Ultimately, the history of these challenges tells the story of humanity itself. Through an unforgettable cast of characters, Pulitzer Prize-winning author Richard Rhodes explains how wood gave way to coal and coal made room for oil, as we now turn to natural gas, nuclear power, and renewable energy. Rhodes looks back on five centuries of progress, through such influential figures as Queen Elizabeth I, King James I, Benjamin Franklin, Herman Melville, John D. Rockefeller, and Henry Ford. In Energy, Rhodes highlights the successes and failures that led to each breakthrough in energy production; from animal and waterpower to the steam engine, from internal-combustion to the electric motor. He addresses how we learned from such challenges, mastered their transitions, and capitalized on their opportunities. Rhodes also looks at the current energy landscape, with a focus on how wind energy is competing for dominance with cast supplies of coal and natural gas. He also addresses the specter of global warming, and a population hurtling towards ten billion by 2100. Human beings have confronted the problem of how to draw life from raw material since the beginning of time. Each invention, each discovery, each adaptation brought further challenges, and through such transformations, we arrived at where we are today. In Rhodes’s singular style, Energy details how this knowledge of our history can inform our way tomorrow.

    Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    It’s not just that the grid has grown old and is now in dire need of basic repair. Today, as we invest great hope in new energy sources--solar, wind, and other alternatives--the grid is what stands most firmly in the way of a brighter energy future. If we hope to realize this future, we need to re-imagine the grid according to twenty-first-century values. It’s a project which forces visionaries to work with bureaucrats, legislators with storm-flattened communities, moneymen with hippies, and the left with the right. And though it might not yet be obvious, this revolution is already well under way.Cultural anthropologist Gretchen Bakke unveils the many facets of America's energy infrastructure, its most dynamic moments and its most stable ones, and its essential role in personal and national life. The grid, she argues, is an essentially American artifact, one which developed with us: a product of bold expansion, the occasional foolhardy vision, some genius technologies, and constant improvisation. Most of all, her focus is on how Americans are changing the grid right now, sometimes with gumption and big dreams and sometimes with legislation or the brandishing of guns.The Grid tells--entertainingly, perceptively--the story of what has been called “the largest machine in the world”: its fascinating history, its problematic present, and its potential role in a brighter, cleaner future.

    We own radiation-emitting phones, regularly get diagnostic x-rays, such as mammograms, and submit to full-body security scans at airports. We worry and debate about the proliferation of nuclear weapons and the safety of nuclear power plants. But how much do we really know about radiation? And what are its actual dangers? An accessible blend of narrative history and science, Strange Glow describes mankind's extraordinary, thorny relationship with radiation, including the hard-won lessons of how radiation helps and harms our health. Timothy Jorgensen explores how our knowledge of and experiences with radiation in the last century can lead us to smarter personal decisions about radiation exposures today.Jorgensen introduces key figures in the story of radiation--from Wilhelm Roentgen, the discoverer of x-rays, and pioneering radioactivity researchers Marie and Pierre Curie, to Thomas Edison and the victims of the recent Fukushima Daiichi nuclear power plant accident. Tracing the most important events in the evolution of radiation, Jorgensen explains exactly what radiation is, how it produces certain health consequences, and how we can protect ourselves from harm. He also considers a range of practical scenarios such as the risks of radon in our basements, radiation levels in the fish we eat, questions about cell-phone use, and radiation's link to cancer. Jorgensen empowers us to make informed choices while offering a clearer understanding of broader societal issues.Investigating radiation's benefits and risks, Strange Glow takes a remarkable look at how, for better or worse, radiation has transformed our society.

