It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

    Here Lawrence M. Krauss, himself a theoretical physicist and best-selling author, offers a unique scientific biography: a rollicking narrative coupled with clear and novel expositions of science at the limits. An immensely colorful persona in and out of the office, Feynman revolutionized our understanding of nature amid a turbulent life. Krauss presents that life—from the death of Feynman’s childhood sweetheart during the Manhattan Project to his reluctant rise as a scientific icon—as seen through the science, providing a new understanding of the legacy of a man who has fascinated millions. An accessible reflection on the issues that drive physics today, Quantum Man captures the story of a man who was willing to break all the rules to tame a theory that broke all the rules.

    Many people think of microbes as germs to be eradicated, but those that live with us—the microbiome—build our bodies, protect our health, shape our identities, and grant us incredible abilities. In this astonishing book, Ed Yong takes us on a grand tour through our microbial partners, and introduces us to the scientists on the front lines of discovery. Yong, whose humor is as evident as his erudition, prompts us to look at ourselves and our animal companions in a new light—less as individuals and more as the interconnected, interdependent multitudes we assuredly are. The microbes in our bodies are part of our immune systems and protect us from disease. Those in cows and termites digest the plants they eat. In the deep oceans, mysterious creatures without mouths or guts depend on microbes for all their energy. Bacteria provide squids with invisibility cloaks, help beetles to bring down forests, and allow worms to cause diseases that afflict millions of people. I Contain Multitudes is the story of these extraordinary partnerships, between the creatures we are familiar with and those we are not. It reveals how we humans are disrupting these partnerships and how we might manipulate them for our own good. It will change both our view of nature and our sense of where we belong in it.

    Freeman tells the story of the factory and examines how it has reflected both our dreams and our nightmares of industrialization and social change. He whisks readers from the early textile mills that powered the Industrial Revolution to the factory towns of New England to today’s behemoths making sneakers, toys, and cellphones in China and Vietnam. Behemoth offers a piercing perspective on how factories have shaped our societies and the challenges we face now.

    Today there is just one. Us. Homo sapiens. How did our species succeed in the battle for dominance? Why did our foraging ancestors come together to create cities and kingdoms? How did we come to believe in gods, nations and human rights; to trust money, books and laws; and to be enslaved by bureaucracy, timetables and consumerism? And what will our world be like in the millennia to come? In Sapiens, Dr Yuval Noah Harari spans the whole of human history, from the very first humans to walk the earth to the radical – and sometimes devastating – breakthroughs of the Cognitive, Agricultural and Scientific Revolutions. Drawing on insights from biology, anthropology, paleontology and economics, he explores how the currents of history have shaped our human societies, the animals and plants around us, and even our personalities. Have we become happier as history has unfolded? Can we ever free our behaviour from the heritage of our ancestors? And what, if anything, can we do to influence the course of the centuries to come? Bold, wide-ranging and provocative, Sapiens challenges everything we thought we knew about being human: our thoughts, our actions, our power ... and our future.

    That nation did not exist when, in the mid-19th century, Europeans first began to explore the possibilities of creating a link between the Atlantic and Pacific oceans through the narrow but mountainous isthmus; Panama was then a remote and overlooked part of Colombia.All that changed, writes David McCullough in his magisterial history of the Canal, in 1848, when prospectors struck gold in California. A wave of fortune seekers descended on Panama from Europe and the eastern United States, seeking quick passage on California-bound ships in the Pacific, and the Panama Railroad, built to serve that traffic, was soon the highest-priced stock listed on the New York Exchange. To build a 51-mile-long ship canal to replace that railroad seemed an easy matter to some investors. But, as McCullough notes, the construction project came to involve the efforts of thousands of workers from many nations over four decades; eventually those workers, laboring in oppressive heat in a vast malarial swamp, removed enough soil and rock to build a pyramid a mile high. In the early years, they toiled under the direction of French entrepreneur Ferdinand de Lesseps, who went bankrupt while pursuing his dream of extending France's empire in the Americas. The United States then entered the picture, with President Theodore Roosevelt orchestrating the purchase of the canal—but not before helping foment a revolution that removed Panama from Colombian rule and placed it squarely in the American camp.

    But in recent decades, these claims have eroded, or even been disproven outright, by a revolution in the study of animal cognition. Take the way octopuses use coconut shells as tools; elephants that classify humans by age, gender, and language; or Ayumu, the young male chimpanzee at Kyoto University whose flash memory puts that of humans to shame. Based on research involving crows, dolphins, parrots, sheep, wasps, bats, whales, and of course chimpanzees and bonobos, Frans de Waal explores both the scope and the depth of animal intelligence. He offers a firsthand account of how science has stood traditional behaviorism on its head by revealing how smart animals really are, and how we’ve underestimated their abilities for too long.People often assume a cognitive ladder, from lower to higher forms, with our own intelligence at the top. But what if it is more like a bush, with cognition taking different forms that are often incomparable to ours? Would you presume yourself dumber than a squirrel because you’re less adept at recalling the locations of hundreds of buried acorns? Or would you judge your perception of your surroundings as more sophisticated than that of a echolocating bat? De Waal reviews the rise and fall of the mechanistic view of animals and opens our minds to the idea that animal minds are far more intricate and complex than we have assumed. De Waal’s landmark work will convince you to rethink everything you thought you knew about animal—and human—intelligence.

