She meets and falls in love with Bassem, a former Free Syrian Army fighter and together they decide to leave behind the hardship and harassment they face in Egypt to flee for Europe, joining the ranks of the thousands of refugees who make the dangerous journey across the Mediterranean on overcrowded and run-down ships to seek asylum overseas and begin a new life. After four days at sea, their boat is sunk by another boat filled with angry men shouting threats and insults. With no land in sight and surrounded by bloated, floating corpses, Doaa is adrift with a child’s inflatable water ring around her waist, while two little girls cling to her neck. Doaa must stay alive for them. She must not lose strength. She must not lose hope.

    The world is changing dramatically and in an age of Brexit and Trump, the themes of isolation and fragmentation permeating the western world stand in sharp contrast to events along the Silk Roads, where ties are being strengthened and mutual cooperation established.This prescient contemporary history provides a timely reminder that we live in a world that is profoundly interconnected. Following the Silk Roads eastwards from Europe through to China, by way of Russia and the Middle East, Peter Frankopan assesses the global reverberations of continual shifts in the centre of power – all too often absent from headlines in the west.The New Silk Roads asks us to re-examine who we are and where we stand in the world, illuminating the themes on which all our lives and livelihoods depend.The Silk Roads, a major reassessment of world history, has sold over 1 million copies worldwide.

    Drawing partly on his own career—from young scientist in awe of his elders to crotchety elder statesman—Tattersall offers an idiosyncratic look at the competitive world of paleoanthropology, beginning with Charles Darwin 150 years ago, and continuing through the Leakey dynasty in Africa, and concluding with the latest astonishing findings in the Caucasus.The book's title refers to the 1856 discovery of a clearly very old skull cap in Germany's Neander Valley. The possessor had a brain as large as a modern human, but a heavy low braincase with a prominent brow ridge. Scientists tried hard to explain away the inconvenient possibility that this was not actually our direct relative. One extreme interpretation suggested that the preserved leg bones were curved by both rickets, and by a life on horseback. The pain of the unfortunate individual's affliction had caused him to chronically furrow his brow in agony, leading to the excessive development of bone above the eye sockets.The subsequent history of human evolutionary studies is full of similarly fanciful interpretations. With tact and humor, Tattersall concludes that we are not the perfected products of natural processes, but instead the result of substantial doses of random happenstance.

    "This is a book," writes Gary Snyder, "about danger: dangerous knowledge, even more dangerous ignorance." Against the greater danger, ignorance, Pendell strikes a formidable blow, as he proves himself a wise and witty guide to our plant teachers, their powers and their poisons. "Pharmako/Poeia is an epic poem on plant humours, an abstruse alchemic treatise, an experiential narrative jigsaw puzzle, a hip and learned wild-nature reference text, a comic paen to cosmic consciousness, an ecological handbook, a dried-herb pastiche, a counterculture encyclopedia of ancient fact and lore." -Allen Ginsberg poet"Dale Pendell reactivates the ancient connection between the bardic poet and the shaman." -Terence McKenna author of True Hallucinations

    Richard Louis Miller discusses what is happening today in psychedelic medicine--and what will happen in the future--with top researchers and thinkers in this field, including Rick Doblin, Stanislav Grof, James Fadiman, Julie Holland, Dennis McKenna, David Nichols, Charles Grob, Phil Wolfson, Michael and Annie Mithoefer, Roland Griffiths, Katherine MacLean, and Robert Whitaker. Dr. Miller and his contributors cover the tumultuous history of early psychedelic research brought to a halt 50 years ago by the U.S. government as well as offering non-technical summaries of the most recent studies with MDMA, psilocybin, LSD, and ayahuasca. They explore the biochemistry of consciousness and the use of psychedelics for self-discovery and healing. They discuss the use of psilocybin for releasing fear in the terminally ill and the potential for MDMA-assisted psychotherapy in the treatment of PTSD. They examine Dr. Charles Grob’s research on the indigenous use and therapeutic properties of ayahuasca and Dr. Gabor Mate’s attempt to transport this plant medicine to a clinical setting with the help of Canada’s Department of National Health. Dr. Miller and his contributors explore the ongoing efforts to restore psychedelic therapies to the health field, the growing threat of overmedication by the pharmaceutical industry, and the links between psychiatric drugs and mental illness. They also discuss the newly shifting political climate and the push for new research, offering hope for an end to the War on Drugs and a potential renaissance of research into psychedelic medicines around the world.

