The Regency (1811–1820) began when the profligate Prince of Wales—the future king George IV—replaced his insane father, George III, as Britain’s ruler.Around the regent surged a society steeped in contrasts: evangelicalism and hedonism, elegance and brutality, exuberance and despair. The arts flourished at this time with a showcase of extraordinary writers and painters such as Jane Austen, Lord Byron, the Shelleys, John Constable, and J. M. W. Turner. Science burgeoned during this decade, too, giving us the steam locomotive and the blueprint for the modern computer.Yet the dark side of the era was visible in poverty, slavery, pornography, opium, and the gothic imaginings that birthed the novel Frankenstein. With the British military in foreign lands, fighting the Napoleonic Wars in Europe and the War of 1812 in the United States, the desire for empire and an expanding colonial enterprise gained unstoppable momentum. Exploring these crosscurrents, Robert Morrison illuminates the profound ways this period shaped and indelibly marked the modern world.

    A slip of the hand and life ebbs away.The balance between life and death is so delicate, and the heart surgeon walks that rope between the two. In the operating room there is no time for doubt. It is flesh, blood, rib-retractors and pumping the vital organ with your bare hand to squeeze the life back into it. An off-day can have dire consequences – this job has a steep learning curve, and the cost is measured in human life. Cardiac surgery is not for the faint of heart.Professor Stephen Westaby took chances and pushed the boundaries of heart surgery. He saved hundreds of lives over the course of a thirty-five year career and now, in his astounding memoir, Westaby details some of his most remarkable and poignant cases – such as the baby who had suffered multiple heart attacks by six months old, a woman who lived the nightmare of locked-in syndrome, and a man whose life was powered by a battery for eight years.A powerful, important and incredibly moving book, Fragile Lives offers an exceptional insight into the exhilarating and sometimes tragic world of heart surgery, and how it feels to hold someone’s life in your hands.

    Michael Mosley'This book is marvellous: buy it, share it, recommend it.... We are fortunate to have dedicated, caring and humble folks such as Doc Morgan on the Critical Care front line. We are even better off when a writer can capture all that this exciting, mad, glorious and even exasperating job means. If you work in healthcare, know somebody that does, or simply inhabit a body then this book is for you: in fact it's critical.' Peter Brindley, Professor of Critical Care Medicine, Anesthesiology, Medical Ethics University of Alberta'Just wonderful. I love the exploration of what it means to survive, at what cost and so on. Such an important factor and it's a real problem with what we do. An old surgeon once told me ‘just because we can, doesn’t mean we should. Operating is the easiest thing in the world, not doing so is incredibly challenging’. A lovely book.' Dr Nikki Stamp FRACS Cardiothoracic and Transplant Surgeon and author of Can You Die of a Broken Heart?‘An illuminating, compassionate insight into the fascinating world of intensive care.’ Leah Hazzard, author of Hard PushedCritical is an intelligent, compelling and profoundly insightful journey into the world of intensive care medicine and the lives of people who have forever been changed by it. Being critically ill means one or more of your vital organs have failed – this could be your lungs, your heart, your kidneys, gut or even your brain. Starting with the first recognised case in which a little girl was saved by intensive care in 1952 in Copenhagen, Matt writes brilliantly about the fascinating history, practices and technology in this newest of all the major medical specialties. Matt guides us around the ICU by guiding us around the body and the different organs, and in this way, we learn not only the stories of many of the patients he’s treated over the years, but also about the various functions different parts of the body.   He draws on his time spent with real patients, on the brink of death, and explains how he and his colleagues fight against the odds to help them live. Happily many of his cases have happy endings, but Matt also writes movingly about those cases which will always remain with him – the cases where the mysteries of the body proved too hard to solve, or diagnoses came too late or made no difference to the outcome.

    Otto’s subjects include the pioneering dentist who made Shirley Temple and Judy Garland’s teeth sparkle on the silver screen and helped create the all-American image of “pearly whites”; Deamonte Driver, the young Maryland boy whose tragic death from an abscessed tooth sparked congressional hearings; and a marketing guru who offers advice to dentists on how to push new and expensive treatments and how to keep Medicaid patients at bay.In one of its most disturbing findings, Teeth reveals that toothaches are not an occasional inconvenience, but rather a chronic reality for millions of people, including disproportionate numbers of the elderly and people of color. Many people, Otto reveals, resort to prayer to counteract the uniquely devastating effects of dental pain.Otto also goes back in time to understand the roots of our predicament in the history of dentistry, showing how it became separated from mainstream medicine, despite a century of growing evidence that oral health and general bodily health are closely related.Muckraking and paradigm-shifting, Teeth exposes for the first time the extent and meaning of our oral health crisis. It joins the small shelf of books that change the way we view society and ourselves—and will spark an urgent conversation about why our teeth matter.This is an alternate cover edition of ISBN 9781620971444.

