Early studies of the functions of the human brain used a simple method: wait for misfortune to strike-strokes, seizures, infectious diseases, lobotomies, horrendous accidents-and see how the victim coped. In many cases survival was miraculous, and observers could only marvel at the transformations that took place afterward, altering victims' personalities. An injury to one section can leave a person unable to recognize loved ones; some brain trauma can even make you a pathological gambler, pedophile, or liar. But a few scientists realized that these injuries were an opportunity for studying brain function at its extremes. With lucid explanations and incisive wit, Sam Kean explains the brain's secret passageways while recounting forgotten stories of common people whose struggles, resiliency, and deep humanity made modern neuroscience possible.

    By allowing women to control their fertility, the birth control pill has revolutionized women's lives. Women are going to college, graduating, and entering the workforce in greater numbers than ever before, and there's good reason to believe that the birth control pill has a lot to do with this. But there's a lot more to the pill than meets the eye.Although women go on the pill for a small handful of targeted effects (pregnancy prevention and clearer skin, yay!), sex hormones can't work that way. Sex hormones impact the activities of billions of cells in the body at once, many of which are in the brain. There, they play a role in influencing attraction, sexual motivation, stress, hunger, eating patterns, emotion regulation, friendships, aggression, mood, learning, and more. This means that being on the birth control pill makes women a different version of themselves than when they are off of it. And this is a big deal. For instance, women on the pill have a dampened cortisol spike in response to stress. While this might sound great (no stress!), it can have negative implications for learning, memory, and mood. Additionally, because the pill influences who women are attracted to, being on the pill may inadvertently influence who women choose as partners, which can have important implications for their relationships once they go off it. Sometimes these changes are for the better . . . but other times, they're for the worse. By changing what women's brains do, the pill also has the ability to have cascading effects on everything and everyone that a woman encounters. This means that the reach of the pill extends far beyond women's own bodies, having a major impact on society and the world.This paradigm-shattering book provides an even-handed, science-based understanding of who women are, both on and off the pill. It will change the way that women think about their hormones and how they view themselves. It also serves as a rallying cry for women to demand more information from science about how their bodies and brains work and to advocate for better research. This book will help women make more informed decisions about their health, whether they're on the pill or off of it.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Celebrating the creative side of failure in a way we can all relate to, F in Exams gathers the most hilarious and inventive test answers provided by students who, faced with a question they have no hope of getting right, decide to have a little fun instead. Whether in science (Q: What is the highest frequency noise that a human can register? A: Mariah Carey), the humanities (Q: What did Mahatma Gandhi and Genghis Khan have in common? A: Unusual names), math, or other subjects, these 250 entries prove that while everyone enjoys the spectacle of failure, it's even sweeter to see a FAIL turn into a WIN.

    “Curiouser and curiouser” —fun and fascinating facts from the world of drugs. Following in the tradition of The Ultimate Book of Useless Information, The Curious World of Drugs and Their Friends is a wry potpourri of interesting information about every conceivable kind of drug. Readers can feed their heads with anecdotes, facts, lists, statistics, and illustrations, including: • The test results of animals on LSD—cats lose their fear of dogs, and goats walk in geometric patterns • Drugs found in nature, from magic mushrooms to St. John’s wort to beaver secretions • Celebrities who overdosed at age 27—Jimi Hendrix, Janis Joplin, Jim Morrison, Kurt Cobain, Brian Jones, and Jean Michel-Basquiat • Imaginary drugs in literature and film, from spice the mélange in Dune to Moloko plus in A Clockwork Orange • Nicknames for a joint—from doobie to giggly stick to Mr. Boom Bizzle • The global percentages of adults who have used cannabis—.004 percent in Singapore and 12.6 percent in the United States • The uses of opium in ancient Rome—from treatments for insomnia and epilepsy to colic and deafness • The most glamorous rehab clinics and their celebrity alumni • Mini-biographies of the biggest drug kingpins around the world Wacky but well-researched, unbiased and shameless, The Curious World of Drugs and Their Friends dares to take readers on a long, strange trivia trip.

