We lose love, lose jobs, lose our sense of self. For Nora McInerny, it was losing her husband, her father, and her unborn second child in one catastrophic year.But in the wake of loss, we get to assemble something new from whatever is left behind. Some circles call finding happiness after loss “Chapter 2”—the continuation of something else. Today, Nora is remarried and mothers four children aged 16 months to 16 years. While her new circumstances bring her extraordinary joy, they are also tinged with sadness over the loved ones she’s lost.Life has made Nora a reluctant expert in hard conversations. On her wildly popular podcast, she talks about painful experiences we inevitably face, and exposes the absurdity of the question “how are you?” that people often ask when we’re coping with the aftermath of emotional catastrophe. She knows intimately that when your life falls apart, there’s a mad rush to be okay—to find a silver lining, to get to the happy ending. In this, her second memoir, Nora offers a tragicomic exploration of the tension between finding happiness and holding space for the unhappy experiences that have shaped us.No Happy Endings is a book for people living life after life has fallen apart. It’s a book for people who know that they’re moving forward, not moving on. It’s a book for people who know life isn’t always happy, but it isn’t the end: there will be unimaginable joy and incomprehensible tragedy. As Nora reminds us, there will be no happy endings—but there will be new beginnings.

    What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world.Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure.

    This is a book about the incentives that shape us, and about how hard it is to see ourselves clearly in a culture that revolves around the self. In each essay, Jia writes about the cultural prisms that have shaped her: the rise of the nightmare social internet; the American scammer as millennial hero; the literary heroine’s journey from brave to blank to bitter; the mandate that everything, including our bodies, should always be getting more efficient and beautiful until we die.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    In her adolescence, she was a religious radical, melting her brother’s boy band cassettes in the oven because music was haram: forbidden by Islamic law. But what a difference an education can make. By her twenties she was a computer security engineer, one of few women working in a desert compound that resembled suburban America. That’s when the Saudi kingdom’s contradictions became too much to bear: she was labeled a slut for chatting with male colleagues, her teenage brother chaperoned her on a business trip, and while she kept a car in her garage, she was forbidden from driving down city streets behind the wheel.Daring to Drive is the fiercely intimate memoir of an accidental activist, a powerfully vivid story of a young Muslim woman who stood up to a kingdom of men—and won. Writing on the cusp of history, Manal offers a rare glimpse into the lives of women in Saudi Arabia today. Her memoir is a remarkable celebration of resilience in the face of tyranny, the extraordinary power of education and female solidarity, and the difficulties, absurdities, and joys of making your voice heard.

    One day he was a doctor treating the dying, and the next he was a patient struggling to live. And just like that, the future he and his wife had imagined evaporated. When Breath Becomes Air chronicles Kalanithi's transformation from a naïve medical student "possessed," as he wrote, "by the question of what, given that all organisms die, makes a virtuous and meaningful life" into a neurosurgeon at Stanford working in the brain, the most critical place for human identity, and finally into a patient and new father confronting his own mortality. What makes life worth living in the face of death? What do you do when the future, no longer a ladder toward your goals in life, flattens out into a perpetual present? What does it mean to have a child, to nurture a new life as another fades away? These are some of the questions Kalanithi wrestles with in this profoundly moving, exquisitely observed memoir. Paul Kalanithi died in March 2015, while working on this book, yet his words live on as a guide and a gift to us all. "I began to realize that coming face to face with my own mortality, in a sense, had changed nothing and everything," he wrote. "Seven words from Samuel Beckett began to repeat in my head: 'I can't go on. I'll go on.'" When Breath Becomes Air is an unforgettable, life-affirming reflection on the challenge of facing death and on the relationship between doctor and patient, from a brilliant writer who became both.

