Mythologized. Controversial.A Harvard evolutionary biologist debunks the myths and cultural stereotypes surrounding testosterone and reveals its far-reaching effects on gender and sexuality, sports, relationships, and many more aspects of our everyday lives.The biological source of virility and masculinity has inspired fascination, investigation, and controversy since antiquity. From the eunuchs in the royal courts of ancient China to the booming market for “elixirs” of youth in nineteenth-century Europe, humans have been obsessed with identifying and manipulating what we now know as testosterone. And the trends show no signs of slowing down—the modern market for testosterone supplements is booming. Thanks to this history and the methods of modern science, today we have a rich body of research about testosterone’s effects in both men and women.The science is clear: testosterone is a major, invisible player in our relationships, sex lives, athletic abilities, childhood play, gender transitions, parenting roles, violent crime, and so much more. But there is still a lot of pushback to the idea that it does, in fact, cause sex differences and significantly influence behavior.Carole Hooven argues in T that acknowledging testosterone as a potent force in society doesn’t reinforce stifling gender norms or patriarchal values. Testosterone and evolution work together to produce a huge variety of human behavior, and that includes a multitude of ways to be masculine or feminine. Understanding the science sheds light on how we work and relate to one another, how we express anger and love, and how we can fight bias and problematic behavior to build a more fair society.

    Brinkley–America’s most brazen young con man–arrived in the tiny town of Milford, Kansas. He set up a medical practice and introduced an outlandish surgical method using goat glands to restore the fading virility of local farmers.It was all nonsense, of course, but thousands of paying customers quickly turned “Dr.” Brinkley into America’s richest and most famous surgeon. His notoriety captured the attention of the great quackbuster Morris Fishbein, who vowed to put the country’s “most daring and dangerous” charlatan out of business.Their cat-and-mouse game lasted throughout the 1920s and ’30s, but despite Fishbein’s efforts Brinkley prospered wildly. When he ran for governor of Kansas, he invented campaigning techniques still used in modern politics. Thumbing his nose at American regulators, he built the world’s most powerful radio transmitter just across the Rio Grande to offer sundry cures, and killed or maimed patients by the score, yet his warped genius produced innovations in broadcasting that endure to this day. By introducing country music and blues to the nation, Brinkley also became a seminal force in rock ’n’ roll. In short, he is the most creative criminal this country has ever produced.Culminating in a decisive courtroom confrontation that pit Brinkley against his nemesis Fishbein, Charlatan is a marvelous portrait of a boundlessly audacious rogue on the loose in an America that was ripe for the bamboozling.

    Some historians have charged that slaveholders actually enshrined human bondage at the nation's founding. Sean Wilentz shares the dismay but sees the Constitution and slavery differently. Although the proslavery side won important concessions, he asserts, antislavery impulses also influenced the framers' work. Far from covering up a crime against humanity, the Constitution restricted slavery's legitimacy under the new national government. In time, that limitation would open the way for the creation of an antislavery politics that led to Southern secession, the Civil War, and Emancipation.Wilentz's controversial reconsideration upends orthodox views of the Constitution. He describes the document as a tortured paradox that abided slavery without legitimizing it. This paradox lay behind the great political battles that fractured the nation over the next seventy years. As Southern Fire-eaters invented a proslavery version of the Constitution, antislavery advocates, including Abraham Lincoln and Frederick Douglass, proclaimed an antislavery version based on the framers' refusal to validate property in man.No Property in Man invites fresh debate about the political and legal struggles over slavery that began during the Revolution and concluded with the Confederacy's defeat. It drives straight to the heart of the most contentious and enduring issue in all of American history.

