This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.

    Exploring the history of cannibalism, the neurology of people who are sexually attracted to animals, the evolution of human body fluids, the science of homosexuality, and serious questions about life and death, Bering astutely covers a generous expanse of our kaleidoscope of quirks and origins.With his characteristic irreverence and trademark cheekiness, Bering leaves no topic unturned or curiosity unexamined, and he does it all with an audaciously original voice. Whether you're interested in the psychological history behind the many facets of sexual desire or the evolutionary patterns that have dictated our current mystique and phallic physique, Why Is the Penis Shaped Like That? is bound to create lively discussion and debate for years to come.

    Along the way, she meets biologists who are trying to preserve the world's rarest fish, which lives in a single tiny pool in the middle of the Mojave; engineers who are turning carbon emissions to stone in Iceland; Australian researchers who are trying to develop a super coral that can survive on a hotter globe; and physicists who are contemplating shooting tiny diamonds into the stratosphere to cool the earth.One way to look at human civilization, says Kolbert, is as a ten-thousand-year exercise in defying nature. In The Sixth Extinction, she explored the ways in which our capacity for destruction has reshaped the natural world. Now she examines how the very sorts of interventions that have imperiled our planet are increasingly seen as the only hope for its salvation.

    Join renowned neuroscientist David Eagleman for a journey into the questions at the mysterious heart of our existence. What is reality? Who are “you”? How do you make decisions? Why does your brain need other people? How is technology poised to change what it means to be human?  In the course of his investigations, Eagleman guides us through the world of extreme sports, criminal justice, facial expressions, genocide, brain surgery, gut feelings, robotics, and the search for immortality.  Strap in for a whistle-stop tour into the inner cosmos. In the infinitely dense tangle of billions of brain cells and their trillions of connections, something emerges that you might not have expected to see in there: you.

    News of both the Ice Man's discovery and his age, which was put at over five thousand years, fascinated scientists and newspapers throughout the world. But what made Sykes's story particularly revelatory was his successful identification of a genetic descendant of the Ice Man, a woman living in Great Britain today. How was Sykes able to locate a living relative of a man who died thousands of years ago?In The Seven Daughters of Eve, he gives us a firsthand account of his research into a remarkable gene, which passes undiluted from generation to generation through the maternal line. After plotting thousands of DNA sequences from all over the world, Sykes found that they clustered around a handful of distinct groups. Among Europeans and North American Caucasians, there are, in fact, only seven. This conclusion was staggering: almost everyone of native European descent, wherever they may live throughout the world, can trace their ancestry back to one of seven women, the Seven Daughters of Eve.Naming them Ursula, Xenia, Helena, Velda, Tara, Katrine, and Jasmine, Sykes has created portraits of their disparate worlds by mapping the migratory patterns followed by millions of their ancestors. In reading the stories of these seven women, we learn exactly how our origins can be traced, how and where our ancient genetic ancestors lived, and how we are each living proof of the almost indestructible strands of DNA, which have survived over so many thousands of years. Indeed, The Seven Daughters of Eve is filled with dramatic stories: from Sykes's identification, using DNA samples from two living relatives, of the remains of Tsar Nicholas and Tsaress Alexandra, to the Caribbean woman whose family had been sold into slavery centuries before and whose ancestry Sykes was able to trace back to the Eastern coast of central Africa. Ultimately, Sykes's investigation reveals that, as a race, what humans have in common is more deeply embedded than what separates us.

    In the past, discoveries often had to wait for the rise of the next generation to see questions in a new light and let go of old truisms. Today, in a world that is defined by a rapid rate of change, staying on the cutting edge has as much to do with shedding outdated notions as adopting new ones. In this spirit, John Brockman, publisher of the online salon Edge.org ("the world's smartest website"—The Guardian), asked 175 of the world's most influential scientists, economists, artists, and philosophers: What scientific idea is ready for retirement?Jared Diamond explores the diverse ways that new ideas emerge * Nassim Nicholas Taleb takes down the standard deviation * Richard Thaler and novelist Ian McEwan reveal the usefulness of "bad" ideas * Steven Pinker dismantles the working theory of human behavior * Richard Dawkins renounces essentialism * Sherry Turkle reevaluates our expectations of artificial intelligence * Physicist Andrei Linde suggests that our universe and its laws may not be as unique as we think * Martin Rees explains why scientific understanding is a limitless goal * Alan Guth rethinks the origins of the universe * Sam Harris argues that our definition of science is too narrow * Nobel Prize winner Frank Wilczek disputes the division between mind and matter * Lawrence Krauss challenges the notion that the laws of physics were preordained * plus contributions from Daniel Goleman, Mihaly Csikszentmihalyi, Nicholas Carr, Rebecca Newberger Goldstein, Matt Ridley, Stewart Brand, Sean Carroll, Daniel C. Dennett, Helen Fisher, Douglas Rushkoff, Lee Smolin, Kevin Kelly, Freeman Dyson, and others.