    Richard Davenport-Hines, an eminent, prize-winning historian, uncovers the centrality of drug abuse in our modern industrial society, from the drug habits of Charles Dickens and John F. Kennedy to today's $400 billion annual worldwide trade in illicit drugs (the same volume as the oil industry). A vivid portrayal of the people and events that have shaped the history of narcotics, The Pursuit of Oblivion reveals that, contrary to the assumption underlying current drug policies, our need to escape reality and our body's need for physical pleasure are both ineradicable aspects of our humanity, unchangeable by government initiative.

    In addition to offering a clear-eyed explanation of the root causes of this insidious and entrenched bias and laying out its effects, she suggests concrete steps we can take to cure it.

    Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities. . . .But, Zimmer writes, "Each of us carries an amalgam of fragments of DNA, stitched together from some of our many ancestors. Each piece has its own ancestry, traveling a different path back through human history. A particular fragment may sometimes be cause for worry, but most of our DNA influences who we are--our appearance, our height, our penchants--in inconceivably subtle ways." Heredity isn't just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors--using a word that once referred to kingdoms and estates--but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable. We need a new definition of what heredity is and, through Carl Zimmer's lucid exposition and storytelling, this resounding tour de force delivers it. Weaving historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world's best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies, but also long-standing presumptions about who we really are and what we can pass on to future generations.

    In the early 1800s, women were dying in large numbers from treatable diseases because they avoided receiving medical care. Examinations performed by male doctors were often demeaning and even painful. In addition, women faced stigma from illness—a diagnosis could greatly limit their ability to find husbands, jobs or be received in polite society.Motivated by personal loss and frustration over inadequate medical care, Elizabeth Blackwell, Elizabeth Garrett Anderson and Sophia Jex-Blake fought for a woman’s place in the male-dominated medical field. For the first time ever, Women in White Coats tells the complete history of these three pioneering women who, despite countless obstacles, earned medical degrees and paved the way for other women to do the same. Though very different in personality and circumstance, together these women built women-run hospitals and teaching colleges—creating for the first time medical care for women by women.With gripping storytelling based on extensive research and access to archival documents, Women in White Coats tells the courageous history these women made by becoming doctors, detailing the boundaries they broke of gender and science to reshape how we receive medical care today.

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    This alarmed authorities, who feared certain "over-sexed" women could destroy civilization if allowed to reproduce and pass on their defects. Set against this backdrop, The Unfit Heiress chronicles the fight for inheritance, both genetic and monetary, between Ann Cooper Hewitt and her mother Maryon.In 1934, aided by a California eugenics law, the socialite Maryon Cooper Hewitt had her "promiscuous" daughter declared feebleminded and sterilized without her knowledge. She did this to deprive Ann of millions of dollars from her father's estate, which contained a child-bearing stipulation. When a sensational court case ensued, the American public was captivated. So were eugenicists, who saw an opportunity to restrict reproductive rights in America for decades to come.

    “He has nerve and he has knowledge.”In the span of fifteen years, Dr. Thomas Neill Cream poisoned at least ten people in the United States, Britain, and Canada, a death toll with almost no precedents. Structured around Cream’s London murder trial in 1892, when he was finally brought to justice, The Case of the Murderous Dr. Cream exposes the blind trust given to medical practitioners, as well as the flawed detection methods, bungled investigations, corrupt officials, and stifling morality of Victorian society that allowed Cream to prey on vulnerable and desperate women, many of whom had turned to him for medical help.Dean Jobb vividly re-creates this largely forgotten historical account against the backdrop of the birth of modern policing and newly adopted forensic methods, though most police departments still scoffed at using science to solve crimes. But then most police departments could hardly imagine that serial killers existed—the term was unknown at the time. As the Chicago Tribune wrote then, Cream’s crimes marked the emergence of a new breed of killer, one who operated without motive or remorse, who “murdered simply for the sake of murder.”

