With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    Although there are more than thirty thousand species of fish—more than all mammals, birds, reptiles, and amphibians combined—we rarely consider how individual fishes think, feel, and behave. Balcombe upends our assumptions about fishes, portraying them not as unfeeling, dead-eyed feeding machines but as sentient, aware, social, and even Machiavellian—in other words, much like us. What a Fish Knows draws on the latest science to present a fresh look at these remarkable creatures in all their breathtaking diversity and beauty. Fishes conduct elaborate courtship rituals and develop lifelong bonds with shoalmates. They also plan, hunt cooperatively, use tools, curry favor, deceive one another, and punish wrongdoers. We may imagine that fishes lead simple, fleeting lives—a mode of existence that boils down to a place on the food chain, rote spawning, and lots of aimless swimming. But, as Balcombe demonstrates, the truth is far richer and more complex, worthy of the grandest social novel. Highlighting breakthrough discoveries from fish enthusiasts and scientists around the world and pondering his own encounters with fishes, Balcombe examines the fascinating means by which fishes gain knowledge of the places they inhabit, from shallow tide pools to the deepest reaches of the ocean. Teeming with insights and exciting discoveries, What a Fish Knows offers a thoughtful appraisal of our relationships with fishes and inspires us to take a more enlightened view of the planet’s increasingly imperiled marine life. What a Fish Knows will forever change how we see our aquatic cousins—the pet goldfish included.

    But soon, Earth's isolation could come to an end. Over the past two decades, astronomers have discovered thousands of planets orbiting other stars. Some of these exoplanets may be mirror images of our own world. And more are being found all the time.Yet as the pace of discovery quickens, an answer to the universe's greatest riddle still remains just out of reach: Is the great silence and emptiness of the cosmos a sign that we and our world are somehow singular, special, and profoundly alone, or does it just mean that we’re looking for life in all the wrong places? As star-gazing scientists come closer to learning the truth, their insights are proving ever more crucial to understanding life’s intricate mysteries and possibilities right here on Earth.Science journalist Lee Billings explores the past and future of the "exoplanet boom" through in-depth reporting and interviews with the astronomers andplanetary scientists at its forefront. He recounts the stories behind their world-changing discoveries and captures the pivotal moments that drove them forward in their historic search for the first habitable planets beyond our solar system. Billings brings readers close to a wide range of fascinating characters, such as:FRANK DRAKE, a pioneer who has used the world’s greatest radio telescopes to conduct the first searches for extraterrestrial intelligence and to transmit a message to the stars so powerful that it briefly outshone our Sun.JIM KASTING, a mild-mannered former NASA scientist whose research into the Earth’s atmosphere and climate reveals the deepest foundations of life on our planet, foretells the end of life on Earth in the distant future, and guides the planet hunters in their search for alien life.SARA SEAGER, a visionary and iron-willed MIT professor who dreams of escaping the solar system and building the giant space telescopes required to discover and study life-bearing planets around hundreds of the Sun’s neighboring stars.Through these and other captivating tales, Billings traces the triumphs, tragedies, and betrayals of the extraordinary men and women seeking life among the stars. In spite of insufficient funding, clashing opinions, and the failings of some of our world’s most prominent and powerful scientific organizations, these planet hunters will not rest until they find the meaning of life in the infinite depths of space. Billings emphasizes that the heroic quest for other Earth-like planets is not only a scientific pursuit, but also a reflection of our own culture’s timeless hopes and fears.

    Comparing gene sequences, examining atomic structures of proteins, and looking into the geochemistry of rocks have helped explain evolution in more detail than ever before. Nick Lane expertly reconstructs the history of life by describing the ten greatest inventions of evolution (including DNA, photosynthesis, sex, and sight), based on their historical impact, role in organisms today, and relevance to current controversies. Who would have guessed that eyes started off as light-sensitive spots used to calibrate photosynthesis in algae? Or that DNA’s building blocks form spontaneously in hydrothermal vents? Lane gives a gripping, lucid account of nature’s ingenuity, and the result is a work of essential reading for anyone who has ever pondered or questioned the science underlying evolution’s greatest gifts to man.

