Elizabeth A. Fenn is the first historian to reveal how deeply variola affected the outcome of the war in every colony and the lives of everyone in North America.By 1776, when military action and political ferment increased the movement of people and microbes, the epidemic worsened. Fenn's remarkable research shows us how smallpox devastated the American troops at Québec and kept them at bay during the British occupation of Boston. Soon the disease affected the war in Virginia, where it ravaged slaves who had escaped to join the British forces. During the terrible winter at Valley Forge, General Washington had to decide if and when to attempt the risky inoculation of his troops. In 1779, while Creeks and Cherokees were dying in Georgia, smallpox broke out in Mexico City, whence it followed travelers going north, striking Santa Fe and outlying pueblos in January 1781. Simultaneously it moved up the Pacific coast and east across the plains as far as Hudson's Bay.The destructive, desolating power of smallpox made for a cascade of public-health crises and heartbreaking human drama. Fenn's innovative work shows how this mega-tragedy was met and what its consequences were for America.

    The discovery initiated Gessen into a club of sorts: the small (but exponentially expanding) group of people in possession of a new and different way of knowing themselves through what is inscribed in the strands of their DNA. As she wrestled with a wrenching personal decision—what to do with such knowledge—Gessen explored the landscape of this brave new world, speaking with others like her and with experts including medical researchers, historians, and religious thinkers. Blood Matters is a much-needed field guide to this unfamiliar and unsettling territory. It explores the way genetic information is shaping the decisions we make, not only about our physical and emotional health but about whom we marry, the children we bear, even the personality traits we long to have. And it helps us come to terms with the radical transformation that genetic information is engineering in our most basic sense of who we are and what we might become.

    Noted historian Steven E. Woodworth tells the story of what many regard as the defining event in United States history. While covering all theaters of war, he emphasizes the importance of action in the region between the Appalachians and the Mississippi River in determining its outcome. Woodworth argues that the Civil War had a distinct purpose that was understood by most of its participants: it was primarily a conflict over the issue of slavery. The soldiers who filled the ranks of the armies on both sides knew what they were fighting for. The outcome of the war after its beginnings at Fort Sumter to the Confederate surrender four years later was the result of the actions and decisions made by those soldiers and millions of other Americans. Written in clear and compelling fashion, This Great Struggle is their story and ours."

    Striking humanity in waves, the cycle of plagues set the tempo of civilizational growth and decline, since common response to the threat was exclusion—quarantining the sick or keeping them out. But the unprecedented hygiene and medical revolutions of the past two centuries have allowed humanity to free itself from the hold of epidemic cycles—resulting in an urbanized, globalized, and unimaginably wealthy world. However, our development has lately become precarious. Climate and population fluctuations and aspects of our prosperity such as global trade have left us more vulnerable than ever to newly emerging plagues. Greater global cooperation toward sustainable health is urgently required—such as the international efforts to harvest a Covid-19 vaccine—with millions of lives and trillions of dollars at stake. Written as colorful history, The Plague Cycle reveals the relationship between civilization, globalization, prosperity, and infectious disease over the past five millennia. It harnesses history, economics, and public health, and charts humanity’s remarkable progress, providing a fascinating and timely look at the cyclical nature of infectious disease.

    With a muckraker's passion, Whitaker argues that modern treatments for the severely mentally ill are just old medicine in new bottles, and that we as a society are deeply deluded about their efficacy. Tracing over three centuries of "cures" for madness, Whitaker shows how medical therapies have been used to silence patients and dull their minds. He tells of the eighteenth- and nineteenth-century practices of "spinning" the insane, extracting their teeth, ovaries, and intestines, and submerging patients in freezing water. The "cures" in the 1920s and 1930s were no less barbaric as eugenic attitudes toward the mentally ill led to brain-damaging lobotomies and electroshock therapy. Perhaps Whitaker's most damning revelation, however, is his report of how drug companies in the 1980s and 1990s skewed their studies in an effort to prove the effectiveness of their products. Based on exhaustive research culled from old patient medical records, historical accounts, numerous interviews, and hundreds of government documents, Mad in America raises important questions about our obligations to the mad, what it means to be "insane," and what we value most about the human mind.

