It is the history of who you are and how you came to be. It is unique to you, as it is to each of the 100 billion modern humans who have ever drawn breath. But it is also our collective story, because in every one of our genomes we each carry the history of our species births, deaths, disease, war, famine, migration, and a lot of sex. Since scientists first read the human genome in 2001, it has been subject to all sorts of claims, counterclaims, and myths. In fact, as Adam Rutherford explains, our genomes should be read not as instruction manuals, but as epic poems. DNA determines far less than we have been led to believe about us as individuals, but vastly more about us as a species. In this captivating journey through the expanding landscape of genetics, Adam Rutherford reveals what our genes now tell us about history, and what history tells us about our genes. From Neanderthals to murder, from redheads to race, dead kings to plague, evolution to epigenetics, this is a demystifying and illuminating new portrait of who we are and how we came to be."

    But he was alive and trapped inside his own body for ten years.In January 1988 Martin Pistorius, aged twelve, fell inexplicably sick. First he lost his voice and stopped eating. Then he slept constantly and shunned human contact. Doctors were mystified. Within eighteen months he was mute and wheelchair-bound. Martin's parents were told an unknown degenerative disease left him with the mind of a baby and less than two years to live.Martin was moved to care centers for severely disabled children. The stress and heartache shook his parents’ marriage and their family to the core. Their boy was gone. Or so they thought.Ghost Boy is the heart-wrenching story of one boy’s return to life through the power of love and faith. In these pages, readers see a parent’s resilience, the consequences of misdiagnosis, abuse at the hands of cruel caretakers, and the unthinkable duration of Martin’s mental alertness betrayed by his lifeless body.We also see a life reclaimed—a business created, a new love kindled—all from a wheelchair. Martin's emergence from his own darkness invites us to celebrate our own lives and fight for a better life for others.

    Sapolsky's storytelling concept is delightful but it also has a powerful intrinsic logic: he starts by looking at the factors that bear on a person's reaction in the precise moment a behavior occurs, and then hops back in time from there, in stages, ultimately ending up at the deep history of our species and its evolutionary legacy.And so the first category of explanation is the neurobiological one. A behavior occurs--whether an example of humans at our best, worst, or somewhere in between. What went on in a person's brain a second before the behavior happened? Then Sapolsky pulls out to a slightly larger field of vision, a little earlier in time: What sight, sound, or smell caused the nervous system to produce that behavior? And then, what hormones acted hours to days earlier to change how responsive that individual is to the stimuli that triggered the nervous system? By now he has increased our field of vision so that we are thinking about neurobiology and the sensory world of our environment and endocrinology in trying to explain what happened.Sapolsky keeps going: How was that behavior influenced by structural changes in the nervous system over the preceding months, by that person's adolescence, childhood, fetal life, and then back to his or her genetic makeup? Finally, he expands the view to encompass factors larger than one individual. How did culture shape that individual's group, what ecological factors millennia old formed that culture? And on and on, back to evolutionary factors millions of years old.The result is one of the most dazzling tours d'horizon of the science of human behavior ever attempted, a majestic synthesis that harvests cutting-edge research across a range of disciplines to provide a subtle and nuanced perspective on why we ultimately do the things we do...for good and for ill. Sapolsky builds on this understanding to wrestle with some of our deepest and thorniest questions relating to tribalism and xenophobia, hierarchy and competition, morality and free will, and war and peace. Wise, humane, often very funny, Behave is a towering achievement, powerfully humanizing, and downright heroic in its own right.