    But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible.Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

    Wars have been fought over it, revolutions have been triggered by it, national diets have been based on it, economies and livelihoods have depended on it. To the millions it has sustained, it has been a treasure more precious that gold. This book spans 1,000 years and four continents. From the Vikings to Clarence Birdseye, Mark Kurlansky introduces the explorers, merchants, writers, chefs and fisherman, whose lives have been interwoven with this prolific fish. He chronicles the cod wars of the 16th and 20th centuries. He blends in recipes and lore from the Middle Ages to the present. In a story that brings world history and human passions into captivating focus, he shows how the most profitable fish in history is today faced with extinction.

    David Schneider’s The Invention of Surgery is an in-depth biography of the practice that has leapt forward over the centuries from the dangerous guesswork of ancient Greek physicians through the world-changing “implant revolution” of the twentieth century.The Invention of Surgery explains this dramatic progress and highlights the personalities of the discipline's most dynamic historical figures. It links together the lives of the pioneering scientists who first understood what causes disease, how organs become infected or cancerous, and how surgery could powerfully intercede in people’s lives, and then shows how the rise of surgery intersected with many of the greatest medical breakthroughs of the last century, including the evolution of medical education, the transformation of the hospital from a place of dying to a habitation of healing, the development of antibiotics, and the rise of transistors and polymer science.And as Schneider argues, surgery has not finished transforming; new technologies are constantly reinventing both the practice of surgery and the nature of the objects we are permanently implanting in our bodies. Schneider considers these latest developments, asking “What’s next?” and analyzing how our conception of surgery has changed alongside our evolving ideas of medicine, technology, and our bodies.

    It was five feet long, with steel-blue scales, luminescent eyes and remarkable limb-like fins, unlike those of any fish she had ever seen. Determined to preserve her unusual find, she searched for days for a way to save it, but ended up with only the skin and a few bones.A charismatic amateur ichthyologist, J.L.B. Smith, saw a thumbnail sketch of the fish and was thunderstruck. He recognized it as a coelacanth (pronounced see-la-kanth), a creature known from fossils dating back 400 million years and thought to have died out with the dinosaurs. With its extraordinary limbs, the coelacanth was believed to be the first fish to crawl from the sea and evolve into reptiles, mammals and eventually mankind. The discovery was immediately dubbed the "greatest scientific find of the century." Smith devoted his life to the search for a complete specimen, afourteen-year odyssey that culminated in a dramatic act of international piracy. As the fame of the coelacanth spread, so did rumors and obsessions. Nations fought over it, multimillion-dollar expeditions were launched, and submarines hand-built to find it. In 1998, the rumors and the truth came together in a gripping climax, which brought the coelacanth back into the international limelight.A Fish Caught in Time is the entrancing story of the most rare and precious fish in the world--our own great uncle forty million times removed.

    of Maryland School of Medicine), offers case histories of the health problems of a dozen long-dead famous figures diagnosed from modern medical perspectives. Illustrations depict patients including the odd-looking Pharaoh Akhenaten, C

    The magic mushroom was rediscovered only fifty years ago but has accumulated all sorts of folktales and urban legends along the way. In this timely and definitive study, Andy Letcher strips away the myths to get at the true story of how hallucinogenic mushrooms, once shunned in the West as the most pernicious of poisons, came to be the illicit drug of choice.Chronicling the history of the magic mushroom, from its use by the Aztecs of Central America and the tribes of Siberia through to the present day, Letcher takes a critical and humorous look at the drug's more recent manifestations. Since the 1970s scientists and others in major Western nations, the United States and the United Kingdom in particular, have identified hundreds of hallucinogenic species, isolated their active ingredients, learned how to cultivate them on an industrial scale, and spread them around the world. More than any other civilization that has come before us, and despite all the myths we have built, we, by all rights, are the true magic mushroom enthusiasts.Informative, lively and impeccably researched, Shroom presents a unique and engaging study of this most extraordinary of psychedelic drugs.

    This book traces the history of human movement and interaction around and across the world's greatest bodies of water, charting our relationship with the oceans from the time of the first voyagers. David Abulafia begins with the earliest of seafaring societies - the Polynesians of the Pacific, the possessors of intuitive navigational skills long before the invention of the compass, who by the first century were trading between their far-flung islands. By the seventh century, trading routes stretched from the coasts of Arabia and Africa to southern China and Japan, bringing together the Indian Ocean and the western Pacific and linking half the world through the international spice trade. In the Atlantic, centuries before the little kingdom of Portugal carved out its powerful, seaborne empire, many peoples sought new lands across the sea - the Bretons, the Frisians and, most notably, the Vikings, now known to be the first Europeans to reach North America. As Portuguese supremacy dwindled in the late sixteenth century, the Spanish, the Dutch and then the British each successively ruled the waves.Following merchants, explorers, pirates, cartographers and travellers in their quests for spices, gold, ivory, slaves, lands for settlement and knowledge of what lay beyond, Abulafia has created an extraordinary narrative of humanity and the oceans. From the earliest forays of peoples in hand-hewn canoes through uncharted waters to the routes now taken daily by supertankers in their thousands, The Boundless Sea shows how maritime networks came to form a continuum of interaction and interconnection across the globe: 90 per cent of global trade is still conducted by sea. This is history of the grandest scale and scope, and from a bracingly different perspective - not, as in most global histories, from the land, but from the boundless seas.

