As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    That's all it took to change Stephanie Wittels Wachs' life forever..Her younger brother Harris, a star in the comedy world known for his work on shows like Parks and Recreation, had died of a heroin overdose. How do you make sense of such a tragic end to a life of so much hilarious brilliance?In beautiful, unsentimental, and surprisingly funny prose, Stephanie Wittels Wachs alternates between her brother's struggle with addiction, which she learned about three days before her wedding, and the first year after his death, in all its emotional devastation. This compelling portrait of a comedic genius and a profound exploration of the love between siblings is A Year of Magical Thinking for a new generation of readers.A heartbreaking but hopeful memoir of addiction, grief, and family, Everything is Horrible and Wonderful will make you laugh, cry, and wonder if that possum on the fence is really your brother's spirit animal.

    Married to a man for nearly a decade and mother to a toddler, Wizenberg tried to return to her life as she knew it, but something inside her had changed irredeemably. Instead, she would discover that the trajectory of our lives is rarely as smooth or as logical as we’d like to believe.   Like many of us, Wizenberg had long understood sexual orientation as a stable part of ourselves: we’re “born this way.” Suddenly she realized that her story was more complicated. Who was she, she wondered, if something at her very core could change so radically? The Fixed Stars is a taut, electrifying memoir exploring timely and timeless questions about desire, identity, and the limits and possibilities of family. In honest and searing prose, Wizenberg forges a new path: through the murk of separation and divorce, coming out to family and friends, learning to co-parent a young child, and realizing a new vision of love. The result is a frank and moving story about letting go of rigid definitions and ideals that no longer fit, and learning instead who we really are.

    For nearly twenty years, until she was correctly diagnosed at age thirty-five, she careened between periods of extreme euphoria and debilitating depression, prone to delusions and panic attacks, temper tantrums, spending sprees, and suicide attempts. Now in A Brilliant Madness Patty Duke joins with medical reporter Gloria Hochman to shed light on this powerful, paradoxical, and destructive illness. From what it's like to live with manic-depressive disorder to the latest findings on its most effective treatments, this compassionate and eloquent book provides profound insight into the challenge of mental illness. And though Patty's story, which ends in a newfound happiness with her cherished family, it offers hope for all those who suffer from mood disorders and for the family, friends, and physicians who love and care for them.

    What surfaced was terrifying: she was inhabited by 'the Troops'-92 individual personalities. This groundbreaking true story is made all the more extraordinary in that it was written by the Troops themselves. What they reveal is a spellbinding descent into a personal hell-and an ultimate deliverance for the woman they became.

    Emboldened by the cool confidence that comes with the end of one's 20s plus the newfound independence of an attachment-free lifestyle, Mamrie commits herself to living life as fully as possible. She seeks out once-in-a-lifetime experiences (like meeting Dolly Parton), bucket-list goals (like visiting the Moulin Rouge), and madcap adventures (like going anchors-away on a Backstreet Boys cruise)--all while diving back into the dating world for the first time in a decade.In I've Got This Round, readers will find the same shameless honesty and I'll-try-anything-once spirit they loved in You Deserve a Drink. Mamrie doubles down on her strong female friendships, her willingness to engage in shenanigans, and her inimitable candor, taking the reader along for a wild and unforgettable journey through adulting.

    But I was getting there. I wanted the world to know that all of this pain I had been feeling…that it was related to my vagina. Thus, Vagina Problems was born. It was a cutesy name. It was my way of taking this pain and saying, “Whatever. I’m here. I have it. It sucks. Let’s talk about it.”In April 2014, Deputy Editorial Director at BuzzFeed Lara Parker opened up to the world in an article on the website: she suffers from endometriosis. And beyond that? She let the whole world know that she wasn’t having any sex, as sex was excruciatingly painful. Less than a year before, she received not only the diagnosis of endometriosis, but also a diagnosis of pelvic floor dysfunction, vulvodynia, vaginismus, and vulvar vestibulitis. Combined, these debilitating conditions have wreaked havoc on her life, causing excruciating pain throughout her body since she was fourteen years old. These are her Vagina Problems. It was five years before Lara learned what was happening to her body. Five years of doctors insisting she just had “bad period cramps,” or implying her pain was psychological. Shamed and stigmatized, Lara fought back against a medical community biased against women and discovered that the ignorance of many doctors about women’s anatomy was damaging more than just her own life. One in ten women have endometriosis and it takes an average of seven years before they receive an accurate diagnosis—or any relief from this incurable illness’ chronic pain. With candid revelations about her vaginal physical therapy, dating as a straight woman without penetrative sex, coping with painful seizures while at the office, diet and wardrobe malfunctions when your vagina hurts all the time, and the depression and anxiety of feeling unloved, Lara tackles it all in Vagina Problems: Endometriosis, Painful Sex, and Other Taboo Topics with courage, wit, love, and a determination to live her best life."

