During that time, the Revolution came closer to being lost than at any time in the previous half dozen. The British still held New York, Savannah, Wilmington, and Charleston; the Royal Navy controlled the seas; the states--despite having signed the Articles of Confederation earlier that year--retained their individual sovereignty and, largely bankrupt themselves, refused to send any money in the new nation's interest; members of Congress were in constant disagreement; and the Continental army was on the verge of mutiny.William Fowler's An American Crisis chronicles these tumultuous and dramatic two years, from Yorktown until the British left New York in November 1783. At their heart was the remarkable speech Gen. George Washington gave to his troops evcamped north of New York in Newburgh, quelling a brewing rebellion that could have overturned the nascent government.

     It is a remarkable portrait, too, of the life of a psychiatric asylum--the sort of community in which, for better and for worse, hundreds of thousands of people lived out their lives.More than four hundred abandoned suitcases filled with patients’ belongings were found when Willard Psychiatric Center closed in 1995 after 125 years of operation. They are skillfully examined here and compared to the written record to create a moving—and devastating—group portrait of twentieth-century American psychiatric care.

    After barely surviving the agony of smallpox themselves, they flouted eighteenth-century medicine by borrowing folk knowledge from African slaves and Eastern women in frantic bids to protect their children. From their heroic struggles stems the modern science of immunology as well as the vaccinations that remain our only hope should the disease ever be unleashed again.Jennifer Lee Carrell transports readers back to the early eighteenth century to tell the tales of Lady Mary Wortley Montagu and Dr. Zabdiel Boylston, two iconoclastic figures who helped save London and Boston from the deadliest disease mankind has known.

    The Sackler name adorns the walls of many storied institutions: Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing OxyContin, a blockbuster painkiller that was a catalyst for the opioid crisis.Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

    In The Poisoner's Handbook Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Drama unfolds case by case as the heroes of The Poisoner's Handbook—chief medical examiner Charles Norris and toxicologist Alexander Gettler—investigate a family mysteriously stricken bald, Barnum and Bailey's Famous Blue Man, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler work with a creativity that rivals that of the most imaginative murderer, creating revolutionary experiments to tease out even the wiliest compounds from human tissue. Yet in the tricky game of toxins, even science can't always be trusted, as proven when one of Gettler's experiments erroneously sets free a suburban housewife later nicknamed "America's Lucretia Borgia" to continue her nefarious work. From the vantage of Norris and Gettler's laboratory in the infamous Bellevue Hospital it becomes clear that killers aren't the only toxic threat to New Yorkers. Modern life has created a kind of poison playground, and danger lurks around every corner. Automobiles choke the city streets with carbon monoxide; potent compounds, such as morphine, can be found on store shelves in products ranging from pesticides to cosmetics. Prohibition incites a chemist's war between bootleggers and government chemists while in Gotham's crowded speakeasies each round of cocktails becomes a game of Russian roulette. Norris and Gettler triumph over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice during a remarkably deadly time. A beguiling concoction that is equal parts true crime, twentieth-century history, and science thriller, The Poisoner's Handbook is a page-turning account of a forgotten New York.

    That is until 1904, when the disease broke out in a household in Oyster Bay, Long Island. Authorities suspected the family cook, Mary Mallon, of being a carrier. But before she could be tested, the woman, soon to be known as Typhoid Mary, had disappeared. Over the course of the next three years, Mary worked at several residences, spreading her pestilence as she went. In 1907, she was traced to a home on Park Avenue, and taken into custody. Institutionalized at Riverside Hospital for three years, she was released only when she promised never to work as a cook again. She promptly disappeared.For the next five years Mary worked in homes and institutions in and around New York, often under assumed names. In February 1915, a devastating outbreak of typhoid at the Sloane Hospital for Women was traced to her. She was finally apprehended and reinstitutionalized at Riverside Hospital, where she would remain for the rest of her life.Typhoid Mary is the story of her infamous life. Anthony Bourdain reveals the seedier side of the early 1900s, and writes with his renowned panache about life in the kitchen, uncovering the horrifying conditions that allowed the deadly spread of typhoid over a decade. Typhoid Mary is a true feast for history lovers and Bourdain lovers alike.

