Hailed as the most outstanding book in the biomedical sciences when it was originally published in 1990, Manic-Depressive Illness was the first to survey this massive body of evidence comprehensively and to assess its meaning for both clinician and scientist. It also vividly portrayed the experience of manic-depressive illness from the perspective of patients, their doctors, and researchers. Encompassing an understanding about the illness as Kraeplin conceived of it- about its cyclical course and about the essential unity of its bipolar and recurrent unipolar forms- the book has become the definitive work on the topic, revered by both specialists and nonspecialists alike. Now, in this magnificent second edition, Drs. Frederick Goodwin and Kay Redfield Jamison bring their unique contribution to mental health science into the 21st century. In collaboration with a team of other leading scientists, a collaboration designed to preserve the unified voice of the two authors, they exhaustively review the biological and genetic literature that has dominated the field in recent years and incorporate cutting-edge research conducted since publication of the first edition. They also update their surveys of psychological and epidemiological evidence, as well as that pertaining to diagnostic issues, course, and outcome, and they offer practical guidelines for differential diagnosis and clinical management. The medical treatment of manic and depressive episodes is described, strategies for preventing future episodes are given in detail, and psychotherapeutic issues common in this illness are considered. Special emphasis is given to fostering compliance with medication regimens and treating patients who abuse drugs and alcohol or who pose a risk of suicide. This book, unique in the way that it retains the distinct perspective of its authors while assuring the maximum in-depth coverage of a vastly expanded base of scientific knowledge, will be a valuable and necessary addition to the libraries of psychiatrists and other physicians, psychologists, clinical social workers, neuroscientists, pharmacologists, and the patients and families who live with manic-depressive illness.

    Throughout history, it has been consumed not just to quench our thirsts or nourish our bodies but also for cultural reasons. It has been associated since antiquity with celebration, creativity, friendship, and danger, for every drinking culture has acknowledged it possesses a dark side. In Drink, Iain Gately traces the course of humanity's 10,000 year old love affair with the substance which has been dubbed the cause of - and solution to - all of life's problems. Along the way he scrutinises the drinking habits of presidents, prophets, and barbarian hordes, and features drinkers as diverse as Homer, Hemmingway, Shakespeare, Al Capone, Benjamin Franklin, and Thomas Jefferson. Covering matters as varied as bacchanals in Imperial Rome, the gin craze in 17th century London, the rise and fall of the temperance movement, and drunk driving, Drink details the benefits and burdens alcohol has conveyed to the societies in which it is consumed. Gately's lively and provocative style brings to life the controversies, past and present, that have raged over alcohol, and uses the authentic voices of drinkers and their detractors to explode myths and reveal truths about this most equivocal of fluids.Drink further documents the contribution of alcohol to the birth and growth of the United States, taking in the war of Independence, the Pennsylvania Whiskey revolt, the slave trade, and the failed experiment of National Prohibition. Finally, it provides a history of the world's best loved drinks. Enthusiasts of craft brews and fine wines will discover the origins of their favorite tipples, and what they have in common with Greek philosophers and medieval princes every time they raise a glass.A rollicking tour through humanity's love affair with alcohol, Drink is an intoxicating history of civilization

    For almost a century they defied classification; they outwitted hunters and escaped trappers, left the public elbowing and zoo turnstiles spinning, were sent on diplomatic journeys, branded onto products and turned into company logos. Thanks to the World Wide Fund for Nature this species became the face of global conservation. Yet in spite of humankind’s evident obsession with the giant panda, it is only in the last few decades that scientific research has begun to show us what this mysterious, frequently misunderstood creature is really like.Henry Nicholls uses the rich and curious history of the giant panda to do several things: to ponder our changing attitudes towards the natural world; to offer a compelling history of the conservation movement; and to chart the rise of modern China on its journey to become the self-sufficient, twenty-first-century superpower it is today.

