Nuland tells the strange story of Ignác Semmelweis with urgency and the insight gained from his own studies and clinical experience. Ignác Semmelweis is remembered for the now-commonplace notion that doctors must wash their hands before examining patients. In mid-nineteenth-century Vienna, however, this was a subversive idea. With deaths from childbed fever exploding, Semmelweis discovered that doctors themselves were spreading the disease. While his simple reforms worked immediately—childbed fever in Vienna all but disappeared—they brought down upon Semmelweis the wrath of the establishment, and led to his tragic end.

    It proved fatal to at least a half-million Americans. Yet, the Spanish flu pandemic is largely forgotten today. In this vivid narrative, Alfred W. Crosby recounts the course of the pandemic during the panic-stricken months of 1918 and 1919, measures its impact on American society, and probes the curious loss of national memory of this cataclysmic event. In a new edition, with a new preface discussing the recent outbreaks of diseases, including the Asian flu and the SARS epidemic, America's Forgotten Pandemic remains both prescient and relevant. Alfred W. Crosby is a Professor Emeritus in American Studies, History and Geography at the University of Texas at Austin, where he taught for over 20 years. His previous books include Throwing Fire (Cambrige, 2002), the Measure of Reality (Cambridge, 1997) and Ecological Imperialism (cambridge, 1986). Ecological Imperialism was the winner of the 1986 Phi Beta Kappa book prize. The Measure of Reality was chosen by the Los Angeles Times as one of the 100 most important books of 1997.

    Richard Rhodes follows virus hunters on three continents as they track the emergence of a deadly new brain disease that first kills cannibals in New Guinea, then cattle and young people in Britain and France—and that has already been traced to food animals in the United States. In a new afterword for the paperback, Rhodes reports the latest US and worldwide developments of a burgeoning global threat.

    The lifesaving serum was a thousand miles away, the port was icebound, and planes couldn't fly in blizzard conditions—only the dogs could make it. The heroic dash of dog teams across the Alaskan wilderness to Nome inspired the annual Iditarod Trail Sled Dog Race and immortalized Balto, the lead dog of the last team whose bronze statue still stands in New York City's Central Park. This is the greatest dog story, never fully told until now.

    Forty-five million called him emperor, and he commanded a nation that was the richest, most cultured, and advanced on earth. No army could stand against his impeccably trained, brilliantly led forces, and his continued sweep across Europe seemed inevitable. Early that year, bolstered by his successes, Napoleon turned his attentions toward Moscow, helming the largest invasion in human history. Surely, Tsar Alexander’s outnumbered troops would crumble against this mighty force. But another powerful and ancient enemy awaited Napoleon’s men in the Russian steppes. Virulent and swift, this microscopic foe would bring the emperor to his knees. Even as the Russians retreated before him in disarray, Napoleon found his army disappearing, his frantic doctors powerless to explain what had struck down a hundred thousand soldiers. The emperor’s vaunted military brilliance suddenly seemed useless, and when the Russians put their own occupied capital to the torch, the campaign became a desperate race through the frozen landscape as troops continued to die by the thousands. Through it all, with tragic heroism, Napoleon’s disease-ravaged, freezing, starving men somehow rallied, again and again, to cries of “Vive l’Empereur!”Yet Talty’s sweeping tale takes us far beyond the doomed heroics and bloody clashes of the battlefield. The Illustrious Dead delves deep into the origins of the pathogen that finally ended the mighty emperor’s dreams of world conquest and exposes this “war plague’s” hidden role throughout history. A tale of two unstoppable forces meeting on the road to Moscow in an epic clash of killer microbe and peerless army, The Illustrious Dead is a historical whodunit in which a million lives hang in the balance.