    The media seized hold of the story and, in the process, helped to launch one of the most devastating health scares ever. In the years to come Wakefield would be revealed as a profiteer in league with class-action lawyers, and he would eventually lose his medical license. Meanwhile, one study after another failed to find any link between childhood vaccines and autism. Yet the myth that vaccines somehow cause developmental disorders lives on. Despite the lack of corroborating evidence, it has been popularized by media personalities such as Oprah Winfrey and Jenny McCarthy and legitimized by journalists who claim that they are just being fair to “both sides” of an issue about which there is little debate. Meanwhile, millions of dollars have been diverted from potential breakthroughs in autism research; families have spent their savings on ineffective “miracle cures"; and declining vaccination rates have led to outbreaks of deadly illnesses like Hib, measles, and whooping cough. Most tragic of all is the increasing number of children dying from vaccine-preventable diseases. In The Panic Virus Seth Mnookin draws on interviews with parents, public-health advocates, scientists, and anti-vaccine activists to tackle a fundamental question: How do we decide what the truth is? The fascinating answer helps explain everything from the persistence of conspiracy theories about 9/11 to the appeal of talk-show hosts who demand that President Obama “prove” he was born in America. The Panic Virus is the ultimate cautionary tale for our time.

    It has built on itself for centuries, becoming vast and increasingly specialized. Most of us are ignorant about the fundamental principles of the civilization that supports us, happily utilizing the latest—or even the most basic—technology without having the slightest idea of why it works or how it came to be. If you had to go back to absolute basics, like some sort of postcataclysmic Robinson Crusoe, would you know how to re-create an internal combustion engine, put together a microscope, get metals out of rock, accurately tell time, weave fibers into clothing, or even how to produce food for yourself? Regarded as one of the brightest young scientists of his generation, Lewis Dartnell proposes that the key to preserving civilization in an apocalyptic scenario is to provide a quickstart guide, adapted to cataclysmic circumstances. The Knowledge describes many of the modern technologies we employ, but first it explains the fundamentals upon which they are built. Every piece of technology rests on an enormous support network of other technologies, all interlinked and mutually dependent. You can’t hope to build a radio, for example, without understanding how to acquire the raw materials it requires, as well as generate the electricity needed to run it. But Dartnell doesn’t just provide specific information for starting over; he also reveals the greatest invention of them all—the phenomenal knowledge-generating machine that is the scientific method itself. This would allow survivors to learn technological advances not explicitly explored in The Knowledge as well as things we have yet to discover. The Knowledge is a brilliantly original guide to the fundamentals of science and how it built our modern world as well as a thought experiment about the very idea of scientific knowledge itself.

    As Brian Fagan shows, every human society has been shaped by its relationship toour most essential resource. Fagan's sweeping narrative moves across the world, from ancient Greece and Rome, whose mighty aqueducts still supply modern cities, to China, where emperors marshaled armies of laborers in a centuries-long struggle to tame powerful rivers. He sets out three ages of water: In the first age, lasting thousands of years, water was scarce or at best unpredictable-so precious that it became sacred in almost every culture. By the time of the Industrial Revolution, human ingenuity had made water flow even in the most arid landscapes.This was the second age: water was no longer a mystical force to be worshipped and husbanded, but a commodity to be exploited. The American desert glittered with swimming pools- with little regard for sustainability. Today, we are entering a third age of water: As the earth's population approaches nine billion and ancient aquifers run dry,we will have to learn once again to show humility, even reverence, for this vital liquid. To solve the water crises of the future, we may need to adapt the water ethos of our ancestors.

    Edward O. Wilson eloquently describes how the species of the world became diverse and why that diversity is threatened today as never before. A great spasm of extinction — the disappearance of whole species — is occurring now, caused this time entirely by humans. Unlike the deterioration of the physical environment, which can be halted, the loss of biodiversity is a far more complex problem — and it is irreversible. Defining a new environmental ethic, Wilson explains why we must rescue whole ecosystems, not only individual species. He calls for an end to conservation versus development arguments, and he outlines the massive shift in priorities needed to address this challenge. No writer, no scientist, is more qualified than Edward O. Wilson to describe, as he does here, the grandeur of evolution and what is at stake. "Engaging and nontechnical prose. . . . Prodigious erudition. . . . Original and fascinating insights." — John Terborgh, New York Review of Books, front page review "Eloquent. . . . A profound and enduring contribution." — Alan Burdick, Audubon

