It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease. Magisterial in its breadth of perspective and depth of research and now revised to reflect the growing danger of the avian flu, The Great Influenza is ultimately a tale of triumph amid tragedy, which provides us with a precise and sobering model as we confront the epidemics looming on our own horizon. John M. Barry has written a new afterword for this edition that brings us up to speed on the terrible threat of the avian flu and suggest ways in which we might head off another flu pandemic.

    She was married with children and a good career. So why did she feel miserable? And why did it seem that other Generation X women were miserable, too?Calhoun decided to find some answers. She looked into housing costs, HR trends, credit card debt averages, and divorce data. At every turn, she saw a pattern: sandwiched between the Boomers and the Millennials, Gen X women were facing new problems as they entered middle age, problems that were being largely overlooked.Speaking with women across America about their experiences as the generation raised to “have it all,” Calhoun found that most were exhausted, terrified about money, under-employed, and overwhelmed. Instead of being heard, they were told instead to lean in, take “me-time,” or make a chore chart to get their lives and homes in order.In Why We Can’t Sleep, Calhoun opens up the cultural and political contexts of Gen X’s predicament and offers solutions for how to pull oneself out of the abyss—and keep the next generation of women from falling in. The result is reassuring, empowering, and essential reading for all middle-aged women, and anyone who hopes to understand them.

    Pink, author of When and Drive SUCCESSFUL AGING delivers powerful insights: - Debunking the myth that memory always declines with age - Confirming that health span--not life span--is what matters - Proving that sixty-plus years is a unique and newly recognized developmental stage - Recommending that people look forward to joy, as reminiscing doesn't promote health Levitin looks at the science behind what we all can learn from those who age joyously, as well as how to adapt our culture to take full advantage of older people's wisdom and experience. Throughout his exploration of what aging really means, using research from developmental neuroscience and the psychology of individual differences, Levitin reveals resilience strategies and practical, cognitive enhancing tricks everyone should do as they age.Successful Aging inspires a powerful new approach to how readers think about our final decades, and it will revolutionize the way we plan for old age as individuals, family members, and citizens within a society where the average life expectancy continues to rise.

    Guy Leschziner's patients, there is no rest for the weary in mind and body. Insomnia, narcolepsy, night terrors, sleep apnea, and sleepwalking are just a sampling of conditions afflicting sufferers who cannot sleep--and their experiences in trying are the stuff of nightmares. Demoniac hallucinations frighten people into paralysis. Restless legs rock both the sleepless and their sleeping partners with unpredictable and uncontrollable kicking. Out-of-sync circadian rhythms confuse the natural body clock's days and nights.Then there are the extreme cases. A woman in a state of deep sleep who gets dressed, unlocks her car, and drives for several miles before returning to bed. The man who has spent decades cleaning out kitchens while "sleep-eating." The teenager prone to the serious, yet unfortunately nicknamed "Sleeping Beauty Syndrome" stuck in a cycle of excessive unconsciousness, binge eating, and uncharacteristic displays of aggression and hyper-sexuality while awake.With compassionate stories of his patients and their conditions, Dr. Leschziner illustrates the neuroscience behind our sleeping minds, revealing the many biological and psychological factors necessary in getting the rest that will not only maintain our physical and mental health, but improve our cognitive abilities and overall happiness.

    If such a plague returned today, taking a comparable percentage of the U.S. population with it, 1.5 million Americans would die.The fascinating, true story of the world's deadliest disease.In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out.Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for "The New York Times," unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.

    She explores every angle of swearing—why we do it, how we do it, and what it tells us about ourselves. Packed with the results of unlikely and often hilarious scientific studies—from the “ice-bucket test” for coping with pain, to the connection between Tourette’s and swearing, to a chimpanzee that curses at her handler in sign language—Swearing Is Good for You presents a lighthearted but convincing case for the foulmouthed.

    In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future

    Charting the most cutting-edge scientific breakthroughs, and marshalling his decades of research and clinical practice, Walker explains how we can harness sleep to improve learning, mood and energy levels, regulate hormones, prevent cancer, Alzheimer's and diabetes, slow the effects of aging, and increase longevity. He also provides actionable steps towards getting a better night's sleep every night.

    In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future. http://us.macmillan.com/missingmicrob...

    Gut, an international bestseller, gives the alimentary canal its long-overdue moment in the spotlight. With quirky charm, rising science star Giulia Enders explains the gut’s magic, answering questions like: Why does acid reflux happen? What’s really up with gluten and lactose intolerance? How does the gut affect obesity and mood? Communication between the gut and the brain is one of the fastest-growing areas of medical research—on par with stem-cell research. Our gut reactions, we learn, are intimately connected with our physical and mental well-being. Enders’s beguiling manifesto will make you finally listen to those butterflies in your stomach: they’re trying to tell you something important.

    By examining fossils and DNA, Shubin shows us that our hands actually resemble fish fins, our head is organized like that of a long-extinct jawless fish, and major parts of our genome look and function like those of worms and bacteria.Shubin makes us see ourselves and our world in a completely new light. Your Inner Fish is science writing at its finest-enlightening, accessible, and told with irresistible enthusiasm.

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    How many of us understand the way seizures affect the brain, how the heart is connected to wellbeing, or the why the foot carries the key to our humanity? In Adventures in Human Being, award-winning author Gavin Francis leads readers on a journey into the hidden pathways of the human body, offering a guide to its inner workings and a celebration of its marvels.Drawing on his experiences as a surgeon, ER specialist, and family physician, Francis blends stories from the clinic with episodes from medical history, philosophy, and literature to describe the body in sickness and in health, in living and in dying. At its heart, Adventures in Human Being is a meditation on what it means to be human. Poetic, eloquent, and profoundly perceptive, this book will transform the way you view your body.

    But in recent decades, these claims have eroded, or even been disproven outright, by a revolution in the study of animal cognition. Take the way octopuses use coconut shells as tools; elephants that classify humans by age, gender, and language; or Ayumu, the young male chimpanzee at Kyoto University whose flash memory puts that of humans to shame. Based on research involving crows, dolphins, parrots, sheep, wasps, bats, whales, and of course chimpanzees and bonobos, Frans de Waal explores both the scope and the depth of animal intelligence. He offers a firsthand account of how science has stood traditional behaviorism on its head by revealing how smart animals really are, and how we’ve underestimated their abilities for too long.People often assume a cognitive ladder, from lower to higher forms, with our own intelligence at the top. But what if it is more like a bush, with cognition taking different forms that are often incomparable to ours? Would you presume yourself dumber than a squirrel because you’re less adept at recalling the locations of hundreds of buried acorns? Or would you judge your perception of your surroundings as more sophisticated than that of a echolocating bat? De Waal reviews the rise and fall of the mechanistic view of animals and opens our minds to the idea that animal minds are far more intricate and complex than we have assumed. De Waal’s landmark work will convince you to rethink everything you thought you knew about animal—and human—intelligence.

    Alongside remarkable stories of people who have lost these abilities but adapted with courage, resilience and ingenuity, there is an added, personal element: one day in late 2005, Sacks became aware of a dazzling, flashing light in one part of his visual field; it was not the familiar migraine aura he had experienced since childhood, and just two days later a malignant tumor in one eye was diagnosed. In subsequent journal entries - some of which are included in The Mind's Eye - he chronicled the experience of living with cancer, recording both the effects of the tumor itself, and radiation therapy. In turning himself into a case history, Sacks has given us perhaps his most intimate, impressive and insightful (no pun intended) book yet.