But how did Watson and Crick do it—and why were they the ones who succeeded?In truth, the discovery of DNA’s structure is the story of five towering minds in pursuit of the advancement of science, and for almost all of them, the prospect of fame and immortality: Watson, Crick, Rosalind Franklin, Maurice Wilkins, and Linus Pauling. Each was fascinating and brilliant, with strong personalities that often clashed. Howard Markel skillfully re-creates the intense intellectual journey, and fraught personal relationships, that ultimately led to a spectacular breakthrough. But it is Rosalind Franklin—fiercely determined, relentless, and an outsider at Cambridge and the University of London in the 1950s, as the lone Jewish woman among young male scientists—who becomes a focal point for Markel.The Secret of Life is a story of genius and perseverance, but also a saga of cronyism, misogyny, anti-Semitism, and misconduct. Drawing on voluminous archival research, including interviews with James Watson and with Franklin’s sister, Jenifer Glynn, Markel provides a fascinating look at how science is done, how reputations are undone, and how history is written, and revised.A vibrant evocation of Cambridge in the 1950s, Markel also provides colorful depictions of Watson and Crick—their competitiveness, idiosyncrasies, and youthful immaturity—and compelling portraits of Wilkins, Pauling, and most cogently, Rosalind Franklin. The Secret of Life is a lively and sweeping narrative of this landmark discovery, one that finally gives the woman at the center of this drama her due.

    In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future. http://us.macmillan.com/missingmicrob...

    It’s an exploration of making, but it’s also a permission slip of sorts from me to you. Permission to grab hold of the things you’re interested in, that fascinate you, and to dive deeper into them to see where they lead you. Through stories from forty-plus years of making and molding, building and break­ing, along with the lessons I learned along the way, this book is meant to be a toolbox of problem solving, complete with a shop’s worth of notes on the tools, techniques, and materials that I use most often. Things like: In Every Tool There Is a Hammer—don’t wait until everything is perfect to begin a project, and if you don’t have the exact right tool for a task, just use whatever’s handy; Increase Your Loose Tolerance—making is messy and filled with screwups, but that’s okay, as creativity is a path with twists and turns and not a straight line to be found; Use More Cooling Fluid—it prolongs the life of blades and bits, and it prevents tool failure, but beyond that it’s a reminder to slow down and reduce the fric­tion in your work and relationships; Screw Before You Glue—mechanical fasteners allow you to change and modify a project while glue is forever but sometimes you just need the right glue, so I dig into which ones will do the job with the least harm and best effects. This toolbox also includes lessons from many other incredible makers and creators, including: Jamie Hyneman, Nick Offerman, Pixar director Andrew Stanton, Oscar-winner Guillermo del Toro, artist Tom Sachs, and chef Traci Des Jardins. And if everything goes well, we will hopefully save you a few mistakes (and maybe fingers) as well as help you turn your curiosities into creations. I hope this book serves as “creative rocket fuel” (Ed Helms) to build, make, invent, explore, and—most of all—enjoy the thrills of being a creator.

    No wonder: it's the most omnipresent subnstance on Earth and, along with air, the primary ingredient for supporting life as we know it. From far, far outside, our planet looks like a blue marble; from deep inside, we ourselves are three-quarters H2O.We know instinctively that being near water makes us healthier and happier, reduces stress, and brings us peace. But why? And what might the answer tell us about how we should be living our lives?After centuries of asking these questions, we can finally answer them - and those answers are life changing. As Wallace J. Nichols reveals in Blue Mind, we are now at the forefront of a wave of neuroscience, evolutionary biology, and medical research that illuminates the phsysiological and brain processes that underlie our transformative connection to water. That research, involving tools like EEGs, MRIs, and fMRIs, is uncovering remarkable truths about water's incredibly powerful, and startlingly profound, effects on our bodies and souls. Drawing on this breakthrough science, and on compelling personal stories from top athletes, leading scientists, military veterans, and gifted artists, Nichols shows precisely how proximity to water can:-improve performance in a wide range of fields-increase calm and diminish anxiety much better than medication-amplify creativity - artistic and otherwise-increase generosity and compassion-increase professional success-improve our overall health and well-being-reinforce our connection to the natural world - and one anotherBlue Mind isn't just about oceans, lakes, and rivers. Water's tremendous benefits stretch from the sea to the swimming pool, from a barrier reef to a glass of water - even a fishbowl, photograph, or painting. So no matter where you live on this big blue marble, it's time to get your brain on water.

