As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    While paintings of Picasso and Jackson Pollock sell for a hundred million dollars or more, and lines from T. S. Eliot are quoted on the yearbook pages of alienated teenagers across the land, twentieth-century classical music still sends ripples of unease through audiences. At the same time, its influence can be felt everywhere. Atonal chords crop up in jazz. Avant-garde sounds populate the soundtracks of Hollywood thrillers. Minimalism has had a huge effect on rock, pop, and dance music from the Velvet Underground onward.The Rest Is Noise shows why twentieth-century composers felt compelled to create a famously bewildering variety of sounds, from the purest beauty to the purest noise. It tells of a remarkable array of maverick personalities who resisted the cult of the classical past, struggled against the indifference of a wide public, and defied the will of dictators. Whether they have charmed audiences with sweet sounds or battered them with dissonance, composers have always been exuberantly of the present, defying the stereotype of classical music as a dying art. The narrative goes from Vienna before the First World War to Paris in the twenties, from Hitler's Germany and Stalin's Russia to downtown New York in the sixties and seventies. We follow the rise of mass culture and mass politics, of dramatic new technologies, of hot and cold wars, of experiments, revolutions, riots, and friendships forged and broken. The end result is not so much a history of twentieth-century music as a history of the twentieth century through its music.

    It was built on the twentieth-century magic called 'the planned economy', which was going to gush forth an abundance of good things that lands of capitalism could never match. And just for a little while, in the heady years of the late 1950's, the magic seemed to be working.Red Plenty is about that moment in history, and how it came, and how it went away; about the brief era when, under the rash leadership of Nikita Khrushchev, the Soviet Union looked forward to a future of rich communists and envious capitalists, when Moscow would out-glitter Manhattan, and every Lada would be better engineered than a Porsche. It's about the scientists who did their genuinely brilliant best to make the dream come true, it give the tyranny its happy ending. It's history, it's fiction. It's a comedy of ideas, and a novel about the cost of ideas.By award-winning (and famously unpredictable) author of The Child That Books Built and Backroom Boys, Red Plenty is as ambitious as Sputnik, as uncompromising as an Aeroflot flight attendant - and as different from what you were expecting as a glass of Soviet champagne.

    From Marilyn Monroe's borderline personality disorder to Charles Darwin's anxiety, Kalb provides compelling insight into a broad range of maladies, using historical records and interviews with leading mental health experts, biographers, sociologists, and other specialists. Packed with intriguing revelations, this smart narrative brings a new perspective to one of the hottest new topics in today's cultural conversation.

    The proliferation of fast-moving technologies, including forms of artificial intelligence, will cause us to confront profound questions about ourselves. The era of human intellectual superiority is ending, and, as a species, we need to plan for this monumental shift.A Human Algorithm: How Artificial Intelligence Is Redefining Who We Are examines the immense impact intelligent technology will have on humanity. These machines, while challenging our personal beliefs and our socio-economic world order, also have the potential to transform our health and well-being, alleviate poverty and suffering, and reveal the mysteries of intelligence and consciousness. International human rights attorney Flynn Coleman deftly argues that it is critical we instill values, ethics, and morals into our robots, algorithms, and other forms of AI. Equally important, we need to develop and implement laws, policies, and oversight mechanisms to protect us from tech’s insidious threats.To realize AI’s transcendent potential, Coleman advocates for inviting a diverse group of voices to participate in designing our intelligent machines and using our moral imagination to ensure that human rights, empathy, and equity are core principles of emerging technologies. Ultimately, A Human Algorithm is a clarion call for building a more humane future and moving conscientiously into a new frontier of our own design.