    David Hogg called out Adult America. The uprising had begun. Cameron Kasky immediately recruited a colorful band of theatre kids and rising activists and brought them together in his living room to map out a movement. Four days after escaping Marjory Stoneman Douglas High School, two dozen extraordinary kids announced the audacious March for Our Lives. A month later, it was the fourth largest protest in American history.Dave Cullen, who has been reporting on the epidemic of school shootings for two decades, takes us along on the students’ nine-month odyssey to the midterms and beyond. With unrivaled access to their friends and families, meetings and homes, he pulls back the curtain to reveal intimate portraits of the quirky, playful organizers that have taken the nation by storm. Cullen brings us onto the bus for the Road to Change tour showing us how these kids seized an opportunity. They hit the highway to organize the young activist groups mushrooming across America in their image. Rattled but undeterred, they pressed on in gun country even as adversaries armed with assault weapons tailed them across Texas and Utah trying to scare them off. The Parkland students are genuinely candid about their experiences. We see them cope with shattered friendships and PTSD, along with the normal day-to-day struggles of school, including AP exams and college acceptances. Yet, with the idealism of youth they are mostly bubbling with fresh ideas. As victims refusing victimhood, they continue to devise clever new tactics to stir their generation to action while building a powerhouse network to match the NRA’s. This spell-binding book is a testament to change and a perceptive examination of a pivotal moment in American culture. After two decades of adult hand-wringing, the MFOL kids are mapping a way out. They see a long road ahead, a generational struggle to save every kid of every color from the ravages of gun violence in America. Parkland is a story of staggering empowerment and hope, told through the wildly creative and wickedly funny voices of a group of remarkable kids.

    Lara, a superstar nurse who tries to battle her way back from a near-ruinous prescription-drug addiction. The outspoken but compassionate Juliette, a fierce advocate for her patients. And Sam, a first-year nurse, struggling to find her way in a gossipy mean-girl climate she likens to “high school, except for the dying people.”The result is a riveting page-turner, insightful and thought-provoking, that will leave readers feeling smarter about their healthcare and undeniably appreciative of the incredible nurses who provide it.

    Every night, he read ten of them before going to bed. This is the story of the profound ways in which they shaped his presidency.Every evening for 8 years, at his request, President Obama received a binder containing ten handpicked letters from ordinary American citizens -- the unfiltered voice of a nation -- from his Office of Presidential Correspondence. He was the first to President to save constituent mail, and this is the story of how those letters affected not only the President and his policies, but also the deeply committed people who were tasked with opening the millions of pleas, rants, thank yous, and apologies that landed in the White House mailroom.Based on the popular New York Times article, "To Obama," Laskas now interviews the letter writers themselves and the White House staff who sifted through the powerful, moving, and incredibly intimate narrative of America during the Obama years emerges: There is Kelli, who saw her grandfathers finally marry - legally -- after 35 years together; Bill, a lifelong Republican whose attitude toward immigration reform was transformed when he met a boy escaping M-16 gang leaders in El Salvador; Heba, a Syrian refugee who wants to forget the day the tanks rolled into her village; Marjorie, who grappled with disturbing feelings of racial bias lurking within her during the George Zimmerman trial; and Vicki, whose family was torn apart by those who voted for Trump and those who did not.They wrote to Obama out of gratitude and desperation, in their darkest times of need, in search of connection. They wrote with anger and respect. And together, this chorus of voices achieves a kind of beautiful harmony: here is a diary of a nation. To Obama is an intimate look at one man's relationship to the American people, and the the intersection of politics and empathy in the White House.

    A bloodthirsty serial killer, self-named "BTK"—for "bind them, torture them, kill them"—he slaughtered men, women, and children alike, eluding the police for decades while bragging of his grisly exploits to the media. The nation was shocked when the fiend who was finally apprehended turned out to be Dennis Rader—a friendly neighbor . . . a devoted husband . . . a helpful Boy Scout dad . . . the respected president of his church.Written by four award-winning crime reporters who covered the story for more than twenty years, Bind, Torture, Kill is the most intimate and complete account of the BTK nightmare told by the people who were there from the beginning. With newly released documents, evidence, and information—and with the full cooperation, for the very first time, of the Wichita Police Department’s BTK Task Force—the authors have put all the pieces of the grisly puzzle into place, thanks to their unparalleled access to the families of the killer and his victims.