     “A pleasure. Ellie Kemper is the kind of stable, intelligent, funny, healthy woman that usually only exists in yogurt commercials. But she’s real and she’s all ours!” —Tina Fey “Ellie is a hilarious and talented writer, although we’ll never know how much of this book the squirrel wrote.”—Mindy KalingMeet Ellie, the best-intentioned redhead next door. You’ll laugh right alongside her as she shares tales of her childhood in St. Louis, whether directing and also starring in her family holiday pageant, washing her dad’s car with a Brillo pad, failing to become friends with a plump squirrel in her backyard, eating her feelings while watching PG-13 movies, or becoming a “sports monster” who ends up warming the bench of her Division 1 field hockey team in college. You’ll learn how she found her comedic calling in the world of improv, became a wife, mother and New Yorker, and landed the role of a bridesmaid (while simultaneously being a bridesmaid) in Bridesmaids. You’ll get to know and love the comic, upbeat, perpetually polite actress playing Erin Hannon on The Office, and the exuberant, pink-pants-wearing star of Unbreakable Kimmy Schmidt. If you’ve ever been curious about what happens behind the scenes of your favorite shows, what it really takes to be a soul cycle “warrior,” how to recover if you accidentally fall on Doris Kearns Goodwin or tell Tina Fey on meeting her for the first time that she has “great hair—really strong and thick,” this is your chance to find out. But it’s also a laugh-out-loud primer on how to keep a positive outlook in a world gone mad and how not to give up on your dreams. Ellie “dives fully into each role—as actor, comedian, writer, and also wife and new mom—with an electric dedication, by which one learns to reframe the picture, and if not exactly become a glass-half-full sort of person, at least become able to appreciate them” (Vogue.com).

    Six years later she made her first suicide attempt, then wandered the streets of New York City dressed in ragged clothes, tormenting voices crying out in her mind. Lori Schiller had entered the horrifying world of full-blown schizophrenia. She began an ordeal of hospitalizations, halfway houses, relapses, more suicide attempts, and constant, withering despair. But against all odds, she survived. Now in this personal account, she tells how she did it, taking us not only into her own shattered world, but drawing on the words of the doctors who treated her and family members who suffered with her.In this new edition, Lori Schiller recounts the dramatic years following the original publication -- a period involving addiction, relapse, and ultimately, love and recovery.Moving, harrowing, and ultimately uplifting, THE QUIET ROOM is a classic testimony to the ravages of mental illness and the power of perseverance and courage.

    Braided with that history is the moving story of Powers's beloved son Kevin--spirited, endearing, and gifted--who triumphed even while suffering from schizophrenia until finally he did not, and the story of his courageous surviving son Dean, who is also schizophrenic.A blend of history, biography, memoir, and current affairs ending with a consideration of where we might go from here, this is a thought-provoking look at a dreaded illness that has long been misunderstood.

    "Because if you were, it would give all of us so much hope."Over the years, DBT had saved the lives of countless people fighting depression and suicidal thoughts, but Linehan had never revealed that her pioneering work was inspired by her own desperate struggles as a young woman. Only when she received this question did she finally decide to tell her story.In this remarkable and inspiring memoir, Linehan describes how, when she was eighteen years old, she began an abrupt downward spiral from popular teenager to suicidal young woman. After several miserable years in a psychiatric institute, Linehan made a vow that if she could get out of emotional hell, she would try to find a way to help others get out of hell too, and to build a life worth living. She went on to put herself through night school and college, living at a YWCA and often scraping together spare change to buy food. She went on to get her PhD in psychology, specializing in behavior therapy. In the 1980s, she achieved a breakthrough when she developed Dialectical Behavioral Therapy, a therapeutic approach that combines acceptance of the self and ways to change. Linehan included mindfulness as a key component in therapy treatment, along with original and specific life-skill techniques. She says, You can't think yourself into new ways of acting; you can only act yourself into new ways of thinking.Throughout her extraordinary scientific career, Marsha Linehan remained a woman of deep spirituality. Her powerful and moving story is one of faith and perseverance. Linehan shows, in Building a Life Worth Living, how the principles of DBT really work--and how, using her life skills and techniques, people can build lives worth living.

