Around the world, we struggle with diseases that were once considered rare. Cancer, heart disease, Alzheimer’s disease, and diabetes affect millions each year; many people are also struggling with hypertension, weight gain, fatty liver, dementia, low testosterone, menstrual irregularities and infertility, and more. We treat the symptoms, not realizing that all of these diseases and disorders have something in common. Each of them is caused or made worse by a condition known as insulin resistance. And you might have it. Odds are you do—over half of all adults in the United States are insulin resistant, with most other countries either worse or not far behind. In Why We Get Sick, internationally renowned scientist and pathophysiology professor Benjamin Bikman explores why insulin resistance has become so prevalent and why it matters. Unless we recognize it and take steps to reverse the trend, major chronic diseases will be even more widespread. But reversing insulin resistance is possible, and Bikman offers an evidence-based plan to stop and prevent it, with helpful food lists, meal suggestions, easy exercise principles, and more. Full of surprising research and practical advice, Why We Get Sick will help you to take control of your health.

    Professor Ridgley has crafted these 24 lectures as an accessible way to engage with thinking that will help you think-and act-more strategically in business and in your own life, whether you're the CEO of a Fortune 500 company or you're preparing to embark on a new career path.These lectures are loosely organized around several key topics central to effective strategic thinking, including: principles of conflict (in which you'll follow the development of strategic theory from its roots in great military campaigns to its modern applications in business); competitive intelligence (which plays an increasingly important role in strategic thinking); and tools of strategy and analysis (which can aid your understanding of the forces that shape our future and can help you make sense of a rapidly changing world).Central to these lectures are the tools and tricks that strategic thinkers have used to better approach problems and seek lasting solutions. Among those you'll learn how to use are the indirect approach (which offers you a much greater utility in achieving your objectives without approaching your opponent head-on); the value chain (a method that divides your team or organization into its value - producing activities so you can better inform yourself on its internal strengths and weaknesses; and the four actions framework (in which you ask yourself four questions to challenge your established logic in an effort to gain a stronger competitive advantage).

     Think back to the job interview you nailed (or blew). The date that went perfectly (or broke down completely.) Or the random encounter with that person who turned out to be your best friend (or the countless others that didn’t). Mere seconds of conversation have the power to alter the course of your life. It’s miraculous then that we are never taught HOW to conduct conversations. How to navigate them so that we get more of the jobs, dates, and best friends we want. It’s as if the world believes amazing conversational skills can’t be learned. Captivate shatters that belief. Inside you'll learn: How to keep conversations going without running out of things to say and facing the dreaded awkward silence How to create interesting "getting to know you" conversations without slipping into boring interview mode and turning off who you're talking to How to start conversations with strangers and approach people you don't know Real life examples of great (and terrible) conversations The two modes of conversation that allow you to connect with anyone, even when you don't have anything in common How to finish a conversation so people walk away planning on reaching out to you Read Captivate and you’ll learn how to have conversations that stand out in people’s minds and make you someone they never want to forget.

    But a medical revolution is underway that can solve this problem: Astonishing new research is revealing that the health of your brain is, to an extraordinary degree, dictated by the state of your microbiome - the vast population of organisms that live in your body and outnumber your own cells ten to one. What's taking place in your intestines today is determining your risk for any number of brain-related conditions.In BRAIN MAKER, Dr. Perlmutter explains the potent interplay between intestinal microbes and the brain, describing how the microbiome develops from birth and evolves based on lifestyle choices, how it can become "sick," and how nurturing gut health through a few easy strategies can alter your brain's destiny for the better. With simple dietary recommendations and a highly practical program of six steps to improving gut ecology, BRAIN MAKER opens the door to unprecedented brain health potential.

    Gut, an international bestseller, gives the alimentary canal its long-overdue moment in the spotlight. With quirky charm, rising science star Giulia Enders explains the gut’s magic, answering questions like: Why does acid reflux happen? What’s really up with gluten and lactose intolerance? How does the gut affect obesity and mood? Communication between the gut and the brain is one of the fastest-growing areas of medical research—on par with stem-cell research. Our gut reactions, we learn, are intimately connected with our physical and mental well-being. Enders’s beguiling manifesto will make you finally listen to those butterflies in your stomach: they’re trying to tell you something important.

