No two bucket lists are the same, but each list has the same ultimate goal—to make the list maker feel like they are doing something useful with their life instead of just sitting around, writing lists, and watching Morgan Freeman movies. Dom had seen some of those lists and they looked so difficult that he wondered whether dying would be a better option than actually ticking off the items. "I am a paid-up life-member of a place called the comfort zone. People always go on about the importance of getting out of your comfort zone. Not me. Any day I can stay inside it is a good day. All of which makes it a bit odd that I decided to complete a bucket list of my own. Not just any bucket list though. This is a reverse bucket list—a bunch of stuff that I could have happily passed away without ever doing—stuff like getting a tattoo I'd instantly regret, arm wrestling a professional rugby player, and being the model for a life drawing class—and I recruited some of my closest family and friends to compile it for me. In hindsight, this was a bad idea. But here it is—my pain, discomfort, and humiliation for your pleasure."

    Out of the blue she went from a fit, healthy, fun-loving wife and mother of two, to not knowing what had happened. Or why.Rushed to hospital by ambulance, it was discovered Julie had a malignant brain tumour. Diagnosed with Stage 4 Metastatic Advanced Melanoma, she was told to get her affairs in order because she didn't have long to live.After getting over the initial shock, Julie fought off the fear and started searching for hope. She found an American experimental drug trial, but was told there was only room for 70 patients and the numbers were full. Julie had promised her teenage daughters that she would find a way to 'fix it' so she refused to take no for an answer. Her tenacity paid off and she flew to Oregon and the Providence Cancer Center. She became PATIENT 71.Not everyone survives a cancer diagnosis. Julie is one of the lucky ones. She discovered that when you push the boundaries, refuse to give up and never lose sight of your goal... extraordinary things can happen.

    For most of that time, she didn't know why. All of her trips to the ER and her daily anguish, pain, and lethargy only ever resulted in one question: How could any one person be this sick? Several drug addictions, three major hospitalizations, and over $100,000 later, she finally had a diagnosis: late-stage Lyme disease. Sick is Khakpour's arduous, emotional journey—as a woman, a writer, and a lifelong sufferer of undiagnosed health problems—through the chronic illness that perpetually left her a victim of anxiety, living a life stymied by an unknown condition.Divided by settings, Khakpour guides the reader through her illness by way of the locations that changed her course—New York, LA, New Mexico, and Germany—as she meditates on both the physical and psychological impacts of uncertainty, and the eventual challenge of accepting the diagnosis she had searched for over the course of her adult life. With candor and grace, she examines her subsequent struggles with mental illness, her addiction to the benzodiazepines prescribed by her psychiatrists, and her ever-deteriorating physical health. A story about survival, pain, and transformation, Sick is a candid, illuminating narrative of hope and uncertainty, boldly examining the deep impact of illness on one woman's life.

    After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins—aspiration, hard work, upward mobility, domestic harmony—and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

    The book is full of many personal stories never told or published before. 16-page photo insert.

    In my case, blinking my left eyelid is my only means of communication.’In December 1995, Jean-Dominique Bauby, editor-in-chief of French ‘Elle’ and the father of two young children, suffered a massive stroke and found himself paralysed and speechless, but entirely conscious, trapped by what doctors call ‘locked-in syndrome’. Using his only functioning muscle – his left eyelid – he began dictating this remarkable story, painstakingly spelling it out letter by letter.His book offers a haunting, harrowing look inside the cruel prison of locked-in syndrome, but it is also a triumph of the human spirit.

    Two ends of the same spectrum. And sometimes the only person standing between is a tired, overworked resident with personal problems of her own.Welcome to the world of Catching Babies. In the halls of a busy metropolitan teaching hospital, a group of OB/GYN doctors complete their residencies and embark on ambitious careers, all while trying to hold their lives together at the seams. Jay is running from a life he’s tried to leave behind, while Katie sacrifices everything she has to serve an endless parade of needy patients. Anna is out trying to save the world, while Tracy is trying to save twins dying in utero. Based on true stories from delivery rooms and labor decks, Catching Babies spins the doctors’ stories into a gripping mosaic of the obsessions, the anxieties, and the heroism of doctors who have chosen to preside over life’s greatest medical drama—high-risk childbirth.

    She draws from her own experiences of illness and bodily injury to engage in an exploration that extends far beyond her life, spanning wide-ranging territory—from poverty tourism to phantom diseases, street violence to reality television, illness to incarceration—in its search for a kind of sight shaped by humility and grace.

