As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    In this extraordinary memoir, she opens a window into the experience of wordlessness—the language paralysis called aphasia. In narrating the recovery of her husband, Paul West, from a stroke that reduced his vast vocabulary to a single syllable, she evokes the joy and mystery of the brain’s ability to find and connect words. Deeply rewarding to readers of all kinds, Ackerman has given us a literary love story, accessible insight into the science and medicine of brain injury,and invaluable spiritual sustenance in the face of life’s myriad physical sufferings.

    Throughout the time he was creating his greatest work, Steinbeck faithfully kept a journal revealing his arduous journey toward its completion.The journal, like the novel it chronicles, tells a tale of dramatic proportions—of dogged determination and inspiration, yet also of paranoia, self-doubt, and obstacles. It records in intimate detail the conception and genesis of The Grapes of Wrath and its huge though controversial success. It is a unique and penetrating portrait of an emblematic American writer creating an essential American masterpiece.

    This critically acclaimed biography offers an unprecedented look at William Masters and Virginia Johnson, their pioneering studies on intimacy, and their lasting impact on the love lives of today's men and women.

    Recounts stories from her vast case files that are alternately terrifying, tragically comic, and profoundly moving, all while she deals with her best friend and fellow doctor's fight with cancer.

    Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.When Death Becomes Life is a thrilling look at how science advances on a grand scale to improve human lives. Mezrich examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the inspiring and heartbreaking stories of his transplant patients. Combining gentle sensitivity with scientific clarity, Mezrich reflects on his calling as a doctor and introduces the modern pioneers who made transplantation a reality—maverick surgeons whose feats of imagination, bold vision, and daring risk taking generated techniques and practices that save millions of lives around the world.Mezrich takes us inside the operating room and unlocks the wondrous process of transplant surgery, a delicate, intense ballet requiring precise timing, breathtaking skill, and at times, creative improvisation. In illuminating this work, Mezrich touches the essence of existence and what it means to be alive. Most physicians fight death, but in transplantation, doctors take from death. Mezrich shares his gratitude and awe for the privilege of being part of this transformative exchange as the dead give their last breath of life to the living. After all, the donors are his patients, too.When Death Becomes Life also engages in fascinating ethical and philosophical debates: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? What defines death, and what role did organ transplantation play in that definition? The human story behind the most exceptional medicine of our time, Mezrich’s riveting book is a beautiful, poignant reminder that a life lost can also offer the hope of a new beginning.

    No money. No passport. No identity.Taken to a mental hospital by the police, MacLean then started to hallucinate so severely he had to be tied down. Soon he could remember song lyrics, but not his family, his friends, or the woman he was told he loved. All of these symptoms, it turned out, were the result of the commonly prescribed malarial medication he had been taking. Upon his return to the States, he struggled to piece together the fragments of his former life in a harrowing, absurd, and unforgettable journey back to himself.The Answer to the Riddle Is Me, drawn from David MacLean’s award-winning This American Life essay, is a deeply felt, closely researched, and intensely personal book. It asks every reader to confront the essential questions of our age: In our geographically and chemically fluid world, what makes me who I am? And how much can be stripped away before I become someone else entirely?

    Here, for the first time, in all its shocking, funny and downright bizarre glory, is the truth of the Olympic experience.It is an unimaginable world: the kitting-out ceremony with its 35kg of team clothing per athletethe pre-Olympic holding camp with its practical jokes, resentment and fighting, and freaky physiological regimesthe politicians' visits with their flirty spousesthe vast range of athletes with their odd body shapes and freakish geneticsthe release post-competion in the Olympic village with all the excessive drinking, eating, partying and sex (not necessarily in that order)the hysteria of homecoming celebrations and the comedown that follows - how do you adjust to life after the Games?The Secret Olympian talks to scores of Olympic athletes - past and present, from Munich 1960 right through to London 2012, including British, American, Australian, Dutch, French, Croatian, German, Canadian and Italian competitors. They all have a tale to tell - and most of those tales would make your eyes pop more than an Olympic weightlifter's.

    (Women who leave wet teaspoons in sugar bowls need not apply)."I haven't woken up with a cup of tea by the bed for seven years. It seems such a small thing but it's one of a thousand things I miss about having someone around to take care of me. I have spent my entire adult life getting things the way I want them and all I want now is someone to give it all up for." Jon RichardsonIs your filing faultless? Your CDs, apostrophes, cutlery all in the right places? Can you eat a biscuit in the correct way? Then Jon Richardson (single for seven years and counting) could be your ideal man.Living alone in a one bedroom flat in Swindon, 27 year old Jon has had far too much time on his hands to think. In fact to obsess. About almost everything. Jon's obsessive compulsive personality disorder has seen him arrange the coins in his pockets in ascending size and colour code his bookshelves. It takes him less than 90 seconds to locate a receipt for a pair of shoes he bought in 1997. Over to the filing cabinet and R for receipts, S for shoes.But Jon doesn't want to be like this, in fact he would quite like to share his life with someone. But who could that someone be? Someone like himself, a quarrelsome perfectionist only with breasts and less body hair? Absolutely not. But who exactly is Jon looking for and where will he find her? Faced with a loveless future filled with his own peculiar quirks and perfectionism, Jon sets about his search for The One. The question is, will he mind her keeping the knives to the left of the forks in the cutlery drawer or organising the CDs by genre and not alphabetically?

