Within a few short decades the most hostile of the world’s environments had all been conquered. Likewise, in the twentieth century, medicine transformed human life. Doctors took what was routinely fatal and made it survivable. As modernity brought us ever more into different kinds of extremis, doctors pushed the bounds of medical advances and human endurance. Extreme exploration challenged the body in ways that only the vanguard of science could answer. Doctors, scientists, and explorers all share a defining trait: they push on in the face of grim odds. Because of their extreme exploration we not only understand our physiology better; we have also made enormous strides in the science of healing.Drawing on his own experience as an anesthesiologist, intensive care expert, and NASA adviser, Dr. Kevin Fong examines how cuttingedge medicine pushes the envelope of human survival by studying the human body’s response when tested by physical extremes. Extreme Medicine explores different limits of endurance and the lens each offers on one of the systems of the body. The challenges of Arctic exploration created opportunities for breakthroughs in open heart surgery; battlefield doctors pioneered techniques for skin grafts, heart surgery, and trauma care; underwater and outer space exploration have revolutionized our understanding of breathing, gravity, and much more. Avant-garde medicine is fundamentally changing our ideas about the nature of life and death.Through astonishing accounts of extraordinary events and pioneering medicine, Fong illustrates the sheer audacity of medical practice at extreme limits, where human life is balanced on a knife’s edge. Extreme Medicine is a gripping debut about the science of healing, but also about exploration in its broadest sense—and about how, by probing the very limits of our biology, we may ultimately return with a better appreciation of how our bodies work, of what life is, and what it means to be human.

    Today he is the director of the Center for Compassion and Altruism Research and Education (CCARE) at Stanford University, of which the Dalai Lama is a founding benefactor. But back then his life was at a dead end until at twelve he wandered into a magic shop looking for a plastic thumb. Instead he met Ruth, a woman who taught him a series of exercises to ease his own suffering and manifest his greatest desires. Her final mandate was that he keep his heart open and teach these techniques to others. She gave him his first glimpse of the unique relationship between the brain and the heart.Doty would go on to put Ruth’s practices to work with extraordinary results—power and wealth that he could only imagine as a twelve-year-old, riding his orange Sting-Ray bike. But he neglects Ruth’s most important lesson, to keep his heart open, with disastrous results—until he has the opportunity to make a spectacular charitable contribution that will virtually ruin him. Part memoir, part science, part inspiration, and part practical instruction, Into the Magic Shop shows us how we can fundamentally change our lives by first changing our brains and our hearts.

    At the time, Watson was only 24, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science's greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions & bitter rivalries. With humility unspoiled by false modesty, Watson relates his & Crick's desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.

    The next morning, things take a sharp turn as she’s led from work to the emergency room. By the end of the week, a neurologist delivers a devastating prognosis: Sarah suffered a traumatic brain injury that has caused her IQ to plummet, with no hope of recovery. Her brain has irrevocably changed.Afraid of judgment and deemed no longer fit for work, Sarah isolates herself from the outside world. She spends months at home, with her dogs as her only source of companionship, battling a personality she no longer recognizes and her shock and rage over losing simple functions she’d taken for granted. Her life is consumed by fear and shame until a chance encounter gives Sarah hope that her brain can heal. That conversation lights a small flame of determination, and Sarah begins to push back, painstakingly reteaching herself to read and write, and eventually reentering the workforce and a new, if unpredictable, life.In this highly intimate account of devastation and renewal, Sarah pulls back the curtain on life with traumatic brain injury, an affliction where the wounds are invisible and the lasting effects are often misunderstood. Over years of frustrating setbacks and uncertain triumphs, Sarah comes to terms with her disability and finds love with a woman who helps her embrace a new, accepting sense of self.