    In Dark Dreams he reveals the twisted motives and perverse thinking that go into the most reprehensible crimes. He also catalogs the innovative and remarkably effective techniques--techniques that he helped pioneer at the FBI's Behavioral Science Unit--that allow Law Enforcement agents to construct psychological profiles of the offenders who comit them.Hazelwood has helped track down some of the most violent and well known criminals in modern history; in Dark Dreams he takes readers into his world--a sinister world inhabited by scores of dangerous offenders for every Roy Hazelwood who would put them behind bars. These are sexual sadists, serial rapists, child molesters, and serial killers. The cases he describes are as shocking as they are perplexing; their resolutions are as fascinating as they are innovative:* A young woman disappears from the convenience store where she works. Her body is later found in a field, strapped to a makeshift St. Andrew's Cross and mutilated beyond description. Who committed this heinous crime? And why?* A teenager's corpse is found hanging in a storm sewer. His clothes are neatly folded by the entrance and a stopwatch lies in the grime beneath him. Is he the victim of a bizarre, ritualistic murder . . . or an elaborate masturbatory fantasy gone awry?* A married couple, driving with their toddler in the back seat, pick up a female hitchhiker. They kidnap her and for seven years keep her in a box under their bed as a sexual slave. The wife had agreed to this inhuman arrangement in exchange for a second child. Who was to blame?But as gruesome as the crimes are and as unsettling as the odds seem, Hazelwood, writing with veteran journalsit Stephen Michaud, proves that the right amounts of determination and logic can bring even the most cunning and devious criminals to justice. Dark Dreams is a 2002 Edgar Award Nominee for Best Fact Crime.

    Many have survived because of an author’s status—part of the reason we have so much of Chaucer’s writing, for example, is because he was a London-based government official first and a poet second. Other works by the less influential have narrowly avoided ruin, like the book of illiterate Margery Kempe, found in a country house closet, the cover nibbled on by mice. Scholar Mary Wellesley recounts the amazing origins of these remarkable manuscripts, surfacing the important roles played by women and ordinary people—the grinders, binders, and scribes—in their creation and survival.  The Gilded Page is the story of the written word in the manuscript age. Rich and surprising, The Gilded Page shows how the most exquisite objects ever made by human hands came from unexpected places.

    Handsome and virile in his youth, a rare medical condition turned Henry VIII into a bloated and grotesque old man. The Dashing and glamourous Henry V probably died of cancer of the rectum, a fate that also befell Edward I. Charles I was beheaded. Henry VI was the victim of a grisly murder. Edward II, attacked with a red hot poker died in agony from traumatic perforation of the rectum. George II died in ignominy enthroned on the lavatory.This book will enthrall and appall.Distinguished surgeon Clifford Brewer T.D F.R.C.S. has made the death of kings the study of a life time, examining every act of violence and each unpleasant disease with a razor sharp eye for detail.

    There was nothing surprising about men turning up dead in the Second City. Life was cheaper than a quart of illicit gin in the gangland capital of the world. But two murders that spring were special - worthy of celebration. So believed Maurine Watkins, a wanna-be playwright and a "girl reporter" for the Chicago Tribune, the city's "hanging paper." Newspaperwomen were supposed to write about clubs, cooking and clothes, but the intrepid Miss Watkins, a minister's daughter from a small town, zeroed in on murderers instead. Looking for subjects to turn into a play, she would make "Stylish Belva" Gaertner and "Beautiful Beulah" Annan - both of whom had brazenly shot down their lovers - the talk of the town. Love-struck men sent flowers to the jail and newly emancipated women sent impassioned letters to the newspapers. Soon more than a dozen women preened and strutted on "Murderesses' Row" as they awaited trial, desperate for the same attention that was being lavished on Maurine Watkins's favorites. In the tradition of Erik Larson's The Devil in the White City and Karen Abbott's Sin in the Second City, Douglas Perry vividly captures Jazz Age Chicago and the sensationalized circus atmosphere that gave rise to the concept of the celebrity criminal. Fueled by rich period detail and enlivened by a cast of characters who seemed destined for the stage, The Girls of Murder City is crackling social history that simultaneously presents the freewheeling spirit of the age and its sober repercussions.