    Now he stands ready to revolutionize both neuroscience and computing in one stroke, with a new understanding of intelligence itself.Hawkins develops a powerful theory of how the human brain works, explaining why computers are not intelligent and how, based on this new theory, we can finally build intelligent machines.The brain is not a computer, but a memory system that stores experiences in a way that reflects the true structure of the world, remembering sequences of events and their nested relationships and making predictions based on those memories. It is this memory-prediction system that forms the basis of intelligence, perception, creativity, and even consciousness.In an engaging style that will captivate audiences from the merely curious to the professional scientist, Hawkins shows how a clear understanding of how the brain works will make it possible for us to build intelligent machines, in silicon, that will exceed our human ability in surprising ways.Written with acclaimed science writer Sandra Blakeslee, On Intelligence promises to completely transfigure the possibilities of the technology age. It is a landmark book in its scope and clarity.

    At the dawn of the Industrial Revolution in eighteenth-century England, standards of measurement were established, giving way to the development of machine tools—machines that make machines. Eventually, the application of precision tools and methods resulted in the creation and mass production of items from guns and glass to mirrors, lenses, and cameras—and eventually gave way to further breakthroughs, including gene splicing, microchips, and the Hadron Collider.Simon Winchester takes us back to origins of the Industrial Age, to England where he introduces the scientific minds that helped usher in modern production: John Wilkinson, Henry Maudslay, Joseph Bramah, Jesse Ramsden, and Joseph Whitworth. It was Thomas Jefferson who later exported their discoveries to the fledgling United States, setting the nation on its course to become a manufacturing titan. Winchester moves forward through time, to today’s cutting-edge developments occurring around the world, from America to Western Europe to Asia.As he introduces the minds and methods that have changed the modern world, Winchester explores fundamental questions. Why is precision important? What are the different tools we use to measure it? Who has invented and perfected it? Has the pursuit of the ultra-precise in so many facets of human life blinded us to other things of equal value, such as an appreciation for the age-old traditions of craftsmanship, art, and high culture? Are we missing something that reflects the world as it is, rather than the world as we think we would wish it to be? And can the precise and the natural co-exist in society?

    Some of their responses to those outbreaks are almost too strange to believe in hindsight. Get Well Soon delivers the gruesome, morbid details of some of the worst plagues we’ve suffered as a species, as well as stories of the heroic figures who selflessly fought to ease the suffering of their fellow man. With her signature mix of in-depth research and storytelling, and not a little dark humor, Jennifer Wright explores history’s most gripping and deadly outbreaks, and ultimately looks at the surprising ways they’ve shaped history and humanity for almost as long as anyone can remember.

    But which one? And how?Over the past fifty years, more than three hundred infectious diseases have either newly emerged or reemerged, appearing in territories where they’ve never been seen before. Ninety percent of epidemiologists expect that one of them will cause a deadly pandemic sometime in the next two generations. It could be Ebola, avian flu, a drug-resistant superbug, or something completely new. While we can’t know which pathogen will cause the next pandemic, by unraveling the story of how pathogens have caused pandemics in the past, we can make predictions about the future. In Pandemic: Tracking Contagions, from Cholera to Ebola and Beyond, the prizewinning journalist Sonia Shah—whose book on malaria, The Fever, was called a “tour-de-force history” (The New York Times) and “revelatory” (The New Republic)—interweaves history, original reportage, and personal narrative to explore the origins of contagions, drawing parallels between cholera, one of history’s most deadly and disruptive pandemic-causing pathogens, and the new diseases that stalk humankind today.To reveal how a new pandemic might develop, Sonia Shah tracks each stage of cholera’s dramatic journey, from its emergence in the South Asian hinterlands as a harmless microbe to its rapid dispersal across the nineteenth-century world, all the way to its latest beachhead in Haiti. Along the way she reports on the pathogens now following in cholera’s footsteps, from the MRSA bacterium that besieges her own family to the never-before-seen killers coming out of China’s wet markets, the surgical wards of New Delhi, and the suburban backyards of the East Coast.By delving into the convoluted science, strange politics, and checkered history of one of the world’s deadliest diseases, Pandemic reveals what the next global contagion might look like— and what we can do to prevent it.

