Now one of the foremost American historians offers the first serious study of this event - what led to it, what really happened, what followed - uncovering a truth more remarkable than the many myths it has inspired. In Paul Revere's Ride, David Hackett Fischer has created an exciting narrative that offers new insight into the coming of the American Revolution. From research in British and American archives, the author unravels a plot that no novelist would dare invent - a true story of high drama and deep suspense, of old-fashioned heroes and unvarnished villains, of a beautiful American spy who betrayed her aristocratic British husband, of violent mobs and marching armies, of brave men dying on their doorsteps, of high courage, desperate fear, and the destiny of nations. The narrative is constructed around two thematic lines. One story centers on the American patriot Paul Revere; the other, on British General Thomas Gage. Both were men of high principle who played larger roles than recent historiography has recognized. Thomas Gage was not the Tory tyrant of patriot legend, but an English Whig who believed in liberty and the rule of law. In 1774 and 1775, General Gage's advice shaped the fatal choices of British leaders, and his actions guided the course of American events. Paul Revere was more than a "simple artizan, " as his most recent biographer described him fifty years ago. The author presents new evidence that revolutionary Boston was a world of many circles - more complex than we have known. Paul Revere and his friend Joseph Warren ranged more widely through those circles than any other leaders. They became the linchpins of the Whig movement. On April 18th, 1775, Paul Revere played that role in a manner that has never been told before. He and William Dawes were not the only midnight riders to ca

    What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world.Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure.

    That is until 1904, when the disease broke out in a household in Oyster Bay, Long Island. Authorities suspected the family cook, Mary Mallon, of being a carrier. But before she could be tested, the woman, soon to be known as Typhoid Mary, had disappeared. Over the course of the next three years, Mary worked at several residences, spreading her pestilence as she went. In 1907, she was traced to a home on Park Avenue, and taken into custody. Institutionalized at Riverside Hospital for three years, she was released only when she promised never to work as a cook again. She promptly disappeared.For the next five years Mary worked in homes and institutions in and around New York, often under assumed names. In February 1915, a devastating outbreak of typhoid at the Sloane Hospital for Women was traced to her. She was finally apprehended and reinstitutionalized at Riverside Hospital, where she would remain for the rest of her life.Typhoid Mary is the story of her infamous life. Anthony Bourdain reveals the seedier side of the early 1900s, and writes with his renowned panache about life in the kitchen, uncovering the horrifying conditions that allowed the deadly spread of typhoid over a decade. Typhoid Mary is a true feast for history lovers and Bourdain lovers alike.

    In this sensational and macabre story, we meet the surgeon who counted not only luminaries Benjamin Franklin, Lord Byron, Adam Smith, and Thomas Gainsborough among his patients but also “resurrection men” among his close acquaintances. A captivating portrait of his ruthless devotion to uncovering the secrets of the human body, and the extraordinary lengths to which he went to do so—including body snatching, performing pioneering medical experiments, and infecting himself with venereal disease—this rich historical narrative at last acknowledges this fascinating man and the debt we owe him today.

    The lifesaving serum was a thousand miles away, the port was icebound, and planes couldn't fly in blizzard conditions—only the dogs could make it. The heroic dash of dog teams across the Alaskan wilderness to Nome inspired the annual Iditarod Trail Sled Dog Race and immortalized Balto, the lead dog of the last team whose bronze statue still stands in New York City's Central Park. This is the greatest dog story, never fully told until now.

    The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . .But all that was about to change. . . . —from The Demon Under the Microscope

    Lab 257 blows the lid off the stunning true nature and checkered history of Plum Island. It shows that the seemingly bucolic island in the shadow of New York City is a ticking biological time bomb that none of us can safely ignore.Based on declassified government documents, in-depth interviews, and access to Plum Island itself, this is an eye-opening, suspenseful account of a federal government germ laboratory gone terribly wrong. For the first time, Lab 257 takes you deep inside this secret world and presents startling revelations on virus outbreaks, biological meltdowns, infected workers, the periodic flushing of contaminated raw sewage into area waters, and the insidious connections between Plum Island, Lyme disease, and the deadly West Nile virus. The book also probes what's in store for Plum Island's new owner, the Department of Homeland Security, in this age of bioterrorism.Lab 257 is a call to action for those concerned with protecting present and future generations from preventable biological catastrophes.

