grocery bag, soda bottle, and credit card. Her conclusion: we cannot stay on our plastic-paved path. And we don’t have to. Plastic points the way toward a new creative partnership with the material we love to hate but can’t seem to live without.

    While this has had the positive effect of equalizing access to knowledge, it also has lowered the bar on what depth of knowledge is required to consider oneself an "expert." A cult of anti-expertise sentiment has coincided with anti-intellectualism, resulting in massively viral yet poorly informed debates ranging from the anti-vaccination movement to attacks on GMOs. This surge in intellectual egalitarianism has altered the landscape of debates-all voices are equal, and "fact" is a subjective term. Browsing WebMD puts one on equal footing with doctors, and Wikipedia allows all to be foreign policy experts, scientists, and more. As Tom Nichols shows in The Death of Expertise, there are a number of reasons why this has occurred-ranging from easy access to Internet search engines to a customer satisfaction model within higher education. The product of these interrelated trends, Nichols argues, is a pervasive distrust of expertise among the public coinciding with an unfounded belief among non-experts that their opinions should have equal standing with those of the experts. The experts are not always right, of course, and Nichols discusses expert failure. The crucial point is that bad decisions by experts can and have been effectively challenged by other well-informed experts. The issue now is that the democratization of information dissemination has created an army of ill-informed citizens who denounce expertise.When challenged, non-experts resort to the false argument that the experts are often wrong. Though it may be true, but the solution is not to jettison expertise as an ideal; it is to improve our expertise. Nichols is certainly not opposed to information democratization, but rather the enlightenment people believe they achieve after superficial internet research. He shows in vivid detail the ways in which this impulse is coursing through our culture and body politic, but the larger goal is to explain the benefits that expertise and rigorous learning regimes bestow upon all societies.

    But power is not merely shifting and dispersing. It is also decaying. Those in power today are more constrained in what they can do with it and more at risk of losing it than ever before. In The End of Power, award-winning columnist and former Foreign Policy editor Moisés Naím illuminates the struggle between once-dominant megaplayers and the new micropowers challenging them in every field of human endeavor. Drawing on provocative, original research, Naím shows how the antiestablishment drive of micropowers can topple tyrants, dislodge monopolies, and open remarkable new opportunities, but it can also lead to chaos and paralysis. Naím deftly covers the seismic changes underway in business, religion, education, within families, and in all matters of war and peace. Examples abound in all walks of life: In 1977, eighty-nine countries were ruled by autocrats while today more than half the world's population lives in democracies. CEO's are more constrained and have shorter tenures than their predecessors. Modern tools of war, cheaper and more accessible, make it possible for groups like Hezbollah to afford their own drones. In the second half of 2010, the top ten hedge funds earned more than the world's largest six banks combined. Those in power retain it by erecting powerful barriers to keep challengers at bay. Today, insurgent forces dismantle those barriers more quickly and easily than ever, only to find that they themselves become vulnerable in the process. Accessible and captivating, Naím offers a revolutionary look at the inevitable end of power—and how it will change your world.

    Following a grand betrayal, Khaled's father and uncles, the respected right-hand men to the King of Afghanistan, become targets of the new regime. Khaled's father is exiled, his uncles are executed, and their families are locked away in a forgotten corner of Kabul. So begins a decades-long struggle in captivity where Khaled faces the hardship of prison life while enduring tragedies as more of his loved ones are executed and succumb to diseases. Despite the tribulations he experiences, Khaled never gives up hope, choosing to make the most of his time by studying five different languages, advanced literature, and philosophy. Eventually, Khaled and his family are released from prison, but are they truly free? Forbidden from leaving the country, one thing continues to haunt Khaled: a longing to reunite with his father. SHACKLED is a raw, heart-opening story about resilience. It follows the Charkhi family from the 1932 coup to the 1979 Soviet invasion. Amidst national and personal upheaval, Khaled finds his freedom by choosing to lead a life of optimism, kindness, joy, and love. Adam Siddiq is the grandson of Khaled Siddiq. Adam wrote SHACKLED alongside his grandfather, Khaled—a shared journey they hope will inspire others to become more involved in the sacred bond between the youth and their elders.