    Veterans and their families deal with the painful aftermath of combat; one in five Americans has been molested; one in four grew up with alcoholics; one in three couples have engaged in physical violence. Such experiences inevitably leave traces on minds, emotions, and even on biology. Sadly, trauma sufferers frequently pass on their stress to their partners and children. Renowned trauma expert Bessel van der Kolk has spent over three decades working with survivors. In The Body Keeps the Score, he transforms our understanding of traumatic stress, revealing how it literally rearranges the brain’s wiring—specifically areas dedicated to pleasure, engagement, control, and trust. He shows how these areas can be reactivated through innovative treatments including neurofeedback, mindfulness techniques, play, yoga, and other therapies. Based on Dr. van der Kolk’s own research and that of other leading specialists, The Body Keeps the Score offers proven alternatives to drugs and talk therapy—and a way to reclaim lives.

    The popularity of murder mystery books, TV series, and even board games shows that there is an appetite for death, and the more unusual or macabre the method, the better. With gunshots or stabbings the cause of death is obvious, but poisons are inherently more mysterious. How are some compounds so deadly in such tiny amounts?Agatha Christie used poison to kill her characters more often than any other crime fiction writer. The poison was a central part of the novel, and her choice of deadly substances was far from random; the chemical and physiological characteristics of each poison provide vital clues to the discovery of the murderer. Christie demonstrated her extensive chemical knowledge (much of it gleaned by working in a pharmacy during both world wars) in many of her novels, but this is rarely appreciated by the reader.Written by former research chemist Kathryn Harkup, each chapter takes a different novel and investigates the poison used by the murderer. Fact- and fun-packed, A is for Arsenic looks at why certain chemicals kill, how they interact with the body, and the feasibility of obtaining, administering, and detecting these poisons, both when Christie was writing and today.

    How is it possible that the Y chromosome, which separated the sexes and allowed humans to rise to the apex of the animal kingdom, also threatens to destroy sexual reproduction altogether? Bryan Sykes confronts recent advances in evolutionary theory to find the answers to the questions that inexorably follow: Is there a genetic cause for men's greed, aggression, and promiscuity? Could a male homosexual gene possibly exist? A must read for anyone interested in popular science, family genealogy, and today's infertility crisis, "Adam's Curse" provokes a shocking debate on the nature of sexual reproduction.

    It's an occasionally ribald, frequently witty and unerringly erudite guided tour of the secret labyrinth that lurks beneath the English language, taking in monks and monkeys, film buffs and buffaloes, and explaining precisely what the Rolling Stones have to do with gardening.

    It rejoices in men and women made of the Wrong Stuff: writers who believed in the power of words, but could never quite find the rights ones; artists and performers who indulged their creative impulse with a passion, if not a sense of the ridiculous, an eye for perspective or the ability to hold down a tune; scientists and businessmen who never quite managed to quit while they were ahead; and sportsmen who seemed to manage always to snatch defeat from the jaws of victory. Like Walter Oudney, one of three men chosen to find the source of the River Niger in Africa, who could not ride a horse, nor speak any foreign languages and who had never travelled more than 30 miles beyond his native Edinburgh; or the explorer-priest Michel Alexandre de Baize, who set off to explore the African continent from east to west equipped with 24 umbrellas, some fireworks, two suits of armor, and a portable organ; or the Scottish army which decided to invade England in 1349 - during the Black Death. Entries include: briefest career in dentistry; least successful bonding exercise; most futile attempt to find a lost tribe; most pointless lines of research by someone who should have known better; least successful celebrity endorsement; least convincing excuse for a war; worst poetic tribute to a root vegetable; least successful display of impartiality by a juror; Devon Loch - sporting metaphor for blowing un unblowable lead; least dignified exit from office by a French president; and least successful expedition by camel.