    

    According to Amy Sedaris, it's often been said that ugly people craft and attractive people have sex. In her new book, Simple Times, she sets the record straight. Demonstrating that crafting is one of life's more pleasurable and constructive leisure activities, Sedaris shows that anyone with a couple of hours to kill and access to pipe cleaners can join the elite society of crafters. You will discover how to make popular crafts, such as: crab-claw roach clips, tinfoil balls, and crepe-paper moccasins, and learn how to: get inspired (Spend time at a Renaissance Fair; Buy fruit, let it get old, and see what shapes it turns into); remember which kind of glue to use with which material (Tacky with Furry, Gummy with Gritty, Paste with Prickly, and always Gloppy with Sandy); create your own craft room and avoid the most common crafting accidents (sawdust fires, feather asphyxia, pine cone lodged in throat); and cook your own edible crafts, from a Crafty Candle Salad to Sugar Skulls, and many more recipes. PLUS whole chapters full of more crafting ideas (Pompom Ringworms! Seashell Toilet Seat Covers!) that will inspire you to create your own hastily constructed obscure d'arts; and much, much more!

    And yet we rarely ask ourselves how we got there or what our occupations mean to us. The Pleasures and Sorrows of Work is an exploration of the joys and perils of the modern workplace, beautifully evoking what other people wake up to do each day–and night–to make the frenzied contemporary world function. With a philosophical eye and his signature combination of wit and wisdom, Alain de Botton leads us on a journey around a deliberately eclectic range of occupations, from rocket science to biscuit manufacture, accountancy to art–in search of what make jobs either fulfilling or soul-destroying.Along the way he tries to answer some of the most urgent questions we can ask about work: Why do we do it? What makes it pleasurable? What is its meaning? And why do we daily exhaust not only ourselves but also the planet? Characteristically lucid, witty and inventive, Alain de Botton’s “song for occupations” is a celebration and exploration of an aspect of life which is all too often ignored and a book that shines a revealing light on the essential meaning of work in our lives.

    Increasingly fascinated by this most shameful of experiences, she began to explore the lonely city by way of art. Moving fluidly between works and lives -- from Edward Hopper's Nighthawks to Andy Warhol's Time Capsules, from Henry Darger's hoarding to the depredations of the AIDS crisis -- Laing conducts an electric, dazzling investigation into what it means to be alone, illuminating not only the causes of loneliness but also how it might be resisted and redeemed.

     Stretching between these figures is a cast of artists, writers, and scientists--mostly women, mostly queer--whose public contribution has risen out of their unclassifiable and often heartbreaking private relationships to change the way we understand, experience, and appreciate the universe. Among them are the astronomer Maria Mitchell, who paved the way for women in science; the sculptor Harriet Hosmer, who did the same in art; the journalist and literary critic Margaret Fuller, who sparked the feminist movement; and the poet Emily Dickinson.Emanating from these lives are larger questions about the measure of a good life and what it means to leave a lasting mark of betterment on an imperfect world: Are achievement and acclaim enough for happiness? Is genius? Is love? Weaving through the narrative is a set of peripheral figures--Ralph Waldo Emerson, Charles Darwin, Elizabeth Barrett Browning, Herman Melville, Frederick Douglass, Nathaniel Hawthorne, and Walt Whitman--and a tapestry of themes spanning music, feminism, the history of science, the rise and decline of religion, and how the intersection of astronomy, poetry, and Transcendentalist philosophy fomented the environmental movement.

    What’s it like to work at Walt Disney World?Amber Sewell spent two semesters “earning her ears” at the Happiest Place on Earth, first in the CareerStart Program and then in the better known Disney College Program.During her time backstage, as the Cast Member areas of the theme park are called, Amber kept a diary of her successes and her failures, her moments of delight and her moments of despair, and most of all, her discoveries about what happens when the pixie dust settles and the guests have gone home.Amber will never feel the same about Walt Disney World again.After you’ve read her book, neither will you.

    It’s a staple of small talk, the app on our smartphones, and often the first thing we check each morning. Yet behind these quotidian interactions is one of the most expansive machines human beings have ever constructed—a triumph of science, technology and global cooperation. But what is this ‘weather machine’ and who created it? In The Weather Machine, Andrew Blum takes readers on a fascinating journey through an everyday miracle. In a quest to understand how the forecast works, he visits old weather stations and watches new satellites blast off. He follows the dogged efforts of scientists to create a supercomputer model of the atmosphere and traces the surprising history of the algorithms that power their work. He discovers that we have quietly entered a golden age of meteorology—our tools allow us to predict weather more accurately than ever, and yet we haven’t learned to trust them, nor can we guarantee the fragile international alliances that allow our modern weather machine to exist.Written with the sharp wit and infectious curiosity Andrew Blum is known for, The Weather Machine pulls back the curtain on a universal part of our everyday lives, illuminating our relationships with technology, the planet, and the global community.

