From distressed small communities in Central Appalachia to wealthy suburbs; from disparate cities to once-idyllic farm towns; it's a heartbreaking trajectory that illustrates how this national crisis has persisted for so long and become so firmly entrenched. Beginning with a single dealer who lands in a small Virginia town and sets about turning high school football stars into heroin overdose statistics, Macy endeavors to answer a grieving mother's question-why her only son died-and comes away with a harrowing story of greed and need. From the introduction of OxyContin in 1996, Macy parses how America embraced a medical culture where overtreatment with painkillers became the norm. In some of the same distressed communities featured in her bestselling book Factory Man, the unemployed use painkillers both to numb the pain of joblessness and pay their bills, while privileged teens trade pills in cul-de-sacs, and even high school standouts fall prey to prostitution, jail, and death.Through unsparing, yet deeply human portraits of the families and first responders struggling to ameliorate this epidemic, each facet of the crisis comes into focus. In these politically fragmented times, Beth Macy shows, astonishingly, that the only thing that unites Americans across geographic and class lines is opioid drug abuse. But in a country unable to provide basic healthcare for all, Macy still finds reason to hope-and signs of the spirit and tenacity necessary in those facing addiction to build a better future for themselves and their families.

    But Cullen was no mercy killer, nor was he a simple monster. He was a favorite son, husband, beloved father, best friend, and celebrated caregiver. Implicated in the deaths of as many as 300 patients, he was also perhaps the most prolific serial killer in American history.Cullen's murderous career in the world's most trusted profession spanned sixteen years and nine hospitals across New Jersey and Pennsylvania. When, in March of 2006, Charles Cullen was marched from his final sentencing in an Allentown, Pennsylvania, courthouse into a waiting police van, it seemed certain that the chilling secrets of his life, career, and capture would disappear with him. Now, in a riveting piece of investigative journalism nearly ten years in the making, journalist Charles Graeber presents the whole story for the first time. Based on hundreds of pages of previously unseen police records, interviews, wire-tap recordings and videotapes, as well as exclusive jailhouse conversations with Cullen himself and the confidential informant who helped bring him down, THE GOOD NURSE weaves an urgent, terrifying tale of murder, friendship, and betrayal.Graeber's portrait of Cullen depicts a surprisingly intelligent and complicated young man whose promising career was overwhelmed by his compulsion to kill, and whose shy demeanor masked a twisted interior life hidden even to his family and friends. Were it not for the hardboiled, unrelenting work of two former Newark homicide detectives racing to put together the pieces of Cullen's professional past, and a fellow nurse willing to put everything at risk, including her job and the safety of her children, there's no telling how many more lives could have been lost.In the tradition of In Cold Blood, THE GOOD NURSE does more than chronicle Cullen's deadly career and the breathless efforts to stop him; it paints an incredibly vivid portrait of madness and offers a penetrating look inside America's medical system. Harrowing and irresistibly paced, this book will make you look at medicine, hospitals, and the people who work in them, in an entirely different way.

    The Sackler name adorns the walls of many storied institutions: Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing OxyContin, a blockbuster painkiller that was a catalyst for the opioid crisis.Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

    Based on more than two hundred personal interviews with both current and former Scientologists--both famous and less well known--and years of archival research, Lawrence Wright uses his extraordinary investigative skills to uncover for us the inner workings of the Church of Scientology: its origins in the imagination of science-fiction writer L. Ron Hubbard; its struggles to find acceptance as a legitimate (and legally acknowledged) religion; its vast, secret campaign to infiltrate the U.S. government; and its dramatic efforts to grow and prevail after the death of Hubbard.At the book's center, two men whom Wright brings vividly to life, showing how they have made Scientology what it is today: The darkly brilliant L. Ron Hubbard--whose restless, expansive mind invented a new religion tailor-made to prosper in the spiritually troubled post-World War II era. And his successor, David Miscavige--tough and driven, with the unenviable task of preserving the church in the face of ongoing scandals and continual legal assaults.We learn about Scientology's esoteric cosmology; about the auditing process that determines an inductee's state of being; about the Bridge to Total Freedom, through which members gain eternal life. We see the ways in which the church pursues celebrities, such as Tom Cruise and John Travolta, and how young idealists who joined the Sea Org, the church's clergy, whose members often enter as children, signing up with a billion-year contract and working with little pay in poor conditions. We meet men and women "disconnected" from friends and family by the church's policy of shunning critical voices. And we discover, through many firsthand stories, the violence that has long permeated the inner sanctum of the church.In Going Clear, Wright examines what fundamentally makes a religion a religion, and whether Scientology is, in fact, deserving of the constitutional protections achieved in its victory over the IRS. Employing all his exceptional journalistic skills of observations, understanding, and synthesis, and his ability to shape a story into a compelling narrative, Lawrence Wright has given us an evenhanded yet keenly incisive book that goes far beyond an immediate exposé and uncovers the very essence of what makes Scientology the institution it is.

