The book drives to the heart of the exciting debate on the origins of life and maintenance of order in complex biological systems. It focuses on the concept of self-organization: the spontaneous emergence of order that is widely observed throughout nature Kauffman argues that self-organization plays an important role in the Darwinian process of natural selection. Yet until now no systematic effort has been made to incorporate the concept of self-organization into evolutionary theory. The construction requirements which permit complex systems to adapt are poorly understood, as is the extent to which selection itself can yield systems able to adapt more successfully. This book explores these themes. It shows how complex systems, contrary to expectations, can spontaneously exhibit stunning degrees of order, and how this order, in turn, is essential for understanding the emergence and development of life on Earth. Topics include the new biotechnology of applied molecular evolution, with its important implications for developing new drugs and vaccines; the balance between order and chaos observed in many naturally occurring systems; new insights concerning the predictive power of statistical mechanics in biology; and other major issues. Indeed, the approaches investigated here may prove to be the new center around which biological science itself will evolve. The work is written for all those interested in the cutting edge of research in the life sciences.

    After all, we ourselves are the product of evolution, and we can tackle many of our gravest challenges –– from lethal resurgence of antiobiotic–resistant diseases to the wave of extinctions that looms before us –– with a sound understanding of the science.

    For decades, these questions have lived exclusively in the realm of science fiction, but as Kevin Davies powerfully reveals in his new book, this is all about to change.Engrossing and page-turning, Editing Humanity takes readers inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code.Davies introduces readers to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.Though the birth of the “CRISPR babies” in China made international news, there is much more to the story of CRISPR than headlines seemingly ripped from science fiction. In Editing Humanity, Davies sheds light on the implications that this new technology can have on our everyday lives and in the lives of generations to come.

    Science Masters Series

    In this Very Short Introduction, renowned evolutionary scholar Bernard Wood traces the history of paleoanthropology from its beginnings inthe eighteenth century to today's latest fossil finds. Along the way we are introduced to the lively cast of characters, past and present, involved in evolutionary research. Although concentrating on the fossil evidence for human evolution, the book also covers the latest genetic evidence aboutregional variations in the modern human genome that relate to our evolutionary history. Wood draws on over thirty years of experience to provide an insiders view of the field, and demonstrates that our understanding of human evolution is critically dependent on advances in related sciences such aspaleoclimatology, geochronology, systematics, genetics, and developmental biology. This is an ideal introduction for anyone interested in the origins and development of humankind.

    Politicians and marketers present shoddy evidence for dubious claims all the time. But smart people make mistakes too, and when it comes to statistics, plenty of otherwise great scientists--yes, even those published in peer-reviewed journals--are doing statistics wrong."Statistics Done Wrong" comes to the rescue with cautionary tales of all-too-common statistical fallacies. It'll help you see where and why researchers often go wrong and teach you the best practices for avoiding their mistakes.In this book, you'll learn: - Why "statistically significant" doesn't necessarily imply practical significance- Ideas behind hypothesis testing and regression analysis, and common misinterpretations of those ideas- How and how not to ask questions, design experiments, and work with data- Why many studies have too little data to detect what they're looking for-and, surprisingly, why this means published results are often overestimates- Why false positives are much more common than "significant at the 5% level" would suggestBy walking through colorful examples of statistics gone awry, the book offers approachable lessons on proper methodology, and each chapter ends with pro tips for practicing scientists and statisticians. No matter what your level of experience, "Statistics Done Wrong" will teach you how to be a better analyst, data scientist, or researcher.

    Buried there lie answers about the origins of humankind. After a century of investigation, scientists have transformed our understanding about the beginnings of human life. But vital clues still remain hidden. In Born in Africa, Martin Meredith follows the trail of discoveries about human origins made by scientists over the last hundred years, recounting their intense rivalry, personal feuds, and fierce controversies as well as their feats of skill and endurance.The results have been momentous. Scientists have identified more than twenty species of extinct humans. They have firmly established Africa as the birthplace not only of humankind but also of modern humans. They have revealed how early technology, language ability, and artistic endeavour all originated in Africa; and they have shown how small groups of Africans spread out from Africa in an exodus sixty thousand years ago to populate the rest of the world. We have all inherited an African past.

    This Penguin Classics edition is edited with an introduction by James Moore and Adrian Desmond.In The Origin of Species, Charles Darwin refused to discuss human evolution, believing the subject too 'surrounded with prejudices'. He had been reworking his notes since the 1830s, but only with trepidation did he finally publish The Descent of Man in 1871. The book notoriously put apes in our family tree and made the races one family, diversified by 'sexual selection' - Darwin's provocative theory that female choice among competing males leads to diverging racial characteristics. Named by Sigmund Freud as 'one of the ten most significant books' ever written, Darwin's Descent of Man continues to shape the way we think about what it is that makes us uniquely human.In their introduction, James Moore and Adrian Desmond, acclaimed biographers of Charles Darwin, call for a radical re-assessment of the book, arguing that its core ideas on race were fired by Darwin's hatred of slavery. The text is the second and definitive edition and this volume also contains suggestions for further reading, a chronology and biographical sketches of prominent individuals mentioned.Charles Darwin (1809-82), a Victorian scientist and naturalist, has become one of the most famous figures of science to date. The advent of On the Origin of Species by Means of Natural Selection in 1859 challenged and contradicted all contemporary biological and religious beliefs.If you enjoyed The Descent of Man, you might like Darwin's On the Origin of Species, also available in Penguin Classics.

