But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

    In Broken, Jenny brings readers along on her mental and physical health journey, offering heartbreaking and hilarious anecdotes along the way.With people experiencing anxiety and depression now more than ever, Jenny humanizes what we all face in an all-too-real way, reassuring us that we’re not alone and making us laugh while doing it. From the business ideas that she wants to pitch to Shark Tank to the reason why Jenny can never go back to the post office, Broken leaves nothing to the imagination in the most satisfying way. And of course, Jenny’s long-suffering husband Victor―the Ricky to Jenny’s Lucille Ball―is present throughout.A treat for Jenny Lawson’s already existing fans, and destined to convert new ones, Broken is a beacon of hope and a wellspring of laughter when we all need it most.

       For nine seasons Rainn Wilson played Dwight Schrute, everyone's favorite work nemesis and beet farmer. Viewers of The Office fell in love with the character and grew to love the actor who played him even more. Rainn founded a website and media company, SoulPancake, that eventually became a bestselling book of the same name. He also started a hilarious Twitter feed (sample tweet: “I'm not on Facebook” is the new “I don't even own a TV”) that now has more than four million followers.   Now, he's ready to tell his own story and explain how he came up with his incredibly unique sense of humor and perspective on life. He explains how he grew up “bone-numbingly nerdy before there was even a modicum of cool attached to the word.” The Bassoon King chronicles his journey from nerd to drama geek (“the highest rung on the vast, pimply ladder of high school losers”), his years of mild debauchery and struggles as a young actor in New York, his many adventures and insights about The Office, and finally, Wilson's achievement of success and satisfaction, both in his career and spiritually, reconnecting with the artistic and creative values of the Bahá’í faith he grew up in.

     “A pleasure. Ellie Kemper is the kind of stable, intelligent, funny, healthy woman that usually only exists in yogurt commercials. But she’s real and she’s all ours!” —Tina Fey “Ellie is a hilarious and talented writer, although we’ll never know how much of this book the squirrel wrote.”—Mindy KalingMeet Ellie, the best-intentioned redhead next door. You’ll laugh right alongside her as she shares tales of her childhood in St. Louis, whether directing and also starring in her family holiday pageant, washing her dad’s car with a Brillo pad, failing to become friends with a plump squirrel in her backyard, eating her feelings while watching PG-13 movies, or becoming a “sports monster” who ends up warming the bench of her Division 1 field hockey team in college. You’ll learn how she found her comedic calling in the world of improv, became a wife, mother and New Yorker, and landed the role of a bridesmaid (while simultaneously being a bridesmaid) in Bridesmaids. You’ll get to know and love the comic, upbeat, perpetually polite actress playing Erin Hannon on The Office, and the exuberant, pink-pants-wearing star of Unbreakable Kimmy Schmidt. If you’ve ever been curious about what happens behind the scenes of your favorite shows, what it really takes to be a soul cycle “warrior,” how to recover if you accidentally fall on Doris Kearns Goodwin or tell Tina Fey on meeting her for the first time that she has “great hair—really strong and thick,” this is your chance to find out. But it’s also a laugh-out-loud primer on how to keep a positive outlook in a world gone mad and how not to give up on your dreams. Ellie “dives fully into each role—as actor, comedian, writer, and also wife and new mom—with an electric dedication, by which one learns to reframe the picture, and if not exactly become a glass-half-full sort of person, at least become able to appreciate them” (Vogue.com).

    One day he was a doctor treating the dying, and the next he was a patient struggling to live. And just like that, the future he and his wife had imagined evaporated. When Breath Becomes Air chronicles Kalanithi's transformation from a naïve medical student "possessed," as he wrote, "by the question of what, given that all organisms die, makes a virtuous and meaningful life" into a neurosurgeon at Stanford working in the brain, the most critical place for human identity, and finally into a patient and new father confronting his own mortality. What makes life worth living in the face of death? What do you do when the future, no longer a ladder toward your goals in life, flattens out into a perpetual present? What does it mean to have a child, to nurture a new life as another fades away? These are some of the questions Kalanithi wrestles with in this profoundly moving, exquisitely observed memoir. Paul Kalanithi died in March 2015, while working on this book, yet his words live on as a guide and a gift to us all. "I began to realize that coming face to face with my own mortality, in a sense, had changed nothing and everything," he wrote. "Seven words from Samuel Beckett began to repeat in my head: 'I can't go on. I'll go on.'" When Breath Becomes Air is an unforgettable, life-affirming reflection on the challenge of facing death and on the relationship between doctor and patient, from a brilliant writer who became both.