    Days later, the madman was dead and Denis was framed for murder. A riveting exposé of the fierce debates, deadly politics, and cutthroat rivalries behind the first transfusion experiments, Blood Work takes us from dissection rooms in palaces to the streets of Paris, providing an unforgettable portrait of an era that wrestled with the same questions about morality and experimentation that haunt medical science today.

    Some facts are too terrifying to teach in school. Unfortunately, Cracked.com is more than happy to fill you in:* A zombie apocalypse? It could happen. 50% of humans are infected with a parasite that can take over your brain.* The FDA wouldn't let you eat bugs, right? Actually, you might want to put down those jelly beans. And that apple. And that strawberry yogurt.* Think dolphins are our friends? Then these sex-crazed thrill killers of the sea have you right where they want you.* The most important discovery in the history of genetics? Francis Crick came up with it while on LSD.* Think you're going to choose whether or not to buy this book? Scientists say your brain secretly makes all your decisions 10 seconds before you even know what they are.If you’re a fan of The Oatmeal or Frak.com and hate being wrong about stuff, you’ll love what you find in You Might Be a Zombie from the twisted minds at Cracked.

    Join renowned neuroscientist David Eagleman for a journey into the questions at the mysterious heart of our existence. What is reality? Who are “you”? How do you make decisions? Why does your brain need other people? How is technology poised to change what it means to be human?  In the course of his investigations, Eagleman guides us through the world of extreme sports, criminal justice, facial expressions, genocide, brain surgery, gut feelings, robotics, and the search for immortality.  Strap in for a whistle-stop tour into the inner cosmos. In the infinitely dense tangle of billions of brain cells and their trillions of connections, something emerges that you might not have expected to see in there: you.

    In The Poisoner's Handbook Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Drama unfolds case by case as the heroes of The Poisoner's Handbook—chief medical examiner Charles Norris and toxicologist Alexander Gettler—investigate a family mysteriously stricken bald, Barnum and Bailey's Famous Blue Man, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler work with a creativity that rivals that of the most imaginative murderer, creating revolutionary experiments to tease out even the wiliest compounds from human tissue. Yet in the tricky game of toxins, even science can't always be trusted, as proven when one of Gettler's experiments erroneously sets free a suburban housewife later nicknamed "America's Lucretia Borgia" to continue her nefarious work. From the vantage of Norris and Gettler's laboratory in the infamous Bellevue Hospital it becomes clear that killers aren't the only toxic threat to New Yorkers. Modern life has created a kind of poison playground, and danger lurks around every corner. Automobiles choke the city streets with carbon monoxide; potent compounds, such as morphine, can be found on store shelves in products ranging from pesticides to cosmetics. Prohibition incites a chemist's war between bootleggers and government chemists while in Gotham's crowded speakeasies each round of cocktails becomes a game of Russian roulette. Norris and Gettler triumph over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice during a remarkably deadly time. A beguiling concoction that is equal parts true crime, twentieth-century history, and science thriller, The Poisoner's Handbook is a page-turning account of a forgotten New York.

    They've since amassed a rabid fan base, making "Stuff You Should Know" one of the most popular podcasts in the world. Armed with their inquisitive natures and a passion for sharing, they uncover the weird, fascinating, delightful, or unexpected elements of a wide variety of topics.The pair have now taken their near-boundless "whys" and "hows" from your earbuds to the pages of a book for the first time—featuring a completely new array of subjects that they’ve long wondered about and wanted to explore. Each chapter is further embellished with snappy visual material to allow for rabbit-hole tangents and digressions—including charts, illustrations, sidebars, and footnotes. Follow along as the two dig into the underlying stories of everything from the origin of Murphy beds, to the history of facial hair, to the psychology of being lost.Have you ever wondered about the world around you, and wished to see the magic in everyday things? Come get curious with Stuff You Should Know. With Josh and Chuck as your guide, there’s something interesting about everything (…except maybe jackhammers).