    For as long as she could remember, Ashley has put her father on a pedestal. Despite having only vague memories of seeing him face-to-face, she believes he's the only person in the entire world who understands her. She thinks she understands him too. He's sensitive like her, an artist, and maybe even just as afraid of the dark. She's certain that one day they'll be reunited again, and she'll finally feel complete. There are just a few problems: he's in prison, and she doesn't know what he did to end up there.Through poverty, puberty, and a fraught relationship with her mother, Ashley returns to her image of her father for hope and encouragement. She doesn't know how to deal with the incessant worries that keep her up at night, or how to handle the changes in her body that draw unwanted attention from men. In her search for unconditional love, Ashley begins dating a boy her mother hates; when the relationship turns sour, he assaults her. Still reeling from the rape, which she keeps secret from her family, Ashley finally finds out why her father is in prison. And that's where the story really begins.Somebody’s Daughter steps into the world of growing up a poor Black girl, exploring how isolating and complex such a childhood can be. As Ashley battles her body and her environment, she provides a poignant coming-of-age recollection that speaks to finding the threads between who you are and what you were born into, and the complicated familial love that often binds them.

    Four years later, she and her mother joined her father in Stillwater, Oklahoma —a move that would be anxiety ridden for any child, but especially for Bassey. Her early years in America would come to be defined by tension: an assimilation further complicated by bipolar II and anxiety that would go undiagnosed for decades.By the time she was in her early twenties, Bassey was a spoken word artist and traveling with HBO's Russell Simmons Def Poetry Jam, channeling her experiences into art. But something wasn’t right—beneath the façade of the confident performer, Bassey’s mental health was in a precipitous decline, culminating in a breakdown that resulted in hospitalization and a diagnosis of Bipolar II.Determined to learn from her experiences—and share them with others—Bassey became a mental health advocate and has spent the fourteen years since her diagnosis examining the ways mental health is inextricably intertwined with every facet of ourselves and our lives. Viscerally raw and honest, the result is an exploration of the stories we tell ourselves to make sense of who we are—and the ways, as honest as we try to be, each of these stories can also be a lie.

    A beach body by summer. A trip to Disneyland around the corner. A promotion on the horizon. Everyone wants to believe that they are headed toward good, better, best. But what happens when the life you hoped for is put on hold indefinitely?Kate Bowler believed that life was a series of unlimited choices, until she discovered, at age 35, that her body was wracked with cancer. In No Cure for Being Human, she searches for a way forward as she mines the wisdom (and absurdity) of today's "best life now" advice industry, which insists on exhausting positivity and on trying to convince us that we can out-eat, out-learn, and out-perform our humanness. We are, she finds, as fragile as the day we were born.With dry wit and unflinching honesty, Kate Bowler grapples with her diagnosis, her ambition, and her faith as she tries to come to terms with her limitations in a culture that says anything is possible. She finds that we need one another if we're going to tell the truth: Life is beautiful and terrible, full of hope and despair and everything in between--and there's no cure for being human.

    When death is sudden or unexplained, it falls to Shepherd to establish the cause. Each post-mortem is a detective story in its own right - and Shepherd has performed over 23,000 of them. Through his skill, dedication and insight, Dr Shepherd solves the puzzle to answer our most pressing question: how did this person die?From serial killer to natural disaster, 'perfect murder' to freak accident, Shepherd takes nothing for granted in pursuit of truth. And while he's been involved in some of the most high-profile cases of recent times, it's often the less well known encounters that prove the most perplexing, intriguing and even bizarre. In or out of the public eye, his evidence has put killers behind bars, freed the innocent and turned open-and-shut cases on their heads.But a life in death, bearing witness to some of humanity's darkest corners, exacts a price and Shepherd doesn't flinch from counting the cost to him and his family.