    Yet, as a species, humans have lost the ability to breathe correctly, with grave consequences.Journalist James Nestor travels the world to figure out what went wrong and how to fix it. The answers aren't found in pulmonology labs, as we might expect, but in the muddy digs of ancient burial sites, secret Soviet facilities, New Jersey choir schools, and the smoggy streets of Sao Paulo. Nestor tracks down men and women exploring the hidden science behind ancient breathing practices like Pranayama, Sudarshan Kriya, and Tummo and teams up with pulmonary tinkerers to scientifically test long-held beliefs about how we breathe.Modern research is showing us that making even slight adjustments to the way we inhale and exhale can jump-start athletic performance; rejuvenate internal organs; halt snoring, asthma, and autoimmune disease; and even straighten scoliotic spines. None of this should be possible, and yet it is.Drawing on thousands of years of medical texts and recent cutting-edge studies in pulmonology, psychology, biochemistry, and human physiology, Breath turns the conventional wisdom of what we thought we knew about our most basic biological function on its head. You will never breathe the same again.

    As Professor of Anatomy and Forensic Anthropology, she focuses on mortal remains in her lab, at burial sites, at scenes of violence, murder and criminal dismemberment, and when investigating mass fatalities due to war, accident or natural disaster. In All that Remains she reveals the many faces of death she has come to know, using key cases to explore how forensic science has developed, and what her work has taught her. Do we expect a book about death to be sad? Macabre? Sue’s book is neither. There is tragedy, but there is also humour in stories as gripping as the best crime novel. Our own death will remain a great unknown. But as an expert witness from the final frontier, Sue Black is the wisest, most reassuring, most compelling of guides.

    In their new book, Stephen Hawking and Leonard Mlodinow present the most recent scientific thinking about the mysteries of the universe, in nontechnical language marked by both brilliance and simplicity. In The Grand Design they explain that according to quantum theory, the cosmos does not have just a single existence or history, but rather that every possible history of the universe exists simultaneously. When applied to the universe as a whole, this idea calls into question the very notion of cause and effect. But the “top-down” approach to cosmology that Hawking and Mlodinow describe would say that the fact that the past takes no definite form means that we create history by observing it, rather than that history creates us. The authors further explain that we ourselves are the product of quantum fluctuations in the very early universe, and show how quantum theory predicts the “multiverse”—the idea that ours is just one of many universes that appeared spontaneously out of nothing, each with different laws of nature.Along the way Hawking and Mlodinow question the conventional concept of reality, posing a “model-dependent” theory of reality as the best we can hope to find. And they conclude with a riveting assessment of M-theory, an explanation of the laws governing us and our universe that is currently the only viable candidate for a complete “theory of everything.” If confirmed, they write, it will be the unified theory that Einstein was looking for, and the ultimate triumph of human reason.A succinct, startling, and lavishly illustrated guide to discoveries that are altering our understanding and threatening some of our most cherished belief systems, The Grand Design is a book that will inform—and provoke—like no other.'

    A strong gravitational wave will briefly change that distance by less than the thickness of a human hair. We have perhaps less than a few tenths of a second to perform this measurement. And we don’t know if this infinitesimal event will come next month, next year or perhaps in thirty years.In 1916 Einstein predicted the existence of gravitational waves: miniscule ripples in the very fabric of spacetime generated by unfathomably powerful events. If such vibrations could somehow be recorded, we could observe our universe for the first time through sound: the hissing of the Big Bang, the whale-like tunes of collapsing stars, the low tones of merging galaxies, the drumbeat of two black holes collapsing into one. For decades, astrophysicists have searched for a way of doing so…In 2016 a team of hundreds of scientists at work on a billion-dollar experiment made history when they announced the first ever detection of a gravitational wave, confirming Einstein’s prediction. This is their story, and the story of the most sensitive scientific instrument ever made: LIGO.Based on complete access to LIGO and the scientists who created it, Black Hole Blues provides a firsthand account of this astonishing achievement: a compelling, intimate portrait of cutting-edge science at its most awe-inspiring and ambitious.

    The media seized hold of the story and, in the process, helped to launch one of the most devastating health scares ever. In the years to come Wakefield would be revealed as a profiteer in league with class-action lawyers, and he would eventually lose his medical license. Meanwhile, one study after another failed to find any link between childhood vaccines and autism. Yet the myth that vaccines somehow cause developmental disorders lives on. Despite the lack of corroborating evidence, it has been popularized by media personalities such as Oprah Winfrey and Jenny McCarthy and legitimized by journalists who claim that they are just being fair to “both sides” of an issue about which there is little debate. Meanwhile, millions of dollars have been diverted from potential breakthroughs in autism research; families have spent their savings on ineffective “miracle cures"; and declining vaccination rates have led to outbreaks of deadly illnesses like Hib, measles, and whooping cough. Most tragic of all is the increasing number of children dying from vaccine-preventable diseases. In The Panic Virus Seth Mnookin draws on interviews with parents, public-health advocates, scientists, and anti-vaccine activists to tackle a fundamental question: How do we decide what the truth is? The fascinating answer helps explain everything from the persistence of conspiracy theories about 9/11 to the appeal of talk-show hosts who demand that President Obama “prove” he was born in America. The Panic Virus is the ultimate cautionary tale for our time.