With rivalries, reversals, and a race against time, the struggle to eradicate polio is one of the great tales of modern history. It begins with the birth of Jonas Salk, shortly before one of the worst polio epidemics in United States history. At the time, the disease was a terrifying enigma: striking from out of nowhere, it afflicted tens of thousands of children in this country each year and left them-literally overnight-paralyzed, and sometimes at death's door. Salk was in medical school just as a president crippled by the disease, Franklin D. Roosevelt, was taking office-and providing the impetus to the drive for studies on polio. By the early 1950s, Salk had already helped create an influenza vaccine, and was hot on the trail of the polio virus. He was nearly thwarted, though, by the politics of medicine and by a rival researcher eager to discredit his proposed solution. Meanwhile, in 1952, polio was spreading in record numbers, with 57,000 cases in the United States that summer alone. In early 1954, Salk was weighing the possibility of trials of a not-yet-perfected vaccine against-as the summer approached-the prospect of thousands more children being struck down by the disease. The results of the history-making trials were announced at a press conference on April 12, 1955: "The vaccine works." The room-and an entire nation-erupted in cheers for this singular medical achievement. Salk became a cultural hero and icon for a whole generation. Now, at the fiftieth anniversary of the first national vaccination program-and as humanity is tantalizingly close to eradicating polio worldwide-comes this unforgettable chronicle. Salk's work was an unparalleled achievement-and it makes for a magnificent read.

    Simon Winchester has also fashioned an enthralling and informative informative look at the tumultuous subterranean world that produces earthquakes, the planet's most sudden and destructive force.In the early morning hours of April 18, 1906, San Francisco and a string of towns to its north-northwest and the south-southeast were overcome by an enormous shaking that was compounded by the violent shocks of an earthquake, registering 8.25 on the Richter scale. The quake resulted from a rupture in a part of the San Andreas fault, which lies underneath the earth's surface along the northern coast of California. Lasting little more than a minute, the earthquake wrecked 490 blocks, toppled a total of 25,000 buildings, broke open gas mains, cut off electric power lines throughout the Bay area, and effectively destroyed the gold rush capital that had stood there for a half century.Perhaps more significant than the tremors and rumbling, which affected a swatch of California more than 200 miles long, were the fires that took over the city for three days, leaving chaos and horror in its wake. The human tragedy included the deaths of upwards of 700 people, with more than 250,000 left homeless. It was perhaps the worst natural disaster in the history of the United States.Simon Winchester brings his inimitable storytelling abilities -- as well as his unique understanding of geology -- to this extraordinary event, exploring not only what happened in northern California in 1906 but what we have learned since about the geological underpinnings that caused the earthquake in the first place. But his achievement is even greater: he positions the quake's significance along the earth's geological timeline and shows the effect it had on the rest of twentieth-century California and American history.A Crack in the Edge of the World is the definitive account of the San Francisco earthquake. It is also a fascinating exploration of a legendary event that changed the way we look at the planet on which we live.

    On March 25, 1911, as workers were getting ready to leave for the day, a fire broke out in the Triangle Shirtwaist factory in New York’s Greenwich Village. Within minutes it spread to consume the building’s upper three stories. Firemen who arrived at the scene were unable to rescue those trapped inside: their ladders simply weren’t tall enough. People on the street watched in horror as desperate workers jumped to their deaths. The final toll was 146 people—123 of them women. It was the worst disaster in New York City history.

    Bowen evokes it as if the reader were actually there, mingling with the delegates, hearing their arguments, witnessing a dramatic moment in history.Here is the fascinating record of the hot, sultry summer months of debate and decision when ideas clashed and tempers flared. Here is the country as it was then, described by contemporaries, by Berkshire farmers in Massachusetts, by Patrick Henry's Kentucky allies, by French and English travelers. Here, too, are the offstage voices--Thomas Jefferson and Tom Paine and John Adams from Europe. In all, fifty-five men attended; and in spite of the heat, in spite of clashing interests--the big states against the little, the slave states against the anti-slave states--in tension and anxiety that mounted week after week, they wrote out a working plan of government and put their signatures to it.