    Their choices are limited by mountains, rivers, seas, and concrete. To understand world events, news organizations and other authorities often focus on people, ideas, and political movements, but without geography, we never have the full picture. Now, in the relevant and timely Prisoners of Geography, seasoned journalist Tim Marshall examines Russia, China, the USA, Latin America, the Middle East, Africa, Europe, Japan and Korea, and Greenland and the Arctic—their weather, seas, mountains, rivers, deserts, and borders—to provide a context often missing from our political reportage: how the physical characteristics of these countries affect their strengths and vulnerabilities and the decisions made by their leaders.In ten, up-to-date maps of each region, Marshall explains in clear and engaging prose the complex geo-political strategies of these key parts of the globe. What does it mean that Russia must have a navy, but also has frozen ports six months a year? How does this affect Putin’s treatment of Ukraine? How is China’s future constrained by its geography? Why will Europe never be united? Why will America never be invaded? Shining a light on the unavoidable physical realities that shape all of our aspirations and endeavors, Prisoners of Geography is the critical guide to one of the major (and most often overlooked) determining factors in world history.

    Rick Strassman conducted US DEA-approved clinical research at the University of New Mexico in which he injected 60 volunteers with DMT, one of the most powerful psychedelics known. His detailed account of those sessions is an inquiry into the nature of the human mind and the therapeutic potential of psychedelics. DMT, a plant-derived chemical that is also manufactured by the human brain, consistently produced near-death and mystical experiences. Many volunteers reported convincing encounters with intelligent nonhuman presences, especially "aliens." Nearly all felt that the sessions were among the most profound experiences of their lives.Strassman's research connects DMT with the pineal gland, considered by Hindus to be the site of the seventh chakra and by René Descartes to be the seat of the soul. DMT: The Spirit Molecule makes the case that DMT, naturally released by the pineal gland, facilitates the soul's movement in and out of the body and is an integral part of the birth and death experiences, as well as the highest states of meditation and even sexual transcendence. Strassman also believes that alien abduction experiences are brought on by accidental releases of DMT. If used wisely, DMT could trigger a period of remarkable progress in the scientific exploration of the most mystical regions of the human mind and soul.

    In fact, a plethora of parasites affect our behavior in ways we have barely begun to understand.  In this mind-bending book, McAuliffe reveals the eons-old war between parasites and other creatures that is playing out in our very own bodies. And more surprising still, she uncovers the decisive role that parasites may have played in the rise and demise of entire civilizations. Our obsession with cleanliness and our experience of disgust are both evolutionary tools for avoiding infection, but they evolved differently for different populations. Political, social, and religious differences among societies may be caused, in part, by the different parasites that prey on us. In the tradition of Jared Diamond’s Guns, Germs, and Steel and Neil Shubin’s Your Inner Fish, This Is Your Brain on Parasites is both a journey into cutting-edge science and a revelatory examination of what it means to be human.

    Here is the sweeping story of a substance that has been feared, revered, mythologized, and used in magic and medicine from earliest times--a substance that has become the center of a huge, secretive, and often dangerous worldwide commerce.Winner of the Los Angeles Times Book Prize, Blood was described by judges as "a gripping page-turner, a significant contribution to the history of medicine and technology and a cautionary tale. Meticulously reported and exhaustively documented."

    Pouring into developing-world “instant cities” like Dubai and Shenzhen, these urban newcomers confront a modern world cobbled together from fragments of a West they have never seen. Do these fantastical boomtowns, where blueprints spring to life overnight on virgin land, represent the dawning of a brave new world? Or is their vaunted newness a mirage?In a captivating blend of history and reportage, Daniel Brook travels to a series of major metropolitan hubs that were once themselves instant cities— St. Petersburg, Shanghai, and Mumbai—to watch their “dress rehearsals for the twenty-first century.” Understanding today’s emerging global order, he argues, requires comprehending the West’s profound and conflicted influence on developing-world cities over the centuries.In 1703, Tsar Peter the Great personally oversaw the construction of a new Russian capital, a “window on the West” carefully modeled on Amsterdam, that he believed would wrench Russia into the modern world. In the nineteenth century, Shanghai became the fastest-growing city on earth as it mushroomed into an English-speaking, Western-looking metropolis that just happened to be in the Far East. Meanwhile, Bombay, the cosmopolitan hub of the British Raj, morphed into a tropical London at the hands of its pith-helmeted imperialists.Juxtaposing the stories of the architects and authoritarians, the artists and revolutionaries who seized the reins to transform each of these precociously modern places into avatars of the global future, Brook demonstrates that the drive for modernization was initially conflated with wholesale Westernization. He shows, too, the ambiguous legacy of that emulation—the birth (and rebirth) of Chinese capitalism in Shanghai, the origins of Bollywood in Bombay’s American-style movie palaces, the combustible mix of revolutionary culture and politics that rocked the Russian capital—and how it may be transcended today.A fascinating, vivid look from the past out toward the horizon, A History of Future Cities is both a crucial reminder of globalization’s long march and an inspiring look into the possibilities of our Asian Century.