    The rest is breathtaking, record-breaking box-office history. Now comes an all-new Indiana Jones feature film: Indiana Jones and the Kingdom of the Crystal Skull. Here’s your chance to go on location for an up-close, all-access tour of the year’s most eagerly anticipated blockbuster, as well as the classics. The Complete Making of Indiana Jones is a crash course in movie magic-making–showcasing the masters of the craft and served up by veteran entertainment chroniclers J. W. Rinzler and Laurent Bouzereau. Inside you’ll find:• exclusive on-set interviews with the entire cast and crew of Indiana Jones and the Kingdom of the Crystal Skull, including Harrison Ford, Shia LaBeouf, Cate Blanchett, Ray Winstone, and John Hurt–plus director Steven Spielberg, executive producer George Lucas, screenwriter David Koepp, and the incredible production team that built some of the most fantastic sets ever.• hundreds of full-color images–from storyboards, concept paintings, and set design schematics to still photos from all four films with candid action shots of the productions in progress• an in-depth chronicle of the making of the first three Indiana Jones movies–Raiders of the Lost Ark, Indiana Jones and the Temple of Doom, and Indiana Jones and the Last Crusade–including transcripts of the original concept meetings, cast and crew anecdotes, production photos, and information on scenes that were cut from the final films• never-before-seen artwork and archival gems from the Lucasfilm Archives• and much more!Don’t miss the thrilling new movie or this definitive making-of opus. It’s as essential to fans as that trusty bullwhip is to Indy!

    The book has the hallmark features for which Lippincott's Illustrated Reviews volumes are so popular: an outline format, over 600 full-color illustrations, end-of-chapter summaries, review questions, plus an entire section of clinical case studies with full-color illustrations. This edition's medical/clinical focus has been sharpened to provide a high-yield review. Five additional case studies have been included, bringing the total to nineteen. Review questions have been reformatted to comply with USMLE Step 1 style, with clinical vignettes.

    From then until 751 AD, Ravenna was first the capital of the Western Roman Empire, then that of the immense kingdom of Theoderic the Goth and finally the centre of Byzantine power in Italy.In this engrossing account Judith Herrin explains how scholars, lawyers, doctors, craftsmen, cosmologists and religious luminaries were drawn to Ravenna where they created a cultural and political capital that dominated northern Italy and the Adriatic. As she traces the lives of Ravenna's rulers, chroniclers and inhabitants, Herrin shows how the city became the meeting place of Greek, Latin, Christian and barbarian cultures and the pivot between East and West. The book offers a fresh account of the waning of Rome, the Gothic and Lombard invasions, the rise of Islam and the devastating divisions within Christianity. It argues that the fifth to eighth centuries should not be perceived as a time of decline from antiquity but rather, thanks to Byzantium, as one of great creativity - the period of 'Early Christendom'. These were the formative centuries of Europe.While Ravenna's palaces have crumbled, its churches have survived. In them, Catholic Romans and Arian Goths competed to produce an unrivalled concentration of spectacular mosaics, many of which still astonish visitors today. Beautifully illustrated with specially commissioned photographs, and drawing on the latest archaeological and documentary discoveries, Ravenna: Capital of Empire, Crucible of Europe brings the early Middle Ages to life through the history of this dazzling city.

    David Abulafia's The Great Sea is the first complete history of the Mediterranean, from the erection of temples on Malta around 3500 BC to modern tourism. Ranging across time and the whole extraordinary space of the Mediterranean from Gibraltar to Jaffa, Genoa to Tunis, and bringing to life pilgrims, pirates, sultans and naval commanders, this is the story of the sea that has shaped much of world history.

    But it is also by turns an intimate story of less eminent individuals, whose adventures, struggles and ambitions were reflected in the fortified residences they constructed. Be it ever so grand or ever so humble, a castle was first and foremost a home.To understand castles—who built them, who lived in them, and why—is to understand the forces that shaped medieval Britain.

    If America could send a man to the moon, shouldn’t the best surgeons in the world be able to build an artificial heart? In Ticker, Texas Monthly executive editor and two time National Magazine Award winner Mimi Swartz shows just how complex and difficult it can be to replicate one of nature’s greatest creations. Part investigative journalism, part medical mystery, Ticker is a dazzling story of modern innovation, recounting fifty years of false starts, abysmal failures and miraculous triumphs, as experienced by one the world’s foremost heart surgeons, O.H. “Bud” Frazier, who has given his life to saving the un-savable. His journey takes him from a small town in west Texas to one of the country’s most prestigious medical institutions, The Texas Heart Institute, from the halls of Congress to the animal laboratories where calves are fitted with new heart designs. The roadblocks to success —medical setbacks, technological shortcomings, government regulations – are immense. Still, Bud and his associates persist, finding inspiration in the unlikeliest of places. A field beside the Nile irrigated by an Archimedes screw. A hardware store in Brisbane, Australia. A seedy bar on the wrong side of Houston. Until post WWII, heart surgery did not exist. Ticker provides a riveting history of the pioneers who gave their all to the courageous process of cutting into the only organ humans cannot live without. Heart surgeons Michael DeBakey and Denton Cooley, whose feud dominated the dramatic beginnings of heart surgery. Christian Barnaard, who changed the world overnight by performing the first heart transplant. Inventor Robert Jarvik, whose artificial heart made patient Barney Clark a worldwide symbol of both the brilliant promise of technology and the devastating evils of experimentation run amuck. Rich in supporting players, Ticker introduces us to Bud’s brilliant colleagues in his quixotic quest to develop an artificial heart: Billy Cohn, the heart surgeon and inventor who devotes his spare time to the pursuit of magic and music; Daniel Timms, the Brisbane biomedical engineer whose design of a lightweight, pulseless heart with but a single moving part offers a new way forward. And, as government money dries up, the unlikeliest of backers, Houston’s furniture king, Mattress Mack. In a sweeping narrative of one man’s obsession, Swartz raises some of the hardest questions of the human condition. What are the tradeoffs of medical progress? What is the cost, in suffering and resources, of offering patients a few more months, or years of life? Must science do harm to do good? Ticker takes us on an unforgettable journey into the power and mystery of the human heart.

