In 1875, tuberculosis was the deadliest disease in the world, accountable for a third of all deaths. A diagnosis of TB—often called consumption—was a death sentence. Then, in a triumph of medical science, a German doctor named Robert Koch deployed an unprecedented scientific rigor to discover the bacteria that caused TB. Koch soon embarked on a remedy—a remedy that would be his undoing.   When Koch announced his cure for consumption, Arthur Conan Doyle, then a small-town doctor in England and sometime writer, went to Berlin to cover the event. Touring the ward of reportedly cured patients, he was horrified. Koch’s "remedy" was either sloppy science or outright fraud.   But to a world desperate for relief, Koch’s remedy wasn’t so easily dismissed. As Europe’s consumptives descended upon Berlin, Koch urgently tried to prove his case. Conan Doyle, meanwhile, returned to England determined to abandon medicine in favor of writing. In particular, he turned to a character inspired by the very scientific methods that Koch had formulated: Sherlock Holmes.   Capturing the moment when mystery and magic began to yield to science, The Remedy chronicles the stunning story of how the germ theory of disease became a true fact, how two men of ambition were emboldened to reach for something more, and how scientific discoveries evolve into social truths.

    Many books on the plague rely on statistics to tell the story: how many people died; how farm output and trade declined. But statistics can’t convey what it was like to sit in Siena or Avignon and hear that a thousand people a day are dying two towns away. Or to have to chose between your own life and your duty to a mortally ill child or spouse. Or to live in a society where the bonds of blood and sentiment and law have lost all meaning, where anyone can murder or rape or plunder anyone else without fear of consequence.In The Great Mortality, author John Kelly lends an air of immediacy and intimacy to his telling of the journey of the plague as it traveled from the steppes of Russia, across Europe, and into England, killing 75 million people—one third of the known population—before it vanished.

    Heinlein was sixty-six, at the height of his literary career; J. Neil Schulman was twenty and hadn't yet started his first novel. Because he was looking for a way to meet his idol, Schulman wangled an assignment from the New York Daily News--at the time the largest circulation newspaper in the U.S.--to interview Heinlein for its Sunday Book Supplement. The resulting taped interview lasted three-and-a-half hours. This turned out to be the longest interview Heinlein ever granted, and the only one in which he talked freely and extensively about his personal philosophy and ideology. "The Robert Heinlein Interview" contains Heinlein you won't find anywhere else--even in Heinlein's own "Expanded Universe." If you wnat to know what Heinlein had to say about UFO's, life after death, epistemology, or libertarianism, this interview is the only source available. Also included in this collection are articles, reviews, and letters that J. Neil Schulman wrote about Heinlein, including the original article written for The Daily News, about which the Heinleins wrote Schulman that it was, "The best article--in style, content, and accuracy--of the many, many written about him over the years." This book is must-reading for any serious student of Heinlein, or any reader seeking to know him better.

    The world of golf is at a crossroads. As tech­nological innovations displace traditional philosophies, the golfing community has splintered into two deeply combative factions: the old-school teachers and players who believe in feel, artistry, and imagination, and the technical minded who want to remake the game around data. In Golf’s Holy War, Brett Cyrgalis takes readers inside the heated battle playing out from weekend hackers to PGA Tour pros. At the Titleist Performance Institute in Oceanside, California, golfers clad in full-body sensors target weaknesses in their biomechanics, while others take part in mental exercises designed to test their brain’s psychological resilience. Meanwhile, coaches like Michael Hebron purge golfers of all technical infor­mation, tapping into the power of intuitive physical learning by playing rudimentary games. From historic St. Andrews to manicured Augusta, experimental com­munes in California to corporatized conferences in Orlando, William James to Ben Hogan to theoretical physics, the factions of the spiritual and technical push to redefine the boundaries of the game. And yet what does it say that Tiger Woods has orchestrated one of the greatest comebacks in sports history without the aid of a formal coach? But Golf’s Holy War is more than just a book about golf—it’s a story about modern life and how we are torn between resisting and embracing the changes brought about by the advancements of science and technology. It’s also an exploration of historical legacies, the enriching bonds of education, and the many interpretations of reality.

    Leeuwenhoek proceeded to examine the microscopic activity of his spittle, teeth plaque, and feces, and as the result of his findings the field of bacteriology was born. Some two hundred years later, Wilhelm Conrad Roentgen, a professor of theoretical physics at the University of Wurzburg, invited his wife to his laboratory, asked her to place her hand on an unexposed photographic plate, turned on an electric current, and showed this terrified woman a picture of the bones of her hand. And so came the discovery of the X-ray.This absorbing book is the first to describe these and eight other monumental medical discoveries throughout history, bringing to life the scientific pioneers responsible for them and the excitement, frustrations, and jealousies that surrounded the final achievements. Two distinguished physicians, Meyer Friedman and Gerald W. Friedland, have drawn on their many years of experience as well as on that of world-renowned antiquarian book dealers, physician collectors of old and new medical publications, and medical school professors to single out these medical breakthroughs from thousands of candidates, and, in several cases, to provide information never before available. Their engrossing stories of the ten most significant discoveries will be read with enjoyment by anyone fascinated by the mysteries of medicine.