    Ellis focuses on six discrete moments that exemplify the most crucial issues facing the fragile new nation: Burr and Hamilton's deadly duel, and what may have really happened; Hamilton, Jefferson, and Madison's secret dinner, during which the seat of the permanent capital was determined in exchange for passage of Hamilton's financial plan; Franklin's petition to end the "peculiar institution" of slavery--his last public act--and Madison's efforts to quash it; Washington's precedent-setting Farewell Address, announcing his retirement from public office and offering his country some final advice; Adams's difficult term as Washington's successor and his alleged scheme to pass the presidency on to his son; and finally, Adams and Jefferson's renewed correspondence at the end of their lives, in which they compared their different views of the Revolution and its legacy.In a lively and engaging narrative, Ellis recounts the sometimes collaborative, sometimes archly antagonistic interactions between these men, and shows us the private characters behind the public personas: Adams, the ever-combative iconoclast, whose closest political collaborator was his wife, Abigail; Burr, crafty, smooth, and one of the most despised public figures of his time; Hamilton, whose audacious manner and deep economic savvy masked his humble origins; Jefferson, renowned for his eloquence, but so reclusive and taciturn that he rarely spoke more than a few sentences in public; Madison, small, sickly, and paralyzingly shy, yet one of the most effective debaters of his generation; and the stiffly formal Washington, the ultimate realist, larger-than-life, and America's only truly indispensable figure.Ellis argues that the checks and balances that permitted the infant American republic to endure were not primarily legal, constitutional, or institutional, but intensely personal, rooted in the dynamic interaction of leaders with quite different visions and values. Revisiting the old-fashioned idea that character matters, Founding Brothers informs our understanding of American politics--then and now--and gives us a new perspective on the unpredictable forces that shape history.

    His full accounting does honor to the medical professionals around the country who've risked their lives to fight the virus, revealing America in all its vulnerability, courage, and potential.

    It ends in around 1800 when the rough outline of the contemporary North America could be perceived.Dropping the usual Anglocentric description of North America's fate, Taylor brilliantly conveys the far more vivid and startling story of the competing interests--Spanish, French, English, Native, Russian--that over the centuries shaped and reshaped both the continent and its 'suburbs' in the Caribbean and the Pacific. It is one of the greatest of all human stories.

    The Tuskegee Study had nothing to do with treatment. Its purpose was to trace the spontaneous evolution of the disease in order to learn how syphilis affected black subjects.The men were not told they had syphilis; they were not warned about what the disease might do to them; and, with the exception of a smattering of medication during the first few months, they were not given health care. Instead of the powerful drugs they required, they were given aspirin for their aches and pains. Health officials systematically deceived the men into believing they were patients in a government study of “bad blood”, a catch-all phrase black sharecroppers used to describe a host of illnesses. At the end of this 40 year deathwatch, more than 100 men had died from syphilis or related complications.“Bad Blood” provides compelling answers to the question of how such a tragedy could have been allowed to occur. Tracing the evolution of medical ethics and the nature of decision making in bureaucracies, Jones attempted to show that the Tuskegee Study was not, in fact, an aberration, but a logical outgrowth of race relations and medical practice in the United States.Now, in this revised edition of “Bad Blood”, Jones traces the tragic consequences of the Tuskegee Study over the last decade. A new introduction explains why the Tuskegee Study has become a symbol of black oppression and a metaphor for medical neglect, inspiring a prize-winning play, a Nova special, and a motion picture. A new concluding chapter shows how the black community's wide-spread anger and distrust caused by the Tuskegee Study has hampered efforts by health officials to combat AIDS in the black community. “Bad Blood” was nominated for the Pulitzer Prize and was one of the “N.Y. Times” 12 best books of the year.