    Taking us into a landscape most of us have never before seen, award-winning journalist Barbara Demick brings to life what it means to be living under the most repressive totalitarian regime today—an Orwellian world that is by choice not connected to the Internet, in which radio and television dials are welded to the one government station, and where displays of affection are punished; a police state where informants are rewarded and where an offhand remark can send a person to the gulag for life. Demick takes us deep inside the country, beyond the reach of government censors. Through meticulous and sensitive reporting, we see her six subjects—average North Korean citizens—fall in love, raise families, nurture ambitions, and struggle for survival. One by one, we experience the moments when they realize that their government has betrayed them.  Nothing to Envy is a groundbreaking addition to the literature of totalitarianism and an eye-opening look at a closed world that is of increasing global importance.

    Markel writes of the physical and emotional damage caused by the then-heralded wonder drug, and how each man ultimately changed the world in spite of it—or because of it. One became the father of psychoanalysis; the other, of modern surgery. Both men were practicing medicine at the same time in the 1880s: Freud at the Vienna General Hospital, Halsted at New York’s Bellevue Hospital. Markel writes that Freud began to experiment with cocaine as a way of studying its therapeutic uses—as an antidote for the overprescribed morphine, which had made addicts of so many, and as a treatment for depression.  Halsted, an acclaimed surgeon even then, was curious about cocaine’s effectiveness as an anesthetic and injected the drug into his arm to prove his theory. Neither Freud nor Halsted, nor their colleagues, had any idea of the drug’s potential to dominate and endanger their lives. Addiction as a bona fide medical diagnosis didn’t even exist in the elite medical circles they inhabited.  In An Anatomy of Addiction, Markel writes about the life and work of each man, showing how each came to know about cocaine; how Freud found that the drug cured his indigestion, dulled his aches, and relieved his depression. The author writes that Freud, after a few months of taking the magical drug, published a treatise on it, Über Coca, in which he described his “most gorgeous excitement.” The paper marked a major shift in Freud’s work: he turned from studying the anatomy of the brain to exploring the human psyche.  Halsted, one of the most revered of American surgeons, became the head of surgery at the newly built Johns Hopkins Hospital and then professor of surgery, the hospital’s most exalted position, committing himself repeatedly to Butler Hospital, an insane asylum, to withdraw from his out-of control cocaine use.  Halsted invented modern surgery as we know it today: devising new ways to safely invade the body in search of cures and pioneering modern surgical techniques that controlled bleeding and promoted healing. He insisted on thorough hand washing, on scrub-downs and whites for doctors and nurses, on sterility in the operating room—even inventing the surgical glove, which he designed and had the Goodyear Rubber Company make for him—accomplishing all of this as he struggled to conquer his unyielding desire for cocaine.  An Anatomy of Addiction tells the tragic and heroic story of each man, accidentally struck down in his prime by an insidious malady: tragic because of the time, relationships, and health cocaine forced each to squander; heroic in the intense battle each man waged to overcome his affliction as he conquered his own world with his visionary healing gifts. Here is the full story, long overlooked, told in its rich historical context.

    Though the world at first recoiled at the notion of a woman studying medicine, her intelligence and intensity ultimately won her the acceptance of the male medical establishment. In 1849, she became the first woman in America to receive an M.D. She was soon joined in her iconic achievement by her younger sister, Emily, who was actually the more brilliant physician.Exploring the sisters’ allies, enemies, and enduring partnership, Janice P. Nimura presents a story of trial and triumph. Together, the Blackwells founded the New York Infirmary for Indigent Women and Children, the first hospital staffed entirely by women. Both sisters were tenacious and visionary, but their convictions did not always align with the emergence of women’s rights—or with each other. From Bristol, Paris, and Edinburgh to the rising cities of antebellum America, this richly researched new biography celebrates two complicated pioneers who exploded the limits of possibility for women in medicine. As Elizabeth herself predicted, "a hundred years hence, women will not be what they are now."

