But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    

    That was ok, as all her friends were, too. But she had an important event to budget for, just a year away. One drunken night, she made a rash decision: to live on just a pound a day for the next twelve months. This book tells her story.

    Travel with him as he chaperones three out-of-control child actors as they barnstorm Japan, almost drowns actress Catherine Keener in her first film role, and transforms a short story about Elvis Presley battling a four thousand year-old Egyptian mummy into a beloved cult classic film.Witness the incredible cast of characters he meets along the way from heavy metal god Ronnie James Dio to first-time filmmakers Quentin Tarantino and Roger Avary. Learn how breaking bread with genre icons Tobe Hooper, John Carpenter and Guillermo Del Toro leads to a major cable series and watch as he and zombie king George A. Romero together take over an unprepared national network television show with their tales of blood and horror.This memoir fits an entire film school education into a single book. It's loaded with behind-the-scenes stories: like setting his face on fire during the making of Phantasm, hearing Bruce Campbell's most important question before agreeing to star in Bubba Ho-tep, and crafting a horror thriller into a franchise phenomenon spanning four decades. Find out how Coscarelli managed to retain creative and financial control of his artistic works in an industry ruled by power-hungry predators, and all without going insane or bankrupt.True Indie will prove indispensable for fans of Coscarelli's movies, aspiring filmmakers, and anyone who loves a story of an underdog who prevails while not betraying what he believes.

    Before being united with Haatchi, Little B was anxious and found it difficult to make friends.Haatchi-an adorable Anatolian Shepherd puppy-was abused and left for dead on railroad tracks. He was struck by an oncoming train, and although his life was saved, his leg and tail were partially severed. Haatchi was left massively disabled and totally dispirited.But kind-hearted Will and Colleen Howkins, Little B's father and step-mother, decided to introduce the big dog and the little boy to each other, and an unbelievable bond was formed that transformed both boy and dog in miraculous ways.Wendy Holden's Haatchi & Little B is the true story of an astonishing little boy, a very special dog, and the inspiring, inseparable pair that they make together.

      Watching the sailboats on the Hudson River during his sunset dinner breaks, Erik dared to dream. What would it be like to leave the hustle of the city and instead spend a year on a sailboat, somewhere beautiful, as a family? Despite having no sailing experience, his wife Emily’s phobia of deep water, and already stretching every dollar to pay rent and buy groceries, the family of seven turned their excuses into reasons and their fears into motivation. Sure, they would miss their friends, they could go broke, they could get injured or die. Worst of all, they could humiliate themselves by trying something audacious and failing. But the little time they still had together as a family, before their oldest daughter left for college, was drifting away. The Ortons cast off the life they knew to begin an uncertain journey of 5,000 miles between New York City and the Caribbean, ultimately arriving at a new place within themselves.   A portrait of a captivating and resilient family and a celebration of the courage it takes to head for something over the horizon, this is a deeply compelling story—told alternately by Erik and Emily—for all those who dream of leaving routine in their wake.

    With exclusive insights from their friends, families, teammates and managers – including interviews with managers Luiz Felipe Scolari and Vicente del Bosque – Caioli presents a unique insight into what makes a modern player not just successful, but truly great.

    Wiggling out of every predicament in unique and unexpected ways, this poet-jester reminds us of Birbal at the court of Akbar. Read his tales and laugh with joy even as his plain common sense leaves you gasping.

    Blake Gopnik's definitive biography digs deep into the contradictions and radical genius that led Andy Warhol to revolutionise our cultural world.Based on years of archival research and on interviews with hundreds of Warhol's surviving friends, lovers and enemies, Warhol traces the artist's path from his origins as the impoverished son of Eastern European immigrants in 1930s Pittsburgh, through his early success as a commercial illustrator and his groundbreaking pivot into fine art, to the society portraiture and popular celebrity of the '70s and '80s, as he reflected and responded to the changing dynamics of commerce and culture.Warhol sought out all the most glamorous figures of his times - Susan Sontag, Mick Jagger, the Barons de Rothschild - despite being burdened with an almost crippling shyness. Behind the public glitter of the artist's Factory, with its superstars, drag queens and socialites, there was a man who lived with his mother for much of his life and guarded the privacy of his home. He overcame the vicious homophobia of his youth to become a symbol of gay achievement, while always seeking the pleasures of traditional romance and coupledom. (Warhol explodes the myth of his asexuality.)Filled with new insights into the artist's work and personality, Warhol asks: Was he a joke or a genius, a radical or a social climber? As Warhol himself would have answered: Yes.

