What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.

    Leslie Jamison deftly excavates the stories we tell about addiction--both her own and others'--and examines what we want these stories to do, and what happens when they fail us.All the while, she offers a fascinating look at the larger history of the recovery movement, and at the literary and artistic geniuses whose lives and works were shaped by alcoholism and substance dependence, including John Berryman, Jean Rhys, Raymond Carver, Billie Holiday, David Foster Wallace, and Denis Johnson, as well as brilliant figures lost to obscurity but newly illuminated here.For the power of her striking language and the sharpness of her piercing observations, Jamison has been compared to such iconic writers as Joan Didion and Susan Sontag. Yet her utterly singular voice also offers something new. With enormous empathy and wisdom, Jamison has given us nothing less than the story of addiction and recovery in America writ large, a definitive and revelatory account that will resonate for years to come.

    Yet somehow, this normal boy became one of the youngest people on whom Dr. Walter Freeman performed his barbaric transorbital—or ice pick—lobotomy.Abandoned by his family within a year of the surgery, Howard spent his teen years in mental institutions, his twenties in jail, and his thirties in a bottle. It wasn’t until he was in his forties that Howard began to pull his life together. But even as he began to live the “normal” life he had been denied, Howard struggled with one question: Why?“October 8, 1960. I gather that Mrs. Dully is perpetually talking, admonishing, correcting, and getting worked up into a spasm, whereas her husband is impatient, explosive, rather brutal, won’t let the boy speak for himself, and calls him numbskull, dimwit, and other uncomplimentary names.”There were only three people who would know the truth: Freeman, the man who performed the procedure; Lou, his cold and demanding stepmother who brought Howard to the doctor’s attention; and his father, Rodney. Of the three, only Rodney, the man who hadn’t intervened on his son’s behalf, was still living. Time was running out. Stable and happy for the first time in decades, Howard began to search for answers. “December 3, 1960. Mr. and Mrs. Dully have apparently decided to have Howard operated on. I suggested [they] not tell Howard anything about it.”Through his research, Howard met other lobotomy patients and their families, talked with one of Freeman’s sons about his father’s controversial life’s work, and confronted Rodney about his complicity. And, in the archive where the doctor’s files are stored, he finally came face to face with the truth.Revealing what happened to a child no one—not his father, not the medical community, not the state—was willing to protect, My Lobotomy exposes a shameful chapter in the history of the treatment of mental illness. Yet, ultimately, this is a powerful and moving chronicle of the life of one man. Without reticence, Howard Dully shares the story of a painfully dysfunctional childhood, a misspent youth, his struggle to claim the life that was taken from him, and his redemption.

    A passionate and urgently needed call to arms, Fight Like A Girl insists on our right to be angry, to be heard and to fight. It'll change lives.' Emily Maguire, author of An Isolated IncidentA friend recently told me that the things I write are powerful for her because they have the effect of making her feel angry instead of just empty. I want to do this for all women and young girls - to take the emptiness and numbness they feel about being a girl in this world and turn it into rage and power. I want to teach all of them how to FIGHT LIKE A GIRL. Clementine FordOnline sensation, fearless feminist heroine and scourge of trolls and misogynists everywhere, Clementine Ford is a beacon of hope and inspiration to thousands of Australian women and girls. Her incendiary debut Fight Like A Girl is an essential manifesto for feminists new, old and soon-to-be, and exposes just how unequal the world continues to be for women. Crucially, it is a call to arms for all women to rediscover the fury that has been suppressed by a society that still considers feminism a threat.Fight Like A Girl will make you laugh, cry and scream. But above all it will make you demand and fight for a world in which women have real equality and not merely the illusion of it.

    She moved from New York to San Francisco, where she landed at a big-data startup in the heart of the Silicon Valley bubble: a world of surreal extravagance, dubious success, and fresh-faced entrepreneurs hell-bent on domination, glory, and, of course, progress.Anna arrived amidst a massive cultural shift, as the tech industry rapidly transformed into a locus of wealth and power rivaling Wall Street. But amid the company ski vacations and in-office speakeasies, boyish camaraderie and ride-or-die corporate fealty, a new Silicon Valley began to emerge: one in far over its head, one that enriched itself at the expense of the idyllic future it claimed to be building.Part coming-age-story, part portrait of an already-bygone era, Anna Wiener’s memoir is a rare first-person glimpse into high-flying, reckless startup culture at a time of unchecked ambition, unregulated surveillance, wild fortune, and accelerating political power. With wit, candor, and heart, Anna deftly charts the tech industry’s shift from self-appointed world savior to democracy-endangering liability, alongside a personal narrative of aspiration, ambivalence, and disillusionment.Unsparing and incisive, Uncanny Valley is a cautionary tale, and a revelatory interrogation of a world reckoning with consequences its unwitting designers are only beginning to understand.

    Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at $9 billion, putting Holmes's worth at an estimated $4.7 billion. There was just one problem: The technology didn't work.For years, Holmes had been misleading investors, FDA officials, and her own employees. When Carreyrou, working at The Wall Street Journal, got a tip from a former Theranos employee and started asking questions, both Carreyrou and the Journal were threatened with lawsuits. Undaunted, the newspaper ran the first of dozens of Theranos articles in late 2015. By early 2017, the company's value was zero and Holmes faced potential legal action from the government and her investors. Here is the riveting story of the biggest corporate fraud since Enron, a disturbing cautionary tale set amid the bold promises and gold-rush frenzy of Silicon Valley.

    By the time the sea retreated, more than 18,500 people had been crushed, burned to death, or drowned.It was Japan’s greatest single loss of life since the atomic bombing of Nagasaki. It set off a national crisis, and the meltdown of a nuclear power plant. And even after the immediate emergency had abated, the trauma of the disaster continued to express itself in bizarre and mysterious ways.Richard Lloyd Parry, an award-winning foreign correspondent, lived through the earthquake in Tokyo, and spent six years reporting from the disaster zone. There he encountered stories of ghosts and hauntings. He met a priest who performed exorcisms on people possessed by the spirits of the dead. And he found himself drawn back again and again to a village which had suffered the greatest loss of all, a community tormented by unbearable mysteries of its own.What really happened to the local children as they waited in the school playground in the moments before the tsunami? Why did their teachers not evacuate them to safety? And why was the unbearable truth being so stubbornly covered up?Ghosts of the Tsunami is a classic of literary non-fiction, a heart-breaking and intimate account of an epic tragedy, told through the personal accounts of those who lived through it. It tells the story of how a nation faced a catastrophe, and the bleak struggle to find consolation in the ruins.

    His full accounting does honor to the medical professionals around the country who've risked their lives to fight the virus, revealing America in all its vulnerability, courage, and potential.

    Few people can imagine living in a world where such situations are part of everyday life. Yet for London Ambulance Paramedic Lysa Walder, these and thousands of other emergency calls are part of a day's work—scenes of tragedy, loss, and horror—but also stories of triumph and humor, and all the results of an urgent 999 call to the biggest and busiest free ambulance service in the world. Here, she tells the inside story behind the screaming sirens and flashing blue lights of the emergency services and reveals what it's really like to work in a job that frequently brings paramedic teams face-to-face with death—and destiny.

    The book soared to the top of bestseller lists internationally, igniting global conversations about women and ambition. Sandberg packed theatres, dominated opinion pages, appeared on every major television show and on the cover of Time magazine, and sparked ferocious debate about women and leadership. Ask most women whether they have the right to equality at work and the answer will be a resounding yes, but ask the same women whether they'd feel confident asking for a raise, a promotion, or equal pay, and some reticence creeps in. The statistics, although an improvement on previous decades, are certainly not in women's favour – of 197 heads of state, only twenty-two are women. Women hold just 20 percent of seats in parliaments globally, and in the world of big business, a meagre eighteen of the Fortune 500 CEOs are women. In Lean In, Sheryl Sandberg – Facebook COO and one of Fortune magazine's Most Powerful Women in Business – draws on her own experience of working in some of the world's most successful businesses and looks at what women can do to help themselves, and make the small changes in their life that can effect change on a more universal scale.

    In addition to offering a clear-eyed explanation of the root causes of this insidious and entrenched bias and laying out its effects, she suggests concrete steps we can take to cure it.

