Over the two hundred-plus years that separate us, these connections are often surprising and always fascinating. Burke turns the signers from historical icons into flesh-and-blood people: Some were shady financial manipulators, most were masterful political operators, a few were good human beings, and some were great men. The network that links them to us is also peopled by all sorts, from spies and assassins to lovers and adulterers, inventors and artists. The ties may be more direct for some of us than others, but we are all linked in some way to these founders of our nation. If you enjoyed Martin Sheen as the president on television's The West Wing, then you're connected to founder Josiah Bartlett. The connection from signer Bartlett to Sheen includes John Paul Jones; Judge William Cooper, father of James Fenimore; Sir Thomas Brisbane, governor of New South Wales; an incestuous astronomer; an itinerant math teacher; early inventors of television; and pioneering TV personality Bishop Fulton J. Sheen, the inspiration for Ramon Estevez's screen name, Martin Sheen.

    His previous books, including the Pulitzer Prize finalist The Blank Slate, have catapulted him into the limelight as one of today's most important and popular science writers. Now, in The Stuff of Thought, Pinker marries two of the subjects he knows best: language and human nature. The result is a fascinating look at how our words explain our nature. What does swearing reveal about our emotions? Why does innuendo disclose something about relationships? Pinker reveals how our use of prepositions and tenses taps into peculiarly human concepts of space and time, and how our nouns and verbs speak to our notions of matter. Even the names we give our babies have important things to say about our relations to our children and to society. With his signature wit and style, Pinker takes on scientific questions like whether language affects thought, as well as forays into everyday life: why is bulk e-mail called spam and how do romantic comedies get such mileage out of the ambiguities of dating? The Stuff of Thought is a brilliantly crafted and highly readable work that will appeal to fans of readers of everything from The Selfish Gene and Blink to Eats, Shoots & Leaves.

      In 1875, tuberculosis was the deadliest disease in the world, accountable for a third of all deaths. A diagnosis of TB—often called consumption—was a death sentence. Then, in a triumph of medical science, a German doctor named Robert Koch deployed an unprecedented scientific rigor to discover the bacteria that caused TB. Koch soon embarked on a remedy—a remedy that would be his undoing.   When Koch announced his cure for consumption, Arthur Conan Doyle, then a small-town doctor in England and sometime writer, went to Berlin to cover the event. Touring the ward of reportedly cured patients, he was horrified. Koch’s "remedy" was either sloppy science or outright fraud.   But to a world desperate for relief, Koch’s remedy wasn’t so easily dismissed. As Europe’s consumptives descended upon Berlin, Koch urgently tried to prove his case. Conan Doyle, meanwhile, returned to England determined to abandon medicine in favor of writing. In particular, he turned to a character inspired by the very scientific methods that Koch had formulated: Sherlock Holmes.   Capturing the moment when mystery and magic began to yield to science, The Remedy chronicles the stunning story of how the germ theory of disease became a true fact, how two men of ambition were emboldened to reach for something more, and how scientific discoveries evolve into social truths.

    The volcano's massive sulfate dust cloud enveloped the Earth, cooling temperatures and disrupting major weather systems for more than three years. Communities worldwide endured famine, disease, and civil unrest on a catastrophic scale.Here, Gillen D'Arcy Wood traces Tambora's global and historical reach: how the volcano's three-year climate change regime initiated the first worldwide cholera pandemic, expanded opium markets in China, and plunged the United States into its first economic depression. Bringing the history of this planetary emergency to life, Tambora sheds light on the fragile interdependence of climate and human societies to offer a cautionary tale about the potential tragic impacts of drastic climate change in our own century.