    Result: The world's first vaccine. Experiment: A slave woman is forced to undergo more than thirty operations without anesthesia. Result: The beginnings of modern gynecology. Experiment: From 1946 to 1953, seventy-four boys are fed oatmeal laced with radioactive iron and calcium. Result: A better understanding of the effects of radioactivity on the human body. Experimental incidents such as these paved the way for crucial medical discoveries and lifesaving cures and procedures. But they also violated the rights of their subjects, many of whom did not give their consent to the experiments. The subjects suffered excruciating pain and humiliation. Some even died as a result of the procedures. Even in the twenty-first century—despite laws, regulations, and ethical conventions—the tension between medical experimentation and patient rights continues. How do doctors balance the need to test new medicines and procedures with their ethical and moral duty to protect the rights of human subjects? What price has been paid for medical knowledge? Can we learn from the broken oaths of the past? Take a harrowing journey through some of history's greatest medical advances—and its most horrifying medical atrocities. You'll read about orphans injected with lethal tuberculosis and concentration camp inmates tortured by Nazi doctors. You’ll also learn about radiation experimentation and present-day clinical trials that prove fatal. Through these stories, explore the human suffering that has gone hand in hand with medical advancement.

    But it’s hardly surprising considering how long it’s had to hone its skills. Forty-thousand years ago, our ancestors set off from the cradle of civilization on their journey towards populating the planet. Tuberculosis hitched a lift and came with us, and it’s been there ever since; waiting, watching, and learning. The organism responsible, Mycobacterium tuberculosis, has had plenty of time to adapt to its chosen habitat--human lungs--and has learned through natural selection to be an almost perfect pathogen. Using our own immune cells as a Trojan Horse to aid its spread, it’s come up with clever ways to avoid being killed by antibiotics. But patience has been its biggest lesson--it can enter into a latent state when times are tough, only to come back to life when a host’s immune system is compromised. Today, more than one million people die of the disease every year and around one-third of the world’s population are believed to be infected. That’s more than two billion people. Throw in the compounding problems of drug resistance, the HIV epidemic, and poverty, and it’s clear that tuberculosis remains one of the most serious problems in world medicine. Catching Breath follows the history of TB through the ages, from its time as an infection of hunter-gatherers to the first human villages, which set it up with everything it needed to become the monstrous disease it is today, through to the perils of industrialization and urbanization. It goes on to look at the latest research in fighting the disease, with stories of modern scientific research, interviews with doctors on the TB frontline, and the personal experiences of those affected by the disease.

    Complications lays bare a science not in its idealized form but as it actually is--uncertain, perplexing, and profoundly human.Complications is a 2002 National Book Award Finalist for Nonfiction.

    But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them.   A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.

    She also reveals her personal odyssey through the land of Lyme after she, her husband and their two sons became seriously ill with the disease beginning in the 1990s. From the microbe causing the infection and the definition of the disease, to the length and type of treatment and the kind of practitioner needed, Lyme is a hotbed of contention. With a CDC-estimated 200,000-plus new cases of Lyme disease a year, it has surpassed both AIDS and TB as the fastest-spreading infectious disease in the U.S. Yet alarmingly, in many cases, because the disease often eludes blood tests and not all patients exhibit the classic "bulls-eye" rash and swollen joints, doctors are woefully unable or unwilling to diagnose Lyme. When that happens, once-treatable infections become chronic, inexorably disseminating to cause disabling conditions that may never be cured. Weintraub reveals why the Lyme epidemic has been allowed to explode, why patients are dismissed, and what can be done to raise awareness in the medical community and find a cure. The most comprehensive book ever written about the past, present and future of Lyme disease, this exposes the ticking clock of a raging epidemic.