    Bennet Omalu, the pathologist who made one of the most significant medical discoveries of the twenty-first century, a discovery that challenges the existence of America’s favorite sport and puts Omalu in the crosshairs of football’s most powerful corporation: the NFL. Jeanne Marie Laskas first met the young forensic pathologist Dr. Bennet Omalu in 2009, while reporting a story for GQ that would go on to inspire the movie Concussion. Omalu told her about a day in September 2002, when, in a dingy morgue in downtown Pittsburgh, he picked up a scalpel and made a discovery that would rattle America in ways he’d never intended. Omalu was new to America, chasing the dream, a deeply spiritual man escaping the wounds of civil war in Nigeria. The body on the slab in front of him belonged to a fifty-year-old named Mike Webster, aka “Iron Mike,” a Hall of Fame center for the Pittsburgh Steelers, one of the greatest ever to play the game. After retiring in 1990, Webster had suffered a dizzyingly steep decline. Toward the end of his life, he was living out of his van, tasering himself to relieve his chronic pain, and fixing his rotting teeth with Super Glue. How did this happen?, Omalu asked himself. How did a young man like Mike Webster end up like this? The search for answers would change Omalu’s life forever and put him in the crosshairs of one of the most powerful corporations in America: the National Football League. What Omalu discovered in Webster’s brain—proof that Iron Mike’s mental deterioration was no accident but a disease caused by blows to the head that could affect everyone playing the game—was the one truth the NFL wanted to ignore.   Taut, gripping, and gorgeously told, Concussion is the stirring story of one unlikely man’s decision to stand up to a multibillion-dollar colossus, and to tell the world the truth.  Advance praise for Concussion “A gripping medical mystery and a dazzling portrait of the young scientist no one wanted to listen to . . . a fabulous, essential read.”—Rebecca Skloot, author of The Immortal Life of Henrietta Lacks“The story of Dr. Bennet Omalu’s battle against the NFL is classic David and Goliath stuff, and Jeanne Marie Laskas—one of my favorite writers on earth—makes it as exciting as any great courtroom or gridiron drama. A riveting, powerful human tale—and a master class on how to tell a story.”—Charles Duhigg, author of The Power of Habit   “Bennet Omalu forced football to reckon with head trauma. The NFL doesn’t want you to hear his story, but Jeanne Marie Laskas makes it unforgettable. This book is gripping, eye-opening, and full of heart.”—Emily Bazelon, author of Sticks and Stones

    His contribution to our understanding not only of mental illness but also of the human condition is truly stunning.The Noonday Demon examines depression in personal, cultural, and scientific terms. Drawing on his own struggles with the illness and interviews with fellow sufferers, doctors and scientists, policymakers and politicians, drug designers and philosophers, Solomon reveals the subtle complexities and sheer agony of the disease. He confronts the challenge of defining the illness and describes the vast range of available medications, the efficacy of alternative treatments, and the impact the malady has had on various demographic populations around the world and throughout history. He also explores the thorny patch of moral and ethical questions posed by emerging biological explanations for mental illness.The depth of human experience Solomon chronicles, the range of his intelligence, and his boundless curiosity and compassion will change the reader's view of the world.

    Eilene Zimmerman noticed that her ex-husband looked thin, seemed distracted, and was frequently absent from activities with their children. She thought he looked sick and needed to see a doctor, and indeed, he told her he had been diagnosed with an autoimmune disorder. Yet in many ways, Peter also seemed to have it all: a beautiful house by the beach purchased after their divorce, expensive cars, and other luxuries that came with an affluent life. Eilene assumed his odd behavior was due to stress and overwork--he was a senior partner at a prominent law firm and had been working more than 60 hours a week for the last 20 years.Although they were divorced, Eilene and Peter had been partners and friends for decades, so, when her calls to Peter were not returned for several days, Eilene went to his house to see if he was OK.So begins Smacked, a brilliant, moving memoir of Eilene's shocking discovery, one that sets her on a journey to find out how a man she knew for nearly 30 years became a drug addict, and hid it so well that neither she nor anyone else in his life suspected what was happening. Eilene discovers that Peter led a secret life, one that started with pills and ended with opioids, cocaine and methamphetamine. Peter was also addicted to work; the last call he ever made was to dial into a conference call.Eilene is determined to learn all she can about Peter's hidden life, and also about drug addiction among ambitious and high achieving professionals like him. Through extensive research and interviews, she presents a picture of drug dependence today in that moneyed, upwardly mobile world. She also embarks on a journey to recreate her life in the wake of loss, both of the person--and the relationship--that profoundly defined the woman she had become.Smacked takes readers on an intimate journey into a little-known part of the drug epidemic, through the story of one man, one woman and one family.

    They are promises. They are the only way to walk from one night to the other."Nina Riggs was just thirty-seven years old when initially diagnosed with breast cancer--one small spot. Within a year, the mother of two sons, ages seven and nine, and married sixteen years to her best friend, received the devastating news that her cancer was terminal.How does one live each day, "unattached to outcome"? How does one approach the moments, big and small, with both love and honesty?Exploring motherhood, marriage, friendship, and memory, even as she wrestles with the legacy of her great-great-great grandfather, Ralph Waldo Emerson, Nina Riggs's breathtaking memoir continues the urgent conversation that Paul Kalanithi began in his gorgeous When Breath Becomes Air. She asks, what makes a meaningful life when one has limited time?Brilliantly written, disarmingly funny, and deeply moving, The Bright Hour is about how to love all the days, even the bad ones, and it's about the way literature, especially Emerson, and Nina's other muse, Montaigne, can be a balm and a form of prayer. It's a book about looking death squarely in the face and saying "this is what will be."Especially poignant in these uncertain times, The Bright Hour urges us to live well and not lose sight of what makes us human: love, art, music, words.