    Many of these stories never made it back home - until now.

     Less than a fortnight after a terrorist killed twenty-two people at her Manchester show, the petite princess stood tall at her tribute concert that united and healed a shaken nation. She was the emotional core of a powerful evening that reminded us all of music's redemptive power.But who is Ariana Grande? This candid book traces the US pop star's story from her childhood in Florida, through her teenage years on Broadway and Nickelodeon, and onto her gleaming pop career which has seen her described as 'the new Mariah Carey'. The only biography of the songbird, it tells her eventful and inspirational story in full for the first time, and shows how she became an award-winning, chart-topping pop idol, as well as an empowering inspiration for a generation of girls. It reveals that there is more to Ariana than the celebrity we all think we know, explaining how her smooth transition from a squeaky-clean teenage pop product to a sophisticated, bold artist was powered by a restless and resilient personality. A must read for all her fans, this is a full, unflinching portrait of a pop sensation and inspiring, uncompromising woman - the small, sassy girl with the ponytail who conquered the world.

    Brave enough to confront the most vicious of demons, and strong enough to destroy them every time, he unfortunately could not conquer his own pride. Foolishly, he turned his adoring brother, Sugreeva, into a mortal enemy and drove him to take the help of that supreme warrior, the mighty Lord Rama.

    Gifted Hands will transplace you into the operating room to witness surgeries that made headlines around the world, and into the private mind of a compassionate, God-fearing physician who lives to help others. In 1987, Dr. Carson gained worldwide recognition for his part in the first successful separation of Siamese twins joined at the back of the head -- an extremely complex and delicate operation that was five months of planning and twenty-two hours of actual surgery, involving a surgical plan that Carson helped initiate. Gifted Hands reveals a man with humility, decency, compassion, courage, and sensitivity who serves as a role model for young people (and everyone else) in need of encouragement to attempt the seemingly impossible and to excel in whatever they attempt. Dr. Carson also describes the key role that his highly intelligent though relatively uneducated mother played in his metamorphosis from an unmotivated ghetto youngster into one of the most respected neurosurgeons in the world.

    A Harvard-trained Palestinian doctor who was born and raised in the Jabalia refugee camp in the Gaza Strip and "who has devoted his life to medicine and reconciliation between Israelis and Palestinians" (New York Times), Abuelaish has been crossing the lines in the sand that divide Israelis and Palestinians for most of his life - as a physician who treats patients on both sides of the line, as a humanitarian who sees the need for improved health and education for women as the way forward in the Middle East. And, most recently, as the father whose daughters were killed by Israeli soldiers on January 16, 2009, during Israel's incursion into the Gaza Strip. His response to this tragedy made news and won him humanitarian awards around the world. Instead of seeking revenge or sinking into hatred, Abuelaish called for the people in the region to start talking to each other. His deepest hope is that his daughters will be "the last sacrifice on the road to peace between Palestinians and Israelis."

    Following their vision of comfortable, fitted T-shirts, they set up shop in Gela’s one-bedroom Hollywood apartment with $200 and one rule: Whatever they did, they both had to be obsessed by it. The best friends’ project became Juicy Couture. Pam and Gela eventually sold their company to Liz Claiborne for $50 million, but not before they created a whole new genre of casual clothing that came to define California cool.   Pamela and Gela built an empire from the ground up, using themselves as models to build their patterns and placing their merchandise by storming into stores and handing out samples. They balanced careful growth with innovative tactics—sending Madonna a tracksuit with her nickname, Madge, embroidered on it—and created a unique, bold, and unconventional business plan that was all their own: the Glitter Plan.   Now, Pam and Gela reveal the secrets of Juicy’s success: how they learned to find and stick with the right colleagues and trust their instincts when it became time to move on to their next project. They also share their missteps and hilarious lessons learned—like the time robbers stole one thousand pairs of maternity shortalls, which the partners took as the first sign to get out of the maternity clothing business.   Told in the bright, cheery voice that defines Juicy style even today, The Glitter Plan shows readers how to transform passion and ideas into business success. Aspiring designers, Juicy fans, and business readers of all stripes will be enthralled by the story of spirit and savvy behind Pam and Gela’s multimillion-dollar fashion empire.