    Entering a room with stainless-steel tables topped by corpses in body bags is shocking no matter how long you've prepared yourself, but a strange thing happened when Montross met her cadaver. Instead of being disgusted by her, she was utterly intrigued-intrigued by the person the woman once was, humbled by the sacrifice she had made in donating her body to science, fascinated by the strange, unsettling beauty of the human form. They called her Eve. This is the story of Montross and Eve-the student and the subject-and the surprising relationship that grew between them. Body of Work is a mesmerizing, rarely seen glimpse into the day-to-day life of a medical student-yet one that follows naturally in the footsteps of recent highly successful literary renderings of the mysteries of medicine such as Atul Gawande's Complications: A Surgeon's Notes on an Imperfect Science. Christine Montross was a poet long before she became a doctor and brings an uncommon perspective to the emotional difficulty of the first year of medical school-the dispiriting task of remaining clinical and detached while in the anatomy lab and the struggle with the line you've crossed by violating another's body once you leave it. Montross was so affected by her experience with Eve that she undertook to learn more about the history of cadavers and the study of anatomy. She visited an autopsy lab in Ireland and the University of Padua in Italy where Vesalius, a forefather of anatomy, once studied; she learned about body snatchers and grave-robbers and anatomists who practiced their work on live criminals. Her disturbing, often entertaining anecdotes enrich this exquisitely crafted memoir, endowing an eerie beauty to the world of a doctor-in-training. Body of Work is an unforgettable examination of the mysteries of the human body and a remarkable look at our relationship with both the living and the dead.

    She shows how the stalling of early twentieth century efforts in this direction allowed Freudians and social scientists to insist, with some justification, that they had better ways of analyzing and fixing minds.But when the Freudians overreached, they drove psychiatry into a state of crisis that a new “biological revolution” was meant to alleviate. Harrington shows how little that biological revolution had to do with breakthroughs in science, and why the field has fallen into a state of crisis in our own time.Mind Fixers makes clear that psychiatry’s waxing and waning biological enthusiasms have been shaped not just by developments in the clinic and lab, but also by a surprising range of social factors, including immigration, warfare, grassroots activism, and assumptions about race and gender. Government programs designed to empty the state mental hospitals, acrid rivalries between different factions in the field, industry profit mongering, consumerism, and an uncritical media have all contributed to the story as well.In focusing particularly on the search for the biological roots of schizophrenia, depression, and bipolar disorder, Harrington underscores the high human stakes for the millions of people who have sought medical answers for their mental suffering. This is not just a story about doctors and scientists, but about countless ordinary people and their loved ones.A clear-eyed, evenhanded, and yet passionate tour de force, Mind Fixers recounts the past and present struggle to make mental illness a biological problem in order to lay the groundwork for creating a better future, both for those who suffer and for those whose job it is to care for them.

    But it took a team of Oxford scientists headed by Howard Florey and Ernst Chain four more years to develop it as the first antibiotic, and the most important family of drugs in the twentieth century. At once the world was transformed—major bacterial scourges such as blood poisoning and pneumonia, scarlet fever and diphtheria, gonorrhea and syphilis were defeated as penicillin helped to foster not only a medical revolution but a sexual one as well. In his wonderfully engaging book, acclaimed author Eric Lax tells the real story behind the discovery and why it took so long to develop the drug. He reveals the reasons why credit for penicillin was misplaced, and why this astonishing achievement garnered a Nobel Prize but no financial rewards for Alexander Fleming, Florey, and his team. The Mold in Dr. Florey’s Coat is the compelling story of the passage of medicine from one era to the next and of the eccentric individuals whose participation in this extraordinary accomplishment has, until now, remained largely unknown.

    Lyme disease, and SARS. According to Walters, we are not only victims of these emerging diseases; we are helping exacerbate their creation and spread.

    In July 1518 a terrifying and mysterious plague struck the medieval city of Strasbourg. Hundreds of men and women danced wildly, day after day, in the punishing summer heat. They did not want to dance, but could not stop. Throughout August and early September more and more were seized by the same terrible compulsion. By the time the epidemic subsided, heat and exhaustion had claimed an untold number of lives, leaving thousands bewildered and bereaved, and an enduring enigma for future generations. Drawing on fresh evidence, John Waller's account of the bizarre events of 1518 explains why Strasbourg's dancing plague took place. In doing so it leads us into a largely vanished world, evoking the sights, sounds, aromas, diseases and hardships, the fervent supernaturalism, and the desperate hedonism of the late medieval world. At the same time, the extraordinary story this book tells offers rich insights into how people behave when driven beyond the limits of endurance. Above all, this is an exploration into the strangest capabilities of the human mind and the extremes to which fear and irrationality can lead us.