    Here, he discovers the enduring power of the four classical elements - fire, water, air, and earth - to transform the stuff of nature into delicious things to eat and drink. Apprenticing himself to a succession of culinary masters, Pollan learns how to grill with fire, cook with liquid, bake bread, and ferment everything from cheese to beer. In the course of his journey, he discovers that the cook occupies a special place in the world, standing squarely between nature and culture. Both realms are transformed by cooking, and so, in the process, is the cook.Each section of Cooked tracks Pollan's effort to master a single classic recipe using one of the four elements. A North Carolina barbecue pit master tutors him in the primal magic of fire; a Chez Panisse-trained cook schools him in the art of braising; a celebrated baker teaches him how air transforms grain and water into a fragrant loaf of bread; and finally, several mad-genius "fermentos" (a tribe that includes brewers, cheese makers, and all kinds of picklers) reveal how fungi and bacteria can perform the most amazing alchemies of all. The listener learns alongside Pollan, but the lessons move beyond the practical to become an investigation of how cooking involves us in a web of social and ecological relationships: with plants and animals, the soil, farmers, our history and culture, and, of course, the people our cooking nourishes and delights. Cooking, above all, connects us.The effects of not cooking are similarly far reaching. Relying upon corporations to process our food means we consume huge quantities of fat, sugar, and salt; disrupt an essential link to the natural world; and weaken our relationships with family and friends. In fact, Cooked argues, taking back control of cooking may be the single most important step anyone can take to help make the American food system healthier and more sustainable. Reclaiming cooking as an act of enjoyment and self-reliance, learning to perform the magic of these everyday transformations, opens the door to a more nourishing life.

    Although her mother won't stop pressuring Ara to think about eligible young men and marriage, she has vowed that she will never marry. But when she unexpectedly meets a handsome Duke, he ignites a fire inside her, in ways that she could never have imagined. Why is she suddenly thinking that marriage to the Duke might be just what she desires when she has always been so vehemently opposed to it?In London, Lord Miles Comerford, younger brother to the Duke of Lancaster, places a bet with his brother. He will pretend to be the Duke, to prove that all the young ladies are only attracted to his brother's title. Even though he has vowed that he will never let another woman touch his heart again, it is a good wager, and Miles is confident that he shall collect the winnings. But when the first young lady he meets is the delectable and fiery Miss Arabella Nott, he finds that the bet might be more of a liability than an asset...When his heart beats faster every time he thinks about her, will he be able to risk it all and reveal the truth?No cheating, no cliffhangers, and a guaranteed happily ever after.

    The 1960–70s image, bolstered by Tom Wolfe and Big Wednesday, was one of mild outlaws―tanned boys refusing to grow up, spending their days drinking beer and smoking joints on the beach in between mindless hours in the water.But in the 1980s, as surf brands morphed into multibillion-dollar companies, the derelict portrait began to harm business. The external surf image became Kelly Slater and Laird Hamilton, beacons of health, vitality, bravery, and clean-living.Internally, though, surfing had moved on from booze and weed to its heart’s true home, its soul’s twin flame: cocaine. The rise of cocaine in American popular culture as the choice of rich, white elites was matched, then quadrupled, within surf culture. The parties got wilder, the nights stretched longer, the stories became more ridiculously unbelievable. And there has been no stopping, no dip in passion.It is a forbidden love, and few, if any, outside the surf world know about this particular rhapsody. Drug use is kept very well-hidden, even from insiders, but evidence of its psychosis rears its head from time to time in the form of overdoses, bar fights, surf contests, murders, and cover-ups.Cocaine + Surfing draws back the curtain on a hopped-up, sometimes-sexy, sometimes-deadly relationship and uses cocaine as the vehicle to expose and explain the utterly absurd surf industry to outsiders.

    As huge as the Pantheon of Rome and as heavy as the Statue of Liberty, this magnificent instrument is so precisely built that its seventeen-foot mirror was hand-polished to a tolerance of 2/1,000,000 of an inch. The telescope's construction drove some to the brink of madness, made others fearful that mortals might glimpse heaven, and transfixed an entire nation. Ronald Florence weaves into his account of the creation of "the perfect machine" a stirring chronicle of the birth of Big Science and a poignant rendering of an America mired in the depression yet reaching for the stars.