    She had fallen in love and moved to Paris to pursue her dream of becoming a war correspondent. The real world she found, however, would take her into a very different kind of conflict zone.It started with an itch—first on her feet, then up her legs, like a thousand invisible mosquito bites. Next came the exhaustion, and the six-hour naps that only deepened her fatigue. Then a trip to the doctor and, a few weeks shy of her twenty-third birthday, a diagnosis: leukemia, with a 35 percent chance of survival. Just like that, the life she had imagined for herself had gone up in flames. By the time Jaouad flew home to New York, she had lost her job, her apartment, and her independence. She would spend much of the next four years in a hospital bed, fighting for her life and chronicling the saga in a column for The New York Times.When Jaouad finally walked out of the cancer ward—after three and a half years of chemo, a clinical trial, and a bone marrow transplant—she was, according to the doctors, cured. But as she would soon learn, a cure is not where the work of healing ends; it’s where it begins. She had spent the past 1,500 days in desperate pursuit of one goal—to survive. And now that she’d done so, she realized that she had no idea how to live.How would she reenter the world and live again? How could she reclaim what had been lost? Jaouad embarked—with her new best friend, Oscar, a scruffy terrier mutt—on a 100-day, 15,000-mile road trip across the country. She set out to meet some of the strangers who had written to her during her years in the hospital: a teenage girl in Florida also recovering from cancer; a teacher in California grieving the death of her son; a death-row inmate in Texas who’d spent his own years confined to a room. What she learned on this trip is that the divide between sick and well is porous, that the vast majority of us will travel back and forth between these realms throughout our lives. Between Two Kingdoms is a profound chronicle of survivorship and a fierce, tender, and inspiring exploration of what it means to begin again.

    Into this crisis stepped Walter Freeman, M.D., who saw a solution in lobotomy, a brain operation intended to reduce the severity of psychotic symptoms. Drawing on Freeman’s documents and interviews with Freeman's family, Jack El-Hai takes a penetrating look at the life and work of this complex scientific genius.The Lobotomist explores one of the darkest chapters of American medicine: the desperate attempt to treat the hundreds of thousands of psychiatric patients in need of help during the middle decades of the twentieth century. Into this crisis stepped Walter Freeman, M.D., who saw a solution in lobotomy, a brain operation intended to reduce the severity of psychotic symptoms. Although many patients did not benefit from the thousands of lobotomies Freeman performed, others believed their lobotomies changed them for the better. Drawing on a rich collection of documents Freeman left behind and interviews with Freeman's family, Jack El-Hai takes a penetrating look into the life of this complex scientific genius and traces the physician's fascinating life and work.

    Yet, despite the astonishing discoveries of science, we still have only the vaguest idea of how the brain works. In The Idea of the Brain, scientist and historian Matthew Cobb traces how our conception of the brain has evolved over the centuries. Although it might seem to be a story of ever-increasing knowledge of biology, Cobb shows how our ideas about the brain have been shaped by each era's most significant technologies. Today we might think the brain is like a supercomputer. In the past, it has been compared to a telegraph, a telephone exchange, or some kind of hydraulic system. What will we think the brain is like tomorrow, when new technology arises? The result is an essential read for anyone interested in the complex processes that drive science and the forces that have shaped our marvelous brains.

    In that short time, many doctors decide on the likely diagnosis and best treatment. Often, decisions made this way are correct, but at crucial moments they can also be wrong -- with catastrophic consequences. In this myth-shattering book, Jerome Groopman pinpoints the forces and thought processes behind the decisions doctors make. Groopman explores why doctors err and shows when and how they can -- with our help -- avoid snap judgments, embrace uncertainty, communicate effectively, and deploy other skills that can profoundly impact our health. This book is the first to describe in detail the warning signs of erroneous medical thinking and reveal how new technologies may actually hinder accurate diagnoses. How Doctors Think offers direct, intelligent questions patients can ask their doctors to help them get back on track.Groopman draws on a wealth of research, extensive interviews with some of the country’s best doctors, and his own experiences as a doctor and as a patient. He has learned many of the lessons in this book the hard way, from his own mistakes and from errors his doctors made in treating his own debilitating medical problems.How Doctors Think reveals a profound new view of twenty-first-century medical practice, giving doctors and patients the vital information they need to make better judgments together.

    Now, at last, the man himself tells us the story of life in the crossfire hurricane.

    Robert Marion asked three of them to keep a careful diary over the course of a year. Andy, Mark, and Amy vividly describe their real-life lessons in treating very sick children; confronting child abuse and the awful human impact of the AIDS epidemic; skirting the indifference of the hospital bureaucracy; and overcoming their own fears, insecurities, and constant fatigue. Their stories are harrowing and often funny; their personal triumph is unforgettable.This updated edition of The Intern Blues includes a new preface from the author discussing the status of medical training in America today and a new afterword updating the reader on the lives of the three young interns who first shared their stories with readers more than a decade ago.