But the president insisted there was nothing to worry about.Fortunately, we are still a nation of skeptics. Fortunately, there are those among us who study pandemics and are willing to look unflinchingly at worst-case scenarios. Michael Lewis’s taut and brilliant nonfiction thriller pits a band of medical visionaries against the wall of ignorance that was the official response of the Trump administration to the outbreak of COVID-19.The characters you will meet in these pages are as fascinating as they are unexpected. A thirteen-year-old girl’s science project on transmission of an airborne pathogen develops into a very grown-up model of disease control. A local public-health officer uses her worm’s-eye view to see what the CDC misses, and reveals great truths about American society. A secret team of dissenting doctors, nicknamed the Wolverines, has everything necessary to fight the pandemic: brilliant backgrounds, world-class labs, prior experience with the pandemic scares of bird flu and swine flu…everything, that is, except official permission to implement their work.Michael Lewis is not shy about calling these people heroes for their refusal to follow directives that they know to be based on misinformation and bad science. Even the internet, as crucial as it is to their exchange of ideas, poses a risk to them. They never know for sure who else might be listening in.

    The book, The Youngest Science, forced Dr. Mukherjee to ask himself an urgent, fundamental question: Is medicine a “science”? Sciences must have laws—statements of truth based on repeated experiments that describe some universal attribute of nature. But does medicine have laws like other sciences?Dr. Mukherjee has spent his career pondering this question—a question that would ultimately produce some of most serious thinking he would do around the tenets of his discipline—culminating in The Laws of Medicine. In this important treatise, he investigates the most perplexing and illuminating cases of his career that ultimately led him to identify the three key principles that govern medicine.Brimming with fascinating historical details and modern medical wonders, this important book is a fascinating glimpse into the struggles and Eureka! moments that people outside of the medical profession rarely see. Written with Dr. Mukherjee’s signature eloquence and passionate prose, The Laws of Medicine is a critical read, not just for those in the medical profession, but for everyone who is moved to better understand how their health and well-being is being treated. Ultimately, this book lays the groundwork for a new way of understanding medicine, now and into the future.

    It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

    His passing on March 6, 1900, would have been unremarkable if a city health officer hadn’t noticed a swollen black lymph node on his groin—a sign of bubonic plague. Empowered by racist pseudoscience, officials rushed to quarantine Chinatown while doctors examined Wong’s tissue for telltale bacteria. If the devastating disease was not contained, San Francisco would become the American epicenter of an outbreak that had already claimed ten million lives worldwide.To local press, railroad barons, and elected officials, such a possibility was inconceivable—or inconvenient. As they mounted a cover-up to obscure the threat, ending the career of one of the most brilliant scientists in the nation in the process, it fell to federal health officer Rupert Blue to save a city that refused to be rescued. Spearheading a relentless crusade for sanitation, Blue and his men patrolled the squalid streets of fast-growing San Francisco, examined gory black buboes, and dissected diseased rats that put the fate of the entire country at risk.In the tradition of Erik Larson and Steven Johnson, Randall spins a spellbinding account of Blue’s race to understand the disease and contain its spread—the only hope of saving San Francisco, and the nation, from a gruesome fate.

    It’s a fly-on-the-wall account of the titanic fight to pass a 961-page law aimed at fixing America’s largest, most dysfunctional industry. It’s a penetrating chronicle of how the profiteering that Brill first identified in his trailblazing Time magazine cover story continues, despite Obamacare. And it is the first complete, inside account of how President Obama persevered to push through the law, but then failed to deal with the staff incompetence and turf wars that crippled its implementation.   But by chance America’s Bitter Pill ends up being much more—because as Brill was completing this book, he had to undergo urgent open-heart surgery. Thus, this also becomes the story of how one patient who thinks he knows everything about healthcare “policy” rethinks it from a hospital gurney—and combines that insight with his brilliant reporting. The result: a surprising new vision of how we can fix American healthcare so that it stops draining the bank accounts of our families and our businesses, and the federal treasury. Praise for America’s Bitter Pill   “A tour de force . . . a comprehensive and suitably furious guide to the political landscape of American healthcare . . . persuasive, shocking.”—The New York Times   “An energetic, picaresque, narrative explanation of much of what has happened in the last seven years of health policy . . . [Brill] has pulled off something extraordinary.” —The New York Times Book Review   “A thunderous indictment of what Brill refers to as the ‘toxicity of our profiteer-dominated healthcare system.’ ”—Los Angeles Times  “A sweeping and spirited new book [that] chronicles the surprisingly juicy tale of reform.”—The Daily Beast  “One of the most important books of our time.”—Walter Isaacson   “Superb . . . Brill has achieved the seemingly impossible—written an exciting book about the American health system.”—The New York Review of Books

    But American Overdose exposes the powerful forces they were up against, including the pharmaceutical industry's coopting of the Food and Drug Administration and Congress in the drive to push painkillers--resulting in the resurgence of heroin cartels in the American heartland. McGreal tells the story, in terms both broad and intimate, of people hit by a catastrophe they never saw coming. Years in the making, its ruinous consequences will stretch years into the future.

