With his classic Why We Get Sick, Dr. Randolph Nesse helped to establish the field of evolutionary medicine. Now he returns with a book that transforms our understanding of mental disorders by exploring a fundamentally new question. Instead of asking why certain people suffer from mental illness, Nesse asks why natural selection has left us all with fragile minds.Drawing on revealing stories from his own clinical practice and insights from evolutionary biology, Nesse shows how negative emotions are useful in certain situations, yet can become overwhelming. Anxiety protects us from harm in the face of danger, but false alarms are inevitable. Low moods prevent us from wasting effort in pursuit of unreachable goals, but they often escalate into pathological depression. Other mental disorders, such as addiction and anorexia, result from the mismatch between modern environment and our ancient human past. And there are good evolutionary reasons for sexual disorders and for why genes for schizophrenia persist. Taken together, these and many more insights help to explain the pervasiveness of human suffering, and show us new paths for relieving it by understanding individuals as individuals.

    But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    Introduction by Professor Stephen HawkingFrom what actually happened in the Big Bang to the accidental discovery of post-it notes, science is packed with surprising discoveries. Did you know, for instance, that if you were to get too close to a black hole it would suck you up like a noodle (it's called spaghettification), why your keyboard is laid out in QWERTY (it's not to make it easier to type) or whether the invention of the wheel was less important to civilisation than the bag (think about it). New Scientist does. And now they and illustrator Jennifer Daniel want to take you on a whistlestop journey from the start of our universe (through the history of stars, galaxies, meteorites, the Moon and dark energy) to our planet (through oceans and weather to oil) and life (through dinosaurs to emotions and sex) to civilisation (from cities to alcohol and cooking), knowledge (from alphabets to alchemy) ending up with technology (computers to rocket science). Witty essays explore the concepts alongside enlightening infographics that zoom from how many people have ever lived to showing you how a left-wing brain differs from a right-wing one.

    Bursting with all the suspense and intrigue of a fast paced adventure novel, here is Johanson’s lively account of the extraordinary discovery of “Lucy.” By expounding the controversial change Lucy makes in our view of human origins, Johanson provides a vivid, behind-the-scenes account of the history of pealeoanthropology and the colorful, eccentric characters who were and are a part of it. Never before have the mystery and intricacy of our origins been so clearly and compellingly explained as in this astonighing and dramatic book.

    In biology labs across the world, fruit flies are turning up answers to some of the basic questions of life. It's business as usual for the fly, which for generations has been defining biology's major landmarks. From genetics to development, behavior to aging, and evolution to the origin of species, the fruit fly has been a key player in some of the twentieth century's greatest biological discoveries.Techniques to pinpoint genes that play a role in human disease depend on genetic mapmaking principles first established with the fly. It was experiments on fruit flies that opened our eyes to the dangers of radiation to human health. In fact, everything from gene therapy to cloning to the Human Genome Project is built on the foundation of fruit fly research. Despite its many achievements, the fruit fly remains an unsung hero in the history of science. At last, here is a book that gives the fly its long overdue credit.In a highly original, witty, and irreverent style, Martin Brookes takes us through successive stages in the life cycle of the fly, each illustrating an important concept in biology. Some, such as the fundamentals of heredity, are well established; others, such as sexual warfare, learning, and memory, are still in their infancy. But whether flies are getting high on crack cocaine, enjoying the pleasures and pains of a boozy night out, being trained by punishment and reward, or struggling with insomnia, this book provides a glimpse of how one short life has informed almost every aspect of human existence. The result is a broad introduction to biology with insights into the practical realities of science.Often dismissed as irrelevant outside academic circles, the fruit fly, through this distinctive biography, will come to be recognized for what it really is: an icon of twentieth-century science and a window on our own biological world.

    Despite not having brains or central nervous systems, plants perceive their surroundings with an even greater sensitivity than animals. They efficiently explore and react promptly to potentially damaging external events thanks to their cooperative, shared systems; without any central command centers, they are able to remember prior catastrophic events and to actively adapt to new ones.Every page of Plant Revolution bubbles over with Stefano Mancuso’s infectious love for plants and for the eye-opening research that makes it more and more clear how remarkable our fellow inhabitants on this planet really are. In his hands, complicated science is wonderfully accessible, and he has loaded the book with gorgeous photographs that make for an unforgettable reading experience. Plant Revolution opens the doors to a new understanding of life on earth.

    Though referenced like a work of research, Brizedine's writing style is fully accessible. Brizendine provides a fascinating look at the life cycle of the female brain from birth ("baby girls will connect emotionally in ways that baby boys don't") to birthing ("Motherhood changes you because it literally alters a woman's brain-structurally, functionally, and in many ways, irreversibly") to menopause (when "the female brain is nowhere near ready to retire") and beyond. At the same time, Brizedine is not above reviewing the basics: "We may think we're a lot more sophisticated than Fred or Wilma Flintstone, but our basic mental outlook and equipment are the same." While this book will be of interest to anyone who wonders why men and women are so different, it will be particularly useful for women and parents of girls.

    There are Douglas firs as tall as skyscrapers, and a banyan tree in Calcutta as big as a football field.From the tallest to the smallest, trees inspire wonder in all of us, and in The Tree, Colin Tudge travels around the world—throughout the United States, the Costa Rican rain forest, Panama and Brazil, India, New Zealand, China, and most of Europe—bringing to life stories and facts about the trees around us: how they grow old, how they eat and reproduce, how they talk to one another (and they do), and why they came to exist in the first place. He considers the pitfalls of being tall; the things that trees produce, from nuts and rubber to wood; and even the complicated debt that we as humans owe them.Tudge takes us to the Amazon in flood, when the water is deep enough to submerge the forest entirely and fish feed on fruit while river dolphins race through the canopy. He explains the “memory” of a tree: how those that have been shaken by wind grow thicker and sturdier, while those attacked by pests grow smaller leaves the following year; and reveals how it is that the same trees found in the United States are also native to China (but not Europe).From tiny saplings to centuries-old redwoods and desert palms, from the backyards of the American heartland to the rain forests of the Amazon and the bamboo forests, Colin Tudge takes the reader on a journey through history and illuminates our ever-present but often ignored companions. A blend of history, science, philosophy, and environmentalism, The Tree is an engaging and elegant look at the life of the tree and what modern research tells us about their future.

    Just about everyone has at least heard of Albert Einstein's formulation of 1905, which came into the world as something of an afterthought. But far fewer can explain his insightful linkage of energy to mass. David Bodanis offers an easily grasped gloss on the equation. Mass, he writes, "is simply the ultimate type of condensed or concentrated energy," whereas energy "is what billows out as an alternate form of mass under the right circumstances." Just what those circumstances are occupies much of Bodanis's book, which pays homage to Einstein and, just as important, to predecessors such as Maxwell, Faraday, and Lavoisier, who are not as well known as Einstein today. Balancing writerly energy and scholarly weight, Bodanis offers a primer in modern physics and cosmology, explaining that the universe today is an expression of mass that will, in some vastly distant future, one day slide back to the energy side of the equation, replacing the "dominion of matter" with "a great stillness"--a vision that is at once lovely and profoundly frightening. Without sliding into easy psychobiography, Bodanis explores other circumstances as well; namely, Einstein's background and character, which combined with a sterling intelligence to afford him an idiosyncratic view of the way things work--a view that would change the world. --Gregory McNamee