Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    When it was first published, the book claimed attention as a moving study of mental illness based on personal knowledge. This fictionalized, brilliant, and uncompromising first-person account of madness and life in an insane asylum was subsequently made into a haunting movie.

    A new mother is admitted with incessant visions of harming her child. A recent graduate, dressed in a tunic and declaring that love emanates from everything around him, is brought to A&E by his alarmed girlfriend. These are among the patients new physician Christine Montross meets during rounds at her hospital’s locked inpatient ward – and who we meet as she struggles to understand the mysteries of the mind, most especially when the tools of modern medicine are failing us. Beautifully written and deeply felt, Falling into the Fire is an intimate portrait of psychiatry and a moving reminder, in the words of the New York Times, of 'our fragile, shared humanity'

    But could our sheltered, temperature-controlled, overfed, underchallenged lives actually be the leading cause of many our most urgent physical and mental health issues? In this gripping investigation, award-winning journalist Michael Easter seeks out off-the-grid visionaries, disruptive genius researchers, and mind-body conditioning trailblazers who are unlocking the life-enhancing secrets of a counterintuitive solution: discomfort. Easter’s journey to understand our evolutionary need to be challenged takes him to meet the NBA’s top exercise scientist, who uses an ancient Japanese practice to build championship athletes; to the mystical country of Bhutan, where an Oxford economist and Buddhist leader are showing the world what death can teach us about happiness; to the outdoor lab of a young neuroscientist who’s found that nature tests our physical and mental endurance in ways that expand creativity while taming burnout and anxiety; to the remote Alaskan backcountry on a demanding thirty-three-day hunting expedition to experience the rewilding secrets of one of the last rugged places on Earth; and more. Along the way, Easter uncovers a blueprint for leveraging the power of discomfort that will dramatically improve our health and happiness, and perhaps even help us understand what it means to be human. The Comfort Crisis is a bold call to break out of your comfort zone and explore the wild within yourself.

    With echoes of Sylvia Plath, and against a cultural backdrop that includes Shakespeare, Woody Allen, and Heathers, Suzanne Scanlon's first novel is both a deeply moving account of a life of crisis and a brilliantly original work of art.

    From Mary Lamb, sister of Charles, who in the throes of a nervous breakdown turned on her mother with a kitchen knife, to Freud, Jung, and Lacan, who developed the new women-centered therapies, Lisa Appignanesi’s research traces how more and more of the inner lives and emotions of women have become a matter for medics and therapists. Here too is the story of how over the years symptoms and diagnoses have developed together to create fashions in illness and how treatments have succeeded or sometimes failed. Mad, Bad, and Sad takes us on a fascinating journey through the fragile, extraordinary human mind.

    Mystery, the marvellous, a city transmuted by love, Sanglot's pursuit of the siren Louise Lame, such are the essential ingredients of this the last masterpiece of early Surrealism to remain untranslated into English. It was originally published in 1924 to immediate and lasting acclaim - except from the public authorities who immediately censored whole sections (here restored). Impossible to describe a novel of such virtuosity and bravura, and one which consistently refuses to behave as one expects, characters appear and vanish according to whim or desire, they walk underwater, nonchalantly accept astounding coincidences. It's a hymn to the erotic, an adventure story darkly illumined by the shades of Sade, Lautreamont and Jack the Ripper, a dream both violent and tender, an obsession, in fact the perfect embodiment of the Surrealist spirit: at once joyful, despairing, and effortlessly scandalous.

    She was ambitious and worked hard; she had just bought an apartment; she was falling in love. But then she started to develop worrying symptoms: her face felt like it was burning whenever she was in front of the computer. Soon this progressed to an intolerance of fluorescent light, then of sunlight itself. The reaction soon spread to her entire body. Now, when her symptoms are at their worst, she must spend months on end in a blacked-out room, losing herself in audio books and elaborate word games in an attempt to ward off despair. It was during this period she began to write this book.