    Ellis, author of Founding Brothers A magnificent account of the revolution in arms and consciousness that gave birth to the American republic. When Abraham Lincoln sought to define the significance of the United States, he naturally looked back to the American Revolution. He knew that the Revolution not only had legally created the United States, but also had produced all of the great hopes and values of the American people. Our noblest ideals and aspirations-our commitments to freedom, constitutionalism, the well-being of ordinary people, and equality-came out of the Revolutionary era. Lincoln saw as well that the Revolution had convinced Americans that they were a special people with a special destiny to lead the world toward liberty. The Revolution, in short, gave birth to whatever sense of nationhood and national purpose Americans have had. No doubt the story is a dramatic one: Thirteen insignificant colonies three thousand miles from the centers of Western civilization fought off British rule to become, in fewer than three decades, a huge, sprawling, rambunctious republic of nearly four million citizens. But the history of the American Revolution, like the history of the nation as a whole, ought not to be viewed simply as a story of right and wrong from which moral lessons are to be drawn. It is a complicated and at times ironic story that needs to be explained and understood, not blindly celebrated or condemned. How did this great revolution come about? What was its character? What were its consequences? These are the questions this short history seeks to answer. That it succeeds in such a profound and enthralling way is a tribute to Gordon Wood’s mastery of his subject, and of the historian’s craft.From the Hardcover edition.

    USS Constitution, "Old Ironsides," proved the mettle of the fledgling American navy; Oliver Hazard Perry hoisted a flag boasting, "Don't Give Up the Ship"; and Andrew Jackson's ragged force stood behind it's cotton bales at New Orleans and bested the pride of British regulars. Here are the stories of commanding generals such as America's double-dealing James Wilkinson, Great Britain's gallant Sir Isaac Brock, Canada's heroine farm wife Laura Secord, and country doctor William Beanes, whose capture set the stage for Francis Scott Key to write "The Star-Spangled Banner." During the War of 1812, the United States cast off its cloak of colonial adolescence and -- with both humiliating and glorious moments -- found the fire that was to forge a nation.This P.S. edition features an extra 16 pages of insights into the book, including author interviews, recommended reading, and more.

    John Snow. It's the summer of 1854, and London is just emerging as one of the first modern cities in the world. But lacking the infrastructure—garbage removal, clean water, sewers—necessary to support its rapidly expanding population, the city has become the perfect breeding ground for a terrifying disease no one knows how to cure. As the cholera outbreak takes hold, a physician and a local curate are spurred to action—and ultimately solve the most pressing medical riddle of their time. In a triumph of multidisciplinary thinking, Johnson illuminates the intertwined histories and inter-connectedness of the spread of disease, contagion theory, the rise of cities, and the nature of scientific inquiry, offering both a riveting history and a powerful explanation of how it has shaped the world we live in.

    In this first-hand account of the Revolutionary War, Joseph Plumb Martin narrates his true adventures as an eighteen-year-old private in the Continental Army -- and gives a rare glimpse of the earthy beginnings of our nation's history.

    Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    Jack Geiger, M.D., New York Times Book Review

    Among them was a thirty-year-old doctor named Benjamin Rush. One of the youngest signatories, he was also, among stiff competition, one of the most visionary.A brilliant physician and writer, Rush was known as the "American Hippocrates" for pioneering national healthcare and revolutionizing treatment of mental illness and addiction. Yet medicine is only part of his legacy. Dr. Rush was both a progressive thorn in the side of the American political establishment--a vocal opponent of slavery, capital punishment, and prejudice by race, religion or gender--and close friends with its most prominent leaders. He was the prot�g� of Franklin, the editor of Common Sense, Washington's surgeon general, and the broker of peace between Adams and Jefferson, yet his stubborn convictions more than once threatened his career and his place in the narrative of America's founding.Drawing on a trove of previously unpublished letters and images, the voluminous correspondence between Rush and his better-known counterparts, and his candid and incisive personal writings, New York Times bestselling author and award-winning journalist Stephen Fried resurrects the most significant Founding Father we've never heard of and finally installs Dr. Rush in the pantheon of great American leaders.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Many books on the plague rely on statistics to tell the story: how many people died; how farm output and trade declined. But statistics can’t convey what it was like to sit in Siena or Avignon and hear that a thousand people a day are dying two towns away. Or to have to chose between your own life and your duty to a mortally ill child or spouse. Or to live in a society where the bonds of blood and sentiment and law have lost all meaning, where anyone can murder or rape or plunder anyone else without fear of consequence.In The Great Mortality, author John Kelly lends an air of immediacy and intimacy to his telling of the journey of the plague as it traveled from the steppes of Russia, across Europe, and into England, killing 75 million people—one third of the known population—before it vanished.