But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    In its companion volume River Notes, Lopez takes us into a different country where a nameless river flows through an animated world of herons, bears, and human beings.There is violence here, in the conflict of natural forces, in the people touching the river. There are landscapes, physical and spiritual, that we have not sensed, rituals we have not understood. Like the earlier peoples of our land, and like few American writers who have reentered this world, Barry Lopez respects the river and its imperatives, understands the language of cottonwoods and the salmon, and brings us in an extraordinary dance with a heron to the oneness with nature which is our heritage. ... [i]n these haunting, passionate stories Lopez brings us home to a deeply comforting unity with the natural world.From the first-edition dustjacket.