    Enduring half a dozen surgeries, the drugs he received were both miraculous and essential to his recovery. But his most profound suffering came several months later when he went into acute opioid withdrawal while following his physician’s orders. Over the course of four excruciating weeks, Rieder learned what it means to be “dope sick”—the physical and mental agony caused by opioid dependence. Clueless how to manage his opioid taper, Travis’s doctors suggested he go back on the drugs and try again later. Yet returning to pills out of fear of withdrawal is one route to full-blown addiction. Instead, Rieder continued the painful process of weaning himself.Rieder’s experience exposes a dark secret of American pain management: a healthcare system so conflicted about opioids, and so inept at managing them, that the crisis currently facing us is both unsurprising and inevitable. As he recounts his story, Rieder provides a fascinating look at the history of these drugs first invented in the 1800s, changing attitudes about pain management over the following decades, and the implementation of the pain scale at the beginning of the twenty-first century. He explores both the science of addiction and the systemic and cultural barriers we must overcome if we are to address the problem effectively in the contemporary American healthcare system.In Pain in America is not only a gripping personal account of dependence, but a groundbreaking exploration of the intractable causes of America’s opioid problem and their implications for resolving the crisis. Rieder makes clear that the opioid crisis exists against a backdrop of real, debilitating pain—and that anyone can fall victim to this epidemic.

    But there is more to Chloe than viewers see on the TV, and the drama doesn’t stop when the camera stops rolling. Just two years ago, Chloe was a single mother struggling to make ends meet doing a string of jobs she hated and wondering if she would ever find happiness. Since joining the cast of The Only Way Is Essex, her life is now a whirlwind of glitzy parties and jet-set holidays, but life hasn’t always dealt Chloe a good hand. Her story is one of triumph over adversity, with plenty of laughs along the way. From her turbulent childhood where she was raised by a neighbor after her mother abandoned her, to battling with bullies and struggling with an eating disorder, to the magical moment when she met the man of her dreams.

    Between two world wars, he became the laureate of cricket by doing the same with words.In The Great Romantic, award-winning author Duncan Hamilton demonstrates how Cardus changed sports journalism for ever. While popularising cricket – while appealing, in Cardus’ words to people who ‘didn’t know a leg-break from the pavilion cat at Lord’s’- he became a star in his own right with exquisite phrase-making, disdain for statistics and a penchant for literary and musical allusions.Among those who venerated Cardus were PG Wodehouse, John Arlott, Harold Pinter, JB Priestley and Don Bradman. However, behind the rhapsody in blue skies, green grass and colourful characters, this richly evocative biography finds that Cardus’ mother was a prostitute, he never knew his father and he received negligible education. Infatuations with younger women ran parallel to a decidedly unromantic marriage. And, astonishingly, the supreme stylist’s aversion to factual accuracy led to his reporting on matches he never attended.Yet Cardus also belied his impoverished origins to prosper in a second class-conscious profession, becoming a music critic of international renown. The Great Romantic uncovers the dark enigma within a golden age.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    

    Styron is perhaps the first writer to convey the full terror of depression's psychic landscape, as well as the illuminating path to recovery.

    She is also a superbly gifted writer–witty, insightful, at once deeply humane and refreshingly wry. In Another Day in the Frontal Lobe, Dr. Firlik draws on this rare combination to create a neurosurgeon’s Kitchen Confidential–a unique insider’s memoir of a fascinating profession.Neurosurgeons are renowned for their big egos and aggressive self-confidence, and Dr. Firlik confirms that timidity is indeed rare in the field. “They’re the kids who never lost at musical chairs,” she writes. A brain surgeon is not only a highly trained scientist and clinician but also a mechanic who of necessity develops an intimate, hands-on familiarity with the gray matter inside our skulls. It’s the balance between cutting-edge medical technology and manual dexterity, between instinct and expertise, that Firlik finds so appealing–and so difficult to master. Firlik recounts how her background as a surgeon’s daughter with a strong stomach and a keen interest in the brain led her to this rarefied specialty, and she describes her challenging, atypical trek from medical student to fully qualified surgeon. Among Firlik’s more memorable cases: a young roofer who walked into the hospital with a three-inch-long barbed nail driven into his forehead, the result of an accident with his partner’s nail gun, and a sweet little seven-year-old boy whose untreated earache had become a raging, potentially fatal infection of the brain lining. From OR theatrics to thorny ethical questions, from the surprisingly primitive tools in a neurosurgeon’s kit to glimpses of future techniques like the “brain lift,” Firlik cracks open medicine’s most prestigious and secretive specialty. Candid, smart, clear-eyed, and unfailingly engaging, Another Day in the Frontal Lobe is a mesmerizing behind-the-scenes glimpse into a world of incredible competition and incalculable rewards.From the Hardcover edition.