But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    It draws on all the latest knowledge from anthropology and archaeology, via genetics and evolution, to psychology and medicine. It tackles issues such as hereditary genes in criminal behaviour and homosexuality.

    

    Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    The authors capture students' interest with up-to-date coverage of cutting edge topics and research. This text will help students connect the science of genetics to the issues of today through interesting and thought-provoking applications. The sixth edition boasts the next generation of media integration including Gen CD-X (student CD-ROM and Companion Website).

    In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future. http://us.macmillan.com/missingmicrob...

    It encompasses lucid descriptions of behaviour, evolutionary history, development, proximate mechanisms and applications.

    And before there were fish in the sea, there were cephalopods - the ancestors of modern squid and Earth’s first truly substantial animals. Cephalopods became the first creatures to rise from the seafloor, essentially inventing the act of swimming. With dozens of tentacles and formidable shells, they presided over an undersea empire for millions of years. But when fish evolved jaws, the ocean’s former top predator became its most delicious snack. Cephalopods had to step up their game. Many species streamlined their shells and added defensive spines, but these enhancements only provided a brief advantage. Some cephalopods then abandoned the shell entirely, which opened the gates to a flood of evolutionary innovations: masterful camouflage, fin-supplemented jet propulsion, perhaps even dolphin-like intelligence. Squid Empire is an epic adventure spanning hundreds of millions of years, from the marine life of the primordial ocean to the calamari on tonight’s menu. Anyone who enjoys the undersea world—along with all those obsessed with things prehistoric—will be interested in the sometimes enormous, often bizarre creatures that ruled the seas long before the first dinosaurs.

    But Maurice Hilleman came close. Maurice Hilleman is the father of modern vaccines. Chief among his accomplishments are nine vaccines that practically every child gets, rendering formerly deadly diseases — including mumps, rubella, and measles — nearly forgotten. Author Paul A. Offit's rich and lively narrative details Hilleman's research and experiences as the basis for a larger exploration of the development of vaccines, covering two hundred years of medical history and traveling across the globe in the process. The history of vaccines necessarily brings with it a cautionary message, as they have come under assault from those insisting they do more harm than good. Paul Offit clearly and compellingly rebuts these arguments, and, by demonstrating how much the work of Hilleman and others has gained for humanity, shows us how much we have to lose.

    Shrouded in mystery, Gregor Mendel's quiet life and discoveries make for fascinating reading. Among his pea plants Henig finds a tale filled with intrigue, jealousy, and a healthy dose of bad timing. She "has done a remarkable job of fleshing out the myth with what few facts there are" (Washington Post Book World) and has delivered Mendel's story with grace and glittering prose. THE MONK IN THE GARDEN is both a "classic tale of redemption" (New York Times Book Review) and a science book of the highest literary order.

    Our Inheritance 2. Mendel and Genes 3. Genes and Chromosomes 4. The Search for the GeneDNA 5. DNA Structure and Replication 6. DNA Expression in Proteins 7. Genes, Enzymes, and Metabolism 8. From DNA to Protein 9. Genomes 10. Manipulating GenesRecombinant DNA 11. Isolating Genes and DNA 12. BiotechnologyGenetic Engineering 13. Biotechnology and the Environment 14. Manipulating DNA by PCR and Other Methods 15. DNA in IdentificationForensics 16. DNA and Evolution 17. DNA and Human Evolution 18. Molecular MedicineGenetic Screening 19. Molecular MedicineThe Immune System 20. Molecular MedicineCancer 21. Molecular MedicineGene Therapy 22. Molecular MedicineCloning and Stem Cells 23. Genetics and Agriculture 24. Biotechnology and Agriculture

    The stewards of Earth, these organisms transformed the chemistry of our planet to make it habitable for plants, animals, and us. Life's Engines takes readers deep into the microscopic world to explore how these marvelous creatures made life on Earth possible--and how human life today would cease to exist without them.Paul Falkowski looks "under the hood" of microbes to find the engines of life, the actual working parts that do the biochemical heavy lifting for every living organism on Earth. With insight and humor, he explains how these miniature engines are built--and how they have been appropriated by and assembled like Lego sets within every creature that walks, swims, or flies. Falkowski shows how evolution works to maintain this core machinery of life, and how we and other animals are veritable conglomerations of microbes.A vibrantly entertaining book about the microbes that support our very existence, Life's Engines will inspire wonder about these elegantly complex nanomachines that have driven life since its origin. It also issues a timely warning about the dangers of tinkering with that machinery to make it more "efficient" at meeting the ever-growing demands of humans in the coming century.

    But what happens when we take animal alteration a step further, engineering a cat that glows green under ultraviolet light or cloning the beloved family Labrador? Science has given us a whole new toolbox for tinkering with life. How are we using it?In Frankenstein's Cat, the journalist Emily Anthes takes us from petri dish to pet store as she explores how biotechnology is shaping the future of our furry and feathered friends. As she ventures from bucolic barnyards to a "frozen zoo" where scientists are storing DNA from the planet's most exotic creatures, she discovers how we can use cloning to protect endangered species, craft prosthetics to save injured animals, and employ genetic engineering to supply farms with disease-resistant livestock. Along the way, we meet some of the animals that are ushering in this astonishing age of enhancement, including sensor-wearing seals, cyborg beetles, a bionic bulldog, and the world's first cloned cat.Through her encounters with scientists, conservationists, ethicists, and entrepreneurs, Anthes reveals that while some of our interventions may be trivial (behold: the GloFish), others could improve the lives of many species-including our own. So what does biotechnology really mean for the world's wild things? And what do our brave new beasts tell us about ourselves?With keen insight and her trademark spunk, Anthes highlights both the peril and the promise of our scientific superpowers, taking us on an adventure into a world where our grandest science fiction fantasies are fast becoming reality.

    The latest studies are revealing exciting new discoveries, such as how the DNA and related chemical compounds in our cells work together to direct the processes of life. Scientists are not only unraveling how life evolved in the ancient past, but are also finding the keys to creating a healthier future.  How does the minuscule chemical cluster in each of our 100 trillion cells accomplish the amazing feat of creating and maintaining our bodies? Frank Ryan, a physician and an evolutionary biologist, describes the complex ways in which the genome operates as a holistic system and not solely through genes coding for proteins—the building blocks of life. Also involved are elaborate switching mechanisms that regulate and control portions of our DNA, as well as the interplay of retroviruses and bacteria.This groundbreaking book explains that we are on the cusp of an amazing era of disease treatment and eradication.

    What is wrong with re-engineering our nature? 'The Case Against Perfection' explores these and other moral quandaries connected with the quest to perfect ourselves and our children.