    This discovery dramatically reshaped how humans understood their place in the cosmos, and once and for all laid to rest the idea that the Milky Way galaxy was alone in the universe. Six years later, continuing research by Hubble and others forced Albert Einstein to renounce his own cosmic model and finally accept the astonishing fact that the universe was not immobile but instead expanding. The fascinating story of these interwoven discoveries includes battles of will, clever insights, and wrong turns made by the early investigators in this great twentieth-century pursuit. It is a story of science in the making that shows how these discoveries were not the work of a lone genius but the combined efforts of many talented scientists and researchers toiling away behind the scenes. The intriguing characters include Henrietta Leavitt, who discovered the means to measure the vast dimensions of the cosmos . . . Vesto Slipher, the first and unheralded discoverer of the universe’s expansion . . . Georges Lemaître, the Jesuit priest who correctly interpreted Einstein’s theories in relation to the universe . . . Milton Humason, who, with only an eighth-grade education, became a world-renowned expert on galaxy motions . . . and Harlow Shapley, Hubble’s nemesis, whose flawed vision of the universe delayed the discovery of its true nature and startling size for more than a decade.Here is a watershed moment in the history of astronomy, brought about by the exceptional combination of human curiosity, intelligence, and enterprise, and vividly told by acclaimed science writer Marcia Bartusiak.

    With the assistance of a co-author, this popular student textbook has now been updated to include techniques such as membrane chromatography, aqueous phase partitioning, engineering recombinant proteins for purification and due to the rapid advances in bioinformatics/proteomics a discussion of the analysis of complex protein mixtures by 2D-electrophoresis and RPHPLC prior to sequencing by mass spectroscopy. Written with the student firmly in mind, no previous knowledge of biochemistry, and little of chemistry, is assumed. It is intended to provide an introduction to enzymology, and a balanced account of all the various theoretical and applied aspects of the subject which are likely to be included in a course.

    From the minds of the world's leading physicists there flowed a river of ideas that would transport mankind to the pinnacle of wonderment and to the very depths of human despair. This was a century that began with the certainties of absolute knowledge and ended with the knowledge of absolute uncertainty. It was a century in which physicists developed weapons with the capacity to destroy our reality, whilst at the same time denying us the possibility that we can ever properly comprehend it.Almost everything we think we know about the nature of our world comes from one theory of physics. This theory was discovered and refined in the first thirty years of the twentieth century and went on to become quite simply the most successful theory of physics ever devised. Its concepts underpin much of the twenty-first century technology that we have learned to take for granted. But its success has come at a price, for it has at the same time completely undermined our ability to make sense of the world at the level of its most fundamental constituents.Rejecting the fundamental elements of uncertainty and chance implied by quantum theory, Albert Einstein once famously declared that 'God does not play dice'. Niels Bohr claimed that anybody who is not shocked by the theory has not understood it. The charismatic American physicist Richard Feynman went further: he claimed that nobody understands it.This is quantum theory, and this book tells its story.Jim Baggott presents a celebration of this wonderful yet wholly disconcerting theory, with a history told in forty episodes -- significant moments of truth or turning points in the theory's development. From its birth in the porcelain furnaces used to study black body radiation in 1900, to the promise of stimulating new quantum phenomena to be revealed by CERN's Large Hadron Collider over a hundred years later, this is the extraordinary story of the quantum world.Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.