    Wendy Suzuki one day woke up and realized she didn’t have a life. As an almost-40-year-old award-winning college professor, world-renowned neuroscientist, she had—what many considered—everything: tenure as a professor at New York University; her own very successful neuroscience research lab; prizes for scientific discoveries on cognition and memory; articles published in prestigious scientific journals. As a woman and a scientist, she was the envy of her peers and lauded by her superiors. On paper, she had a stellar career and an impeccable record. What could she possibly be missing? Everything else. Suzuki was overweight. She was tired. She was lonely, had strained work relationships, and for the first time in her life, completely without direction. So she resolved to change her life. The first step--get moving. Everyone knows that exercise makes you feel better—that when you hit the gym despite the dread, you leave in a better mood. Healthy Brain, Happy Life offers the real science of how exercise effects your mind. Using Wendy’s journey from frumpy, fat and frustrated to fit and fabulous as a guide, Healthy Brain offers not just the HOWS of making exercise an important part of life, but the WHYS of the benefits it brings. But movement is just the first step to being Brain Healthy. Once you get your body and mind hooked on exercise, you bring in practices in mindfullness to calm stress and allow your minds to wander to unlock creativity. As your brain begins to change (something called neuroplasticity), the benefits build--you get fitter, improve your memory, increase your ability to work quickly and move from task to task easily. Along with Dr. Suzuki’s 4 minute Brain Hacks, Healthy Brain, Happy Life offers a simple program for changing your life, straight from a leading scientist’s personal experience.

    In The Demon in the Freezer, his first nonfiction book since The Hot Zone, a #1 New York Times bestseller, Richard Preston takes us into the heart of Usamriid, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the U.S. biological weapons program and now the epicenter of national biodefense.Peter Jahrling, the top scientist at Usamriid, a wry virologist who cut his teeth on Ebola, one of the world’s most lethal emerging viruses, has ORCON security clearance that gives him access to top secret information on bioweapons. His most urgent priority is to develop a drug that will take on smallpox-and win. Eradicated from the planet in 1979 in one of the great triumphs of modern science, the smallpox virus now resides, officially, in only two high-security freezers-at the Centers for Disease Control in Atlanta and in Siberia, at a Russian virology institute called Vector. But the demon in the freezer has been set loose. It is almost certain that illegal stocks are in the possession of hostile states, including Iraq and North Korea. Jahrling is haunted by the thought that biologists in secret labs are using genetic engineering to create a new superpox virus, a smallpox resistant to all vaccines.Usamriid went into a state of Delta Alert on September 11 and activated its emergency response teams when the first anthrax letters were opened in New York and Washington, D.C. Preston reports, in unprecedented detail, on the government’s response to the attacks and takes us into the ongoing FBI investigation. His story is based on interviews with top-level FBI agents and with Dr. Steven Hatfill.Jahrling is leading a team of scientists doing controversial experiments with live smallpox virus at CDC. Preston takes us into the lab where Jahrling is reawakening smallpox and explains, with cool and devastating precision, what may be at stake if his last bold experiment fails.

    But did you know your hair color may also affect how often you get sunburned? Or how often you need to take vitamin supplements?What's in Your Genes? goes beyond Gregor Mendel and dominant/recessive genes to show you all the ins and outs of what determines your DNA. Each entry provides you with a sneak peek into your DNA sequence and teaches you exactly how your body is able to create that wonderful you-ness that no one else has. From your tastebuds to your eye color to your obsession with clinical-strength deodorants, this book not only guides you through the history and study of genetics, but also shows you how those four little letters in your DNA make you who you are.Complete with imaginative illustrations, What's in Your Genes? reveals all there is to know about heredity--like the science behind vibrant red hair, perfect teeth, and your ability to see in color.

    The prolonged encounter between the Cro-Magnons and the archaic Neanderthals and between 45,000 and 30,000 years ago was one of the defining moments of history. The Neanderthals survived for some 15,000 years in the face of the newcomers, but were finally pushed aside by the Cro-Magnons' vastly superior intellectual abilities and cutting-edge technologies, which allowed them to thrive in the intensely challenging climate of the Ice Age.What do we know about this remarkable takeover? Who were the first modern Europeans and what were they like? How did they manage to thrive in such an extreme environment? And what legacy did they leave behind them after the cold millennia? The age of the Cro-Magnons lasted some 30,000 years?longer than all of recorded history. Cro-Magnon is the story of a little known, yet seminal, chapter of human experience.

