. . alive and fascinating and provocative on every page."—Oliver Sacks, M.D.Porter's charting of the history of medicine affords readers the opportunity as never before to assess its culture and science and its costs and benefits to humankind. "A splendid and thoroughly engrossing book."--"L.A. Times." of illustrations.

    With his classic Why We Get Sick, Dr. Randolph Nesse helped to establish the field of evolutionary medicine. Now he returns with a book that transforms our understanding of mental disorders by exploring a fundamentally new question. Instead of asking why certain people suffer from mental illness, Nesse asks why natural selection has left us all with fragile minds.Drawing on revealing stories from his own clinical practice and insights from evolutionary biology, Nesse shows how negative emotions are useful in certain situations, yet can become overwhelming. Anxiety protects us from harm in the face of danger, but false alarms are inevitable. Low moods prevent us from wasting effort in pursuit of unreachable goals, but they often escalate into pathological depression. Other mental disorders, such as addiction and anorexia, result from the mismatch between modern environment and our ancient human past. And there are good evolutionary reasons for sexual disorders and for why genes for schizophrenia persist. Taken together, these and many more insights help to explain the pervasiveness of human suffering, and show us new paths for relieving it by understanding individuals as individuals.

    Doctor, Harvard professor, renowned infectious-disease specialist, anthropologist, the recipient of a MacArthur "genius" grant, world-class Robin Hood, Farmer was brought up in a bus and on a boat, and in medical school found his life’s calling: to diagnose and cure infectious diseases and to bring the lifesaving tools of modern medicine to those who need them most.Mountains Beyond Mountains takes us from Harvard to Haiti, Peru, Cuba, and Russia as Farmer changes minds and practices through his dedication to the philosophy that "the only real nation is humanity"—a philosophy that is embodied in the small public charity he founded, Partners in Health. He enlists the help of the Gates Foundation, George Soros, the U.N.’s World Health Organization, and others in his quest to cure the world. At the heart of this book is the example of a life based on hope, and on an understanding of the truth of the Haitian proverb "Beyond mountains there are mountains": as you solve one problem, another problem presents itself, and so you go on and try to solve that one too.

    Craig Venter became the first to successfully create synthetic life putting humankind at the threshold of the most important and exciting phase of biological research, one that will enable us to actually write the genetic code for designing new species to help us adapt and evolve for long-term survival. The science of synthetic genomics will have a profound impact on human existence, including chemical and energy generation, health, clean water and food production, environmental control, and possibly even our evolution. In "Life at the Speed of Light," Venter presents a fascinating and authoritative study of this emerging field from the inside detailing its origins, current challenges and controversies, and projected effects on our lives. This scientific frontier provides an opportunity to ponder anew the age-old question What is life? and examine what we really mean by playing God. " Life at the Speed of Light "is a landmark work, written by a visionary at the dawn of a new era of biological engineering."

    A strong gravitational wave will briefly change that distance by less than the thickness of a human hair. We have perhaps less than a few tenths of a second to perform this measurement. And we don’t know if this infinitesimal event will come next month, next year or perhaps in thirty years.In 1916 Einstein predicted the existence of gravitational waves: miniscule ripples in the very fabric of spacetime generated by unfathomably powerful events. If such vibrations could somehow be recorded, we could observe our universe for the first time through sound: the hissing of the Big Bang, the whale-like tunes of collapsing stars, the low tones of merging galaxies, the drumbeat of two black holes collapsing into one. For decades, astrophysicists have searched for a way of doing so…In 2016 a team of hundreds of scientists at work on a billion-dollar experiment made history when they announced the first ever detection of a gravitational wave, confirming Einstein’s prediction. This is their story, and the story of the most sensitive scientific instrument ever made: LIGO.Based on complete access to LIGO and the scientists who created it, Black Hole Blues provides a firsthand account of this astonishing achievement: a compelling, intimate portrait of cutting-edge science at its most awe-inspiring and ambitious.

    Astrophysicist Adam Frank traces the question of alien life and intelligence from the ancient Greeks to the leading thinkers of our own time, and shows how we as a civilization can only hope to survive climate change if we recognize what science has recently discovered: that we are just one of ten billion trillion planets in the Universe, and it’s highly likely that many of those planets hosted technologically advanced alien civilizations. What’s more, each of those civilizations must have faced the same challenge of civilization-driven climate change.Written with great clarity and conviction, Light of the Stars builds on the inspiring work of pioneering scientists such as Frank Drake and Carl Sagan, whose work at the dawn of the space age began building the new science of astrobiology; Jack James, the Texas-born engineer who drove NASA’s first planetary missions to success; Vladimir Vernadsky, the Russian geochemist who first envisioned the Earth’s biosphere; and James Lovelock and Lynn Margulis, who invented Gaia theory. Frank recounts the perilous journey NASA undertook across millions of miles of deep space to get its probes to Venus and Mars, yielding our first view of the cosmic laws of planets and climate that changed our understanding of our place in the universe.Thrilling science at the grandest of scales, Light of the Stars explores what may be the largest question of all: What can the likely presence of life on other worlds tell us about our own fate?

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    Now he makes the case that living on Mars is not just plausible, but inevitable.It sounds like science fiction, but Stephen Petranek considers it fact: Within twenty years, humans will live on Mars. We'll need to. In this sweeping, provocative book that mixes business, science, and human reporting, Petranek makes the case that living on Mars is an essential back-up plan for humanity and explains in fascinating detail just how it will happen.The race is on. Private companies, driven by iconoclastic entrepreneurs, such as Elon Musk, Jeff Bezos, Paul Allen, and Sir Richard Branson; Dutch reality show and space mission Mars One; NASA; and the Chinese government are among the many groups competing to plant the first stake on Mars and open the door for human habitation. Why go to Mars? Life on Mars has potential life-saving possibilities for everyone on earth. Depleting water supplies, overwhelming climate change, and a host of other disasters — from terrorist attacks to meteor strikes — all loom large. We must become a space-faring species to survive. We have the technology not only to get humans to Mars, but to convert Mars into another habitable planet. It will likely take 300 years to "terraform" Mars, as the jargon goes, but we can turn it into a veritable second Garden of Eden. And we can live there, in specially designed habitations, within the next twenty years.In this exciting chronicle, Petranek introduces the circus of lively characters all engaged in a dramatic effort to be the first to settle the Red Planet. How We'll Live on Mars brings firsthand reporting, interviews with key participants, and extensive research to bear on the question of how we can expect to see life on Mars within the next twenty years.

    Famously bipartisan, he advised presidents and Congress on health reform and originated central features of the Affordable Care Act. In Priced Out, Reinhardt offers an engaging and enlightening account of today's U.S. health care system, explaining why it costs so much more and delivers so much less than the systems of every other advanced country, why this situation is morally indefensible, and how we might improve it.The problem, Reinhardt says, is not one of economics but of social ethics. There is no American political consensus on a fundamental question other countries settled long ago: to what extent should we be our brothers' and sisters' keepers when it comes to health care? Drawing on the best evidence, he guides readers through the chaotic, secretive, and inefficient way America finances health care, and he offers a penetrating ethical analysis of recent reform proposals. At this point, he argues, the United States appears to have three stark choices: the government can make the rich help pay for the health care of the poor, ration care by income, or control costs. Reinhardt proposes an alternative path: that by age 26 all Americans must choose either to join an insurance arrangement with community-rated premiums, or take a chance on being uninsured or relying on a health insurance market that charges premiums based on health status.An incisive look at the American health care system, Priced Out dispels the confusion, ignorance, myths, and misinformation that hinder effective reform.