    That book was the last surviving manuscript of an ancient Roman philosophical epic, On the Nature of Things, by Lucretius—a beautiful poem of the most dangerous ideas: that the universe functioned without the aid of gods, that religious fear was damaging to human life, and that matter was made up of very small particles in eternal motion, colliding and swerving in new directions.The copying and translation of this ancient book—the greatest discovery of the greatest book-hunter of his age—fueled the Renaissance, inspiring artists such as Botticelli and thinkers such as Giordano Bruno; shaped the thought of Galileo and Freud, Darwin and Einstein; and had a revolutionary influence on writers such as Montaigne and Shakespeare and even Thomas Jefferson.

    When he died in London in 1727 he was so renowned he was given a state funeral—an unheard-of honor for a subject whose achievements were in the realm of the intellect. During the years he was an irascible presence at Trinity College, Cambridge, Newton imagined properties of nature and gave them names—mass, gravity, velocity—things our science now takes for granted. Inspired by Aristotle, spurred on by Galileo’s discoveries and the philosophy of Descartes, Newton grasped the intangible and dared to take its measure, a leap of the mind unparalleled in his generation.James Gleick, the author of Chaos and Genius, and one of the most acclaimed science writers of his generation, brings the reader into Newton’s reclusive life and provides startlingly clear explanations of the concepts that changed forever our perception of bodies, rest, and motion. Ideas so basic to the twenty-first century we literally take them for granted.

    This is but a fraction of one man’s life spent collecting every book on every subject – including antique and modern worlds, science and law, as well as playing cards, pornography, and popular music.Who was Hernando Columbus and how did he achieve this?Set to the backdrop of Christopher Columbus’ paradigm-defining explorations of the New World and beyond, and cutting across events of the Renaissance and Reformation, this book follows Hernando Columbus’ bibliomania and curation of the first ever library of its kind.

    A beach body by summer. A trip to Disneyland around the corner. A promotion on the horizon. Everyone wants to believe that they are headed toward good, better, best. But what happens when the life you hoped for is put on hold indefinitely?Kate Bowler believed that life was a series of unlimited choices, until she discovered, at age 35, that her body was wracked with cancer. In No Cure for Being Human, she searches for a way forward as she mines the wisdom (and absurdity) of today's "best life now" advice industry, which insists on exhausting positivity and on trying to convince us that we can out-eat, out-learn, and out-perform our humanness. We are, she finds, as fragile as the day we were born.With dry wit and unflinching honesty, Kate Bowler grapples with her diagnosis, her ambition, and her faith as she tries to come to terms with her limitations in a culture that says anything is possible. She finds that we need one another if we're going to tell the truth: Life is beautiful and terrible, full of hope and despair and everything in between--and there's no cure for being human.

    From miraculous pregnancies to dirty protests, and from violent attacks on prisoners to heartbreaking acts of self-harm, she has witnessed it all. In this memoir, Amanda reveals the stories, the patients and the cases that have shaped a career helping those most of us would rather forget.

    He boarded a friend’s yacht, sailed into the calm blue waters of Long Island Sound, and--poof!--disappeared. He would not be heard from again for five days. What happened during those five days, and in the days and weeks that followed, was so incredible that, even when the truth was finally revealed, many Americans simply would not believe it.The President Is a Sick Man details an extraordinary but almost unknown chapter in American history: Grover Cleveland’s secret cancer surgery and the brazen political cover-up by a politician whose most memorable quote was “Tell the truth.” When an enterprising reporter named E. J. Edwards exposed the secret operation, Cleveland denied it. The public believed the “Honest President,” and Edwards was dismissed as “a disgrace to journalism.” The facts concerning the disappearance of Grover Cleveland that summer were so well concealed that even more than a century later a full and fair account has never been published. Until now.