    But Folds will be the first to tell you he's an unconventional icon, more normcore than hardcore. Now, in his first book, Folds looks back at his life so far in a charming and wise chronicle of his artistic coming of age, infused with the wry observations of a natural storyteller.In the title chapter, "A Dream About Lightning Bugs," Folds recalls his earliest childhood dream--and realizes how much it influenced his understanding of what it means to be an artist. In "Measure Twice, Cut Once" he learns to resist the urge to skip steps during the creative process. In "Hall Pass" he recounts his 1970s North Carolina working-class childhood, and in "Cheap Lessons" he returns to the painful life lessons he learned the hard way--but that luckily didn't kill him.In his inimitable voice, both relatable and thought-provoking, Folds digs deep into the life experiences that shaped him, imparting hard-earned wisdom about both art and life. Collectively, these stories embody the message Folds has been singing about for years: Smile like you've got nothing to prove, because it hurts to grow up, and life flies by in seconds.

    Alexander von Humboldt (1769 – 1859) was an intrepid explorer and the most famous scientist of his age. In North America, his name still graces four counties, thirteen towns, a river, parks, bays, lakes, and mountains. His restless life was packed with adventure and discovery, whether he was climbing the highest volcanoes in the world or racing through anthrax-infected Siberia or translating his research into bestselling publications that changed science and thinking. Among Humboldt's most revolutionary ideas was a radical vision of nature, that it is a complex and interconnected global force that does not exist for the use of humankind alone. Now Andrea Wulf brings the man and his achievements back into focus: his daring expeditions and investigation of wild environments around the world and his discoveries of similarities between climate and vegetation zones on different continents. She also discusses his prediction of human-induced climate change, his remarkable ability to fashion poetic narrative out of scientific observation, and his relationships with iconic figures such as Simón Bolívar and Thomas Jefferson. Wulf examines how Humboldt's writings inspired other naturalists and poets such as Darwin, Wordsworth, and Goethe, and she makes the compelling case that it was Humboldt's influence that led John Muir to his ideas of natural preservation and that shaped Thoreau's Walden.With this brilliantly researched and compellingly written book, Andrea Wulf shows the myriad fundamental ways in which Humboldt created our understanding of the natural world, and she champions a renewed interest in this vital and lost player in environmental history and science.

    This is the remarkable true story of a man who lived alone in the woods of Maine for 27 years, making this dream a reality--not out of anger at the world, but simply because he preferred to live on his own.In 1986, a shy and intelligent twenty-year-old named Christopher Knight left his home in Massachusetts, drove to Maine, and disappeared into the forest. He would not have a conversation with another human being until nearly three decades later, when he was arrested for stealing food. Living in a tent even through brutal winters, he had survived by his wits and courage, developing ingenious ways to store edibles and water, and to avoid freezing to death. He broke into nearby cottages for food, clothing, reading material, and other provisions, taking only what he needed but terrifying a community never able to solve the mysterious burglaries. Based on extensive interviews with Knight himself, this is a vividly detailed account of his secluded life--why did he leave? what did he learn?--as well as the challenges he has faced since returning to the world. It is a gripping story of survival that asks fundamental questions about solitude, community, and what makes a good life, and a deeply moving portrait of a man who was determined to live his own way, and succeeded.

    In these pages, I’ve tried to do this.” —Bruce Springsteen, from the pages of Born to RunIn 2009, Bruce Springsteen and the E Street Band performed at the Super Bowl’s halftime show. The experience was so exhilarating that Bruce decided to write about it. That’s how this extraordinary autobiography began. Over the past seven years, Bruce Springsteen has privately devoted himself to writing the story of his life, bringing to these pages the same honesty, humor, and originality found in his songs. He describes growing up Catholic in Freehold, New Jersey, amid the poetry, danger, and darkness that fueled his imagination, leading up to the moment he refers to as “The Big Bang”: seeing Elvis Presley’s debut on The Ed Sullivan Show. He vividly recounts his relentless drive to become a musician, his early days as a bar band king in Asbury Park, and the rise of the E Street Band. With disarming candor, he also tells for the first time the story of the personal struggles that inspired his best work, and shows us why the song “Born to Run” reveals more than we previously realized. Born to Run will be revelatory for anyone who has ever enjoyed Bruce Springsteen, but this book is much more than a legendary rock star’s memoir. This is a book for workers and dreamers, parents and children, lovers and loners, artists, freaks, or anyone who has ever wanted to be baptized in the holy river of rock and roll. Rarely has a performer told his own story with such force and sweep. Like many of his songs (“Thunder Road,” “Badlands,” “Darkness on the Edge of Town,” “The River,” “Born in the U.S.A.,” “The Rising,” and “The Ghost of Tom Joad,” to name just a few), Bruce Springsteen’s autobiography is written with the lyricism of a singular songwriter and the wisdom of a man who has thought deeply about his experiences.