    As we reel from the latest horror . . . " So begins a new epilogue, illustrating how Columbine became the template for nearly two decades of "spectacle murders." It is a false script, seized upon by a generation of new killers. In the wake of Newtown, Aurora, and Virginia Tech, the imperative to understand the crime that sparked this plague grows more urgent every year.What really happened April 20, 1999? The horror left an indelible stamp on the American psyche, but most of what we "know" is wrong. It wasn't about jocks, Goths, or the Trench Coat Mafia. Dave Cullen was one of the first reporters on scene, and spent ten years on this book-widely recognized as the definitive account. With a keen investigative eye and psychological acumen, he draws on mountains of evidence, insight from the world's leading forensic psychologists, and the killers' own words and drawings-several reproduced in a new appendix. Cullen paints raw portraits of two polar opposite killers. They contrast starkly with the flashes of resilience and redemption among the survivors.

    From body lotion to tonic water, the popular new element shines bright in the otherwise dark years of the First World War.Meanwhile, hundreds of girls toil amidst the glowing dust of the radium-dial factories. The glittering chemical covers their bodies from head to toe; they light up the night like industrious fireflies. With such a coveted job, these "shining girls" are the luckiest alive—until they begin to fall mysteriously ill.But the factories that once offered golden opportunities are now ignoring all claims of the gruesome side effects, and the women's cries of corruption. And as the fatal poison of the radium takes hold, the brave shining girls find themselves embroiled in one of the biggest scandals of America's early 20th century, and in a groundbreaking battle for workers' rights that will echo for centuries to come.Written with a sparkling voice and breakneck pace, The Radium Girls fully illuminates the inspiring young women exposed to the "wonder" substance of radium, and their awe-inspiring strength in the face of almost impossible circumstances. Their courage and tenacity led to life-changing regulations, research into nuclear bombing, and ultimately saved hundreds of thousands of lives.

    After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins—aspiration, hard work, upward mobility, domestic harmony—and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

    But in the inevitable condition of aging and death, the goals of medicine seem too frequently to run counter to the interest of the human spirit. Nursing homes, preoccupied with safety, pin patients into railed beds and wheelchairs. Hospitals isolate the dying, checking for vital signs long after the goals of cure have become moot. Doctors, committed to extending life, continue to carry out devastating procedures that in the end extend suffering.Gawande, a practicing surgeon, addresses his profession's ultimate limitation, arguing that quality of life is the desired goal for patients and families. Gawande offers examples of freer, more socially fulfilling models for assisting the infirm and dependent elderly, and he explores the varieties of hospice care to demonstrate that a person's last weeks or months may be rich and dignified.

