In 1875, tuberculosis was the deadliest disease in the world, accountable for a third of all deaths. A diagnosis of TB—often called consumption—was a death sentence. Then, in a triumph of medical science, a German doctor named Robert Koch deployed an unprecedented scientific rigor to discover the bacteria that caused TB. Koch soon embarked on a remedy—a remedy that would be his undoing.   When Koch announced his cure for consumption, Arthur Conan Doyle, then a small-town doctor in England and sometime writer, went to Berlin to cover the event. Touring the ward of reportedly cured patients, he was horrified. Koch’s "remedy" was either sloppy science or outright fraud.   But to a world desperate for relief, Koch’s remedy wasn’t so easily dismissed. As Europe’s consumptives descended upon Berlin, Koch urgently tried to prove his case. Conan Doyle, meanwhile, returned to England determined to abandon medicine in favor of writing. In particular, he turned to a character inspired by the very scientific methods that Koch had formulated: Sherlock Holmes.   Capturing the moment when mystery and magic began to yield to science, The Remedy chronicles the stunning story of how the germ theory of disease became a true fact, how two men of ambition were emboldened to reach for something more, and how scientific discoveries evolve into social truths.

    And he's ringing the changes. In a contest of change, which century from the past millennium would come up trumps? Imagine the Black Death took on the female vote in a pub brawl, or the Industrial Revolution faced the internet in a medieval joust - whose side would you be on? In this hugely entertaining book, celebrated historian Ian Mortimer takes us on a whirlwind tour of Western history, pitting one century against another in his quest to measure change. We journey from a time when there was a fair chance of your village being burnt to the ground by invaders, and dried human dung was a recommended cure for cancer, to a world in which explorers sailed into the unknown and civilisations came into conflict with each other on an epic scale. Here is a story of godly scientists, shrewd farmers, cold-hearted entrepreneurs and strong-minded women - a story of discovery, invention, revolution and cataclysmic shifts in perspective. Bursting with ideas and underscored by a wry sense of humour, this is a journey into the past like no other. Our understanding of change will never be the same again - and the lessons we learn along the way are profound ones for us all.

    A killer with little respect for class or wealth, cholera ravaged the squalid streets of Soho and rocked the great centers of Victorian power. In this gripping book, Sandra Hempel tells the story of John Snow, a reclusive doctor without money or social position, who—alone and unrecognized—had the genius to look beyond the conventional wisdom of his day and uncover the truth behind the pandemic. She describes how Snow discovered that cholera was spread through drinking water and how this subsequently laid the foundations for the modern, scientific investigation of today's fatal plagues. A dramatic account with a colorful cast of characters, The Strange Case of the Broad Street Pump features diversions into fascinating facets of medical and social history, such as Snow's tending of Queen Victoria in childbirth, Dutch microbiologist Leeuwenhoek's deliberate breeding of lice in his socks, Dickensian children's farms, and riotous nineteenth-century anesthesia parties. An afterword discusses the new threat of infectious diseases—including malaria, yellow fever, and cholera—with today's global warming. Copub: Granta

    Eerie aspects of the incident—unexplained violent injuries, signs that they cut open and fled the tent without proper clothing or shoes, a strange final photograph taken by one of the hikers, and elevated levels of radiation found on some of their clothes—have led to decades of speculation over what really happened. This gripping work of literary nonfiction delves into the mystery through unprecedented access to the hikers' own journals and photographs, rarely seen government records, dozens of interviews, and the author's retracing of the hikers' fateful journey in the Russian winter. A fascinating portrait of the young hikers in the Soviet era, and a skillful interweaving of the hikers narrative, the investigators' efforts, and the author's investigations, here for the first time is the real story of what happened that night on Dead Mountain

    In this absorbing, surprising, and undeniably compelling book, forensics expert Emily Craig tells her own story of a life spent teasing secrets from the dead.Emily Craig has been a witness to history, helping to seek justice for thousands of murder victims, both famous and unknown. It's a personal story that you won't soon forget.Emily first became intrigued by forensics work when, as a respected medical illustrator, she was called in by the local police to create a model of a murder victim's face. Her fascination with that case led to a dramatic midlife career change: She would go back to school to become a forensic anthropologist——and one of the most respected and best-known "bone hunters" in the nation.As a student working with the FBI in Waco, Emily helped uncover definitive proof that many of the Branch Davidians had been shot to death before the fire, including their leader, David Koresh, whose bullet-pierced skull she reconstructed with her own hands. Upon graduation, Emily landed a prestigious full-time job as forensic anthropologist for the Commonwealth of Kentucky, a state with an alarmingly high murder rate and thousands of square miles of rural backcountry, where bodies are dumped and discovered on a regular basis. But even with her work there, Emily has been regularly called to investigations across the country, including the site of terrorist attack on the the Murrah Building in Oklahoma City, where a mysterious body part——a dismembered leg——was found at the scene and did not match any of the known victims. Through careful scientific analysis, Emily was able to help identify the leg's owner, a pivotal piece of evidence that helped convict Timothy McVeigh.In September 2001, Emily recieved a phone call summoning her to New York City, where she directed the night-shift triage at the World Trade Centre's body identification site, collaborating with forensics experts from all over the country to collect and identify the remains of September 11 victims.From the biggest new stories of our time to stranger-than-true local mysteries, these are unforgettable stories from the case files of Emily Craig's remarkable career.

