Kenzo Tenma is the only one who can stop him! Conspiracies, serial murders, and a scathing indictment of hospital politics are all masterfully woven together in this compelling manga thriller. Tenma risks his promising medical career to save the life of a critically wounded young boy. Unbeknownst to him, this child is destined for a terrible fate. Who could have known that Tenma would create a monster!

    But in addition to that, he also has the ability to talk to animals. One day when he rescues a strange black cat named Ragou, he learns that the world is filled with spirits called mononoke that can take the form of both people and animals. However, their meeting is cut short when they are attacked by a hostile mononoke who is after Ragou's power.

    Why is Setsuna so mixed up? Despite his attempts to be noble, he'll fight anyone anytime; he ignores all authority; and he harbors feelings for his sister that can only be described as "incestuous." Why is he such a mess? The reason may be found with two demons from the underworld and their enemy, an insane angel who is distributing an insidious computer game called Angel Santuary.