    Combining the political and the personal, he provides a compelling account of the key events that precipitated the war, from the Stamp Act to the Tea Act, tracing the gradual gathering of American resistance that culminated in the Boston Tea Party and "the shot heard 'round the world." The heart of the book features a vivid description of the eight-year-long war, with gripping accounts of battles and campaigns, ranging from Bunker Hill and Washington's crossing of the Delaware to the brilliant victory at Hannah's Cowpens and the final triumph at Yorktown, paying particular attention to what made men fight in these bloody encounters. The book concludes with an insightful look at the making of the Constitution in the Philadelphia Convention of 1787 and the struggle over ratification. Through it all, Middlekauff gives the reader a vivid sense of how the colonists saw these events and the importance they gave to them. Common soldiers and great generals, Sons of Liberty and African slaves, town committee-men and representatives in congress--all receive their due. And there are particularly insightful portraits of such figures as Sam and John Adams, James Otis, Thomas Jefferson, George Washington, and many others.This new edition has been revised and expanded, with fresh coverage of topics such as mob reactions to British measures before the War, military medicine, women's role in the Revolution, American Indians, the different kinds of war fought by the Americans and the British, and the ratification of the Constitution. The book also has a new epilogue and an updated bibliography.The cause for which the colonists fought, liberty and independence, was glorious indeed. Here is an equally glorious narrative of an event that changed the world, capturing the profound and passionate struggle to found a free nation.The Oxford History of the United StatesThe Oxford History of the United States is the most respected multi-volume history of our nation. The series includes three Pulitzer Prize winners, a New York Times bestseller, and winners of the Bancroft and Parkman Prizes. The Atlantic Monthly has praised it as "the most distinguished series in American historical scholarship," a series that "synthesizes a generation's worth of historical inquiry and knowledge into one literally state-of-the-art book." Conceived under the general editorship of C. Vann Woodward and Richard Hofstadter, and now under the editorship of David M. Kennedy, this renowned series blends social, political, economic, cultural, diplomatic, and military history into coherent and vividly written narrative.

    But for thousands of years, people have done things like this—and things that make radioactive underpants seem downright sensible! In their hit podcast, Sawbones, Sydnee and Justin McElroy breakdown the weird and wonderful way we got to modern healthcare. And some of the terrifying detours along the way.Every week, Dr. Sydnee McElroy and her husband Justin amaze, amuse, and gross out (depending on the week) hundreds of thousands of avid listeners to their podcast, Sawbones. Consistently rated a top podcast on iTunes, with over 15 million total downloads, this rollicking journey through thousands of years of medical mishaps and miracles is not only hilarious but downright educational. While you may never even consider applying  boiled weasel to your forehead (once the height of sophistication when it came to headache cures), you will almost certainly face some questionable medical advice in your everyday life (we’re looking at you, raw water!) and be better able to figure out if this is a miracle cure (it’s not) or a scam. Table of Contents:Part One: The Unnerving The Resurrection Men Fun w Galvanism Weird Weight Loss Miracle Cure: Opium Black Plague Heroes of Misguided Medicine: Pliny the Elder Erectile Dysfunction The Doctor Is In: Listener Questions Answered Don’t Drill a Hole in Your HeadPart Two: The Gross Mummy Medicine The Guthole Bromance The Unkillable Phineas Gage Max Drank Poopy Water Heroes of Misguided Medicine: Robert Liston Golden Showers of Health Miracle Cure-All: Radium Dr. John Romulus Brinkley The Doctor Is In Q&A Just (Four) Humour Me The Camel Dung MiraclePart Three: The Weird The Dancing Plague Bad Medicine: Tobacco for Health The Seasick-Proof Saloon Miracle Cure-All: Vinegar The Doctor Is In Q&A Heroes of Misguided MedicinePart Four: The Awesome The Poison Squad Bad Medicine: Self Experimentation Eat Your Chocolate! Heroes of Misguided Medicine Parrot Fever Miracle Cure-All: Honey The Miraculous Polio Vaccine The Doctor Is In

    But getting here has not been a simple story of selfless men working tirelessly in the pursuit of medical advancement. Instead it's a bloodstained tale of blunders, arrogance, mishap and murder. In trying to keep us alive, surgeons have all too often killed us off, and life-saving solutions have often come from the most surprising places. Accompanying a major BBC series, "Blood and Guts" is an incredible story of stolen corpses, medical fraud, lobotomized patients - and every now and then courageous advances that have saved the lives of millions around the world. You may think twice before going under the knife.

    A killer with little respect for class or wealth, cholera ravaged the squalid streets of Soho and rocked the great centers of Victorian power. In this gripping book, Sandra Hempel tells the story of John Snow, a reclusive doctor without money or social position, who—alone and unrecognized—had the genius to look beyond the conventional wisdom of his day and uncover the truth behind the pandemic. She describes how Snow discovered that cholera was spread through drinking water and how this subsequently laid the foundations for the modern, scientific investigation of today's fatal plagues. A dramatic account with a colorful cast of characters, The Strange Case of the Broad Street Pump features diversions into fascinating facets of medical and social history, such as Snow's tending of Queen Victoria in childbirth, Dutch microbiologist Leeuwenhoek's deliberate breeding of lice in his socks, Dickensian children's farms, and riotous nineteenth-century anesthesia parties. An afterword discusses the new threat of infectious diseases—including malaria, yellow fever, and cholera—with today's global warming. Copub: Granta