While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject.The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.

    Born and raised in a small town, they enjoy a close relationship, though each has her own tastes and personality. But the Hensels also share a body. Their two heads sit side-by-side on a single torso, with two arms and two legs. They have not only survived, but have developed into athletic, graceful young women. And that, writes Mark S. Blumberg, opens an extraordinary window onto human development and evolution.In Freaks of Nature, Blumberg turns a scientist's eye on the oddities of nature, showing how a subject once relegated to the sideshow can help explain some of the deepest complexities of biology. Why, for example, does a two-headed human so resemble a two-headed minnow? What we need to understand, Blumberg argues, is that anomalies are the natural products of development, and it is through developmental mechanisms that evolution works. Freaks of Nature induces a kind of intellectual vertigo as it upends our intuitive understanding of biology. What really is an anomaly? Why is a limbless human a freak, but a limbless reptile-a snake-a successful variation?What we see as deformities, Blumberg writes, are merely alternative paths for development, which challenge both the creature itself and our ability to fit it into our familiar categories. Rather than mere dead-ends, many anomalies prove surprisingly survivable-as in the case of the goat without forelimbs that learned to walk upright. Blumberg explains how such variations occur, and points to the success of the Hensel sisters and the goat as examples of the extraordinary flexibility inherent in individual development.In taking seriously a subject that has often been shunned as discomfiting and embarrassing, Mark Blumberg sheds new light on how individuals-and entire species-develop, survive, and evolve.

    But more than that, as Doug Macdougall makes clear, the science also provides important clues to the future of the planet. In an entertaining and accessibly written narrative, Macdougall gives an overview of Earth’s astonishing history based on information extracted from rocks, ice cores, and other natural archives. He explores such questions as: What is the risk of an asteroid striking Earth? Why does the temperature of the ocean millions of years ago matter today? How are efforts to predict earthquakes progressing? Macdougall also explains the legacy of greenhouse gases from Earth’s past and shows how that legacy shapes our understanding of today’s human-caused climate change. We find that geoscience in fact illuminates many of today’s most pressing issues—the availability of energy, access to fresh water, sustainable agriculture, maintaining biodiversity—and we discover how, by applying new technologies and ideas, we can use it to prepare for the future.

    These transitions include the origin of life itself, the first eukaryotic cells, reproduction by sexual means, the appearance ofmulticellular plants and animals, the emergence of cooperation and of animal societies, and the unique language ability of humans. This ambitious book provides the first unified discussion of the full range of these transitions. The authors highlight the similarities between differenttransitions--between the union of replicating molecules to form chromosomes and of cells to form multicellular organisms, for example--and show how understanding one transition sheds light on others. They trace a common theme throughout the history of evolution: after a major transition someentities lose the ability to replicate independently, becoming able to reproduce only as part of a larger whole. The authors investigate this pattern and why selection between entities at a lower level does not disrupt selection at more complex levels. Their explanation encompasses a compellingtheory of the evolution of cooperation at all levels of complexity. Engagingly written and filled with numerous illustrations, this book can be read with enjoyment by anyone with an undergraduate training in biology. It is ideal for advanced discussion groups on evolution and includes accessiblediscussions of a wide range of topics, from molecular biology and linguistics to insect societies.

    He had no way of knowing it was to e the autumn of his youth, and that his entire generation would soon be thrust into the most devastating conflict in history.Seven decades later, author John J. Newkirk retraces this epic ride with his father, Jack, in a silent hope the old soldier will still be proud of the America he fought for. Each mile brings discovery as the author learns of his namesake, the heroic Squadron Leader of the legendar Flying Tigers, and of his father's life on the road and in the jungles of the South Pacific during World War II.The result is quintessential Americana, a sweeping portrait of the grit, guts, ingenuity, and sacrifice that defined a nation, and a timely lesson from the Greatest Generation on how we can overcome our most pressing challenges and reclaim the American Dream."

    New stadiums in this completely revised and updated edition include Citizens Bank Ballpark (Philadelphia), PETCO Park (San Diego), and the newly renovated RFK Stadium (Washington, D.C.) home to the Washington Nationals. Crammed with the statistics baseball fans love, Take Me Out to the Ballpark will hit a home run with legions of new readers this fall.