    The only medieval chronicle to have Orkney as the central place of action, it tells of an era when the islands were still part of the Viking world, beginning with their conquest by the kings of Norway in the ninth century. The saga describes the subsequent history of the Earldom of Orkney and the adventures of great Norsemen such as Sigurd the Powerful, St Magnus the Martyr and Hrolf, the conqueror of Normandy. Savagely powerful and poetic, this is a fascinating depiction of an age of brutal battles, murder, sorcery and bitter family feuds.

    Opium: A History traces the drug's astounding impact on world culture-from its religious use by prehistoric peoples to its influence on the imaginations of the Romantic writers; from the earliest medical science to the Sino-British opium wars. And, in the present day, as the addict population rises and penetrates every walk of life, Opium shows how the international multibillion-dollar heroin industry operates with terrifying efficiency and forms an integral part of the world's money markets.In this first full-length history of opium, acclaimed author Martin Booth uncovers the multifaceted nature of this remarkable narcotic and the bittersweet effects of a simple poppy with a deadly legacy.

    Crank. Bennies. Dexies. Greenies. Black Beauties. Purple Hearts. Crystal. Ice. And, of course, Speed. Whatever their street names at the moment, amphetamines have been an insistent force in American life since they were marketed as the original antidepressants in the 1930s. On Speed tells the remarkable story of their rise, their fall, and their surprising resurgence. Along the way, it discusses the influence of pharmaceutical marketing on medicine, the evolving scientific understanding of how the human brain works, the role of drugs in maintaining the social order, and the centrality of pills in American life. Above all, however, this is a highly readable biography of a very popular drug. And it is a riveting story.Incorporating extensive new research, On Speed describes the ups and downs (fittingly, there are mostly ups) in the history of amphetamines, and their remarkable pervasiveness. For example, at the same time that amphetamines were becoming part of the diet of many GIs in World War II, an amphetamine-abusing counterculture began to flourish among civilians. In the 1950s, psychiatrists and family doctors alike prescribed amphetamines for a wide variety of ailments, from mental disorders to obesity to emotional distress. By the late 1960s, speed had become a fixture in everyday life: up to ten percent of Americans were thought to be using amphetamines at least occasionally.Although their use was regulated in the 1970s, it didn't take long for amphetamines to make a major comeback, with the discovery of Attention Deficit Disorder and the role that one drug in the amphetamine family--Ritalin--could play in treating it. Today's most popular diet-assistance drugs differ little from the diet pills of years gone by, still speed at their core. And some of our most popular recreational drugs--including the -mellow- drug, Ecstasy--are also amphetamines. Whether we want to admit it or not, writes Rasmussen, we're still a nation on speed.

    When first published in 1969, this study was described by the Guardian as …as exciting and readable an account as you could wish." This new edition of the major study on the subject is illustrated by over seventy contemporary black and white illustrations and eight pages of color.A series of natural disasters in the furthest reaches of the Orient during the third of the fourteenth century heralded what was, for the population of Europe, the most devastating period of death and destruction in its history. By the autumn of 1347 the Black Death had reached the shores of the eastern Mediterranean, and the years that followed were to witness a horrifying and apparently relentless epidemic.One third of England's population died between the years 1347 and 1350, and over one thousand villages were deserted, never to be repopulated. In towns and cities the cemeteries were unable to provide space for all the dead, and violence and crime spiraled. Travel became dangerous and interruption of food and other supplies across the country added hunger and deprivation to the problems of people already overwhelmed by the threat of the vilest of deaths. In the countryside the population was halved in places, and as land became plentiful, landowners' profits fell and the government tried in vain to fix labourers' wages and prices, peasant unrest accelerated and the manorial system disintegrated, culminating eventually in the Peasants' Revolt of 1381. Throughout Europe whole societies were disrupted; racial tensions built as a direct result of the plague, and persecution of Jews began in earnest throughout the continent. The social and economic consequences of the period were to reach far into the following century.