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    In these lectures, you’ll consider a range of fundamental issues, including Christianity's birth and expansion across the Mediterranean world, the development of its doctrine, its transformation after Christianity became the imperial religion of Rome, its many and deep connections to Western culture, and tensions within Christianity today. Professor Johnson's synthetic approach provides first an overview of the Christian story, how it understands history, the relation of scripture to that history, and the Christian creed (what Christians believe about God, Jesus, the Holy Spirit, and the church). He explains Christian practice as expressed, in turn, by the structure of the community and its sacraments, by the struggles of Christians to find a coherent and consistent moral teaching, and by various manifestations of Christianity's more radical edge in martyrs, monks, mendicants, missionaries, and mystics. By the conclusion of his last lecture, you’ll have a firm grasp of Christianity's distinctive character, the major turning points in its history, its shared beliefs and practices, its sharp internal divisions, its struggles to adapt to changing circumstances, and its continuing appeal to many of the world's peoples.

    

    From living longer to getting smarter, maximizing performance to practicing mindfulness, Dave’s followers look to him for his take on the most effective techniques to become healthier and more powerful than most doctors think is possible.Asprey has been fasting for years, long before it gained widespread popularity, and if you’re a fan of Bulletproof coffee and The Bulletproof Diet, you have been enjoying some of the benefits of Intermittent Fasting too.In Fast This Way, Dave asks readers to forget everything they think they know about the ancient practice and takes them on a journey through cutting-edge science to examine the ways novice fasters and Intermittent Fasting loyalists can up-end their relationship with food and upgrade their fasting game beyond calorie restriction.  What IF eating the right foods at the right time can actually enhance your fast?  What IF how you work out and sleep could trick your body into thinking you are fasting? What IF it were easy to skip a meal, or two, or three?  What IF fasting is different for women, can be personalized to your genes, and can impact your mental health? What IF all fasts could be created equal?Fast This Way is a compelling read through the latest thinking on fasting and gives readers the manual and toolkit to make the most of their fasts and their personal biology.

    in Manhattan, where a woman's body had fallen from a twelfth-story window. The woman s husband, Herbert Weinstein, soon confessed to having hit and strangled his wife after an argument, then dropping her body out of their apartment window to make it look like a suicide. The 65-year-old Weinstein, a quiet, unassuming retired advertising executive, had no criminal record, no history of violent behavior not even a short temper. How, then, to explain this horrific act? Journalist Kevin Davis uses the perplexing story of the Weinstein murder to present a riveting, deeply researched exploration of the intersection of neuroscience and criminal justice. Shortly after Weinstein was arrested, an MRI revealed a cyst the size of an orange on his brain's frontal lobe, the part of the brain that governs judgment and impulse control. Weinstein's lawyer seized on that discovery, arguing that the cyst had impaired Weinstein's judgment and that he should not be held criminally responsible for the murder. It was the first case in the United States in which a judge allowed a scan showing a defendant's brain activity to be admitted as evidence to support a claim of innocence. The Weinstein case marked the dawn of a new era in America's courtrooms, raising complex and often troubling questions about how we define responsibility and free will, how we view the purpose of punishment, and how strongly we are willing to bring scientific evidence to bear on moral questions. Davis brings to light not only the intricacies of the Weinstein case but also the broader history linking brain injuries and aberrant behavior, from the bizarre stories of Phineas Gage and Charles Whitman, perpetrator of the 1966 Texas Tower massacre, to the role that brain damage may play in violence carried out by football players and troubled veterans of America s twenty-first century wars. The Weinstein case opened the door for a novel defense that continues to transform the legal system: Criminal lawyers are increasingly turning to neuroscience and introducing the effects of brain injuries whether caused by trauma or by tumors, cancer, or drug or alcohol abuse and arguing that such damage should be considered in determining guilt or innocence, the death penalty or years behind bars. As he takes stock of the past, present and future of neuroscience in the courts, Davis offers a powerful account of its potential and its hazards. Thought-provoking and brilliantly crafted, The Brain Defensemarries a murder mystery complete with colorful characters and courtroom drama with a sophisticated discussion of how our legal system has changed and must continue to change as we broaden our understanding of the human mind."