    Anthony Fauci is a hero. He is anything but. As director of the National Institute of Allergy and Infectious Diseases (NIAID), Dr. Anthony Fauci dispenses $6.1 billion in annual taxpayer-provided funding for scientific research, allowing him to dictate the subject, content, and outcome of scientific health research across the globe. Fauci uses the financial clout at his disposal to wield extraordinary influence over hospitals, universities, journals, and thousands of influential doctors and scientists—whose careers and institutions he has the power to ruin, advance, or reward. During more than a year of painstaking and meticulous research, Robert F. Kennedy Jr. unearthed a shocking story that obliterates media spin on Dr. Fauci . . . and that will alarm every American—Democrat or Republican—who cares about democracy, our Constitution, and the future of our children’s health. The Real Anthony Fauci reveals how “America’s Doctor” launched his career during the early AIDS crisis by partnering with pharmaceutical companies to sabotage safe and effective off-patent therapeutic treatments for AIDS. Fauci orchestrated fraudulent studies, and then pressured US Food and Drug Administration (FDA) regulators into approving a deadly chemotherapy treatment he had good reason to know was worthless against AIDS. Fauci repeatedly violated federal laws to allow his Pharma partners to use impoverished and dark-skinned children as lab rats in deadly experiments with toxic AIDS and cancer chemotherapies. In early 2000, Fauci shook hands with Bill Gates in the library of Gates’ $147 million Seattle mansion, cementing a partnership that would aim to control an increasingly profitable $60 billion global vaccine enterprise with unlimited growth potential. Through funding leverage and carefully cultivated personal relationships with heads of state and leading media and social media institutions, the Pharma-Fauci-Gates alliance exercises dominion over global health policy. The Real Anthony Fauci details how Fauci, Gates, and their cohorts use their control of media outlets, scientific journals, key government and quasi-governmental agencies, global intelligence agencies, and influential scientists and physicians to flood the public with fearful propaganda about COVID-19 virulence and pathogenesis, and to muzzle debate and ruthlessly censor dissent.

    But it’s hardly surprising considering how long it’s had to hone its skills. Forty-thousand years ago, our ancestors set off from the cradle of civilization on their journey towards populating the planet. Tuberculosis hitched a lift and came with us, and it’s been there ever since; waiting, watching, and learning. The organism responsible, Mycobacterium tuberculosis, has had plenty of time to adapt to its chosen habitat--human lungs--and has learned through natural selection to be an almost perfect pathogen. Using our own immune cells as a Trojan Horse to aid its spread, it’s come up with clever ways to avoid being killed by antibiotics. But patience has been its biggest lesson--it can enter into a latent state when times are tough, only to come back to life when a host’s immune system is compromised. Today, more than one million people die of the disease every year and around one-third of the world’s population are believed to be infected. That’s more than two billion people. Throw in the compounding problems of drug resistance, the HIV epidemic, and poverty, and it’s clear that tuberculosis remains one of the most serious problems in world medicine. Catching Breath follows the history of TB through the ages, from its time as an infection of hunter-gatherers to the first human villages, which set it up with everything it needed to become the monstrous disease it is today, through to the perils of industrialization and urbanization. It goes on to look at the latest research in fighting the disease, with stories of modern scientific research, interviews with doctors on the TB frontline, and the personal experiences of those affected by the disease.

    Jen Gunter now delivers the definitive book on vaginal health, answering the questions you've always had but were afraid to ask--or couldn't find the right answers to. She has been called Twitter's resident gynecologist, the Internet's OB/GYN, and one of the fiercest advocates for women's health...and she's here to give you the straight talk on the topics she knows best.Does eating sugar cause yeast infections? Does pubic hair have a function? Should you have a vulvovaginal care regimen?Will your vagina shrivel up if you go without sex?What's the truth about the HPV vaccine?So many important questions, so much convincing, confusing, contradictory misinformation! In this age of click bait, pseudoscience, and celebrity-endorsed products, it's easy to be overwhelmed--whether it's websites, advice from well-meaning friends, uneducated partners, and even healthcare providers. So how do you separate facts from fiction? OB-GYN Jen Gunter, an expert on women's health--and the internet's most popular go-to doc--comes to the rescue with a book that debunks the myths and educates and empowers women. From reproductive health to the impact of antibiotics and probiotics, and the latest trends, including vaginal steaming, vaginal marijuana products, and jade eggs, Gunter takes us on a factual, fun-filled journey. Discover the truth about:- The vaginal microbiome - Genital hygiene, lubricants, and hormone myths and fallacies - How diet impacts vaginal health - Stem cells and the vagina - Cosmetic vaginal surgery - What changes to expect during pregnancy, after childbirth, and through menopause - How medicine fails women by dismissing symptomsPlus: - Thongs vs. lace: the best underwear for vaginal health - How to select a tampon - The full glory of the clitoris and the myth of the G Spot... And so much more. Whether you're a twenty-six-year-old worried that her labia are "uncool" or a sixty-six-year-old dealing with painful sex, this comprehensive guide is sure to become a lifelong trusted resource.

    Lieberman illuminates how these ongoing changes have brought many benefits, but also have created novel conditions to which our bodies are not entirely adapted, resulting in a growing incidence of obesity and new but avoidable diseases, including type-2 diabetes. He proposes that many of these chronic illnesses persist and in some cases are intensifying because of "dysevolution," a pernicious dynamic whereby only the symptoms rather than the causes of these maladies are treated. And finally—provocatively—he advocates the use of evolutionary information to help nudge, push, and sometimes oblige us to create a more salubrious environment.(With charts and line drawings throughout.)From the Hardcover edition.