    As the moments passed, the patrons and staff who had been cleared out of the building realized this was not the usual fire alarm. As one fireman recounted, “Once that first stack got going, it was ‘Goodbye, Charlie.’” The fire was disastrous: it reached 2000 degrees and burned for more than seven hours. By the time it was extinguished, it had consumed four hundred thousand books and damaged seven hundred thousand more. Investigators descended on the scene, but more than thirty years later, the mystery remains: Did someone purposefully set fire to the library—and if so, who?Weaving her lifelong love of books and reading into an investigation of the fire, award-winning New Yorker reporter and New York Times bestselling author Susan Orlean delivers a mesmerizing and uniquely compelling book that manages to tell the broader story of libraries and librarians in a way that has never been done before.In The Library Book, Orlean chronicles the LAPL fire and its aftermath to showcase the larger, crucial role that libraries play in our lives; delves into the evolution of libraries across the country and around the world, from their humble beginnings as a metropolitan charitable initiative to their current status as a cornerstone of national identity; brings each department of the library to vivid life through on-the-ground reporting; studies arson and attempts to burn a copy of a book herself; reflects on her own experiences in libraries; and reexamines the case of Harry Peak, the blond-haired actor long suspected of setting fire to the LAPL more than thirty years ago.Along the way, Orlean introduces us to an unforgettable cast of characters from libraries past and present—from Mary Foy, who in 1880 at eighteen years old was named the head of the Los Angeles Public Library at a time when men still dominated the role, to Dr. C.J.K. Jones, a pastor, citrus farmer, and polymath known as “The Human Encyclopedia” who roamed the library dispensing information; from Charles Lummis, a wildly eccentric journalist and adventurer who was determined to make the L.A. library one of the best in the world, to the current staff, who do heroic work every day to ensure that their institution remains a vital part of the city it serves.Brimming with her signature wit, insight, compassion, and talent for deep research, The Library Book is Susan Orlean’s thrilling journey through the stacks that reveals how these beloved institutions provide much more than just books—and why they remain an essential part of the heart, mind, and soul of our country. It is also a master journalist’s reminder that, perhaps especially in the digital era, they are more necessary than ever.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    Communities where heroin had never been seen before—from Charlotte, NC and Huntington, WVA, to Salt Lake City and Portland, OR—were overrun with it. Local police and residents were stunned. How could heroin, long considered a drug found only in the dense, urban environments along the East Coast, and trafficked into the United States by enormous Colombian drug cartels, be so incredibly ubiquitous in the American heartland? Who was bringing it here, and perhaps more importantly, why were so many townspeople suddenly eager for the comparatively cheap high it offered?With the same dramatic drive of El Narco and Methland, Sam Quinones weaves together two classic tales of American capitalism: The stories of young men in Mexico, independent of the drug cartels, in search of their own American Dream via the fast and enormous profits of trafficking cheap black-tar heroin to America’s rural and suburban addicts; and that of Purdue Pharma in Stamford, Connecticut, determined to corner the market on pain with its new and expensive miracle drug, Oxycontin; extremely addictive in its own right. Quinones illuminates just how these two stories fit together as cause and effect: hooked on costly Oxycontin, American addicts were lured to much cheaper black tar heroin and its powerful and dangerous long-lasting high. Embroiled alongside the suppliers and buyers are DEA agents, local, small-town sheriffs, and the US attorney from eastern Virginia whose case against Purdue Pharma and Oxycontin made him an enemy of the Bush-era Justice Department, ultimately stalling and destroying his career in public service.Dreamland is a scathing and incendiary account of drug culture and addiction spreading to every part of the American landscape.

    In The Poisoner's Handbook Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Drama unfolds case by case as the heroes of The Poisoner's Handbook—chief medical examiner Charles Norris and toxicologist Alexander Gettler—investigate a family mysteriously stricken bald, Barnum and Bailey's Famous Blue Man, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler work with a creativity that rivals that of the most imaginative murderer, creating revolutionary experiments to tease out even the wiliest compounds from human tissue. Yet in the tricky game of toxins, even science can't always be trusted, as proven when one of Gettler's experiments erroneously sets free a suburban housewife later nicknamed "America's Lucretia Borgia" to continue her nefarious work. From the vantage of Norris and Gettler's laboratory in the infamous Bellevue Hospital it becomes clear that killers aren't the only toxic threat to New Yorkers. Modern life has created a kind of poison playground, and danger lurks around every corner. Automobiles choke the city streets with carbon monoxide; potent compounds, such as morphine, can be found on store shelves in products ranging from pesticides to cosmetics. Prohibition incites a chemist's war between bootleggers and government chemists while in Gotham's crowded speakeasies each round of cocktails becomes a game of Russian roulette. Norris and Gettler triumph over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice during a remarkably deadly time. A beguiling concoction that is equal parts true crime, twentieth-century history, and science thriller, The Poisoner's Handbook is a page-turning account of a forgotten New York.