    It is a symptom.Recent years have seen a shocking increase in antidepressant use the world over, with 1 in 4 women starting their day with medication. These drugs have steadily become the panacea for everything from grief, irritability, panic attacks, to insomnia, PMS, and stress.  But the truth is, what women really need can’t be found at a pharmacy.According to Dr. Kelly Brogan, antidepressants not only overpromise and underdeliver, but their use may permanently disable the body’s self-healing potential. We need a new paradigm: The best way to heal the mind is to heal the whole body.In this groundbreaking, science-based and holistic approach, Dr. Brogan shatters the mythology conventional medicine has built around the causes and treatment of depression. Based on her expert interpretation of published medical findings, combined with years of experience from her clinical practice, Dr. Brogan illuminates the true cause of depression: it is not simply a chemical imbalance, but a lifestyle crisis that demands a reset. It is a signal that the interconnected systems in the body are out of balance – from blood sugar, to gut health, to thyroid function– and inflammation is at the root.A Mind of Your Own offers an achievable, step-by-step 30-day action plan—including powerful dietary interventions, targeted nutrient support, detoxification, sleep, and stress reframing techniques—women can use to heal their bodies, alleviate inflammation, and feel like themselves again without a single prescription.Bold, brave, and revolutionary, A Mind of Your Own takes readers on a journey of self-empowerment for radical transformation that goes far beyond symptom relief.

    On playing fields across America, lives are being derailed by seemingly innocuous jolts to the head. From the peewees to the pros, concussions are reaching epidemic proportions. This book brings that hidden epidemic and its consequences out of the shadows. As frightening as the numbers are—estimates of sports-related concussions range from 1.6 million to 3.8 million annually in the United States—they can’t begin to explain the profound impact of a hidden health problem that can strike any of us. It is becoming increasingly clear that concussions, like severe head traumas, can rob us of our memory, our mental abilities, our very sense of self. Because the damage caused by a concussion is rarely visible to the naked eye or even on a brain scan, no one knows how many millions might be living lives devastated by an invisible injury too often shrugged off as “just a bump on the head.” This book puts a human face on a huge public health crisis. Through narratives that chronicle the poignant experiences of real people struggling with this invisible and often unrecognized brain injury, Linda Carroll and David Rosner bring home its potentially devastating consequences. Among those you will meet are a high school football player whose college dreams were derailed by a series of undiagnosed concussions, a hard-driving soccer star whose own struggles with concussions pushed her to crusade for safety reform as a coach and soccer mom, and an economist who lost her career because of lingering concussion symptoms from a fender bender. The Concussion Crisis weaves these human dramas with compelling stories of scientists and doctors who are unraveling the mysteries of how an invisible injury can wreak such havoc. It takes readers into the top labs, where scientists are teasing out what goes wrong in the brain after a jolt to the head, and into the nation’s leading concussion clinic, where patients get cutting-edge management and treatment. Carroll and Rosner analyze the cultural factors that allowed this burgeoning epidemic to fester unseen and untreated. They chronicle the growing public awareness sparked by the premature retirements of superstars like NFL quarterbacks Troy Aikman and Steve Young. And they argue for an immediate change in a macho culture that minimizes the dangers inherent in repeated jolts to the head. The Concussion Crisis sounds an urgent wake-up call to parents, coaches, trainers, doctors, and the athletes themselves. The book will stand as the definitive exploration of this heretofore-silent health crisis. It should be required reading for every parent with a child playing sports—in fact, by everyone who has ever suffered a hard bump on the head.