    William Maples can deduce the age, gender, and ethnicity of a murder victim, the manner in which the person was dispatched, and, ultimately, the identity of the killer.  In Dead Men Do Tell Tales, Dr. Maples revisits his strangest, most interesting, and most horrific investigations, from the baffling cases of conquistador Francisco Pizarro and Vietnam MIAs to the mysterious deaths of President Zachary Taylor and the family of Czar Nicholas II.

    This fascinating collection of historical curiosities explores some of the strangest cases that have perplexed doctors across the world.From seventeenth-century Holland to Tsarist Russia, from rural Canada to a whaler in the Pacific, many are monuments to human stupidity – such as the sailor who swallowed dozens of penknives to amuse his shipmates, or the chemistry student who in 1850 arrived at a hospital in New York with his penis trapped inside a bottle, having unwisely decided to relieve himself into a vessel containing highly reactive potassium. Others demonstrate exceptional surgical ingenuity long before the advent of anaesthesia – such as a daring nineteenth-century operation to remove a metal fragment from beneath a conscious patient’s heart. We also hear of the weird, often hilarious remedies employed by physicians of yore – from crow’s vomit to port-wine enemas – the hazards of such everyday objects as cucumbers and false teeth, and miraculous recovery from apparently terminal injuries.

    The emergence of factories, railroads, and gunboats propelled the West’s rise to power in the nineteenth century, and the development of computers and nuclear weapons in the twentieth century secured its global supremacy. Now, at the beginning of the twenty-first century, many worry that the emerging economic power of China and India spells the end of the West as a superpower. In order to understand this possibility, we need to look back in time. Why has the West dominated the globe for the past two hundred years, and will its power last?Describing the patterns of human history, the archaeologist and historian Ian Morris offers surprising new answers to both questions. It is not, he reveals, differences of race or culture, or even the strivings of great individuals, that explain Western dominance. It is the effects of geography on the everyday efforts of ordinary people as they deal with crises of resources, disease, migration, and climate. As geography and human ingenuity continue to interact, the world will change in astonishing ways, transforming Western rule in the process.Deeply researched and brilliantly argued, Why the West Rules—for Now spans fifty thousand years of history and offers fresh insights on nearly every page. The book brings together the latest findings across disciplines—from ancient history to neuroscience—not only to explain why the West came to rule the world but also to predict what the future will bring in the next hundred years.

    He shows how oxygen underpins the origin of biological complexity, the birth of photosynthesis, the sudden evolution of animals, the need for two sexes, the accelerated aging of cloned animals like Dolly the sheep, and the surprisingly long lives of bats and birds. Drawing on this grand evolutionary canvas, Oxygen offers fresh perspectives on our own lives and deaths, explaining modern killer diseases, why we age, and what we can do about it. Advancing revelatory new ideas, following chains of evidence, the book ranges through many disciplines, from environmental sciences to molecular medicine. The result is a captivating vision of contemporary science and a humane synthesis of our place in nature. This remarkable book will redefine the way we think about the world.

    Adopting those aspects of the religion that suited his purposes, he turned Rome on a course from the relatively open, tolerant and pluralistic civilization of the Hellenistic world, towards a culture that was based on the rule of fixed authority, whether that of the Bible, or the writings of Ptolemy in astronomy and of Galen and Hippocrates in medicine. Only a thousand years later, with the advent of the Renaissance and the emergence of modern science, did Europe begin to free itself from the effects of Constantine's decision, yet the effects of his establishment of Christianity as a state religion remain with us, in many respects, today. Brilliantly wide-ranging and ambitious, this is a major work of history.

    If such a plague returned today, taking a comparable percentage of the U.S. population with it, 1.5 million Americans would die.The fascinating, true story of the world's deadliest disease.In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out.Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for "The New York Times," unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.

    David Abulafia's The Great Sea is the first complete history of the Mediterranean, from the erection of temples on Malta around 3500 BC to modern tourism. Ranging across time and the whole extraordinary space of the Mediterranean from Gibraltar to Jaffa, Genoa to Tunis, and bringing to life pilgrims, pirates, sultans and naval commanders, this is the story of the sea that has shaped much of world history.

    They have the physicists. They have the will. What they don’t have is enough “heavy water," an essential ingredient for their nuclear designs. For two years, the Nazis have occupied Norway, and with it the Vemork hydroelectric plant, a massive industrial complex nestled on a precipice of a gorge. Vemork is the world’s sole supplier of heavy water, and under the threat of death, its engineers pushed production into overtime. For the Allies, Vemork must be destroyed. But how would they reach the castle fortress high in a mountainous valley? The answer became the most dramatic commando raid of the war. The British Special Operations Executive together a brilliant scientist and eleven refugee Norwegian commandos, who, with little more than parachutes, skis, and Tommy Guns, would destroy Hitler’s nuclear ambitions and help end the reign of the Third Reich. Based on exhaustive research and never-before-seen diaries and letters of the saboteurs, The Winter Fortress is a compulsively readable narrative about a group of young men who endured soul-crushing setbacks and Gestapo hunts and survived in one of the coldest, most inhospitable places on earth to save the world from destruction.