    If America could send a man to the moon, shouldn’t the best surgeons in the world be able to build an artificial heart? In Ticker, Texas Monthly executive editor and two time National Magazine Award winner Mimi Swartz shows just how complex and difficult it can be to replicate one of nature’s greatest creations. Part investigative journalism, part medical mystery, Ticker is a dazzling story of modern innovation, recounting fifty years of false starts, abysmal failures and miraculous triumphs, as experienced by one the world’s foremost heart surgeons, O.H. “Bud” Frazier, who has given his life to saving the un-savable. His journey takes him from a small town in west Texas to one of the country’s most prestigious medical institutions, The Texas Heart Institute, from the halls of Congress to the animal laboratories where calves are fitted with new heart designs. The roadblocks to success —medical setbacks, technological shortcomings, government regulations – are immense. Still, Bud and his associates persist, finding inspiration in the unlikeliest of places. A field beside the Nile irrigated by an Archimedes screw. A hardware store in Brisbane, Australia. A seedy bar on the wrong side of Houston. Until post WWII, heart surgery did not exist. Ticker provides a riveting history of the pioneers who gave their all to the courageous process of cutting into the only organ humans cannot live without. Heart surgeons Michael DeBakey and Denton Cooley, whose feud dominated the dramatic beginnings of heart surgery. Christian Barnaard, who changed the world overnight by performing the first heart transplant. Inventor Robert Jarvik, whose artificial heart made patient Barney Clark a worldwide symbol of both the brilliant promise of technology and the devastating evils of experimentation run amuck. Rich in supporting players, Ticker introduces us to Bud’s brilliant colleagues in his quixotic quest to develop an artificial heart: Billy Cohn, the heart surgeon and inventor who devotes his spare time to the pursuit of magic and music; Daniel Timms, the Brisbane biomedical engineer whose design of a lightweight, pulseless heart with but a single moving part offers a new way forward. And, as government money dries up, the unlikeliest of backers, Houston’s furniture king, Mattress Mack. In a sweeping narrative of one man’s obsession, Swartz raises some of the hardest questions of the human condition. What are the tradeoffs of medical progress? What is the cost, in suffering and resources, of offering patients a few more months, or years of life? Must science do harm to do good? Ticker takes us on an unforgettable journey into the power and mystery of the human heart.

    This is just as well, according to Mark Lynas in Nuclear 2.0, because nuclear energy is essential to avoid catastrophic global warming. Using the latest world energy statistics Lynas shows that with wind and solar still at only about 1 percent of global primary energy, asking renewables to deliver all the world’s power is “dangerously delusional”. Moreover, there is no possibility of using less energy, he reminds us, when the developing world is fast extricating itself from poverty and adding the equivalent of a new Brazil to global electricity consumption each year. The anti-nuclear movement of the 1970s and 80s succeeded only in making the world more dependent on fossil fuels, he shows: its history is “not lit by sunshine, but shrouded in coal smoke”. Instead of making the same mistake again, all those who want to see a low-carbon future need to join forces, he insists, concluding the book with an ambitious proposal for an Apollo Program-style combined investment in wind, solar and nuclear power. Mark Lynas is an environmental writer and campaigner. His previous books have drawn attention to the perils of global warming, and he was Climate Advisor to the President of the Maldives from 2009-2011. He is a Visiting Research Associate at Oxford University’s School of Geography and the Environment, and a member of the World Economic Forum’s Global Agenda Council on Emerging Technologies. He recently featured in the movie documentary Pandora’s Promise, which inspired the writing of this book.