    A neurologist's insightful and compassionate look into the misunderstood world of psychosomatic disorders, told through individual case histories

    The room is dark. She hears yelling, smashed plates, and wishes it was all a terrible dream. But it isn't. This is what it was like growing up as a Hemingway. In this deeply moving, searingly honest new memoir, actress and mental health icon Mariel Hemingway shares in candid detail the story of her troubled childhood in a famous family haunted by depression, alcoholism, illness, and suicide. Born just a few months after her grandfather, Ernest Hemingway, shot himself, it was Mariel's mission as a girl to escape the desperate cycles of severe mental health issues that had plagued generations of her family. Surrounded by a family tortured by alcoholism (both parents), depression (her sister Margaux), suicide (her grandfather and four other members of her family), schizophrenia (her sister Muffet), and cancer (mother), it was all the young Mariel could do to keep her head. In a compassionate voice she reveals her painful struggle to stay sane as the youngest child in her family, and how she coped with the chaos by becoming OCD and obsessive about her food, schedule, and organization. The twisted legacy of her family has never quite let go of Mariel, but now in this memoir she opens up about her claustrophobic marriage, her acting career, and turning to spiritual healers and charlatans for solace. Ultimately Mariel has written a story of triumph about learning to overcome her family's demons and developing love and deep compassion for them. At last, in this memoir she can finally tell the true story of the tragedies and troubles of the Hemingway family, and she delivers a book that beckons comparisons with Mary Karr and Jeanette Walls.

    As a contented wife and mother, she should have everything to live for. Yet a blackness has started to leak into her thoughts. Images flash through her head leaving her stunned and breathless. On the face of it there is no rational explanation for the way she feels. Linda believes there is something malign inside her. But in the back of her mind a voice tells her over and over again that everything will be OK. When it finally gets too much, she can always simply die. 'How shall I die if that time comes? I need to know these things. They have to be planned.' It must look like an accident. She will deliberately drive off the road on her way home from her weekly shopping trip. After all, who commits suicide with a load of groceries in their car?The raw and powerful journey Linda takes with her psychotherapist Robin Royston to discover what lies at the heart of her deptression will leave you shocked. The secrets in her African childhood and adolescence are buried so deep that to reveal them may destroy her completely. Together Linda and Robin race to unravel the clues, before it is too late.OUT OF THE DARK is Linda Caine's remarkable and uplifting story from the agonies of mental breakdown to the painful piecing together of the past that was vital for her survival. Both her courage and Robin's persistence during the process show the power of the human spirit at its most indomitable and inspiring.

    It is not a case history or study. I like to think it is a hymn to reality." —Joanne Greenberg

    In this extraordinary work Nietzsche traces his life, work and development as a philosopher, examines the heroes he has identified with, struggled against and then overcome - Schopenhauer, Wagner, Socrates, Christ - and predicts the cataclysmic impact of his 'forthcoming revelation of all values'. Both self-celebrating and self-mocking, penetrating and strange, Ecce Homo gives the final, definitive expression to Nietzsche's main beliefs and is in every way his last testament.

    Swallow Me Whole is a love story carried by rolling fog, terminal illness, hallucination, apophenia, insect armies, secrets held, unshakeable faith, and the search for a master pattern to make sense of one's unraveling.In his most ambitious book to date, Nate Powell quietly explores the dark corners of adolescence -- not the clich�d melodramatic outbursts of rebellion, but the countless tiny moments of madness, the vague relief of medication, and mixed blessing of family ties. As the story unfolds, two stepsiblings hold together amidst schizophrenia, obsessive compulsive disorder, family breakdown, animal telepathy, misguided love, and the tiniest hope that everything will someday make sense.Deliberately paced, delicately drawn, and drenched in shadows, Swallow Me Whole is a landmark achievement for Nate Powell and a suburban ghost story that will haunt readers long after its final pages.

    Elizabeth Ford went through medical school unsure of where she belonged. It wasn’t until she did her psychiatry rotation that she found her calling—to care for one of the most vulnerable populations of mentally ill people, the inmates of New York's jails, including Rikers Island, who are so sick that they are sent to the Bellevue Hospital Prison Ward for care.These men were broken, unloved, without resources or support, and very ill. They could be violent, unpredictable, but they could also be funny and tender and needy. Mostly, they were human and they awakened in Ford a boundless compassion. Her patients made her a great doctor and a better person and, as she treated these men, she learned about doctoring, about nurturing, about parenting, and about love. While Ford was a psychiatrist at Bellevue she becomes a wife and a mother. In her book she shares her struggles to balance her life and her work, to care for her children and her patients, and to maintain the empathy that is essential to her practice—all in the face of a jaded institution, an exhausting workload, and the deeply emotionally taxing nature of her work. Ford brings humor, grace, and humanity to the lives of the patients in her care and in beautifully rendered prose illuminates the inner workings (and failings) of our mental health system, our justice system, and the prison system.