    The lectures lead a startling voyage into the human mind, explaining not only how the various aspects of your memory operate, but the impact memory has on your daily experience of life.The various memory systems provide the continuity of consciousness that allows the concept of "you" to make sense, creating the ongoing narrative that makes your life truly yours. Without those systems and the overall experience of memory they make possible, you would have no context for the most crucial decisions of your life. You would have to make—without the benefit of experience and knowledge—the decisions that determine not only your quality of life, but your very survival. And your ability to learn, or even to form the personality that makes you unique, would similarly be set adrift.Course Lecture Titles24 Lectures, 30 minutes per lecture 1.Memory Is a PartyUsing the metaphor of a party whose “guests” include the different components of the complex interactions that make up memory, Professor Joordens introduces you to several kinds of memory—including episodic, semantic, and procedural—to arrive at an initial understanding of the variety of processes at work in human “memory.”2. The Ancient “Art of Memory”Techniques to embed and retrieve memories more easily—so-called mnemonic strategies—date back at least to classical Greece. See how one such technique—the Method of Loci—can help improve the episodic memory you depend on to recall a group of items such as grocery or to-do lists.3. Rote Memorization and a Science of ForgettingIs a mnemonic strategy always the most useful? Examine rote memorization and how it differs from mnemonics. Also, get an introduction to the work of Hermann Ebbinghaus, whose 19th-century experiments in remembering and forgetting marked the first scientific examination of memory.4. Sensory Memory—Brief Traces of the PastBegin a deeper discussion of the different kinds of memory, beginning with sensory memory and how its brief retentive power lets you switch from one stimulus to another—and even gives you your sense of “the present moment.” Here, the focus is on iconic (or visual) memory and its auditory counterpart, echoic memory.5. The Conveyor Belt of Working MemoryPlunge into the mental processes that allow you to work with information, often with the goal of solving a problem. You learn that these processes can also be used to keep information briefly “in mind,” though they require effort and are prone to interference.6. Encoding—Our Gateway into Long-Term MemoryHow does information make its way from your temporary working memory into long-term memory so you can access it again when you need it? This introduction to encoding explains the process and offers useful tips for improving your own recall.7. Episodic and Semantic Long-Term MemoryStrengthen your grasp of how these two key memory systems function. You explore the relationship between them with analogies that range from the job requirements of London taxi drivers to the famed “holo-deck” of the Star Trek television series.8. The Secret Passage—Implicit MemoryEncounter still another category of memory—a way in which your experiences can enter long-term memory without the kind of “effortful encoding” discussed earlier. You learn why this sort of memory creation is vitally important, yet also unreliable as a substitute for conscious effort.9. From Procedural Memory to HabitIn this lecture, you see that your memory for procedures is useful not only in the “muscle memory” of physical skills, but also in cognitive processes. Also, learn about constructivist learning, in which the explicit structure of a procedure—which is usually taught verbally—instead is learned implicitly during exploratory practice.10. When Memory Systems Battle—Habits vs. GoalsWhat happens when implicit or procedural memories become so powerful they seize control? In this examination of the tenacity of habits, learn how and why habits are formed and what steps might be useful in changing them, or at least regaining control.11. Sleep and the Consolidation of MemoriesDoes sleep play a role in strengthening memories of your experiences during the day? Gain a sense of the latest research about a subject that is difficult to study as you explore the relationship between sleep and memory, including the possible link between specific sleep stages and specific kinds of memory.12. Infant and Early Childhood MemoryHow does the maturation of memory fit into a child’s overall brain development? Gain invaluable and surprising insights into the month-by-month and year-by-year development of a child’s capacity for memory, beginning in the womb and continuing on with its dramatic development after entry into the world.13. Animal Cognition and MemoryDoes an elephant really never forget? Expand your study of memory to investigate the extent to which the mysterious abilities of humans may also exist in animals and, if so, how they might differ from our own.14. Mapping Memory in the BrainAlmost two decades since its revolutionary appearance, fMRI—functional magnetic resonance imaging—is allowing researchers to watch the living human brain at work, with no harm or discomfort to the subject. Explore what happens in several areas of the brain as memories are created or retrieved.15. Neural Network ModelsCan computer models mimic the operations of the human brain? Examine the use of neural network modeling, in which biologically inspired models posited by researchers in cognitive neuroscience are advancing our understanding of just how those operations take place.16. Learning from Brain Damage and AmnesiasLeave the world of computers for that of neuropsychology as you focus on the life situations of several patients who have suffered some form of brain injury. You learn how damage to different areas of the brain can have dramatically different impacts on memory and how these patients experience the world.17. The Many Challenges of Alzheimer’s DiseaseIn a lecture that explores one of our most frightening diseases from both the caregiver’s and sufferer’s perspectives, learn how Alzheimer’s progresses, how that progression may be forestalled, and ways in which technology may be able to help through the emerging field of “cognitive prosthetics.”18. That Powerful Glow of Warm FamiliarityWhy does something familiar to us actually feel that way? Discover the sources of familiarity as you are introduced to the concepts of perceptual fluency and prototypes, and explore some surprising ways that those feelings of familiarity can trump other considerations.19. Déjà Vu and the Illusion of MemoryIs déjà vu simply an illusion of memory? If so, can we learn more about memory by trying to understand how this common phenomenon comes about? Examine some of the theories that have 20. Recovered Memories or False Memories?Is episodic memory subject to the same pitfalls as misattributed feelings of familiarity? Can we “remember” things that never took place with the same intensity and certainty as those that did? Gain new insights into what is at stake when long-forgotten “memories” resurface.21. Mind the Gaps! Memory as ReconstructionMetaphors for memory usually reference information storehouses of some kind, such as library stacks or computer hard drives, from which episodic memories are “retrieved.” Learn about the extent to which we actually construct our memories anew each time we summon them and how this explains common memory errors.22. How We Choose What's Important to RememberDoes our brain always make decisions for us about which aspects of our experience to encode for later recall, or can we influence that process ourselves? Learn potentially powerful techniques for influencing the shape of future memories.23. Aging, Memory, and Cognitive TransitionApply a reality check to the popularly held belief that memory naturally declines as we age. Learn what happened when a researcher corrected for the age-related variables long-ignored by traditional testers—and what conclusions we can draw about what lies ahead for us as we grow older.24. The Monster at the End of the BookContemplate the significance of what you’ve learned, with special attention to the common question of whether you can improve your episodic memory—remembering what you want to recall, forgetting what you’d rather not, and making choices about how to achieve a balance.