    According to this false-yet-familiar story, the divisions between men and women are in nature alone and not part of culture. Drawing on evolutionary science, psychology, neuroscience, endocrinology, and philosophy, Testosterone Rex disproves this ingrained myth and calls for a more equal society based on both sexes’ full human potential.

    The effects of homeopathy don’t go away under rigorous scientific conditions. The laws of nature aren’t what they used to be. Thirty years on, no one has an explanation for a seemingly intelligent signal received from outer space. The US Department of Energy is re-examining cold fusion because the experimental evidence seems too solid to ignore. The placebo effect is put to work in medicine while doctors can’t agree whether it even exists.In an age when science is supposed to be king, scientists are beset by experimental results they simply can’t explain. But, if the past is anything to go by, these anomalies contain the seeds of future revolutions. While taking readers on an entertaining tour d’horizon of the strangest of scientific findings – involving everything from our lack of free will to Martian methane that offers new evidence of life on the planet – Michael Brooks argues that the things we don’t understand are the key to what we are about to discover.This mind-boggling but entirely accessible survey of the outer limits of human knowledge is based on a short article by Michael Brooks for New Scientist magazine. It became the sixth most circulated story on the internet in 2005, and provoked widespread comment and compliments (Google “13 things that do not make sense” to see).Michael Brooks has now dug deeply into those mysteries, with extraordinary results.

    In the midst of all this death, a bizarre disease appeared in Europe. Eventually known as encephalitis lethargica, or sleeping sickness, it would spread across the world, leaving millions dead or locked in institutions. Then, in 1927, it would disappear as suddenly as it had arrived-or so the doctors at first thought. Asleep, set in 1920s and '30s New York, follows a group of neurologists through hospitals and insane asylums as they try to solve this worldwide epidemic. The symptoms could include not only unending sleep but dangerous insomnia, facial tics, catatonia, Parkinson's, and even violent insanity. Molly Caldwell Crosby, acclaimed author of The American Plague, explores the frightening history of this forgotten disease- and details the frantic effort to conquer it before it strikes again.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Many women in America have experienced it. What’s expected of women and what it’s really like to be a woman in today’s world are two very different things—and women exhaust themselves trying to close the gap between them. How can you “love your body” when every magazine cover has ten diet tips for becoming “your best self”? How do you “lean in” at work when you’re already operating at 110 percent and aren’t recognized for it? How can you live happily and healthily in a sexist world that is constantly telling you you’re too fat, too needy, too noisy, and too selfish?Sisters Emily Nagoski, PhD, and Amelia Nagoski, DMA, are here to help end the cycle of feeling overwhelmed and exhausted. Instead of asking us to ignore the very real obstacles and societal pressures that stand between women and well-being, they explain with compassion and optimism what we’re up against—and show us how to fight back. In these pages you’ll learn• what you can do to complete the biological stress cycle—and return your body to a state of relaxation• how to manage the “monitor” in your brain that regulates the emotion of frustration• how the Bikini Industrial Complex makes it difficult for women to love their bodies—and how to defend yourself against it• why rest, human connection, and befriending your inner critic are keys to recovering and preventing burnoutWith the help of eye-opening science, prescriptive advice, and helpful worksheets and exercises, all women will find something transformative in these pages—and will be empowered to create positive change. Emily and Amelia aren’t here to preach the broad platitudes of expensive self-care or insist that we strive for the impossible goal of “having it all.” Instead, they tell us that we are enough, just as we are—and that wellness, true wellness, is within our reach.

    But Shep Doeleman and a global coalition of scientists are on the cusp of doing just that.With exclusive access to the team, journalist Seth Fletcher spent five years following Shep and an extraordinary cast of characters as they assembled the Event Horizon Telescope, a virtual radio observatory the size of the Earth. He witnessed their struggles, setbacks, and breakthroughs, and along the way, he explored the latest thinking on the most profound questions about black holes. Do they represent a limit to our ability to understand reality? Or will they reveal the clues that lead to the long-sought Theory of Everything?Fletcher transforms astrophysics into something exciting, accessible, and immediate, taking us on an incredible adventure to better understand the complexity of our galaxy, the boundaries of human perception and knowledge, and how the messy human endeavor of science really works.Weaving a compelling narrative account of human ingenuity with excursions into cutting-edge science, Einstein’s Shadow is a tale of great minds on a mission to change the way we understand our universe—and our place in it.