    That simple act became a national news story because Abby was the director of a Planned Parenthood clinic in Texas who, after participating in her first actual abortion procedure, walked across the road to join the Coalition for Life. "Unplanned" is a heartstopping personal drama of life-and-death encounters, a courtroom battle, and spiritual transformation that speaks hope and compassion into the political controversy that surrounds this issue. Telling Abby’s story from both sides of the abortion clinic property line, this book is a must-read for anyone who cares about the life versus rights debate and helping women who face crisis pregnancies.

    So Tyson brings the universe down to Earth succinctly and clearly, with sparkling wit, in tasty chapters consumable anytime and anywhere in your busy day.

    (I understand that it’s likely the former, which is a fancy “book” way of saying “the first one.”) I talk about my grandparents, doing stand-up comedy as a teenager, bar mitzvahs, and Jewish summer camp, and tell way more stories about doing drugs than my mother would like. I also talk about some of my adventures in Los Angeles, and surely say things about other famous people that will create a wildly awkward conversation for me at a party one day. I hope you enjoy the book should you buy it, and if you don’t enjoy it, I’m sorry. If you ever see me on the street and explain the situation, I’ll do my best to make it up to you.

    But that November 1, her life was shattered when her roommate, British student Meredith Kercher, was murdered in their apartment. Five days later, Amanda was taken into custody and charged by the Italian police; her arrest and the subsequent investigation ignited an international media firestorm. Overnight, this ordinary young American student became the subject of intense scrutiny, forced to endure a barrage of innuendo and speculation. Two years later, after an extremely controversial trial, Amanda was convicted and imprisoned. But in 2011 an appeals court overturned her conviction and vacated the charges. Free at last, she immediately returned home to the U.S., where she has remained silent, until now.

    Louis. With a theater degree in hand, she was certain everything would fall easily into place. Never mind that she didn’t know a single person in the entertainment industry. She was determined, she was confident, she was ready to work hard. So, what could go wrong?Uh, basically everything. It would be eight long years before she landed her Emmy-nominated role of Pam Beesley on The Office—nearly a decade of failure, struggle, rejection and doubt. The path to professional acting was more competitive than she’d ever imagined. Headshots, agents, classes, auditions . . . there was a lot to learn. And with so many obstacles to navigate, it wasn’t always easy to fight off discouragement. If only she’d had a handbook for the struggling actor. Or, better yet, someone to show her the way—an established actor who could manage her expectations, educate her about the business, and reassure her in those moments of despair.Jenna Fischer wants to be that person for you. With candor and wit, Fischer lays out what it takes to establish yourself in the profession. Based on her own memorable and hilarious experiences, she provides invaluable advice on how to get the right head shot, what to look for in representation, and the importance of getting out there and just doing something. She also provides helpful hints on how to be gutsy and take risks, the tricks to good auditioning and callbacks, and how not to fall for certain scams. (Auditions in a guy’s apartment are probably not legit—or at least not for the kind of part you’re looking for!)Fischer’s inspiring guidance will make you feel like you have a trusted friend who’s made the journey and has now returned to walk beside you, pointing out the pitfalls as you blaze your own path toward the life of a professional actor.

    Maybe I’ll have another five years. Maybe, with the advances in oncology, they’ll find new treatments for my cancer that will extend my life. Maybe I’ll be gone before you read this. My predicament is, well, rather unpredictable. But I’m prepared for either contingency, or at least I’m getting prepared. I have some things I’d like to take care of first, some work that needs finishing, and some people I need to see. And I want to talk to my fellow Americans a little more if I may.So writes John McCain in this inspiring, moving, frank, and deeply personal memoir. Written while confronting a mortal illness, McCain looks back with appreciation on his years in the Senate, his historic 2008 campaign for the presidency against Barack Obama, and his crusades on behalf of democracy and human rights in Eastern Europe and the Middle East.Always the fighter, McCain attacks the “spurious nationalism” and political polarization afflicting American policy. He makes an impassioned case for democratic internationalism and bi-partisanship. He tells stories of his most satisfying moments of public service, including his work with another giant of the Senate, Edward M. Kennedy. Senator McCain recalls his disagreements with several presidents, and minces no words in his objections to some of President Trump’s statements and policies. At the same time, he offers a positive vision of America that looks beyond the Trump presidency.The Restless Wave is John McCain at his best.