    Since then, the ways we process written language have changed dramatically with many concerned about both their own changes and that of children. New research on the reading brain chronicles these changes in the brains of children and adults as they learn to read while immersed in a digitally dominated medium.Drawing deeply on this research, this book comprises a series of letters Wolf writes to us—her beloved readers—to describe her concerns and her hopes about what is happening to the reading brain as it unavoidably changes to adapt to digital mediums. Wolf raises difficult questions, including:Will children learn to incorporate the full range of "deep reading" processes that are at the core of the expert reading brain?Will the mix of a seemingly infinite set of distractions for children’s attention and their quick access to immediate, voluminous information alter their ability to think for themselves?With information at their fingertips, will the next generation learn to build their own storehouse of knowledge, which could impede the ability to make analogies and draw inferences from what they know?Will all these influences, in turn, change the formation in children and the use in adults of "slower" cognitive processes like critical thinking, personal reflection, imagination, and empathy that comprise deep reading and that influence both how we think and how we live our lives?Will the chain of digital influences ultimately influence the use of the critical analytical and empathic capacities necessary for a democratic society?How can we preserve deep reading processes in future iterations of the reading brain?Who are the "good readers" of every epoch?Concerns about attention span, critical reasoning, and over-reliance on technology are never just about children—Wolf herself has found that, though she is a reading expert, her ability to read deeply has been impacted as she has become, inevitably, increasingly dependent on screens.Wolf draws on neuroscience, literature, education, technology, and philosophy and blends historical, literary, and scientific facts with down-to-earth examples and warm anecdotes to illuminate complex ideas that culminate in a proposal for a biliterate reading brain. Provocative and intriguing, Reader, Come Home is a roadmap that provides a cautionary but hopeful perspective on the impact of technology on our brains and our most essential intellectual capacities—and what this could mean for our future.

    It's impossible to look up at the stars and NOT think about it: Are we alone in the universe? Books, movies and television shows proliferate that attempt to answer this question and explore it. In Out There Space.com senior writer Dr. Michael Wall treats that question as merely the beginning, touching off a wild ride of exploration into the final frontier. He considers, for instance, the myriad of questions that would arise once we do discover life beyond Earth (an eventuality which, top NASA officials told Wall, is only drawing closer). What would the first aliens we meet look like?Would they be little green men or mere microbes?Would they be found on a planet in our own solar system or orbiting a star far, far away?Would they intend to harm us, and if so, how might they do it?And might they already have visited?Out There is arranged in a simple question-and-answer format. The answers are delivered in Dr. Wall's informal but informative style, which mixes in a healthy dose of humor and pop culture to make big ideas easier to swallow. Dr. Wall covers questions far beyond alien life, venturing into astronomy, physics, and the practical realities of what long-term life might be like for we mere humans in outer space, such as the idea of lunar colonies, and even economic implications. Dr. Wall also shares the insights of some of the leading lights in space exploration today, and shows how the next space age might be brighter than ever.

    In Empires of Light, historian Jill Jonnes portrays this extraordinary trio and their riveting and ruthless world of cutting-edge science, invention, intrigue, money, death, and hard-eyed Wall Street millionaires. At the heart of the story are Thomas Alva Edison, the nation’s most famous and folksy inventor, creator of the incandescent light bulb and mastermind of the world’s first direct current electrical light networks; the Serbian wizard of invention Nikola Tesla, elegant, highly eccentric, a dreamer who revolutionized the generation and delivery of electricity; and the charismatic George Westinghouse, Pittsburgh inventor and tough corporate entrepreneur, an industrial idealist who in the era of gaslight imagined a world powered by cheap and plentiful electricity and worked heart and soul to create it. Edison struggled to introduce his radical new direct current (DC) technology into the hurly-burly of New York City as Tesla and Westinghouse challenged his dominance with their alternating current (AC), thus setting the stage for one of the eeriest feuds in American corporate history, the War of the Electric Currents. The battlegrounds: Wall Street, the 1893 Chicago World’s Fair, Niagara Falls, and, finally, the death chamber - Jonnes takes us on the tense walk down a prison hallway and into the sunlit room where William Kemmler, convicted ax murderer, became the first man to die in the electric chair. Empires of Light is the gripping history of electricity, the “mysterious fluid,” and how the fateful collision of Edison, Tesla, and Westinghouse left the world utterly transformed.