    15,000 BC) to today. Delving further back into human history and deeper into the human psyche than Serial Killers--Vronsky's 2004 book, which has been called "the definitive history of the phenomenon of serial murder"--he focuses strictly on sexual serial killers: thrill killers who engage in murder, rape, torture, cannibalism and necrophilia, as opposed to for-profit serial killers, including hit men, or "political" serial killers, like terrorists or genocidal murderers.These sexual serial killers differ from all other serial killers in their motives and their foundations. They are uniquely human and--as popular culture has demonstrated--uniquely fascinating.

    Warnings that depressive disorder is a leading cause of worldwide disability have been accompanied by a massive upsurge in the consumption of antidepressant medication, widespread screening for depression in clinics and schools, and a push to diagnose depression early, on the basis of just a few symptoms, in order to prevent more severe conditions from developing.In The Loss of Sadness, Allan V. Horwitz and Jerome C. Wakefield argue that, while depressive disorder certainly exists and can be a devastating condition warranting medical attention, the apparent epidemic in fact reflects the way the psychiatric profession has understood and reclassified normal human sadness as largely an abnormal experience. With the 1980 publication of the landmark third edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), mental health professionals began diagnosing depression based on symptoms—such as depressed mood, loss of appetite, and fatigue—that lasted for at least two weeks. This system is fundamentally flawed, the authors maintain, because it fails to take into account the context in which the symptoms occur. They stress the importance of distinguishing between abnormal reactions due to internal dysfunction and normal sadness brought on by external circumstances. Under the current DSM classification system, however, this distinction is impossible to make, so the expected emotional distress caused by upsetting events—for example, the loss of a job or the end of a relationship—could lead to a mistaken diagnosis of depressive disorder. Indeed, it is this very mistake that lies at the root of the presumed epidemic of major depression in our midst.

    It reveals - among other things - how 'President' Bush stole an election aided only by his brother, cousin and dad's cronies, electoral fraud and tame judges; how the rich stay rich while forcing the rest of us to live in economic fear; and how politicians have whored themselves to big business. Whether he's calling for United Nations action to overthrow the Bush Family Junta, calling on African-Americans to place whites-only signs over the entrances of unfriendly businesses, or praying that Jesse Helms will get kissed by a man, Stupid White Men is Michael Moore's Manifesto on Malfeasance and Mediocrity. A hilarious must-read for anyone who wants to know what the con is and how 'they' get away with it, Stupid White Men is only available uncensored because public pressure forced the original publishers to publish a book they felt was too hot to handle. Now it's time to find out why. 'A really great, hilarious, rollicking, fantastic read'  Newsnight Review 'Caustic, breakneck, tell-it-like-it-is ... He's a genuine populist; a twenty-first-century pamphleteer'  Observer 'Furious and funny. A great book'  Time Out 'Hysterically funny. The angrier Moore gets, the funnier he gets. Sensational'  San Francisco Chronicle Author of international bestsellers Stupid White Men and Dude, Where's My Country, Michael Moore's 2002 film Bowling for Columbine won the Anniversary Prize at the Cannes Film Festival and the 2002 Academy Award for Best Documentary. His 2004 film Fahrenheit 9-11 won the 2004 Palme d'Or at the Cannes Film Festival, and is the highest-grossing documentary of all time. Released in 2007, Moore's documentary Sicko, focused on the American healthcare system, was nominated for an Oscar.