    The uniquely multicultural nature of life on a seventeenth-century Barbadan sugar plantation--defined by a mixture of English, American Indian, and African ways and folklore--indelibly shaped the young Tituba's world and the mental images she brought with her to Massachusetts.Breslaw divides Tituba's story into two parts. The first focuses on Tituba's roots in Barbados, the second on her life in the New World. The author emphasizes the inextricably linked worlds of the Caribbean and the North American colonies, illustrating how the Puritan worldview was influenced by its perception of possessed Indians. Breslaw argues that Tituba's confession to practicing witchcraft clearly reveals her savvy and determined efforts to protect herself by actively manipulating Puritan fears. This confession, perceived as evidence of a diabolical conspiracy, was the central agent in the cataclysmic series of events that saw 19 people executed and over 150 imprisoned, including a young girl of 5.A landmark contribution to women's history and early American history, Tituba, Reluctant Witch of Salem sheds new light on one of the most painful episodes in American history, through the eyes of its most crucial participant.

    In a book of unprecedented scope, McGilchrist draws on a vast body of recent brain research, illustrated with case histories, to reveal that the difference is profound—not just this or that function, but two whole, coherent, but incompatible ways of experiencing the world. The left hemisphere is detail oriented, prefers mechanisms to living things & is inclined to self-interest. The right hemisphere has greater breadth, flexibility & generosity. This division helps explain the origins of music & language, & casts new light on the history of philosophy, as well as on some mental illnesses. The 2nd part of the book takes a journey thru the history of Western culture, illustrating the tension between these two worlds as revealed in the thought & belief of thinkers & artists, from Aeschylus to Magritte. He argues that, despite its inferior grasp of reality, the left hemisphere is increasingly taking precedence in the modern world, with potentially disastrous consequences.List of IllustrationsAcknowledgmentsIntroductionAsymmetry and the brain --What do the two hemispheres 'do'? --Language, truth and music --The nature of the two worlds --The primacy of the right hemisphere --The triumph of the left hemisphere --Imitation and the evolution of culture --The ancient world --The Renaissance and the Reformation --The Enlightenment --Romanticism and the Industrial Revolution --The modern and post-modern worldsConclusionNotes BibliographyIndex

    From its origins in 1738 as an almshouse and pesthouse, Bellevue today is a revered public hospital bringing first-class care to anyone in need. With its diverse, ailing, and unprotesting patient population, the hospital was a natural laboratory for the nation's first clinical research. It treated tens of thousands of Civil War soldiers, launched the first civilian ambulance corps and the first nursing school for women, pioneered medical photography and psychiatric treatment, and spurred New York City to establish the country's first official Board of Health. As medical technology advanced, "voluntary" hospitals began to seek out patients willing to pay for their care. For charity cases, it was left to Bellevue to fill the void. The latter decades of the twentieth century brought rampant crime, drug addiction, and homelessness to the nation's struggling cities problems that called a public hospital's very survival into question. It took the AIDS crisis to cement Bellevue's enduring place as New York's ultimate safety net, the iconic hospital of last resort.

    . . . And we are trying to do what’s right even when Donald Trump won’t.”—An anonymous senior administrative official in an op-ed published in a New York Times op-ed, September 5, 2018 Every president faces criticism and caricature. Donald Trump, however, is unique in that he is routinely characterized in ways more suitable for a toddler. What’s more, it is not just Democrats, pundits, or protestors who compare the president to a child; Trump’s staffers, subordinates, and allies on Capitol Hill also describe Trump like a small, badly behaved preschooler.            In April 2017, Daniel W. Drezner began curating every example he could find of a Trump ally describing the president like a toddler. So far, he’s collected more than one thousand tweets—a rate of more than one a day. In The Toddler-in-Chief, Drezner draws on these examples to take readers through the different dimensions of Trump’s infantile behavior, from temper tantrums to poor impulse control to the possibility that the President has had too much screen time. How much damage can really be done by a giant man-baby? Quite a lot, Drezner argues, due to the winnowing away of presidential checks and balances over the past fifty years. In these pages, Drezner follows his theme—the specific ways in which sharing some of the traits of a toddler makes a person ill-suited to the presidency—to show the lasting, deleterious impact the Trump administration will have on American foreign policy and democracy.            The “adults in the room” may not be able to rein in Trump’s toddler-like behavior, but, with the 2020 election fast approaching, the American people can think about whether they want the most powerful office turned into a poorly run political day care facility. Drezner exhorts us to elect a commander-in-chief, not a toddler-in-chief. And along the way, he shows how we must rethink the terrifying powers we have given the presidency.

