In June 1962, a young biologist in Philadelphia, using tissue extracted from an aborted fetus from Sweden, produced safe, clean cells that allowed the creation of vaccines against rubella and other common childhood diseases. Two years later, in the midst of a devastating German measles epidemic, his colleague developed the vaccine that would one day wipe out homegrown rubella. The rubella vaccine and others made with those fetal cells have protected more than 150 million people in the United States, the vast majority of them preschoolers. The new cells and the method of making them also led to vaccines that have protected billions of people around the world from polio, rabies, chicken pox, measles, hepatitis A, shingles and adenovirus. Meredith Wadman’s masterful account recovers not only the science of this urgent race, but also the political roadblocks that nearly stopped the scientists. She describes the terrible dilemmas of pregnant women exposed to German measles and recounts testing on infants, prisoners, orphans, and the intellectually disabled, which was common in the era. These events take place at the dawn of the battle over using human fetal tissue in research, during the arrival of big commerce in campus labs, and as huge changes take place in the laws and practices governing who “owns” research cells and the profits made from biological inventions. It is also the story of yet one more unrecognized woman whose cells have been used to save countless lives. With another frightening virus imperiling pregnant women on the rise today, no medical story could have more human drama, impact, or urgency today than The Vaccine Race.

    From Sarajevo under siege in 1993 to clandestine hospitals in rebel-held eastern Aleppo, he has carried out lifesaving operations in the most challenging conditions, and with none of the resources of a major metropolitan hospital. He is now widely acknowledged as the most experienced trauma surgeon in the world.War Doctor is his extraordinary story, encompassing his surgeries in nearly every major conflict zone since the end of the Cold War, as well as his struggles to return to a “normal” life and routine after each trip. Culminating in his recent trips to war-torn Syria—and the untold story of his efforts to help secure a humanitarian corridor out of besieged Aleppo to evacuate some 50,000 people—War Doctor is a blend of medical memoir, personal journey, and nonfiction thriller that provides unforgettable, at times raw, insight into the human toll of war.

    By focusing on the experiences of ordinary villagers as they lived-and died-during the Black Death (1345-50), Hatcher vividly places the reader directly inside those tumultuous times and describes in fascinating detail the day-to-day existence of people struggling with the tragic effects of the plague. Dramatic scenes portray how contemporaries must have felt and thought about these momentous events: what they knew and didn't know about the horrors of the disease, what they believed about death and God's vengeance, and how they tried to make sense of it all despite frantic rumors, frightening tales, and fearful sermons.

    A peasant girl who hears voices from God. A warrior leading an army to victory, in an age that believes women cannot fight. The Maid of Orleans, and the saviour of France. Burned at the stake as a heretic at the age of just nineteen. Five hundred years later, a saint. Her case was heard in court twice over. One trial, in 1431, condemned her; the other, twenty-five years after her death, cleared her name. In the transcripts, we hear first-hand testimony from Joan, her family and her friends: a rare survival from the medieval world. What could be more revealing?

    In The Demon in the Freezer, his first nonfiction book since The Hot Zone, a #1 New York Times bestseller, Richard Preston takes us into the heart of Usamriid, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the U.S. biological weapons program and now the epicenter of national biodefense.Peter Jahrling, the top scientist at Usamriid, a wry virologist who cut his teeth on Ebola, one of the world’s most lethal emerging viruses, has ORCON security clearance that gives him access to top secret information on bioweapons. His most urgent priority is to develop a drug that will take on smallpox-and win. Eradicated from the planet in 1979 in one of the great triumphs of modern science, the smallpox virus now resides, officially, in only two high-security freezers-at the Centers for Disease Control in Atlanta and in Siberia, at a Russian virology institute called Vector. But the demon in the freezer has been set loose. It is almost certain that illegal stocks are in the possession of hostile states, including Iraq and North Korea. Jahrling is haunted by the thought that biologists in secret labs are using genetic engineering to create a new superpox virus, a smallpox resistant to all vaccines.Usamriid went into a state of Delta Alert on September 11 and activated its emergency response teams when the first anthrax letters were opened in New York and Washington, D.C. Preston reports, in unprecedented detail, on the government’s response to the attacks and takes us into the ongoing FBI investigation. His story is based on interviews with top-level FBI agents and with Dr. Steven Hatfill.Jahrling is leading a team of scientists doing controversial experiments with live smallpox virus at CDC. Preston takes us into the lab where Jahrling is reawakening smallpox and explains, with cool and devastating precision, what may be at stake if his last bold experiment fails.