    Part culinary history, part cultural commentary, Vanilla tells the remarkable story of the world's most popular flavor and scent. The Spanish considered vanilla the ultimate aphrodisiac, the Totonac Indians called it the fruit of the gods, and the Aztecs taxed the Mayans in vanilla beans, using the beans as currency. Today, vanilla is in our coffee, our perfume, tea, home products, body lotion, and just about anything imaginable. Patricia Rain explores the incredibly diverse effect of vanilla on the worlds of food, medicine, psychology, and even politics. She intertwines the fields of cultural anthropology, botany, folklore, and economics, tracing the marvelous path of vanilla throughout world history. Vanilla shows how the impact and marketing of this ubiquitous little bean over the last eight hundred years saved the indigenous peoples of Mexico and Tahiti, put Madagascar on the map, drove the success of the great Parisian perfume houses and Europe's confection industry, and spurred trade routes across the Indian Ocean. Rain examines the rich history of vanilla with exacting detail and discusses its current role in our lives and the modern retail world, where the "vanilla boom" has caused the prices of many common consumer items to skyrocket. Filled with fascinating insights, quirky characters, trivia, and even recipes, this beautifully written book is perfect for vanilla lovers, history buffs, and anyone interested in a real-life captivating story.

    The custodian of the tomb was so shaken by the incident that he willingly dedicated the rest of his life to protecting the president's corpse.In a lively and dramatic narrative, Thomas J. Craughwell returns to this bizarre, and largely forgotten, event with the first book to place the grave robbery in historical context. He takes us through the planning and execution of the crime and the outcome of the investigation. He describes the reactions of Mary Todd Lincoln and Robert Todd Lincoln to the theft - and the peculiar silence of the nation. He follows the unlikely tale of what happened to Lincoln's remains after the attempted robbery and details the plan devised by the Lincoln Guard of Honor to prevent a similar abominable occurrence.Along the way, Craughwell offers entertaining sidelights on the rise of counterfeiting in America and the establishment of the Secret Service to combat it; the prevalence of grave robberies; the art of nineteenth-century embalming; and the emergence among Irish immigrants of an ambitious middle class - and a criminal underclass.This rousing story of hapless con men, intrepid federal agents, and ordinary Springfield citizens who honored their native son by keeping a valuable, burdensome secret for decades offers a riveting glimpse into late nineteenth-century America and underscores that truth really is sometimes stranger than fiction.

    Viruses are disarmingly small and simple. Nevertheless, the smallpox virus killed over 300 million people in the twentieth century before it was eradicated in 1980. The AIDSvirus, HIV, is now the world's biggest killer infection and the single most common cause of death in Africa. In recent years, the outbreaks of several lethal viruses such as Ebola and Hantavirus have caused great public concern--yet most people remain woefully ill-informed.In this fascinating new book, Dorothy Crawford explains lucidly and accessibly all aspects of the natural history of these deadly parasites and discusses controversial subjects such as CFS and Gulf War Syndrome. The book considers issues such as how man has coped with viruses in the past, where newviruses come from, and whether it would be possible for a new virus to wipe out the human race. Professor Crawford illustrates her arguments with vivid and wide-ranging examples. The result is an informative and highly readable book, which will be read by all those who seek a deeper understanding ofthese minute but remarkably efficient killers.

    But for most of human history, practically no one slept this way. Tracing sleep's transformation since the dawn of the industrial age, Reiss weaves together insights from literature, social and medical history, and cutting-edge science to show how and why we have tried and failed to tame sleep. In lyrical prose, he leads readers from bedrooms and laboratories to factories and battlefields to Henry David Thoreau's famous cabin at Walden Pond, telling the stories of troubled sleepers, hibernating peasants, sleepwalking preachers, cave-dwelling sleep researchers, slaves who led nighttime uprisings, rebellious workers, spectacularly frazzled parents, and utopian dreamers. We are hardly the first people, Reiss makes clear, to chafe against our modern rules for sleeping.A stirring testament to sleep's diversity, Wild Nights offers a profound reminder that in the vulnerability of slumber we can find our shared humanity. By peeling back the covers of history, Reiss recaptures sleep's mystery and grandeur and offers hope to weary readers: as sleep was transformed once before, so too can it change today.