    For centuries, royal families have feared the gut-roiling, vomit-inducing agony of a little something added to their food or wine by an enemy. To avoid poison, they depended on tasters, unicorn horns, and antidotes tested on condemned prisoners. Servants licked the royal family’s spoons, tried on their underpants and tested their chamber pots.Ironically, royals terrified of poison were unknowingly poisoning themselves daily with their cosmetics, medications, and filthy living conditions. Women wore makeup made with mercury and lead. Men rubbed turds on their bald spots. Physicians prescribed mercury enemas, arsenic skin cream, drinks of lead filings, and potions of human fat and skull, fresh from the executioner. The most gorgeous palaces were little better than filthy latrines. Gazing at gorgeous portraits of centuries past, we don’t see what lies beneath the royal robes and the stench of unwashed bodies; the lice feasting on private parts; and worms nesting in the intestines.In The Royal Art of Poison, Eleanor Herman combines her unique access to royal archives with cutting-edge forensic discoveries to tell the true story of Europe’s glittering palaces: one of medical bafflement, poisonous cosmetics, ever-present excrement, festering natural illness, and, sometimes, murder.

    Ross A. Slotten signed more death certificates in Chicago—and, by inference, the state of Illinois—than anyone else. As a family physician, he was trained to care for patients from birth to death, but when he completed his residency in 1984, he had no idea that many of his future patients would be cut down in the prime of their lives. Among those patients were friends, colleagues, and lovers, shunned by most of the medical community because they were gay and HIV positive. Slotten wasn’t an infectious disease specialist, but because of his unique position as both a gay man and a young physician, he became an unlikely pioneer, swept up in one of the worst epidemics in modern history.Plague Years is an unprecedented first-person account of that epidemic, spanning not just the city of Chicago but four continents as well. Slotten provides an intimate yet comprehensive view of the disease’s spread alongside heartfelt portraits of his patients and his own conflicted feelings as a medical professional, drawn from more than thirty years of personal notebooks. In telling the story of someone who was as much a potential patient as a doctor, Plague Years sheds light on the darkest hours in the history of the LGBT community in ways that no previous medical memoir has.

    What's the prescription for success? National Geographic Explorer Dan Buettner has traveled the globe to uncover the best strategies for longevity found in the Blue Zones: places in the world where higher percentages of people enjoy remarkably long, full lives. And in this dynamic book he discloses the recipe, blending this unique lifestyle formula with the latest scientific findings to inspire easy, lasting change that may add years to your life.Buettner's colossal research effort, funded in part by the National Institute on Aging, has taken him from Costa Rica to Italy to Japan and beyond. In the societies he visits, it's no coincidence that the way people interact with each other, shed stress, nourish their bodies, and view their world yields more good years of life. You'll meet a 94-year-old farmer and self-confessed "ladies man" in Costa Rica, an 102-year-old grandmother in Okinawa, a 102-year-old Sardinian who hikes at least six miles a day, and others. By observing their lifestyles, Buettner's teams have identified critical everyday choices that correspond with the cutting edge of longevity research-and distilled them into a few simple but powerful habits that anyone can embrace.

    She did.Sophie navigates being the only black scientist in her lab while studying the very disease, HIV, that she hides from her coworkers.For Victoria, coming out as a transgender woman was less difficult than coming out as bipolar.Author Michele Lent Hirsch knew she couldn't be the only woman who's faced serious health issues at a young age, as well as the resulting effects on her career, her relationships, and her sense of self. What she found while researching Invisible was a surprisingly large and overlooked population with important stories to tell.Though young women with serious illness tend to be seen as outliers, young female patients are in fact the primary demographic for many illnesses. They are also one of the most ignored groups in our medical system--a system where young women, especially women of color and trans women, are invisible.And because of expectations about gender and age, young women with health issues must often deal with bias in their careers and personal lives. Not only do they feel pressured to seem perfect and youthful, they also find themselves amid labyrinthine obstacles in a culture that has one narrow idea of womanhood.Lent Hirsch weaves her own harrowing experiences together with stories from other women, perspectives from sociologists on structural inequality, and insights from neuroscientists on misogyny in health research. She shows how health issues and disabilities amplify what women in general already confront: warped beauty standards, workplace sexism, worries about romantic partners, and mistrust of their own bodies. By shining a light on this hidden demographic, Lent Hirsch explores the challenges that all women face.