    But getting here has not been a simple story of selfless men working tirelessly in the pursuit of medical advancement. Instead it's a bloodstained tale of blunders, arrogance, mishap and murder. In trying to keep us alive, surgeons have all too often killed us off, and life-saving solutions have often come from the most surprising places. Accompanying a major BBC series, "Blood and Guts" is an incredible story of stolen corpses, medical fraud, lobotomized patients - and every now and then courageous advances that have saved the lives of millions around the world. You may think twice before going under the knife.

    In 1474, when most women were almost powerless, twenty-three-year-old Isabella defied a hostile brother and mercurial husband to seize control of Castile and León.Her subsequent feats were legendary. She ended a twenty-four-generation struggle between Muslims and Christians, forcing Moorish invaders back over the Mediterranean Sea. She laid the foundation for a unified Spain. She sponsored Columbus's trip to the Indies and negotiated Spanish control over much of the New World with the help of Rodrigo Borgia, the infamous Pope Alexander VI. She also annihilated all who stood against her by establishing a bloody religious Inquisition that would darken Spain's reputation for centuries.Whether saintly or satanic, no female leader has done more to shape our modern world, where millions of people in two hemispheres speak Spanish and practice Catholicism. Yet history has all but forgotten Isabella's influence, due to hundreds of years of misreporting that often attributed her accomplishments to Ferdinand, the bold and philandering husband she adored.Using new scholarship, Downey's luminous biography tells the story of this brilliant, fervent, forgotten woman, the faith that propelled her through life, and the land of ancient conflicts and intrigue she brought under her command.

    Suzanne O'Sullivan's THE SLEEPING BEAUTIES, an exploration of different aspects of psychosomatic disorders, mass hysteria, culture bound syndromes (a set of symptoms that exist only within a particular society), using as its starting point a particular case of more than 400 migrant children in Sweden who have fallen into a "waking coma", to Dan Frank at Pantheon, in a pre-empt.

    In Under the Knife, surgeon Arnold Van de Laar uses his own experience and expertise to tell the witty history of the past, present and future of surgery.From the story of the desperate man from seventeenth-century Amsterdam who grimly cut a stone out of his own bladder to Bob Marley's deadly toe, Under the Knife offers all kinds of fascinating and unforgettable insights into medicine and history via the operating theatre.What happens during an operation? How does the human body respond to being attacked by a knife, a bacterium, a cancer cell or a bullet? And, as medical advances continuously push the boundaries of what medicine can cure, what are the limits of surgery?From the dark centuries of bloodletting and of amputations without anaesthetic to today's sterile, high-tech operating theatres, Under the Knife is both a rich cultural history, and a modern anatomy class for us all.

    A dashing young orator during the Great Hunger of the 1840s, Thomas Francis Meagher led a failed uprising against British rule, for which he was banished to a Tasmanian prison colony for life. But two years later he was “back from the dead” and in New York, instantly the most famous Irishman in America. Meagher’s rebirth included his leading the newly formed Irish Brigade in many of the fiercest battles of the Civil War. Afterward, he tried to build a new Ireland in the wild west of Montana—a quixotic adventure that ended in the  great mystery of his disappearance, which Egan resolves convincingly at last.

    It is up to you.Eddie Jaku always considered himself a German first, a Jew second. He was proud of his country. But all of that changed in November 1938, when he was beaten, arrested and taken to a concentration camp.Over the next seven years, Eddie faced unimaginable horrors every day, first in Buchenwald, then in Auschwitz, then on a Nazi death march. He lost family, friends, his country.Because he survived, Eddie made the vow to smile every day. He pays tribute to those who were lost by telling his story, sharing his wisdom and living his best possible life. He now believes he is the 'happiest man on earth'.Published as Eddie turns 100, this is a powerful, heartbreaking and ultimately hopeful memoir of how happiness can be found even in the darkest of times.