    Then he discovered that the olive grove in front of their 14th century farmhouse had been the scene of the most infamous double-murders in Italian history, committed by a serial killer known as the Monster of Florence. Preston, intrigued, meets Italian investigative journalist Mario Spezi to learn more.This is the true story of their search for—and identification of—the man they believe committed the crimes, and their chilling interview with him. And then, in a strange twist of fate, Preston and Spezi themselves become targets of the police investigation. Preston has his phone tapped, is interrogated, and told to leave the country. Spezi fares worse: he is thrown into Italy's grim Capanne prison, accused of being the Monster of Florence himself. Like one of Preston's thrillers, The Monster of Florence, tells a remarkable and harrowing story involving murder, mutilation, and suicide—and at the center of it, Preston and Spezi, caught in a bizarre prosecutorial vendetta.

    The following winter, her dismembered remains were found buried in a seaside cave. The seven months in between had seen a massive search for the missing girl, involving Japanese policemen; British private detectives; Australian dowsers; and Lucie's desperate, but bitterly divided, parents. As the case unfolded, it drew the attention of prime ministers and sado-masochists, ambassadors and con-men, and reporters from across the world. Had Lucie been abducted by a religious cult, or snatched by human traffickers? Who was the mysterious man she had gone to meet? And what did her work, as a "hostess" in the notorious Roppongi district of Tokyo, really involve?Richard Lloyd Parry, an award-winning foreign correspondent, followed the case since Lucie's disappearance. Over the course of a decade, he traveled to four continents to interview those caught up in the story, fought off a legal attack in the Japanese courts, and worked undercover as a bartender in a Roppongi strip club. He talked exhaustively with Lucie's friends and family and won unique access to the Japanese detectives who investigated the case. And he delved into the mind and background of the man accused of the crime--Joji Obara, described by the judge as "unprecedented and extremely evil." With the finesse of a novelist, he reveals the astonishing truth about Lucie and her fate. People Who Eat Darkness is, by turns, a non-fiction thriller, a courtroom drama, and the biography of both a victim and a killer. It is the story of a young woman who fell prey to unspeakable evil, and of a loving family torn apart by grief. And it is a fascinating insight into one of the world's most baffling and mysterious societies, a light shone into dark corners of Japan that the rest of the world has never glimpsed before.

    Communities where heroin had never been seen before—from Charlotte, NC and Huntington, WVA, to Salt Lake City and Portland, OR—were overrun with it. Local police and residents were stunned. How could heroin, long considered a drug found only in the dense, urban environments along the East Coast, and trafficked into the United States by enormous Colombian drug cartels, be so incredibly ubiquitous in the American heartland? Who was bringing it here, and perhaps more importantly, why were so many townspeople suddenly eager for the comparatively cheap high it offered?With the same dramatic drive of El Narco and Methland, Sam Quinones weaves together two classic tales of American capitalism: The stories of young men in Mexico, independent of the drug cartels, in search of their own American Dream via the fast and enormous profits of trafficking cheap black-tar heroin to America’s rural and suburban addicts; and that of Purdue Pharma in Stamford, Connecticut, determined to corner the market on pain with its new and expensive miracle drug, Oxycontin; extremely addictive in its own right. Quinones illuminates just how these two stories fit together as cause and effect: hooked on costly Oxycontin, American addicts were lured to much cheaper black tar heroin and its powerful and dangerous long-lasting high. Embroiled alongside the suppliers and buyers are DEA agents, local, small-town sheriffs, and the US attorney from eastern Virginia whose case against Purdue Pharma and Oxycontin made him an enemy of the Bush-era Justice Department, ultimately stalling and destroying his career in public service.Dreamland is a scathing and incendiary account of drug culture and addiction spreading to every part of the American landscape.

