The Christodora is home to Milly and Jared, a privileged young couple with artistic ambitions. Their neighbor, Hector, a Puerto Rican gay man who was once a celebrated AIDS activist but is now a lonely addict, becomes connected to Milly and Jared’s lives in ways none of them can anticipate. Meanwhile, Milly and Jared’s adopted son Mateo grows to see the opportunity for both self-realization and oblivion that New York offers. As the junkies and protesters of the 1980's give way to the hipsters of the 2000's and they, in turn, to the wealthy residents of the crowded, glass-towered city of the 2020's, enormous changes rock the personal lives of Milly and Jared and the constellation of people around them. Moving kaleidoscopically from the Tompkins Square Riots and attempts by activists to galvanize a true response to the AIDS epidemic, to the New York City of the future, Christodora recounts the heartbreak wrought by AIDS, illustrates the allure and destructive power of hard drugs, and brings to life the ever-changing city itself.

    Crowds throng the Boston station, mesmerized by the mechanical wonder huffing on the rails: the Pullman Hotel Express, the first train to travel from coast to coast. Boarding the train are congressmen, railroad presidents, and even George Pullman himself. For two young women, strangers until this fateful day, it’s the beginning of a journey that will change their lives.Sensitive Louisa dreads the trip, but with limited prospects, she’s reluctantly joined the excursion as a governess to a wealthy family. Hattie is traveling to San Francisco to meet her fiancé, yet she’s far more interested in the workings of the locomotive than she is in the man awaiting her arrival. As the celebrated train moves westward, the women move toward one another, pulled by an unexpected attraction.But there is danger in this closeness, just as there is in the wilds of the frontier and in the lengths the railroad men will go to protect their investments. Before their journey is over, Louisa and Hattie will find themselves very far from where they intended to go.