    There is every reason to believe that, within a few weeks of its onset, the infection was universally present in the nose and throat of the people, disseminated by mouth spray given off on talking by innumerable carriers and, in addition, by the coughing and sneezing of the sick. Susceptibility was very general, though it varied greatly in degree. Among those who escaped well marked sickness there are few who could not recall having had an occluded or running nose, or a raw feeling in the throat, or a cough, or aches and pains, at some time during the period of the prevalence of the disease, these probably representing the price such persons paid for their immunization." - Dr. Bernard Fantus In many ways, it is hard for modern people living in First World countries to conceive of a pandemic sweeping around the world and killing millions of people, and it is even harder to believe that something as common as influenza could cause such widespread illness and death. Although the flu still takes hundreds of lives each year, most of those lost are very young or old or ill with something else that had already weakened them. In fact, most people contract influenza at least once, and many suffer from the flu several times in their lives and survive it with a minimum amount of medical attention. In 1918, the world was still in the throes of the Great War, the deadliest conflict in human history at that point, but while World War I would be a catastrophic war surpassed only by World War II, an unprecedented influenza outbreak that same year inflicted casualties that would make both wars pale in comparison. An illness, or more likely a collection of illnesses, Spanish influenza quickly spread across the world and may have killed upwards of 100 million people, decimating populations across developed nations and possibly wiping out as much as 5% of the world’s population. If anything, the ongoing war and the censorship maintained by the countries fighting it may have resulted in the actual toll of the outbreak being underestimated based on the way soldiers’ deaths were categorized. World War I may have distracted people about the unprecedented nature of the outbreak, but the most alarming aspect of the outbreak in 1918 was the indiscriminate nature in which the scourge attacked young and old, healthy and unhealthy, and rich and poor alike. In fact, the popular name for the outbreak was a reference to the fact that Spain’s own king was stricken with the disease. While he and President Woodrow Wilson ended up surviving it, former First Lady Rose Cleveland did not. The staggering number of fatalities, and the way in which seemingly anybody could suffer during the outbreak, taught people in the early 20th century that regardless of the tremendous strides made by technology, and no matter how stalemated the war was, nobody was safe from nature itself. Of course, it also demonstrated how much more work could be done to prevent similar occurrences. The 1918 pandemic was neither the first nor the last outbreak of the flu, but it was by far the worst, and it forever changed the face of medicine and public health care in both North America and Europe. The 1918 Spanish Flu Pandemic: The History and Legacy of the World’s Deadliest Outbreak chronicles the devastating disease and the damage it wrought across the globe.

    Sometimes Brilliant is the adventures of a philosopher, mystic, hippie, doctor, groundbreaking tech innovator, and key player in the eradication of one of the worst pandemics in human history. His story, of what happens when love, compassion and determination meet the right circumstances to effect positive change, is the kind that keeps hope and the sense of possibility alive.After sitting at the feet of Martin Luther King at the University of Michigan in 1963, Larry Brilliant was swept up into the civil rights movement, marching and protesting across America and Europe. As a radical young doctor he followed the hippie trail from London over the Khyber Pass with his wife Girija, Wavy Gravy and the Hog Farm commune to India. There, he found himself in a Himalayan ashram wondering whether he had stumbled into a cult. Instead, one of India’s greatest spiritual teachers, Neem Karoli Baba, opened Larry’s heart and told him his destiny was to work for the World Health Organization to help eradicate killer smallpox. He would never have believed he would become a key player in eliminating a 10,000-year-old disease that killed more than half a billion people in the 20th century alone.Brilliant’s unlikely trajectory, chronicled in Sometimes Brilliant, has brought him into close proximity with political leaders, spiritual masters, cultural heroes, and titans of technology around the world—from the Grateful Dead to Mikhail Gorbachev, from Ram Dass, the Dalai Lama, Lama Govinda, and Karmapa to Steve Jobs and the founders of Google, Salesforce, Facebook, Microsoft and eBay and Presidents Carter, Clinton, Bush and Obama. Anchored by the engrossing account of the heroic efforts of the extraordinary people involved in smallpox eradication in India, this is a riveting and fascinating epidemiological adventure, an honest reckoning of an entire generation, and a deeply moving spiritual memoir. It is a testament to faith, love, service, and what it means to engage with life’s most important questions in pursuit of a better, more brilliant existence.

    The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . .But all that was about to change. . . . —from The Demon Under the Microscope