    It’s what I won a Pulitzer Prize for, years ago. I go to epidemics, wars, places where people are struggling to cope with disasters, and I carefully log the accounts and events, trying to represent the lives and experiences of others. The position of “outsider” is emotionally safe, even as agonizing events unfold. But I could not distance myself from the extraordinary sequence of events that fell on America, and especially my home town of New York City, in 2001. A decade later I am still trying to understand how the attacks on the World Trade Center and the anthrax mailings affected me, and those I love. I heard the first jet slam into the north tower of the World Trade Center, and from the rooftop of my apartment building watched the second commercial jet veer towards lower Manhattan, change its trajectory, and slice across the upper floors of the south tower. I was standing on the Manhattan anchorage of the Brooklyn Bridge when the first tower crumbled like a deflated accordion, spewing dust and debris in every direction and crushing the life out of thousands of people within. And a month later, as people started falling ill from inhalation of anthrax spores, one of the nation’s top bioterrorism experts called me to warn that I was a likely target: Stop opening your mail. The flow of these events, from the hijacking of four commercial jets on September 11th to the November death of an anthrax-infected Connecticut villager, took most of the world population from a remarkably united emotional and political place, to a deeply divided, frustrated, angry position. The arc of the response matters: It ultimately determined the course of historic events worldwide and tore America asunder, the people having lost trust in their government and without it, most forms of social cohesion. By the end of the winter of 2002 the arc had completed, from spectacular unity and confidence in governance to deep division and accusations of American arrogance. Through the frustrated anthrax investigations and drumbeats of war, the global community, especially Americans, moved in just a few months’ time from collectivism to fragmentation.This book is structured in two parts. The first, THE END OF THE AGE OF INNOCENCE, is written in the present tense, describing almost hourly the events that unfolded primarily in Washington DC and New York City over 120 days in the fall and winter of 2001 and 2002. Each day is a chapter that opens with the actual diary entry that I sent on that date to a list of friends all over the world. The entry is followed by a detailed breakdown of the day’s events, unfolding like a novel.Part two, NEW WORLD ORDER, details the repercussions of these events, transformations of critical government institutions, public health disasters, and what, in particular, the specter of terrorism meant for the American people. Revelations abound in this book, including:• The bizarre chemistry of The Plume that rose from the burning crushed World Trade Center for four months, endangering the health of hundreds of thousands of New Yorkers.• Evidence that al-Qaeda may have been behind the anthrax mailings.• Devastating spending and restructuring followed the attacks, leaving the nation less prepared for terrorism ten years later, and broke.• Each incident following the opening of anthrax-laden letters reveals countless errors and misjudgments.• There was no “weapons-grade anthrax” in those letters – a finding with profound health and political implications.

    Unable to stand, barely able to think, he waited for hours in an emergency room before being correctly diagnosed and rushed into surgery. Over the next few days, as he clung to life and the first light of a new year came through his window, he found himself reflecting on the fragility of health, not recognized in America as a human right but without which all rights and freedoms have no meaning.And that was before the pandemic. We have since watched American hospitals, long understaffed and undersupplied, buckling under waves of coronavirus patients. The federal government made matters worse through willful ignorance, misinformation, and profiteering. Our system of commercial medicine failed the ultimate test, and thousands of Americans died.In this eye-opening cri de coeur, Snyder traces the societal forces that led us here and outlines the lessons we must learn to survive. In examining some of the darkest moments of recent history and of his own life, Snyder finds glimmers of hope and principles that could lead us out of our current malaise. Only by enshrining healthcare as a human right, elevating the authority of doctors and medical knowledge, and planning for our children's future can we create an America where everyone is truly free.

    But as costs levitate, that argument becomes more difficult to make. Today, we spend twice as much as Japan on health care—yet few would argue that our health care system is twice as good.Instead, startling new evidence suggests that one out of every three of our health care dollars is squandered on unnecessary or redundant tests; unproven, sometimes unwanted procedures; and overpriced drugs and devices that, too often, are no better than the less expensive products they have replaced.How did this happen? In Money-Driven Medicine, Maggie Mahar takes the reader behind the scenes of a $2 trillion industry to witness how billions of dollars are wasted in a Hobbesian marketplace that pits the industry's players against each other. In remarkably candid interviews, doctors, hospital administrators, patients, health care economists, corporate executives, and Wall Street analysts describe a war of "all against all" that can turn physicians, hospitals, insurers, drugmakers, and device makers into blood rivals. Rather than collaborating, doctors and hospitals compete. Rather than sharing knowledge, drugmakers and device makers divide value. Rather than thinking about long-term collective goals, the imperatives of an impatient marketplace force health care providers to focus on short-term fiscal imperatives. And so investments in untested bleeding-edge medical technologies crowd out investments in information technology that might, in the long run, not only reduce errors but contain costs.In theory, free market competition should tame health care inflation. In fact, Mahar demonstrates, when it comes to medicine, the traditional laws of supply and demand do not apply. Normally, when supply expands, prices fall. But in the health care industry, as the number and variety of drugs, devices, and treatments multiplies, demand rises to absorb the excess, and prices climb. Meanwhile, the perverse incentives of a fee-for-service system reward health care providers for doing more, not less.In this superbly written book, Mahar shows why doctors must take responsibility for the future of our health care industry. Today, she observes, "physicians have been stripped of their standing as professionals: Insurers address them as vendors ('Dear Health Care Provider'), drugmakers and device makers see them as customers (someone you might take to lunch or a strip club), while . . . consumers (aka patients) are encouraged to see their doctors as overpaid retailers. . . . Before patients can reclaim their rightful place as the center—and indeed as the raison d'être—of our health care system," Mahar suggests, "we must once again empower doctors . . . to practice patient-centered medicine—based not on corporate imperatives, doctors' druthers, or even patients' demands," but on the best scientific research available.