    From such twenty-first-century forces, we have seen declines in previous global health gains, with sharp increases in vaccine-preventable and neglected diseases on the Arabian Peninsula, in Venezuela, in parts of Africa, and even on the Gulf Coast of the United States. In Preventing the Next Pandemic, international vaccine scientist and tropical disease and coronavirus expert Peter J. Hotez, MD, PhD, argues that we can--and must--rely on vaccine diplomacy to address this new world order in disease and global health. Detailing his years in the lab developing new vaccines, Hotez also recounts his travels around the world to shape vaccine partnerships with people in countries both rich and poor in an attempt to head off major health problems. Building on the legacy of Dr. Albert Sabin, who developed the oral polio vaccine with Soviet scientists at the height of the Cold War, he explains how he is still working to refresh and redirect vaccine diplomacy toward neglected and newly emerging diseases.Hotez reveals how--during his Obama-era tenure as the US Science Envoy for the Middle East and North Africa, which coincided with both the rise in these geopolitical forces and climate change--he witnessed tropical infectious diseases and established vaccine partnerships that may still combat them up close. He explores why, since 2015, we've seen the decline of global cooperation and cohesion, to the detriment of those programs that are meant to benefit the most vulnerable people in the world. Unfortunately, Hotez asserts, these negative global events kick off a never-ending loop. Problems in a country may lead to disease outbreaks, but those outbreaks can lead to further problems--such as the impact of coronavirus on China's society and economy, which has been felt around the globe. Zeroing in on the sociopolitical and environmental factors that drive our most controversial and pressing global health concerns, Hotez proposes historically proven methods to soothe fraught international relations while preparing us for a safer, healthier future. He hammers home the importance of public engagement to communicate the urgency of embracing science during troubled times.Touching on a range of disease, from leishmaniasis, schistosomiasis, and Middle East Respiratory Syndrome (MERS) to COVID-19, Preventing the Next Pandemic has always been a timely goal, but it will be even more important in a COVID and post-COVID world.

    But getting here has not been a simple story of selfless men working tirelessly in the pursuit of medical advancement. Instead it's a bloodstained tale of blunders, arrogance, mishap and murder. In trying to keep us alive, surgeons have all too often killed us off, and life-saving solutions have often come from the most surprising places. Accompanying a major BBC series, "Blood and Guts" is an incredible story of stolen corpses, medical fraud, lobotomized patients - and every now and then courageous advances that have saved the lives of millions around the world. You may think twice before going under the knife.

    Such anomalous evidence, contradicting Darwinian evolution, catalyzed a global inquiry: “If we did not evolve from apes then where did we come from?”Human Devolution is Michael A. Cremo’s definitive answer to that question: “We did not evolve up from matter; instead we devolved, or came down, from the realm of pure consciousness, spirit.” Basing his response on modern science and the world’s great wisdom traditions, including the Vedic philosophy of ancient India, Cremo proposes that before we ask the question, “Where did human beings come from?” we should first contemplate, “What is a human being?” For much of the twentieth century, most scientists assumed that a human being is simply a combination of ordinary physical elements. In Human Devolution, Cremo says it is more reasonable to assume that a human being is a combination of three distinct substances: matter, mind, and consciousness (or spirit). He shows how solid scientific evidence for a subtle mind element and a conscious self that can exist apart from the body has been systematically eliminated from mainstream science by a process of “knowledge filtration.”

    Radiometric dating of nearby rocks indicated the skeleton, classified as Ardipithecus ramidus, was 4.4 million years old, more than a million years older than "Lucy," then the oldest known human ancestor. The findings challenged many assumptions about human evolution--how we started walking upright, how we evolved our nimble hands, and, most significantly, whether we were descended from an ancestor that resembled today's chimpanzee--and repudiated a half-century of paleoanthropological orthodoxy.Fossil Men is the first full-length exploration of Ardi, the fossil men who found her, and her impact on what we know about the origins of the human species. It is a scientific detective story played out in anatomy and the natural history of the human body. Kermit Pattison brings into focus a cast of eccentric, obsessive scientists, including one of the world's greatest fossil hunters, Tim White--an exacting and unforgiving fossil hunter whose virtuoso skills in the field were matched only by his propensity for making enemies; Gen Suwa, a Japanese savant who sometimes didn't bother going home at night to devote more hours to science; Owen Lovejoy, a onetime creationist-turned-paleoanthropologist; Berhane Asfaw, who survived imprisonment and torture to become Ethiopia's most senior paleoanthropologist and who fought for African scientists to gain equal footing in the study of human origins; and the Leakeys, for decades the most famous family in paloanthropology.An intriguing tale of scientific discovery, obsession and rivalry that moves from the sun-baked desert of Africa and a nation caught in a brutal civil war, to modern high-tech labs and academic lecture halls, Fossil Men is popular science at its best, and a must read for fans of Jared Diamond, Richard Dawkins, and Edward O. Wilson.