    It’s so bound up with our deepest feelings that emotional trauma causes it to change shape.Practising cardiologist Sandeep Jauhar beautifully weaves his own experiences with the defining discoveries of the past to tell the story of our most vital organ. He looks at some of the pioneers who risked their careers and their patients’ lives to better understand the heart. People like Daniel Hale Williams, who performed the world’s first documented heart surgery, and Wilson Greatbatch, who accidentally invented the pacemaker.Amid gripping scenes from the operating theatre, Jauhar interweaves stories about the patients he’s treated with the moving tale of his family’s own history of heart problems, from his grandfather’s sudden death in India – an event that sparked his life-long obsession – to the ominous signs of how he himself might die.He also confronts the limits of medical technology and argues that future progress will be determined more by how we choose to live rather than by any device we invent.

    history. The Tennessee town of Oak Ridge was created from scratch in 1942. One of the Manhattan Project’s secret cities, it didn’t appear on any maps until 1949, and yet at the height of World War II it was using more electricity than New York City and was home to more than 75,000 people, many of them young women recruited from small towns across the South. Their jobs were shrouded in mystery, but they were buoyed by a sense of shared purpose, close friendships—and a surplus of handsome scientists and Army men!But against this vibrant wartime backdrop, a darker story was unfolding. The penalty for talking about their work—even the most innocuous details—was job loss and eviction. One woman was recruited to spy on her coworkers. They all knew something big was happening at Oak Ridge, but few could piece together the true nature of their work until the bomb "Little Boy" was dropped over Hiroshima, Japan, and the secret was out. The shocking revelation: the residents of Oak Ridge were enriching uranium for the atomic bomb.Though the young women originally believed they would leave Oak Ridge after the war, many met husbands there, made lifelong friends, and still call the seventy-year-old town home. The reverberations from their work there—work they didn’t fully understand at the time—are still being felt today. In The Girls of Atomic City, Denise Kiernan traces the astonishing story of these unsung WWII workers through interviews with dozens of surviving women and other Oak Ridge residents. Like The Immortal Life of Henrietta Lacks, this is history and science made fresh and vibrant—a beautifully told, deeply researched story that unfolds in a suspenseful and exciting way.

    Starting with the earliest encounters between black Americans and Western medical researchers and the racist pseudoscience that resulted, it details the ways both slaves and freedmen were used in hospitals for experiments conducted without their knowledge—a tradition that continues today within some black populations. It reveals how blacks have historically been prey to grave-robbing as well as unauthorized autopsies and dissections. Moving into the twentieth century, it shows how the pseudoscience of eugenics and social Darwinism was used to justify experimental exploitation and shoddy medical treatment of blacks, and the view that they were biologically inferior, oversexed, and unfit for adult responsibilities. Shocking new details about the government’s notorious Tuskegee experiment are revealed, as are similar, less-well-known medical atrocities conducted by the government, the armed forces, prisons, and private institutions.The product of years of prodigious research into medical journals and experimental reports long undisturbed, Medical Apartheid reveals the hidden underbelly of scientific research and makes possible, for the first time, an understanding of the roots of the African American health deficit. At last, it provides the fullest possible context for comprehending the behavioral fallout that has caused black Americans to view researchers—and indeed the whole medical establishment—with such deep distrust. No one concerned with issues of public health and racial justice can afford not to read Medical Apartheid, a masterful book that will stir up both controversy and long-needed debate.

    Ironically, the "discovery" was really no discovery at all: Ether and nitrous oxide had been known for more than forty years to cause insensitivity to pain, yet, with names like "laughing gas," they were used almost solely for entertainment. Meanwhile, patients still underwent operations during which they saw, heard, and felt every cut the surgeon made. The image of a grim and grisly operating room, like the one in Mary Shelley's Frankenstein, was in fact starkly accurate in portraying the conditions of surgery before anesthesia.With hope for relief seemingly long gone, the breakthrough finally came about by means of a combination of coincidence and character, as a cunning Boston dentist crossed paths with an inventive colleague from Hartford and a brilliant Harvard-trained physician. William Morton, Horace Wells, and Charles Jackson: a con man, a dreamer, and an intellectual. Though Wells was crushed by derision when he tried to introduce anesthetics, Morton prevailed, with help from Jackson. The result was Ether Day, October 16, 1846, celebrated around the world. By that point, though, no honor was enough. Ether Day was not only the dawn of modern surgery, but the beginning of commercialized medicine as well, as Morton patented the discovery.What followed was a battle so bitter that it sent all three men spiraling wildly out of control, at the same time that anesthetics began saving countless lives. Meticulously researched and masterfully written, Ether Day is a riveting look at one of history's most remarkable untold stories.

    What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.