    Supernatural magic is what our ancestors used in order to explain the world before they developed the scientific method. The ancient Egyptians explained the night by suggesting the goddess Nut swallowed the sun. The Vikings believed a rainbow was the gods’ bridge to earth. The Japanese used to explain earthquakes by conjuring a gigantic catfish that carried the world on its back—earthquakes occurred each time it flipped its tail. These are magical, extraordinary tales. But there is another kind of magic, and it lies in the exhilaration of discovering the real answers to these questions. It is the magic of reality—science.Packed with clever thought experiments, dazzling illustrations and jaw-dropping facts, The Magic of Reality explains a stunningly wide range of natural phenomena. What is stuff made of? How old is the universe? Why do the continents look like disconnected pieces of a puzzle? What causes tsunamis? Why are there so many kinds of plants and animals? Who was the first man, or woman? This is a page-turning, graphic detective story that not only mines all the sciences for its clues but primes the reader to think like a scientist as well.Richard Dawkins, the world’s most famous evolutionary biologist and one of science education’s most passionate advocates, has spent his career elucidating the wonders of science for adult readers. But now, in a dramatic departure, he has teamed up with acclaimed artist Dave McKean and used his unrivaled explanatory powers to share the magic of science with readers of all ages. This is a treasure trove for anyone who has ever wondered how the world works. Dawkins and McKean have created an illustrated guide to the secrets of our world—and the universe beyond—that will entertain and inform for years to come.

    Many people think of microbes as germs to be eradicated, but those that live with us—the microbiome—build our bodies, protect our health, shape our identities, and grant us incredible abilities. In this astonishing book, Ed Yong takes us on a grand tour through our microbial partners, and introduces us to the scientists on the front lines of discovery. Yong, whose humor is as evident as his erudition, prompts us to look at ourselves and our animal companions in a new light—less as individuals and more as the interconnected, interdependent multitudes we assuredly are. The microbes in our bodies are part of our immune systems and protect us from disease. Those in cows and termites digest the plants they eat. In the deep oceans, mysterious creatures without mouths or guts depend on microbes for all their energy. Bacteria provide squids with invisibility cloaks, help beetles to bring down forests, and allow worms to cause diseases that afflict millions of people. I Contain Multitudes is the story of these extraordinary partnerships, between the creatures we are familiar with and those we are not. It reveals how we humans are disrupting these partnerships and how we might manipulate them for our own good. It will change both our view of nature and our sense of where we belong in it.

    Philosophers, artists and poets have long explored its meaning while scientists have found that its structure is different from the simple intuition we have of it. From Boltzmann to quantum theory, from Einstein to loop quantum gravity, our understanding of time has been undergoing radical transformations. Time flows at different speeds in different places, the past and the future differ far less than we might think and the very notion of the present evaporates in the vast universe. With his extraordinary charm and sense of wonder, bringing together science, philosophy and art, Carlo Rovelli unravels this mystery, inviting us to imagine a world where time is in us and we are not in time.

    But its toxic effects on society are plain to see—feeding white nationalism, fueling hatred, endangering lives, and corroding our discourse on everything from sports to intelligence. Even well-intentioned people repeat stereotypes based on “science,” because cutting-edge genetics are hard to grasp—and all too easy to distort. Paradoxically, these misconceptions are multiplying even as scientists make unprecedented discoveries in human genetics—findings that, when accurately understood, are powerful evidence against racism. We’ve never had clearer answers about who we are and where we come from, but this knowledge is sorely needed in our casual conversations about race.How to Argue With a Racist emphatically dismantles outdated notions of race by illuminating what modern genetics actually can and can’t tell us about human difference. We now know that the racial categories still dividing us do not align with observable genetic differences. In fact, our differences are so minute that, most of all, they serve as evidence of our shared humanity.

    In his own lifetime, Suzuki has witnessed an explosion of scientific knowledge as well as a huge change in our relationship with the planet-a tripling of the world's population, a greatly increased ecological footprint through the global economy, and a huge growth in technological capacity. These changes have had a dire effect on Earth's ecosystems and consequently on our own well-being. To deal with this crisis, we must realize that the laws of nature have priority over the forces of economics and that the planet simply cannot sustain unfettered growth. We must also recognize the limits of scientific reductionism and the need to adopt a more holistic point of view. Perhaps most important, we must join together as a single species to respond to the problems we face. Suzuki ends by saying that change begins with each of us; all it takes is imagination and a faith in the inherent generosity of Mother Earth.Published in partnership with the David Suzuki Foundation. Also available in hardcover.