    In an intellectual adventure like Sarah Bakewell's book about Montaigne, How to Live, Hugh Aldersey-Williams sets off not just to tell the story of Browne's life but to champion his skeptical nature and inquiring mind.Mixing botany, etymology, medicine, and literary history, Aldersey-Williams journeys in his hero's footsteps to introduce us to witches, zealots, natural wonders, and fabulous creatures of Browne's time and ours. We meet Browne the master prose stylist, responsible for introducing hundreds of words into English, including electricity, hallucination, and suicide. Aldersey-Williams reveals how Browne’s preoccupations—how to disabuse the credulous of their foolish beliefs, what to make of order in nature, how to unite science and religion—are relevant today.In Search of Sir Thomas Browne is more than just a biography—it is a cabinet of wonders and an argument that Browne, standing at the very gates of modern science, remains an inquiring mind for our own time. As Stephen Greenblatt has written, Browne is "unnervingly one of our most adventurous contemporaries."

    As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power.The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village.Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable.Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito's reign through human history and her indelible impact on our modern world order.

    But what makes Schmidt even more compelling to us is his day job. For forty-five years, Schmidt was an efficient and prolific public executioner, employed by the state to extract confessions and put convicted criminals to death. In his years of service, he executed 361 people and tortured, flogged, or disfigured hundreds more. Is it possible that a man who practiced such cruelty could also be insightful, compassionate, humane—even progressive? In his groundbreaking book, the historian Joel F. Harrington looks for the answer in Schmidt’s journal, whose immense significance has been ignored until now. Harrington uncovers details of Schmidt’s medical practice, his marriage to a woman ten years older than him, his efforts at penal reform, his almost touching obsession with social status, and most of all his conflicted relationship with his own craft and the growing sense that it could not be squared with his faith. A biography of an ordinary man struggling for his soul, The Faithful Executioner is also an unparalleled portrait of Europe on the cusp of modernity, yet riven by conflict and encumbered by paranoia, superstition, and abuses of power. In his intimate portrait of a Nuremberg executioner, Harrington also sheds light on our own fraught historical moment.

    In riveting first-person prose, Dr. Brendan Reilly takes us to the front lines of medicine today. Whipsawed by daily crises and frustrations, Reilly must deal with several daunting challenges simultaneously: the extraordinary patients under his care on the teeming wards of a renowned teaching hospital; the life-threatening illnesses of both of his ninety-year-old parents; and the tragic memory of a cold case from long ago that haunts him still. As Reilly’s patients and their families survive close calls, struggle with heartrending decisions, and confront the limits of medicine’s power to cure, One Doctor lays bare a fragmented, depersonalized, business-driven health-care system where real caring is hard to find. Every day, Reilly sees patients who fall through the cracks and suffer harm because they lack one doctor who knows them well and relentlessly advocates for their best interests.Filled with fascinating characters in New York City and rural New England — people with dark secrets, mysterious illnesses, impossible dreams, and many kinds of courage — One Doctor tells their stories with sensitivity and empathy, reminding us of professional values once held dear by all physicians. But medicine has changed enormously during Reilly’s career, for both better and worse, and One Doctor is a cautionary tale about those changes. It is also a hopeful, inspiring account of medicine’s potential to improve people’s lives, Reilly’s quest to understand the "truth" about doctoring, and a moving testament to the difference one doctor can make.

    Snyder exposes the political passions, religious impulses, friendships, rivalries, and love of knowledge—and power—that drove these extraordinary men.  Whewell (who not only invented the word “scientist,” but also founded the fields of crystallography, mathematical economics, and the science of tides), Babbage (a mathematical genius who invented the modern computer), Herschel (who mapped the skies of the Southern Hemisphere and contributed to the invention of photography), and Jones (a curate who shaped the science of economics) were at the vanguard of the modernization of science.  This absorbing narrative of people, science and ideas  chronicles the intellectual revolution inaugurated by these men, one that continues to mold our understanding of the world around us and of our place within it.  Drawing upon the voluminous correspondence between the four men over the fifty years of their work, Laura J. Snyder shows how friendship worked to spur the men on to greater accomplishments, and how it enabled them to transform science and help create the modern world.