    But aging does not have to mean decline. World-renowned surgeon Dr. Steven Gundry has been treating mature patients for most of his career. He knows that everyone thinks they want to live forever, until they hit middle age and witness the suffering of their parents and even their peers. So how do we solve the paradox of wanting to live to a ripe old age—but enjoy the benefits of youth?This groundbreaking book holds the answer. Working with thousands of patients, Dr. Gundry has discovered that the “diseases of aging” we most fear are not simply a function of age; rather, they are a byproduct of the way we have lived over the decades. In The Longevity Paradox, he maps out a new approach to aging well—one that is based on supporting the health of the “oldest” parts of us: the microorganisms that live within our bodies.Our gut bugs—the bacteria that make up the microbiome—largely determine our health over the years. From diseases like cancer and Alzheimer’s to common ailments like arthritis to our weight and the appearance of our skin, these bugs are in the driver’s seat, controlling our quality of life as we age.The good news is, it’s never too late to support these microbes and give them what they need to help them—and you—thrive. In The Longevity Paradox, Dr. Gundry outlines a nutrition and lifestyle plan to support gut health and live well for decades to come. A progressive take on the new science of aging, The Longevity Paradox offers an action plan to prevent and reverse disease as well as simple hacks to help anyone look and feel younger and more vital.

    But getting here has not been a simple story of selfless men working tirelessly in the pursuit of medical advancement. Instead it's a bloodstained tale of blunders, arrogance, mishap and murder. In trying to keep us alive, surgeons have all too often killed us off, and life-saving solutions have often come from the most surprising places. Accompanying a major BBC series, "Blood and Guts" is an incredible story of stolen corpses, medical fraud, lobotomized patients - and every now and then courageous advances that have saved the lives of millions around the world. You may think twice before going under the knife.