    Increasingly, the decisions that affect our lives--where we go to school, whether we can get a job or a loan, how much we pay for health insurance--are being made not by humans, but by machines. In theory, this should lead to greater fairness: Everyone is judged according to the same rules.But as mathematician and data scientist Cathy O'Neil reveals, the mathematical models being used today are unregulated and uncontestable, even when they're wrong. Most troubling, they reinforce discrimination--propping up the lucky, punishing the downtrodden, and undermining our democracy in the process.

    Einstein famously quipped that God does not play dice with the universe, and Schrödinger is equally well known for his thought experiment about the cat in the box who ends up “spread out” in a probabilistic state, neither wholly alive nor wholly dead. Both of these famous images arose from these two men’s dissatisfaction with quantum weirdness and with their assertion that underneath it all, there must be some essentially deterministic world. Even though it was Einstein’s own theories that made quantum mechanics possible, both he and Schrödinger could not bear the idea that the universe was, at its most fundamental level, random.As the Second World War raged, both men struggled to produce a theory that would describe in full the universe’s ultimate design, first as collaborators, then as competitors. They both ultimately failed in their search for a Grand Unified Theory—not only because quantum mechanics is true, but because Einstein and Schrödinger were also missing a key component: of the four forces we recognize today (gravity, electromagnetism, the weak force, and the strong force), only gravity and electromagnetism were known at the time.Despite their failures, though, much of modern physics remains focused on the search for a Grand Unified Theory. As Halpern explains, the recent discovery of the Higgs Boson makes the Standard Model—the closest thing we have to a unified theory—nearly complete. And while Einstein and Schrödinger tried and failed to explain everything in the cosmos through pure geometry, the development of string theory has, in its own quantum way, brought this idea back into vogue. As in so many things, even when he was wrong, Einstein couldn’t help but be right.

    Today there are three cats for every dog on the planet, and yet cats remain more mysterious, even to their most adoring owners. Unlike dogs, cats evolved as solitary hunters, and, while many have learned to live alongside humans and even feel affection for us, they still don’t quite get us” the way dogs do, and perhaps they never will. But cats have rich emotional lives that we need to respect and understand if they are to thrive in our company.In Cat Sense, renowned anthrozoologist John Bradshaw takes us further into the mind of the domestic cat than ever before, using cutting-edge scientific research to dispel the myths and explain the true nature of our feline friends. Tracing the cat’s evolution from lone predator to domesticated companion, Bradshaw shows that although cats and humans have been living together for at least eight thousand years, cats remain independent, predatory, and wary of contact with their own kind, qualities that often clash with our modern lifestyles. Cats still have three out of four paws firmly planted in the wild, and within only a few generations can easily revert back to the independent way of life that was the exclusive preserve of their predecessors some 10,000 years ago. Cats are astonishingly flexible, and given the right environment they can adapt to a life of domesticity with their owners—but to continue do so, they will increasingly need our help. If we’re to live in harmony with our cats, Bradshaw explains, we first need to understand their inherited quirks: understanding their body language, keeping their environments—however small—sufficiently interesting, and becoming more proactive in managing both their natural hunting instincts and their relationships with other cats.A must-read for any cat lover, Cat Sense offers humane, penetrating insights about the domestic cat that challenge our most basic assumptions and promise to dramatically improve our pets’ lives—and ours.

    The universe is all about extremes, and in this engaging and thought-provoking book, astronomer Bryan Gaensler gives a whirlwind tour of the galaxies, with an emphasis on its fastest, hottest, heaviest, brightest, oldest, densest, and even loudest elements. From supernova explosions a billion times brighter than the sun to an asteroid the size of a beach ball, Extreme Cosmos offers a fascinating, fresh, and informed perspective of the remarkable richness of the universe, and the incredible physics that modern astronomy has revealed.

    The book takes us from the Greeks' earliest scientific observations through Einstein and beyond in an inspiring celebration of human curiosity. It ends with the quest for the Higgs boson, nicknamed the God Particle, which scientists hypothesize will help unlock the last secrets of the subatomic universe. With a new preface by Lederman, The God Particle will leave you marveling at our continuing pursuit of the infinitesimal.