    Mary Laura Philpott thought she’d cracked the code: Always be right, and you’ll always be happy. But once she’d completed her life’s to-do list (job, spouse, house, babies—check!), she found that instead of feeling content and successful, she felt anxious. Lost. Stuck in a daily grind of overflowing calendars, grueling small talk, and sprawling traffic. She’d done everything “right,” but she felt all wrong. What’s the worse failure, she wondered: smiling and staying the course, or blowing it all up and running away? And are those the only options? In this memoir-in-essays full of spot-on observations about home, work, and creative life, Philpott takes on the conflicting pressures of modern adulthood with wit and heart. She offers up her own stories to show that identity crises don’t happen just once or only at midlife; reassures us that small, recurring personal re-inventions are both normal and necessary; and advises that if you’re going to faint, you should get low to the ground first. Most of all, Philpott shows that when you stop feeling satisfied with your life, you don’t have to burn it all down and set off on a transcontinental hike (unless you want to, of course). You can call upon your many selves to figure out who you are, who you’re not, and where you belong. Who among us isn’t trying to do that? Like a pep talk from a sister, I Miss You When I Blink is the funny, poignant, and deeply affecting book you’ll want to share with all your friends, as you learn what Philpott has figured out along the way: that multiple things can be true of us at once—and that sometimes doing things wrong is the way to do life right.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    The daughter of immigrants, she was raised in an Oakland, California community that cared deeply about social justice; her parents--an esteemed economist from Jamaica and an admired cancer researcher from India--met as activists in the civil rights movement when they were graduate students at Berkeley. Growing up, Harris herself never hid her passion for justice, and when she became a prosecutor out of law school, a deputy district attorney, she quickly established herself as one of the most innovative change agents in American law enforcement. She progressed rapidly to become the elected District Attorney for San Francisco, and then the chief law enforcement officer of the state of California as a whole. Known for bringing a voice to the voiceless, she took on the big banks during the foreclosure crisis, winning a historic settlement for California's working families. Her hallmarks were applying a holistic, data-driven approach to many of California's thorniest issues, always eschewing stale "tough on crime" rhetoric as presenting a series of false choices. Neither "tough" nor "soft" but smart on crime became her mantra. Being smart means learning the truths that can make us better as a community, and supporting those truths with all our might. That has been the pole star that guided Harris to a transformational career as the top law enforcement official in California, and it is guiding her now as a transformational United States Senator, grappling with an array of complex issues that affect her state, our country, and the world, from health care and the new economy to immigration, national security, the opioid crisis, and accelerating inequality.By reckoning with the big challenges we face together, drawing on the hard-won wisdom and insight from her own career and the work of those who have most inspired her, Kamala Harris offers in The Truths We Hold a master class in problem-solving, in crisis management, and leadership in challenging times. Through the arc of her own life, on into the great work of our day, she communicates a vision of shared struggle, shared purpose, and shared values. In a book rich in many home truths, not least is that a relatively small number of people work very hard to convince a great many of us that we have less in common than we actually do, but it falls to us to look past them and get on with the good work of living our common truth. When we do, our shared effort will continue to sustain us and this great nation, now and in the years to come.

    These periods of dislocation can be lonely and unexpected. For May, her husband fell ill, her son stopped attending school, and her own medical issues led her to leave a demanding job. Wintering explores how she not only endured this painful time, but embraced the singular opportunities it offered.A moving personal narrative shot through with lessons from literature, mythology, and the natural world, May’s story offers instruction on the transformative power of rest and retreat. Illumination emerges from many sources: solstice celebrations and dormice hibernation, C.S. Lewis and Sylvia Plath, swimming in icy waters and sailing arctic seas.Ultimately Wintering invites us to change how we relate to our own fallow times. May models an active acceptance of sadness and finds nourishment in deep retreat, joy in the hushed beauty of winter, and encouragement in understanding life as cyclical, not linear. A secular mystic, May forms a guiding philosophy for transforming the hardships that arise before the ushering in of a new season.

    As the cancer progressed and was treated, the author experienced behavioral and cognitive symptoms connected to a range of mental disorders, including her professional specialty, schizophrenia. Lipska's family and associates were alarmed by the changes in her behavior, which she failed to acknowledge herself. Gradually, after a course of immunotherapy, Lipska returned to normal functioning, recalled her experience and, through her knowledge of neuroscience, identified the ways in which her brain changed during treatment. Lipska admits her condition was unusual; after recovery she was able to return to her research and resume her athletic training and compete in a triathalon. Most patients with similar brain cancers rarely survive to describe their ordeal. Lipska's memoir, coauthored with journalist McArdle, shows that strength and courage but also a encouraging support network are vital to recovery