    Indeed our ability to do so is what separates we humans from the rest of the animal world. The moment man first converted a stone to a useful tool set him on a relentless path toward greater power over his environment. But have our creative ideas always produced desirable results in line with their original good intention? Have they really served us well?BAD IDEAS? traces the fascinating history of our attempts at self-improvement but also questions their value. The dubious consequences of the development of weaponry, for example, is self-evident. But what of apparently more innocuous inventions such as farming, writing or medicine? All started off for the greater good but have since produced unforeseen fallout that continues to this day. What are their undesirable side-effects, when did they emerge and where will they take us in the future?Written against a huge historical canvas, we join Robert Winston on a thrilling journey from our earliest days to the present. We learn about the history of modern science, engineering, IT and much more. We meet the individuals who played a key role in their development, and share quirky anecdotes about their lives and brainwaves. Inspiring, unusual, and at times controversial, BAD IDEAS? assesses the past and also looks forward to the opportunities and ethical challenges of the future. In so doing it celebrates man's extraordinary capacity for achievement whilst warning us that his good intentions can sometimes end up as thoroughly bad ideas.

    What we eat has tremendous implications not just for our waistlines, but also for the planet, society, and the global economy. What we do to our bodies, we do to the planet; and what we do to the planet, we do to our bodies.In Food Fix, #1 bestselling author Mark Hyman explains how our food and agriculture policies are corrupted by money and lobbies that drive our biggest global crises: the spread of obesity and food-related chronic disease, climate change, poverty, violence, educational achievement gaps, and more.Pairing the latest developments in nutritional and environmental science with an unflinching look at the dark realities of the global food system and the policies that make it possible, Food Fix is a hard-hitting manifesto that will change the way you think about -- and eat -- food forever, and will provide solutions for citizens, businesses, and policy makers to create a healthier world, society, and planet.

    Vanishing and mutilated cattle. Unidentified Flying Objects. The appearance of huge, otherworldly creatures. Invisible objects emitting magnetic fields with the power to spark a cattle stampede. Flying orbs of light with dazzling maneuverability and lethal consequences. For one family, life on the Skinwalker Ranch had become a life under siege by an unknown enemy or enemies. Nothing else could explain the horrors that surrounded them -- perhaps science could. Leading a first-class team of research scientists on a disturbing odyssey into the unknown, Colm Kelleher spent hundreds of days and nights on the Skinwalker property and experienced firsthand many of its haunting mysteries. With investigative reporter George Knapp -- the only journalist allowed to witness and document the team's work -- Kelleher chronicles in superb detail the spectacular happenings the team observed personally, and the theories of modern physics behind the phenomena. Far from the coldly detached findings one might expect, their conclusions are utterly hair-raising in their implications. Opening a door to the unseen world around us, Hunt for the Skinwalker is a clarion call to expand our vision far beyond what we know.

    In fact, our ability to curse comes from a different part of the brain than other parts of speech--the urgency with which we say "f&*k!" is instead related to the instinct that tells us to flee from danger.Language evolves with time, and so does what we consider profane or unspeakable. Nine Nasty Words is a rollicking examination of profanity, explored from every angle: historical, sociological, political, linguistic. In a particularly coarse moment, when the public discourse is shaped in part by once-shocking words, nothing could be timelier.

    Today’s "machine-learning" systems, trained by data, are so effective that we’ve invited them to see and hear for us?and to make decisions on our behalf. But alarm bells are ringing. Recent years have seen an eruption of concern as the field of machine learning advances. When the systems we attempt to teach will not, in the end, do what we want or what we expect, ethical and potentially existential risks emerge. Researchers call this the alignment problem.Systems cull résumés until, years later, we discover that they have inherent gender biases. Algorithms decide bail and parole?and appear to assess Black and White defendants differently. We can no longer assume that our mortgage application, or even our medical tests, will be seen by human eyes. And as autonomous vehicles share our streets, we are increasingly putting our lives in their hands.The mathematical and computational models driving these changes range in complexity from something that can fit on a spreadsheet to a complex system that might credibly be called “artificial intelligence.” They are steadily replacing both human judgment and explicitly programmed software.In best-selling author Brian Christian’s riveting account, we meet the alignment problem’s “first-responders,” and learn their ambitious plan to solve it before our hands are completely off the wheel. In a masterful blend of history and on-the ground reporting, Christian traces the explosive growth in the field of machine learning and surveys its current, sprawling frontier. Readers encounter a discipline finding its legs amid exhilarating and sometimes terrifying progress. Whether they—and we—succeed or fail in solving the alignment problem will be a defining human story.The Alignment Problem offers an unflinching reckoning with humanity’s biases and blind spots, our own unstated assumptions and often contradictory goals. A dazzlingly interdisciplinary work, it takes a hard look not only at our technology but at our culture—and finds a story by turns harrowing and hopeful.