    Sparking the idea for this book was Carroll’s visit to the spot where Abraham Lincoln’s son was saved by the brother of Lincoln’s assassin. Carroll wondered, How many other unmarked places are there where intriguing events have unfolded and that we walk past every day, not realizing their significance? To answer that question, Carroll ultimately trekked to every region of the country -- by car, train, plane, helicopter, bus, bike, and kayak and on foot. Among the things he learned: *Where in North America the oldest sample of human DNA was discovered * Where America’s deadliest maritime disaster took place, a calamity worse than the fate of the Titanic *Which virtually unknown American scientist saved hundreds of millions of lives *Which famous Prohibition agent was the brother of a notorious gangster *How a 14-year-old farm boy’s brainstorm led to the creation of television Featured prominently in Here Is Where are an abundance of firsts (from the first use of modern anesthesia to the first cremation to the first murder conviction based on forensic evidence); outrages (from riots to massacres to forced sterilizations); and breakthroughs (from the invention, inside a prison, of a revolutionary weapon; to the recovery, deep in the Alaskan tundra, of a super-virus; to the building of the rocket that made possible space travel). Here Is Where is thoroughly entertaining, but it’s also a profound reminder that the places we pass by often harbor amazing secrets and that there are countless other astonishing stories still out there, waiting to be found.

    Includes timelines, boxed features on significant medical breakthroughs, fascinating case histories, anecdotes and medical curiosities. Contains 150 color photographs.

    This was a military expedition into hostile territory'. In 1803 President Thomas Jefferson selected his personal secretary, Captain Meriwether Lewis, to lead a pioneering voyage across the Great Plains and into the Rockies. It was completely uncharted territory; a wild, vast land ruled by the Indians. Charismatic and brave, Lewis was the perfect choice and he experienced the savage North American continent before any other white man. UNDAUNTED COURAGE is the tale of a hero, but it is also a tragedy. Lewis may have received a hero's welcome on his return to Washington in 1806, but his discoveries did not match the president's fantasies of sweeping, fertile plains ripe for the taking. Feeling the expedition had been a failure, Lewis took to drink and piled up debts. Full of colourful characters - Jefferson, the president obsessed with conquering the west; William Clark, the rugged frontiersman; Sacagawea, the Indian girl who accompanied the expedition; Drouillard, the French-Indian hunter - this is one of the great adventure stories of all time and it shot to the top of the US bestseller charts. Drama, suspense, danger and diplomacy combine with romance and personal tragedy making UNDAUNTED COURAGE an outstanding work of scholarship and a thrilling adventure.

    In that fateful year, the Spanish landed in San Francisco, the Russians pushed into Alaska to hunt valuable sea otters, and the Sioux discovered the Black Hills. Hailed by critics for challenging our conventional view of the birth of America, West of the Revolution “[coaxes] our vision away from the Atlantic seaboard” and “exposes a continent seething with peoples and purposes beyond Minutemen and Redcoats” (Wall Street Journal).

    Based on eight years of research, extensive archival materials, new documents, and exclusive access to Perkins’s family members and friends, this biography is the first complete portrait of a devoted public servant with a passionate personal life, a mother who changed the landscape of American business and society.Frances Perkins was named Secretary of Labor by Franklin Roosevelt in 1933. As the first female cabinet secretary, she spearheaded the fight to improve the lives of America’s working people while juggling her own complex family responsibilities. Perkins’s ideas became the cornerstones of the most important social welfare and legislation in the nation’s history, including unemployment compensation, child labor laws, and the forty-hour work week. Arriving in Washington at the height of the Great Depression, Perkins pushed for massive public works projects that created millions of jobs for unemployed workers. She breathed life back into the nation’s labor movement, boosting living standards across the country. As head of the Immigration Service, she fought to bring European refugees to safety in the United States. Her greatest triumph was creating Social Security. Written with a wit that echoes Frances Perkins’s own, award-winning journalist Kirstin Downey gives us a riveting exploration of how and why Perkins slipped into historical oblivion, and restores Perkins to her proper place in history.

    Beginning with a dramatic account of the SARS pandemic at the start of the 21st century, Dorothy Crawford takes us back in time to follow the interlinked history of microbes and humanity, offering an up-to-date look at ancient plagues and epidemics, and identifying key changes in the way humans have lived--such as our move from hunter-gatherer to farmer to city-dweller--which made us ever more vulnerable to microbe attack. Showing that how we live our lives today--with increased crowding and air travel--puts us once again at risk, Crawford asks whether we might ever conquer microbes completely. Among the possible answers, one thing becomes clear: that for generations to come, our deadly companions will continue to influence our lives. New in Paperback