    When the great blizzard of 1888 crippled the entire northeast, a solution had to be found. Two brothers from one of the nation's great families-Henry Melville Whitney of Boston and William Collins Whitney of New York-pursued the dream of his city digging America's first subway, and the great race was on. The competition between Boston and New York played out in an era not unlike our own, one of economic upheaval, life-changing innovations, class warfare, bitter political tensions, and the question of America's place in the world.The Race Underground is peopled with the famous, like Boss Tweed, Grover Cleveland and Thomas Edison, and the not-so-famous, from brilliant engineers to the countless "sandhogs" who shoveled, hoisted and blasted their way into the earth's crust, sometimes losing their lives in the construction of the tunnels. Doug Most chronicles the science of the subway, looks at the centuries of fears people overcame about traveling underground and tells a story as exciting as any ever ripped from the pages of U.S. history. The Race Underground is a great American saga of two rival American cities, their rich, powerful and sometimes corrupt interests, and an invention that changed the lives of millions.

    And we know that another global disaster is eventually headed our way. Can we survive it? How?As a species, Homo sapiens is at a crossroads. Study of our planet’s turbulent past suggests that we are overdue for a catastrophic disaster, whether caused by nature or by human interference.It’s a frightening prospect, as each of the Earth’s past major disasters—from meteor strikes to bombardment by cosmic radiation—resulted in a mass extinction, where more than 75 percent of the planet’s species died out. But in Scatter, Adapt, and Remember, Annalee Newitz, science journalist and editor of the science Web site io9.com explains that although global disaster is all but inevitable, our chances of long-term species survival are better than ever. Life on Earth has come close to annihilation—humans have, more than once, narrowly avoided extinction just during the last million years—but every single time a few creatures survived, evolving to adapt to the harshest of conditions.      This brilliantly speculative work of popular science focuses on humanity’s long history of dodging the bullet, as well as on new threats that we may face in years to come. Most important, it explores how scientific breakthroughs today will help us avoid disasters tomorrow. From simulating tsunamis to studying central Turkey’s ancient underground cities; from cultivating cyanobacteria for “living cities” to designing space elevators to make space colonies cost-effective; from using math to stop pandemics to studying the remarkable survival strategies of gray whales, scientists and researchers the world over are discovering the keys to long-term resilience and learning how humans can choose life over death.     Newitz’s remarkable and fascinating journey through the science of mass extinctions is a powerful argument about human ingenuity and our ability to change. In a world populated by doomsday preppers and media commentators obsessively forecasting our demise, Scatter, Adapt, and Remember is a compelling voice of hope. It leads us away from apocalyptic thinking into a future where we live to build a better world—on this planet and perhaps on others. Readers of this book will be equipped scientifically, intellectually, and emotionally to face whatever the future holds.

    But they've often been hidden in plain sight, their inventions and contributions touching our lives in ways we don't even realize.Author Claire L. Evans finally gives these unsung female heroes their due with her social history of the Broad Band, the women who made the internet what it is today. Learn from Ada Lovelace, the daughter of Lord Byron, who wove numbers into the first program for a mechanical computer in 1842. Seek inspiration from Grace Hopper, the tenacious mathematician who democratized computing by leading the charge for machine-independent programming languages after World War II. Meet Elizabeth "Jake" Feinler, the one-woman Google who kept the earliest version of the Internet online, and Stacy Horn, who ran one of the first-ever social networks on a shoestring out of her New York City apartment in the 1980s. Evans shows us how these women built and colored the technologies we can't imagine life without.Join the ranks of the pioneers who defied social convention and the longest odds to become database poets, information-wranglers, hypertext dreamers, and glass ceiling-shattering dot com-era entrepreneurs.

    Photographs, illustrations, screen shots, and images of 3D models are included for each project.This unique resource emphasizes using off-the-shelf components, readily available materials, and accessible fabrication techniques. Simple projects give you hands-on practice applying the skills covered in each chapter, and more complex projects at the end of the book incorporate topics from multiple chapters. Turn your imaginative ideas into reality with help from this practical, inventive guide.Discover how to:Find and select materialsFasten and join partsMeasure force, friction, and torqueUnderstand mechanical and electrical power, work, and energyCreate and control motionWork with bearings, couplers, gears, screws, and springsCombine simple machines for work and funProjects include:Rube Goldberg breakfast machineMousetrap powered carDIY motor with magnet wireMotor direction and speed controlDesigning and fabricating spur gearsAnimated creations in paperAn interactive rotating platformSmall vertical axis wind turbineSADbot: the seasonally affected drawing robotMake Great Stuff!TAB, an imprint of McGraw-Hill Professional, is a leading publisher of DIY technology books for makers, hackers, and electronics hobbyists.