    The term “complexity” can be misleading, however, because what makes West’s discoveries so beautiful is that he has found an underlying simplicity that unites the seemingly complex and diverse phenomena of living systems, including our bodies, our cities and our businesses. Fascinated by issues of aging and mortality, West applied the rigor of a physicist to the biological question of why we live as long as we do and no longer. The result was astonishing, and changed science, creating a new understanding of energy use and metabolism: West found that despite the riotous diversity in the sizes of mammals, they are all, to a large degree, scaled versions of each other. If you know the size of a mammal, you can use scaling laws to learn everything from how much food it eats per day, what its heart-rate is, how long it will take to mature, its lifespan, and so on. Furthermore, the efficiency of the mammal’s circulatory systems scales up precisely based on weight: if you compare a mouse, a human and an elephant on a logarithmic graph, you find with every doubling of average weight, a species gets 25% more efficient—and lives 25% longer. This speaks to everything from how long we can expect to live to how many hours of sleep we need. Fundamentally, he has proven, the issue has to do with the fractal geometry of the networks that supply energy and remove waste from the organism's body. West's work has been game-changing for biologists, but then he made the even bolder move of exploring his work's applicability to cities. Cities, too, are constellations of networks and laws of scalability relate with eerie precision to them. For every doubling in a city's size, the city needs 15% less road, electrical wire, and gas stations to support the same population. More amazingly, for every doubling in size, cities produce 15% more patents and more wealth, as well as 15% more crime and disease. This broad pattern lays the groundwork for a new science of cities. Recently, West has applied his revolutionary work on cities and biological life to the business world. This investigation has led to powerful insights into why some companies thrive while others fail. The implications of these discoveries are far-reaching, and are just beginning to be explored. Scale is a thrilling scientific adventure story about the elemental natural laws that bind us together in simple but profound ways. Through the brilliant mind of Geoffrey West, we can envision how cities, companies and biological life alike are dancing to the same simple, powerful tune, however diverse and unrelated they are to each other.From the Hardcover edition.

    Republished in book form shortly thereafter, it has since gone through four hardcover and sixteen paperback printings. It is a revolutionary work, astounding in its foresight and contemporaneity. The University of Illinois Press is pleased and honored to issue this commemorative reprinting of a classic.

    The result is a wealth of stimulating ideas set among clear explanations drawn from a revelatory decade in biology."—Andrew H. Knoll, author of Life on a Young Planet"Thought-provoking and lucidly written. . . . The Plausibility of Life will help readers understand not just the plausibility of evolution, but its remarkable, inventive powers." —Sean Carroll, author of Endless Forms Most Beautiful: The New Science of Evo Devo“Remarkably lucid and comprehensive, this new theoretical synthesis will . . . shift the grounds for debate in the controversy surrounding organic evolution.”—Booklist (starred review)

    Based on her work at the Santa Fe Institute and drawing on its interdisciplinary strategies, Mitchell brings clarity to the workings of complexity across a broad range of biological, technological, and social phenomena, seeking out the general principles or laws that apply to all of them. Richly illustrated, Complexity: A Guided Tour--winner of the 2010 Phi Beta Kappa Book Award in Science--offers a wide-ranging overview of the ideas underlying complex systems science, the current research at the forefront of this field, and the prospects for its contribution to solving some of the most important scientific questions of our time.

    Maybe it's made of silicon! Maybe it has wheels! Or maybe it doesn't. In The Equations of Life, biologist Charles S. Cockell makes the forceful argument that the laws of physics narrowly constrain how life can evolve, making evolution's outcomes predictable. If we were to find on a distant planet something very much like a lady bug eating something like an aphid, we shouldn't be surprised. The forms of life are guided by a limited set of rules, and as a result, there is a narrow set of solutions to the challenges of existence.A remarkable scientific contribution breathing new life into Darwin's theory of evolution, The Equations of Life makes a radical argument about what life can -- and can't -- be.

    Polya, How to Solve It will show anyone in any field how to think straight. In lucid and appealing prose, Polya reveals how the mathematical method of demonstrating a proof or finding an unknown can be of help in attacking any problem that can be reasoned out--from building a bridge to winning a game of anagrams. Generations of readers have relished Polya's deft--indeed, brilliant--instructions on stripping away irrelevancies and going straight to the heart of the problem.

    Inside PFTB (Proofs from The Book) is indeed a glimpse of mathematical heaven, where clever insights and beautiful ideas combine in astonishing and glorious ways. There is vast wealth within its pages, one gem after another. Some of the proofs are classics, but many are new and brilliant proofs of classical results. ...Aigner and Ziegler... write: ..". all we offer is the examples that we have selected, hoping that our readers will share our enthusiasm about brilliant ideas, clever insights and wonderful observations." I do. ... " Notices of the AMS, August 1999..". the style is clear and entertaining, the level is close to elementary ... and the proofs are brilliant. ..." LMS Newsletter, January 1999This third edition offers two new chapters, on partition identities, and on card shuffling. Three proofs of Euler's most famous infinite series appear in a separate chapter. There is also a number of other improvements, such as an exciting new way to "enumerate the rationals."