    This is the account of 23 men torturing and killing by experiment in the name of scientific research and patriotism. The book includes trial transcripts that have not been easily available to the general public and previously unpublished photographs used as evidence in the trial. The author describes the experience of being in bombed-out, dangerous, post-war Nuremberg, where she lived for two years while working on the trial. Once a Nazi sympathiser tossed bombs into the dining room of the hotel where she lived moments before she arrived for dinner. She takes us into the courtroom to hear the dramatic testimony and see the reactions of the defendants to the proceedings. The doctors tell of experiments involving depriving concentration camp inmates of oxygen; freezing them; injecting them with malaria, typhus, and jaundice; amputating healthy limbs; forcing them to drink seawater for weeks at a time; and other horrors.

    In Under the Knife, surgeon Arnold Van de Laar uses his own experience and expertise to tell the witty history of the past, present and future of surgery.From the story of the desperate man from seventeenth-century Amsterdam who grimly cut a stone out of his own bladder to Bob Marley's deadly toe, Under the Knife offers all kinds of fascinating and unforgettable insights into medicine and history via the operating theatre.What happens during an operation? How does the human body respond to being attacked by a knife, a bacterium, a cancer cell or a bullet? And, as medical advances continuously push the boundaries of what medicine can cure, what are the limits of surgery?From the dark centuries of bloodletting and of amputations without anaesthetic to today's sterile, high-tech operating theatres, Under the Knife is both a rich cultural history, and a modern anatomy class for us all.

    Victoria's matchmaking plans were further complicated by the tumultuous international upheavals of the time: revolution and war were in the air, and kings and queens, princes and princesses were vulnerable targets.Queen Victoria's Matchmaking travels through the glittering, decadent palaces of Russia and Europe, weaving in scandals, political machinations and family tensions to enthralling effect. It is at once an intimate portrait of a royal family and an examination of the conflict caused by the marriages the Queen arranged. At the heart of it all is Victoria herself: doting grandmother one moment; determined Queen Empress the next.

    These are today's sins of science—as deplorable as mistaken past ideas about advocating racial purity or using lobotomies as a cure for mental illness. These unwitting errors add up to seven lessons both cautionary and profound, narrated by renowned author and speaker Paul A. Offit. Offit uses these lessons to investigate how we can separate good science from bad, using some of today's most controversial creations—e-cigarettes, GMOs, drug treatments for ADHD—as case studies. For every "Aha!" moment that should have been an "Oh no," this book is an engrossing account of how science has been misused disastrously—and how we can learn to use its power for good.

    In Wicked Plants, Stewart takes on over two hundred of Mother Nature’s most appalling creations. It’s an A to Z of plants that kill, maim, intoxicate, and otherwise offend. You’ll learn which plants to avoid (like exploding shrubs), which plants make themselves exceedingly unwelcome (like the vine that ate the South), and which ones have been killing for centuries (like the weed that killed Abraham Lincoln's mother). Menacing botanical illustrations and splendidly ghastly drawings create a fascinating portrait of the evildoers that may be lurking in your own backyard. Drawing on history, medicine, science, and legend, this compendium of bloodcurdling botany will entertain, alarm, and enlighten even the most intrepid gardeners and nature lovers.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    The popular image of the Regency continues to be mythologized by the hundreds of romance novels set in the period, which focus almost exclusively on wealthy, white, Christian members of the upper classes.But there are hundreds of fascinating women who don't fit history books limited perception of what was historically accurate for early 19th century England. Women like Dido Elizabeth Belle, whose mother was a slave but was raised by her white father's family in England, Caroline Herschel, who acted as her brother's assistant as he hunted the heavens for comets, and ended up discovering eight on her own, Anne Lister, who lived on her own terms with her common-law wife at Shibden Hall, and Judith Montefiore, a Jewish woman who wrote the first English language Kosher cookbook.As one of the owners of the successful romance-only bookstore The Ripped Bodice, Bea Koch has had a front row seat to controversies surrounding what is accepted as "historically accurate" for the wildly popular Regency period. Following in the popular footsteps of books like Ann Shen's Bad Girls Throughout History, Koch takes the Regency, one of the most loved and idealized historical time periods and a huge inspiration for American pop culture, and reveals the independent-minded, standard-breaking real historical women who lived life on their terms. She also examines broader questions of culture in chapters that focus on the LGBTQ and Jewish communities, the lives of women of color in the Regency, and women who broke barriers in fields like astronomy and paleontology. In Mad and Bad, we look beyond popular perception of the Regency into the even more vibrant, diverse, and fascinating historical truth.