    . . . Gould is the Stan Musial of essay writing. He can work himself into a corkscrew of ideas and improbable allusions paragraph after paragraph and then, uncoiling, hit it with such power that his fans know they are experiencing the game of essay writing at its best."--John Noble Wilford, New York Times Book Review

    His simple but staggering theory of quantum evolution shows how quantum mechanics gives living organisms the ability to initiate specific actions, including new mutations. As Paul Davies exclaims, "if these ideas are right, they will transform our understanding of the relationship between physics and biology" and may radically revise the notion of random evolution and the debate over consciousness and free will.

    Using this example as a springboard, David M. Raup leaps into an egaging discussion of the theories, assumptions, and difficulties associated with the science of species extinction. Woven is along the way are stories of the trilobite eye, tropical reefs, flying reptiles, and the fate of the heath hen on Martha's Vineyard, a very modern extinction.

    Kramer, Author of Listening to Prozac and Should You Leave?Nowhere is the nature-nuture controversy being more arduously tested than in the labs of world-renowned molecular scientist Dean Hamer, whose cutting-edge research has indisputably linked specific genes to behavioral traits, such as anxiety, thrill-seeking, and homosexuality. The culmination of that research os this provocative book, Living with Our Genes. In it, Dr. Hamer reveals that much of our behavior—how much we eat and weigh, whether we drink or use drugs, how often we have sex—is heavily influenced by genes. His findings help explain why one brother becomes a Wall Street trader, while his sibling remains content as a librarian, or why some people like to bungee-jump, while others prefer Scrabble. Dr. Hamer also sheds light on some of the most compelling and vexing aspects of personality, such as shyness, aggression, depression, and intelligence.   In the tradition of the bestselling book Listening to Prozac, Living with Our Genes is the first comprehensive investigation of the crucial link between our DNA and our behavior."Compulsive reading, reminiscent of Jared Diamond, froma scientsit who knows his stuff and communicates it well."—Kirkus Reviews"A pioneer in the field of molecular psychology, Hamer is exploring the role genes play in governing the very core of our individuality. Accessible...provocative." —Time"Absolutely terrific! I couldn't put it down."—Professor Robert Plomin, Social, Genetic & Developmental Psychiatry Research Center, Institute of Psychiatry

    You can experience salvation and receive a new heart but still miss receiving your full spiritual inheritance. Juanita Bynum, best-selling author of Matters of the Heart, minces no words in explaining the scriptural significance for believers to understand the role spiritual authority plays in your inheriting all God destines for you. Your Spiritual inheritance comes only from submission. Looking in-depth at the lives of Samson, Saul, Uzziah, and Jesus, as well as her own life, Bynum explains the pattern for receiving - and not squandering - the mantle of anointing from God. Discover how submission to instruction and receiving correction from spiritual authority can draw you into destiny. The Bible's pattern is clear - spiritual leaders are to lead, and believers are to submit to their leadership for spiritual direction. Your spiritual inheritance - reserved especially for you - is awaiting your full obedience. Will you embrace the greatness God has put within you?

    Written by Blaine T. Bettinger, PhD, JD, and Debbie Parker Wayne, CG, CGL, the book provides family historians and genealogists who have just begun to explore genetic genealogy practical, easy to understand information that they can apply to their research. As Wayne notes in her blog, Deb’s "Delvings in Genealogy," “DNA can seem complex to many of us, but this book will guide you and help build your knowledge level one step at a time.” At their own pace, readers learn the basic concepts of genetic genealogy. They then build on that knowledge as they study the testing, analysis, and application of YDNA, X-DNA, mitochondrial DNA (mtDNA), and autosomal DNA (atDNA) to reach and support genealogical conclusions. Each chapter includes exercises with answer keys for hands-on practice. Blaine Bettinger is an intellectual property attorney in Syracuse, New York. The author of The Genetic Genealogist blog, he is a genealogy educator, a trustee of the New York Genealogical and Biographical Society, and organizer of the Shared cM Project, a crowdsourced project examining the associations between genetic data and genealogical relationships. Debbie Parker Wayne is a professional genealogist who has conducted research for individuals as well as for the PBS series “Finding Your Roots” with Henry Louis Gates Jr. and other television shows. She is an award-winning author, the coordinator for genetic genealogy institute courses, and the DNA Project Chair for the Texas State Genealogical Society.