    For every one of the cells that make up the vessel that you call your body, there are nine impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and skin, but also bacteria and fungi. Over your lifetime, you will carry the equivalent weight of five African elephants in microbes. You are not an individual but a colony.Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them.In this riveting, shocking, and beautifully written book, biologist Alanna Collen draws on the latest scientific research to show how our personal colony of microbes influences our weight, our immune system, our mental health, and even our choice of partner. She argues that so many of our modern diseases—obesity, autism, mental illness, digestive disorders, allergies, autoimmunity afflictions, and even cancer—have their root in our failure to cherish our most fundamental and enduring relationship: that with our personal colony of microbes.Many of the questions about modern diseases left unanswered by the Human Genome Project are illuminated by this new science. And the good news is that unlike our human cells, we can change our microbes for the better. Collen's book is a revelatory and indispensable guide. It is science writing at its most relevant: life—and your body—will never seem the same again.

    She could have sailed home to England and comfortably dined out on her fame for the remainder of her long days. Instead, she conducted a ruthless post-mortem on every moment of her wartime service and found herself entirely wanting. She did not try to hide her mistakes; instead, she sought to broadcast them so that everyone would understand what happens in unsanitary medical facilities. She could well have slid into self-pity and inertia, yet she spent the next several decades campaigning for reforms. One hundred and fifty years ago, the respect we now have for nurses and the intense training that nurses must undergo was nothing but a seed in Florence Nightingale's imagination. If we believe that nurses are some of the most respectable and hardworking people in our community, we owe that belief to Florence Nightingale. But she never took the credit. As an old woman of seventy-seven, she deflected all her accomplishments onto God with the words, "How inefficient I was in the Crimea! Yet He has raised up Trained Nursing from it!"

    In this compelling memoir, his first wife, Jane Hawking, relates the inside story of their extraordinary marriage. As Stephen's academic renown soared, his body was collapsing under the assaults of a motor neuron disease. Jane's candid account of trying to balance his 24-hour care with the needs of their growing family reveals the inner strength of the author, while the self-evident character and achievements of her husband make for an incredible tale presented with unflinching honesty. Jane's candor is no less apparent when the marriage finally ends in a high-profile meltdown, with Stephen leaving Jane for one of his nurses and Jane marrying an old family friend. In this exceptionally open, moving, and often funny memoir, Jane Hawking confronts not only the acutely complicated and painful dilemmas of her first marriage, but also the relationship's fault lines exposed by the pervasive effects of fame and wealth. The result is a book about optimism, love, and change that will resonate with readers everywhere.

     It is a remarkable portrait, too, of the life of a psychiatric asylum--the sort of community in which, for better and for worse, hundreds of thousands of people lived out their lives.More than four hundred abandoned suitcases filled with patients’ belongings were found when Willard Psychiatric Center closed in 1995 after 125 years of operation. They are skillfully examined here and compared to the written record to create a moving—and devastating—group portrait of twentieth-century American psychiatric care.

    Where can a tin of tuna buy you clean clothes? Which British education system struggles with 50% illiteracy? Where do teetotal Muslims attend AA meetings? Where is it easier to get 'spice' than paracetamol? Where does self-harm barely raise an eyebrow?Welcome to Her Majesty's Prison Service, a creaking and surreal world that has been left to rot for decades in the shadows of polite society. Like most people, documentary-maker Chris Atkins didn't spend much time thinking about prisons. But after becoming embroiled in a dodgy scheme to fund his latest film, he was sent down for five years. His new home would be HMP Wandsworth, one of the oldest, largest, and most dysfunctional prisons in Europe.Horrifying, moving, and darkly funny, this is the unvarnished depiction of what he found. With a cast of characters ranging from wily drug dealers to corrupt screws to senior officials bent on endless (and fruitless) reform, this is the reality behind the locked gates. Full of incredible and hilarious stories, A Bit of a Stretch reveals the true scale of our prison crisis and why it is costing us all.