    He insists that such a move could bring new luster to a tired field, one that in some respects is among “the most backwards disciplines in the academy.” Literary study, he argues, has been random and unsystematic. For any given period scholars focus on a select group of a mere few hundred texts: the canon. As a result, they have allowed a narrow distorting slice of history to pass for the total picture.Moretti offers bar charts, maps, and time lines instead, developing the idea of “distant reading,” set forth in his path-breaking essay “Conjectures on World Literature,” into a full-blown experiment in literary historiography, where the canon disappears into the larger literary system. Charting entire genres—the epistolary, the gothic, and the historical novel—as well as the literary output of countries such as Japan, Italy, Spain, and Nigeria, he shows how literary history looks significantly different from what is commonly supposed and how the concept of aesthetic form can be radically redefined.

    Throughout his life, Churchill painted to relieve his mind from the demands of leadership—and to stave off depression. Included in this volume are Churchill’s meditations on painting as a salve for the spirit and an important method of relaxation—particularly for people under considerable stress over a long period of time. In addition, it includes 18 reprints of Churchill’s original work in oil, giving the reader a window into the little-known creative and artistic talent of this prominent figure in contemporary history. ABOUT THE AUTHOR Sir Winston Churchill was awarded the Nobel Prize in Literature in 1953 “for his mastery of historical and biographical description as well as for brilliant oratory in defending exalted human values.” Over a 64-year span, Churchill published over 40 books, many multi-volume definitive accounts of historical events to which he was a witness and participant. All are beautifully written and as accessible and relevant today as when first published. During his fifty-year political career, Churchill served twice as Prime Minister in addition to other prominent positions—including President of the Board of Trade, First Lord of the Admiralty, Chancellor of the Exchequer, and Home Secretary. In the 1930s, Churchill was one of the first to recognize the danger of the rising Nazi power in Germany and to campaign for rearmament in Britain. His leadership and inspired broadcasts and speeches during World War II helped strengthen British resistance to Adolf Hitler—and played an important part in the Allies’ eventual triumph. One of the most inspiring wartime leaders of modern history, Churchill was also an orator, a historian, a journalist, and an artist. All of these aspects of Churchill are fully represented in this collection of his works. ABOUT THE SERIES When the Conservative government was defeated in Britain’s 1929 general election, Winston Churchill was exiled from the party—chiefly because of his disagreements with party leaders over Indian Home Rule and protective tariffs, as well as his connections with financiers, press barons, and others who were not trusted by Conservative leadership. This period, between 1929 and 1939, came to be known as Churchill’s “wilderness years.” During this time, he focused on his writing—and served as an important voice for British armament against the rise of Hitler. Many of his works published during this time—including collections of newspaper articles and one very rare short story—are considered lost classics in the Churchill canon.

    In his eagerly anticipated, deeply researched new book, Schreier trains his investigative eye on the volatility of the video game industry and the resilience of the people who work in it. The business of videogames is both a prestige industry and an opaque one. Based on dozens of first-hand interviews that cover the development of landmark games -- Bioshock Infinite, Epic Mickey, Dead Space, and more -- on to the shocking closures of the studios that made them, PRESS RESET tells the stories of how real people are affected by game studio shutdowns, and how they recover, move on, or escape the industry entirely. Schreier's insider interviews cover hostile takeovers, abusive bosses, corporate drama, bounced checks, and that one time the Boston Red Sox's Curt Schilling decided he was going to lead a game studio that would take out World of Warcraft. Along the way, he asks pressing questions about why, when the video game industry is more successful than ever, it's become so hard to make a stable living making video games -- and whether the business of making games can change before it's too late.