    They always keep a bag packed. They seldom have more than twenty-four hours' notice before they are dispatched. The phone calls that tell them to head to the airport, sometimes in the middle of the night, may give them no more information than the country they are traveling to and the epidemic they will tackle when they get there.The universal human instinct is to run from an outbreak of disease. These doctors run toward it.They are the disease detective corps of the U.S. Centers for Disease Control and Prevention (CDC), the federal agency that tracks and tries to prevent disease outbreaks and bioterrorist attacks around the world. They are formally called the Epidemic Intelligence Service (EIS) -- a group founded more than fifty years ago out of fear that the Korean War might bring the use of biological weapons -- and, like intelligence operatives in the traditional sense, they perform their work largely in anonymity. They are not household names, but over the years they were first to confront the outbreaks that became known as hantavirus, Ebola virus, and AIDS. Now they hunt down the deadly threats that dominate our headlines: West Nile virus, anthrax, and SARS.In this riveting narrative, Maryn McKenna -- the only journalist ever given full access to the EIS in its fifty-three-year history -- follows the first class of disease detectives to come to the CDC after September 11, the first to confront not just naturally occurring outbreaks but the man-made threat of bioterrorism. They are talented researchers -- many with young families -- who trade two years of low pay and extremely long hours for the chance to be part of the group that has helped eradicate smallpox, push back polio, and solve the first major outbreaks of Legionnaires' disease, toxic shock syndrome, and "E. coli" O157.Urgent, exhilarating, and compelling, "Beating Back the Devil" goes with the EIS as they try to stop epidemics -- before the epidemics stop us.

    Personal, poignant, and meticulously precise, these stories evoke Chekhov, Maugham, and William Carlos Williams, admitting readers to the beating heart of medicine. Internal Medicine is an account of what it means to be a doctor, to be mortal, and to be human.

    In 'Bad Science', Ben Goldacre hilariously exposed the tricks that quacks and journalists use to distort science. In 'Bad Pharma', he put the $600 billion global pharmaceutical industry under the microscope. Now the pick of the journalism by one of our wittiest, most indignant and most fearless commentators on the worlds of medicine and science is collected in one volume.

    For the parents of sick and premature babies, some weighing less than a pound and no bigger than a can of cola, the Neonatal Intensive Care Unit -- the "Baby ER" -- is their one bastion of hope during the most terrifying moments of their lives, when their children's very survival hangs in the balance. Given unprecedented access to this normally private world, Humes witnesses the midnight deliveries, the harrowing Code Blues, the heart-wrenching setbacks; be there when a young mother first holds her son as he finally emerges from the incubator, and for the triumphant day of discharge, when families are at last made whole.Set in Southern California's Long Beach Memorial Medical Center, home to one of the largest and most respected neonatal units in the nation, "Baby ER" also describes the inspiring and dramatic efforts of the uniquely gifted physicians, nurses and other healers who work medicine's tiniest miracles, bringing life to a place where, for all but a minute fraction of human history, death has reigned supreme. The neonatal unit has been transformed in recent years by revolutionary advances that have enabled impossibly small preemies not only to survive but to thrive. Children born so early they would have been considered miscarriages fifteen years ago are now going home in their car seats thanks to state-of-the-art care; parents who would have faced unspeakable lossnow have diapers to change.But there is also a cost to the wonders of technology and skill that preserve such fragile lives. Though joy is most often the result of this remarkable brand of medicine called neonatology, a life saved does not always lead to a life worth living. The accompanying burdens -- sometimes grievous ones -- raise difficult moral, ethical and financial questions. In a narrative both lyrical and intense, Humes does not skirt these tough questions, nor do the talented physicians at the center of "Baby ER," who must ask themselves not only how far they can go to save a child, but how far they should go. In an era when aggressive new fertility treatments have created an epidemic of high-risk multiple births, and one in ten babies in the U.S. is born premature, "Baby ER" provides a timely and compelling portrait of medicine's brave new world.

    At his death last spring, Roueche left behind seven new narratives that have never been published in book form. This book collects these works along with one earlier classic--all relating true tales of strange illnesses, rare diseases, and the brilliant minds who race to understand and conquer them.

    Jack Geiger, M.D., New York Times Book Review