    But one of the challenges of a standard low-carb, high-fat keto diet is that it can be hard to stick to.Dr Michael Mosley's Fast 800 Keto is both more effective than a conventional keto regime, and healthier and more sustainable. The secret to this new approach is that it combines keto with intermittent fasting, which means you go into ketosis faster, while also being able to enjoy delicious Mediterranean-style food.Based on the latest dietary science, this book presents a simple, highly flexible three-step programme to ensure you lose weight rapidly and safely, while preserving your metabolic rate. It includes protein-rich, low-carb recipes and easy-to- follow menus from bestselling author Dr Clare Bailey, and all the other tools you need to shift stubborn fat and transform your health for good.

    Drugs, transplants, and surgery don’t work for 90 percent of our aches and pains and, while we are grateful for life-saving developments, we know that most come with risks that we ignore at our peril.Long hailed as one of the founding fathers of mind-body medicine, Larry Dossey directs our attention to simple sources of healing that have been available for centuries—treasures often hidden in plain sight—from the power of optimism and of tears to speed recovery to the surprising usefulness of dirt and bugs in curing disease and infection to the benefits of doing nothing.Exploring the medical research that validates these simple remedies, Dossey encourages us to align ourselves with the wisdom of nature and allow true healing to take place. The Extraordinary Healing Power of Ordinary Things can transform our view of what health is all about, whether our concern is cancer or the common cold.From the Hardcover edition.

    His theories on the evolutionary tensions between parent and offspring, sibling and sibling, man and woman, friend and friend, and a person and himself or herself have not only revolutionized genetics and evolutionary biology but have influenced disciplines from medicine and the social sciences to history, economics, and literary studies. But unlike other renowned scientists, Trivers has spent time behind bars, drove a getaway car for Huey P. Newton, and founded an armed group in Jamaica to protect gay men from mob violence. Now, in the entertaining tradition of Surely You're Joking Mr. Feynman, Trivers tell us in his inimitable voice about the inimitable life behind the revolutionary science. He comments with irreverent wit and penetrating insight on everything from American racism to the history of psychiatry to who killed Peter Tosh, musical heir to Bob Marley. Sprinkled with anecdotes about such luminaries as Richard Dawkins and Stephen Jay Gould, and with photographs throughout, this volume is sure to enlighten and entertain anyone with an interest in science, the human condition, or the nature of creative genius. PRAISE FOR WILD LIFE"To call Robert Trivers an acclaimed biologist is an understatement akin to calling the late Richard Feynman a popular professor of physics." -- PSYCHOLOGY TODAY"Who would have guessed that arguably today’s most original thinker in evolutionary theory could possibly have led the extraordinary life Robert Trivers recounts in these pages. We are taken on a wild trip from inspired meditations on the biology of self deception, through a steamy Jamaican underworld, to Black Panthers in California, to frank appraisals of distinguished or over-rated scientists, the whole adding up to a disarmingly frank and utterly unique memoir of a rollercoaster of a life. -- RICHARD DAWKINS, bestselling author of The Selfish Gene and The God Delusion“Robert Trivers is not just a brilliant evolutionary thinker but a world-class raconteur, adventurer, kibitzer, people-watcher, jester, and provocateur. This memoir is filled with sharp and hilarious observations about the living world, not least a certain species of hairless primate, not least a certain member of that species named Robert Trivers.” – STEVEN PINKER,best-selling author of How the Mind Works and The Better Angels of Our Nature: Why Violence Has Declined“It would not be hyperbole to say that Robert Trivers is one of the most important evolutionary theorists since Charles Darwin. But contrary to the image most people have of theoretical scientists as stodgy intellectuals holed up in their offices buried in paper, Trivers' memoir reveals a man whose life has been wild in every sense of the word. A lust for life doesn’t begin to sum up a career devoted to truth, courage, and the audacity to think what no one else has thought, and to act in ways few others would dare (you’ll even learn how to defend yourself in a knife fight). If that were not enough, Trivers is witty, clever, and compassionate. This book is destined to become a classic in scientific autobiography." -- MICHAEL SHERMER, Editor in Chief, The SkepticABOUT THE AUTHORRobert Trivers is a professor of anthropology and biological sciences at Rutgers University.