    According to historian Joseph Ellis, Alexander Hamilton is “a robust full-length portrait, in my view the best ever written, of the most brilliant, charismatic and dangerous founder of them all.”Few figures in American history have been more hotly debated or more grossly misunderstood than Alexander Hamilton. Chernow’s biography gives Hamilton his due and sets the record straight, deftly illustrating that the political and economic greatness of today’s America is the result of Hamilton’s countless sacrifices to champion ideas that were often wildly disputed during his time. “To repudiate his legacy,” Chernow writes, “is, in many ways, to repudiate the modern world.” Chernow here recounts Hamilton’s turbulent life: an illegitimate, largely self-taught orphan from the Caribbean, he came out of nowhere to take America by storm, rising to become George Washington’s aide-de-camp in the Continental Army, coauthoring The Federalist Papers, founding the Bank of New York, leading the Federalist Party, and becoming the first Treasury Secretary of the United States.Historians have long told the story of America’s birth as the triumph of Jefferson’s democratic ideals over the aristocratic intentions of Hamilton. Chernow presents an entirely different man, whose legendary ambitions were motivated not merely by self-interest but by passionate patriotism and a stubborn will to build the foundations of American prosperity and power. His is a Hamilton far more human than we’ve encountered before—from his shame about his birth to his fiery aspirations, from his intimate relationships with childhood friends to his titanic feuds with Jefferson, Madison, Adams, Monroe, and Burr, and from his highly public affair with Maria Reynolds to his loving marriage to his loyal wife Eliza. And never before has there been a more vivid account of Hamilton’s famous and mysterious death in a duel with Aaron Burr in July of 1804.Chernow’s biography is not just a portrait of Hamilton, but the story of America’s birth seen through its most central figure. At a critical time to look back to our roots, Alexander Hamilton will remind readers of the purpose of our institutions and our heritage as Americans.

    But as bad as this looks, it's not what worries her the most. With the unwanted media attention now surrounding her, it's only a matter of time before someone from her long hidden past recognizes her and destroys the new life she's worked so hard to build, along with any chance of a future.Twenty-five years earlier, Ruby Reyes, known as the Ice Queen, was convicted of a similar murder in a trial that riveted Canada in the early nineties. Reyes knows who Paris really is, and when she's unexpectedly released from prison, she threatens to expose all of Paris's secrets. Left with no other choice, Paris must finally confront the dark past she escaped, once and for all.Because the only thing worse than a murder charge are two murder charges.Things We Do in the Dark is a brilliant new thriller from Jennifer Hillier, the award-winning author of the breakout novels Little Secrets and Jar of Hearts. Paris Peralta is suspected of killing her celebrity husband, and her long-hidden past now threatens to destroy her future.

    history. The Tennessee town of Oak Ridge was created from scratch in 1942. One of the Manhattan Project’s secret cities, it didn’t appear on any maps until 1949, and yet at the height of World War II it was using more electricity than New York City and was home to more than 75,000 people, many of them young women recruited from small towns across the South. Their jobs were shrouded in mystery, but they were buoyed by a sense of shared purpose, close friendships—and a surplus of handsome scientists and Army men!But against this vibrant wartime backdrop, a darker story was unfolding. The penalty for talking about their work—even the most innocuous details—was job loss and eviction. One woman was recruited to spy on her coworkers. They all knew something big was happening at Oak Ridge, but few could piece together the true nature of their work until the bomb "Little Boy" was dropped over Hiroshima, Japan, and the secret was out. The shocking revelation: the residents of Oak Ridge were enriching uranium for the atomic bomb.Though the young women originally believed they would leave Oak Ridge after the war, many met husbands there, made lifelong friends, and still call the seventy-year-old town home. The reverberations from their work there—work they didn’t fully understand at the time—are still being felt today. In The Girls of Atomic City, Denise Kiernan traces the astonishing story of these unsung WWII workers through interviews with dozens of surviving women and other Oak Ridge residents. Like The Immortal Life of Henrietta Lacks, this is history and science made fresh and vibrant—a beautifully told, deeply researched story that unfolds in a suspenseful and exciting way.

    Later, during three years of brutal captivity at the hands of the Japanese, they also demonstrated their ability to survive. Filled with the thoughts and impressions of the women who lived it, "every page of this history is fascinating" (The Washington Post). "We Band of Angels"In the fall of 1941, the Philippines was a gardenia-scented paradise for the American Army and Navy nurses stationed there. War was a distant rumor, life a routine of easy shifts and evenings of dinner and dancing under the stars. On December 8 all that changed, as Japanese bombs rained on American bases in Luzon, and the women's paradise became a fiery hell. Caught in the raging battle, the nurses set up field hospitals in the jungles of Bataan and the tunnels of Corregidor, where they saw the most devastating injuries of war, and suffered the terrors of shells and shrapnel.But the worst was yet to come. As Bataan and Corregidor fell, a few nurses escaped, but most were herded into internment camps enduring three years of fear and starvation. Once liberated, they returned to an America that at first celebrated them, but later refused to honor their leaders with the medals they clearly deserved. Here, in letters, diaries, and firsthand accounts, is the story of what really happened during those dark days, woven together in a compelling saga of women in war.