    This is vintage Krakauer, an utterly compelling work of nonfiction that illuminates an otherwise confounding realm of human behavior.Jon Krakauer’s literary reputation rests on insightful chronicles of lives conducted at the outer limits. In Under The Banner of Heaven: A Story of Violent Faith, he shifts his focus from extremes of physical adventure to extremes of religious belief within our own borders. At the core of his book is an appalling double murder committed by two Mormon Fundamentalist brothers, Ron and Dan Lafferty, who insist they received a revelation from God commanding them to kill their blameless victims. Beginning with a meticulously researched account of this "divinely inspired" crime, Krakauer constructs a multilayered, bone-chilling narrative of messianic delusion, savage violence, polygamy, and unyielding faith. Along the way, he uncovers a shadowy offshoot of America’s fastest-growing religion, and raises provocative questions about the nature of religious belief.Krakauer takes readers inside isolated communities in the American West, Canada, and Mexico, where some forty-thousand Mormon Fundamentalists believe the mainstream Mormon Church went unforgivably astray when it renounced polygamy. Defying both civil authorities and the Mormon establishment in Salt Lake City, the leaders of these outlaw sects are zealots who answer only to God. Marrying prodigiously and with virtual impunity (the leader of the largest fundamentalist church took seventy-five "plural wives," several of whom were wed to him when they were fourteen or fifteen and he was in his eighties), fundamentalist prophets exercise absolute control over the lives of their followers, and preach that any day now the world will be swept clean in a hurricane of fire, sparing only their most obedient adherents.Weaving the story of the Lafferty brothers and their fanatical brethren with a clear-eyed look at Mormonism’s violent past, Krakauer examines the underbelly of the most successful homegrown faith in the United States, and finds a distinctly American brand of religious extremism. The result is vintage Krakauer, an utterly compelling work of nonfiction that illuminates an otherwise confounding realm of human behavior.

    Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at $9 billion, putting Holmes's worth at an estimated $4.7 billion. There was just one problem: The technology didn't work.For years, Holmes had been misleading investors, FDA officials, and her own employees. When Carreyrou, working at The Wall Street Journal, got a tip from a former Theranos employee and started asking questions, both Carreyrou and the Journal were threatened with lawsuits. Undaunted, the newspaper ran the first of dozens of Theranos articles in late 2015. By early 2017, the company's value was zero and Holmes faced potential legal action from the government and her investors. Here is the riveting story of the biggest corporate fraud since Enron, a disturbing cautionary tale set amid the bold promises and gold-rush frenzy of Silicon Valley.

    No one has insight into their true character like the people who serve their meals and make their beds every day. Full of stories and details by turns dramatic, humorous, and heartwarming, The Residence reveals daily life in the White House as it is really lived through the voices of the maids, butlers, cooks, florists, doormen, engineers, and others who tend to the needs of the President and First Family.These dedicated professionals maintain the six-floor mansion’s 132 rooms, 35 bathrooms, 28 fireplaces, three elevators, and eight staircases, and prepare everything from hors d’oeuvres for intimate gatherings to meals served at elaborate state dinners. Over the course of the day, they gather in the lower level’s basement kitchen to share stories, trade secrets, forge lifelong friendships, and sometimes even fall in love.Combining incredible first-person anecdotes from extensive interviews with scores of White House staff members—many speaking for the first time—with archival research, Kate Andersen Brower tells their story. She reveals the intimacy between the First Family and the people who serve them, as well as tension that has shaken the staff over the decades. From the housekeeper and engineer who fell in love while serving President Reagan to Jackie Kennedy’s private moment of grief with a beloved staffer after her husband’s assassination to the tumultuous days surrounding President Nixon’s resignation and President Clinton’s impeachment battle, The Residence is full of surprising and moving details that illuminate day-to-day life at the White House.