    It contains millions of neurons—as many as you would find in the brain of a cat—and is home to the microbiome, an army of tiny organisms that influence your mood, your immune system, and even your appetite.In this groundbreaking book, Dr. Mosley takes us on a revelatory journey through the gut, showing how junk food and overuse of antibiotics have wiped out many “good” gut bacteria leading to a modern plague of allergies, food intolerances, and obesity. Drawing from the latest cutting-edge research, Dr. Mosley provides scientifically proven ways to control your cravings, boost your mood, and lose weight by feeding the “good” bacteria that keep you healthy and lean, while staving off “bad” bacteria that contribute to weight gain and disease.Dr. Mosley also shares a simple two-phase healing program, an effective way to repair and replenish the microbiome and to ease intestinal distress. Discover how foods like chocolate, red wine, and cheese can be part of a gut-healthy diet; how fasting can strengthen the gut and boost “good” bacteria; how changing your microbiome can undo the damage of yo-yo dieting; and how opening a window (and other simple acts) can improve gut health.Packed with delicious, healing recipes, meal plans, checklists, and tips, The Clever Gut Diet includes all the tools you need to transform your gut and your health for the rest of your life.

    After 3.8 billion years humankind is about to start evolving by new rules...From leading geopolitical expert and technology futurist Jamie Metzl comes a groundbreaking exploration of the many ways genetic-engineering is shaking the core foundations of our lives -- sex, war, love, and death.At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race.Enter the laboratories where scientists are turning science fiction into reality. Look towards a future where our deepest beliefs, morals, religions, and politics are challenged like never before and the very essence of what it means to be human is at play. When we can engineer our future children, massively extend our lifespans, build life from scratch, and recreate the plant and animal world, should we?

    In that short time, many doctors decide on the likely diagnosis and best treatment. Often, decisions made this way are correct, but at crucial moments they can also be wrong -- with catastrophic consequences. In this myth-shattering book, Jerome Groopman pinpoints the forces and thought processes behind the decisions doctors make. Groopman explores why doctors err and shows when and how they can -- with our help -- avoid snap judgments, embrace uncertainty, communicate effectively, and deploy other skills that can profoundly impact our health. This book is the first to describe in detail the warning signs of erroneous medical thinking and reveal how new technologies may actually hinder accurate diagnoses. How Doctors Think offers direct, intelligent questions patients can ask their doctors to help them get back on track.Groopman draws on a wealth of research, extensive interviews with some of the country’s best doctors, and his own experiences as a doctor and as a patient. He has learned many of the lessons in this book the hard way, from his own mistakes and from errors his doctors made in treating his own debilitating medical problems.How Doctors Think reveals a profound new view of twenty-first-century medical practice, giving doctors and patients the vital information they need to make better judgments together.

    You can't be a woman or girl (or, increasingly, a man or boy) in America today and not grapple with the size and shape of your body, your daughter's body, other women's bodies. Even the most confident people have to find a way through a daily gauntlet of voices and images talking, admonishing, warning us about what size we should be, how much we should weigh, what we should eat and what we shouldn't. Obsessing about weight has become a ritual and a refrain, punctuating our every relationship, including the ones with ourselves. It's time to change the conversation around weight. Harriet Brown has explored the conundrums of weight and body image for more than a decade, as a science journalist, as a woman who has struggled with weight, as a mother, wife, and professor. In this book, she describes how biology, psychology, metabolism, media, and culture come together to shape our ongoing obsession with our bodies, and what we can learn from them to help us shift the way we think. Brown exposes some of the myths behind the rhetoric of obesity, gives historical and contemporary context for what it means to be "fat," and offers readers ways to set aside the hysteria and think about weight and health in more nuanced and accurate ways.