    Until now. A Game for Hooligans brings the game's colourful story up to date to include the 2007 World Cup. It covers all of the great matches, teams and players but also explores the social, political and economic changes that have affected the course of rugby's development. It is an international history, covering not only Britain and France but also the great rugby powers of the southern hemisphere and other successful rugby nations, including Argentina, Fiji and Japan. Contained within are the answers to many intriguing questions concerning the game, such as why 1895 is the most important date in both rugby-union and rugby-league history and how New Zealand became so good and have remained so good for so long. There is also a wealth of anecdotes, including allegations of devil-worship at a Welsh rugby club and an account of the game's contribution to the Cuban Revolution. This is a must-read for any fan of the oval ball.

    The Perfection Point is ideal for sports fans interested in the scientific basis of athletic excellence and a fascinating read for science fans interested in the physics of sports.

    We know her today primarily as a saintly character, perhaps as a heroic reformer of Britain’s health-care system. The reality is more involved and far more fascinating. In an utterly beguiling narrative that reads like the best Victorian fiction, acclaimed author Gillian Gill tells the story of this richly complex woman and her extraordinary family.Born to an adoring wealthy, cultivated father and a mother whose conventional facade concealed a surprisingly unfettered intelligence, Florence was connected by kinship or friendship to the cream of Victorian England’s intellectual aristocracy. Though moving in a world of ease and privilege, the Nightingales came from solidly middle-class stock with deep traditions of hard work, natural curiosity, and moral clarity. So it should have come as no surprise to William Edward and Fanny Nightingale when their younger daughter, Florence, showed an early passion for helping others combined with a precocious bent for power. Far more problematic was Florence’s inexplicable refusal to marry the well-connected Richard Monckton Milnes. As Gill so brilliantly shows, this matrimonial refusal was at once an act of religious dedication and a cry for her freedom–as a woman and as a leader. Florence’s later insistence on traveling to the Crimea at the height of war to tend to wounded soldiers was all but incendiary–especially for her older sister, Parthenope, whose frustration at being in the shade of her more charismatic sibling often led to illness. Florence succeeded beyond her wildest dreams. But at the height of her celebrity, at the age of thirty-seven, she retired to her bedroom and remained there for most of the rest of her life, allowing visitors only by appointment.Combining biography, politics, social history, and consummate storytelling, Nightingales is a dazzling portrait of an amazing woman, her difficult but loving family, and the high Victorian era they so perfectly epitomized. Beautifully written, witty, and irresistible, Nightingales is truly a tour de force.From the Hardcover edition.

    In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future

    “He has nerve and he has knowledge.”In the span of fifteen years, Dr. Thomas Neill Cream poisoned at least ten people in the United States, Britain, and Canada, a death toll with almost no precedents. Structured around Cream’s London murder trial in 1892, when he was finally brought to justice, The Case of the Murderous Dr. Cream exposes the blind trust given to medical practitioners, as well as the flawed detection methods, bungled investigations, corrupt officials, and stifling morality of Victorian society that allowed Cream to prey on vulnerable and desperate women, many of whom had turned to him for medical help.Dean Jobb vividly re-creates this largely forgotten historical account against the backdrop of the birth of modern policing and newly adopted forensic methods, though most police departments still scoffed at using science to solve crimes. But then most police departments could hardly imagine that serial killers existed—the term was unknown at the time. As the Chicago Tribune wrote then, Cream’s crimes marked the emergence of a new breed of killer, one who operated without motive or remorse, who “murdered simply for the sake of murder.”

    Each case includes an extended discussion, definition of terms, clinical pearls, and USMLE format review questions. This interactive learning system helps you understand essential concepts instead of memorizing facts.

    That book was the last surviving manuscript of an ancient Roman philosophical epic, On the Nature of Things, by Lucretius—a beautiful poem of the most dangerous ideas: that the universe functioned without the aid of gods, that religious fear was damaging to human life, and that matter was made up of very small particles in eternal motion, colliding and swerving in new directions.The copying and translation of this ancient book—the greatest discovery of the greatest book-hunter of his age—fueled the Renaissance, inspiring artists such as Botticelli and thinkers such as Giordano Bruno; shaped the thought of Galileo and Freud, Darwin and Einstein; and had a revolutionary influence on writers such as Montaigne and Shakespeare and even Thomas Jefferson.

    The Barbary Plague transports us to the Gold Rush boomtown in 1900, at the end of the city’s Gilded Age. With a deep understanding of the effects on public health of politics, race, and geography, Chase shows how one city triumphed over perhaps the most frightening and deadly of all scourges.

    Historically accurate, it is a story of murder and betrayal, of a failed rebellion, and the love of a national scandal.  Charles Trevelyan was Secretary of the Treasury, and Director of the Famine Relief Programme at a time when famine raged and antipathy in English politics towards the plight of those affected raged equally. Kathryn, Charles' daughter, likewise felt no sympathy until the very scale of the tragedy became apparent. Joining the underground, she preached insurrection, stole food for the starving, and became the lover of the leader of the rebellion. She became known as Dark Rosaleen, the heroine of banned nationalist poem, was branded as both traitor and cause celebré. This is her story.