    What is going on? Anatomy of an Epidemic challenges readers to think through that question themselves. First, Whitaker investigates what is known today about the biological causes of mental disorders. Do psychiatric medications fix “chemical imbalances” in the brain, or do they, in fact, create them? Researchers spent decades studying that question, and by the late 1980s, they had their answer. Readers will be startled—and dismayed—to discover what was reported in the scientific journals. Then comes the scientific query at the heart of this book: During the past fifty years, when investigators looked at how psychiatric drugs affected long-term outcomes, what did they find? Did they discover that the drugs help people stay well? Function better? Enjoy good physical health? Or did they find that these medications, for some paradoxical reason, increase the likelihood that people will become chronically ill, less able to function well, more prone to physical illness?  This is the first book to look at the merits of psychiatric medications through the prism of long-term results. Are long-term recovery rates higher for medicated or unmedicated schizophrenia patients? Does taking an antidepressant decrease or increase the risk that a depressed person will become disabled by the disorder? Do bipolar patients fare better today than they did forty years ago, or much worse? When the National Institute of Mental Health (NIMH) studied the long-term outcomes of children with ADHD, did they determine that stimulants provide any benefit?  By the end of this review of the outcomes literature, readers are certain to have a haunting question of their own: Why have the results from these long-term studies—all of which point to the same startling conclusion—been kept from the public?  In this compelling history, Whitaker also tells the personal stories of children and adults swept up in this epidemic. Finally, he reports on innovative programs of psychiatric care in Europe and the United States that are producing good long-term outcomes. Our nation has been hit by an epidemic of disabling mental illness, and yet, as Anatomy of an Epidemic reveals, the medical blueprints for curbing that epidemic have already been drawn up.

    Nixon had left the White House in disgrace, the nation was reeling from the catastrophe of Vietnam, and in 1979--the year the book appeared--Americans were being held hostage by Iranian militants. Yet it was exactly the anachronistic courage of his subjects that captivated Wolfe. In his foreword, he notes that as late as 1970, almost one in four career Navy pilots died in accidents. "The Right Stuff," he explains, "became a story of why men were willing--willing?--delighted!--to take on such odds in this, an era literary people had long since characterized as the age of the anti-hero." Wolfe's roots in New Journalism were intertwined with the nonfiction novel that Truman Capote had pioneered with In Cold Blood. As Capote did, Wolfe tells his story from a limited omniscient perspective, dropping into the lives of his "characters" as each in turn becomes a major player in the space program. After an opening chapter on the terror of being a test pilot's wife, the story cuts back to the late 1940s, when Americans were first attempting to break the sound barrier. Test pilots, we discover, are people who live fast lives with dangerous machines, not all of them airborne. Chuck Yeager was certainly among the fastest, and his determination to push through Mach 1--a feat that some had predicted would cause the destruction of any aircraft--makes him the book's guiding spirit. Yet soon the focus shifts to the seven initial astronauts. Wolfe traces Alan Shepard's suborbital flight and Gus Grissom's embarrassing panic on the high seas (making the controversial claim that Grissom flooded his Liberty capsule by blowing the escape hatch too soon). The author also produces an admiring portrait of John Glenn's apple-pie heroism and selfless dedication. By the time Wolfe concludes with a return to Yeager and his late-career exploits, the narrative's epic proportions and literary merits are secure. Certainly The Right Stuff is the best, the funniest, and the most vivid book ever written about America's manned space program. --Patrick O'Kelley