Worse, as they failed to cure her, they hinted that her devastating symptoms were psychological.The Lady's Handbook for Her Mysterious Illness is a memoir with a mission, to help the millions of (mostly) women who suffer from unnamed or misunderstood conditions.Ramey's pursuit of a diagnosis and cure for her own mysterious illness is a medical mystery that she says reveals a new understanding of today's chronic illnesses as ecological in nature, driven by modern changes to the basic foundations of health, from the quality of our sleep, diet, and social connection to the state of our microbiomes.

    A neighborhood restaurant turned to-go place where one has a shared drink-on either end of a bar-with the owner. These scenes, among many others, became the new normal as soon as the world began to face the COVID-19 pandemic.In How We Live Now, author and photographer Bill Hayes, with his signature insight and grace, captures these moments of life in real time-as things unfold day-by-day, hour-by-hour, in this strange new world we're now in (for who knows how long?), with its new sets of rules and guidelines, its suddenly deserted streets, shuttered restaurants, bars, shops, and stores. As he wanders the increasingly empty streets of Manhattan, Hayes meets fellow New Yorkers and discovers stories to tell, but he also shares the unexpected moments of grace and gratitude he finds from within his apartment, where he lives alone and-like everyone else-is staying home, trying to keep busy and not bored as he adjusts to enforced solitude with reading, cooking, reconnecting with loved ones, reflecting on the past-and writing. Featuring Hayes's inimitable street photographs, How We Live Now chronicles an unimaginable moment in time, offering a long-lasting reminder that what will gets us through this unprecedented, deadly crisis is each other.

    They are promises. They are the only way to walk from one night to the other."Nina Riggs was just thirty-seven years old when initially diagnosed with breast cancer--one small spot. Within a year, the mother of two sons, ages seven and nine, and married sixteen years to her best friend, received the devastating news that her cancer was terminal.How does one live each day, "unattached to outcome"? How does one approach the moments, big and small, with both love and honesty?Exploring motherhood, marriage, friendship, and memory, even as she wrestles with the legacy of her great-great-great grandfather, Ralph Waldo Emerson, Nina Riggs's breathtaking memoir continues the urgent conversation that Paul Kalanithi began in his gorgeous When Breath Becomes Air. She asks, what makes a meaningful life when one has limited time?Brilliantly written, disarmingly funny, and deeply moving, The Bright Hour is about how to love all the days, even the bad ones, and it's about the way literature, especially Emerson, and Nina's other muse, Montaigne, can be a balm and a form of prayer. It's a book about looking death squarely in the face and saying "this is what will be."Especially poignant in these uncertain times, The Bright Hour urges us to live well and not lose sight of what makes us human: love, art, music, words.

    She lost thirty pounds, chugged antacid, and visited doctors for three months before she was finally diagnosed with Stage IV colon cancer.As she navigates the aftermath of her diagnosis, Kate pulls the reader deeply into her life, which is populated with a colorful, often hilarious collection of friends, pastors, parents, and doctors, and shares her laser-sharp reflections on faith, friendship, love, and death. She wonders why suffering makes her feel like a loser and explores the burden of positivity. Trying to relish the time she still has with her son and husband, she realizes she must change her habit of skipping to the end and planning the next move. A historian of the "American prosperity gospel"--the creed of the mega-churches that promises believers a cure for tragedy, if they just want it badly enough--Bowler finds that, in the wake of her diagnosis, she craves these same "outrageous certainties." She wants to know why it's so hard to surrender control over that which you have no control. She contends with the terrifying fact that, even for her husband and child, she is not the lynchpin of existence, and that even without her, life will go on.On the page, Kate Bowler is warm, witty, and ruthless, and, like Paul Kalanithi, one of the talented, courageous few who can articulate the grief she feels as she contemplates her own mortality.

    The Sackler name adorns the walls of many storied institutions: Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing OxyContin, a blockbuster painkiller that was a catalyst for the opioid crisis.Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

    Newly widowed and faced with a deadly brain tumour, she was given two years to live. She wanted more…When her six-year-old daughter found her collapsed on the kitchen floor, Rachel had no idea how much her life was about to change.A brain scan revealed a dark shadowy mass, a huge abnormal growth of tissue that, whilst benign, was still growing and would surely kill her. It was too big to operate on. It needed to be ‘managed’, and Rachel had, at best, two years to live.Refusing to accept the bleak prognosis, Rachel was determined to stay alive. She had already lost far too much. She had already watched her brother succumb, at only twenty-eight, to cancer. She had already lost her beloved husband in a terrible scuba diving accident when she was six months pregnant. So she did the only thing she knew how to do. She fought for her life.This gripping and inspiring memoir about overcoming tragedy and trauma charts one tenacious woman’s incredible fight to find light in the darkest of journeys. It is a life-affirming tale of positivity and hope in the face of the most difficult of human experiences.

    His plan began when he adopted Maude’s mother and indoctrinated her with his esoteric ideals. Her mission was to give him a daughter as blonde as she was, and then to take charge of the child’s education. That child was Maude, on whom her father conducted his outrageous experiment—to raise the perfect ‘super-human’ being.The three lived in an isolated mansion in northern France, where her father made her undergo endless horrifying endurance tests. Maude had to hold an electric fence without flinching. Her parents locked her in a cellar overnight and ordered her to sit still on a stool in the dark, contemplating death, while rats scurried around her feet.How did this girl, with her loveless and lonely childhood, emerge so unscathed, so full of the empathy that was absent in her childhood? How did she manage to escape?Maude was sustained by her love of nature and animals and her passion for literature. In writing this memoir, Maude Julien shows that it is possible to overcome severe trauma. She recounts her chilling and deeply moving story in a compelling and compassionate voice.

    Stories that exist because impossible-to-explain coincidences change everything. Except in real life, not all of them have conventional, happily-ever-after endings. When Harry Met Minnie is that kind of fairy tale, with the vibrant, romantic New York City backdrop of its namesake, the movie When Harry Met Sally, and the bittersweet wisdom of Tuesdays with Morrie.There's a special camaraderie among early-morning dog walkers. Gathering at dog runs in the park, or strolling through the farmer's market at Union Square before the bustling crowd appears, fellow pet owners become familiar-as do the personalities of their beloved animals. In this special space and time, a chance encounter with an old acquaintance changed Martha Teichner's world. As fate would have it, her friend knew someone who was dying of cancer, from exposure to toxins after 9/11, and desperate to find a home for her dog, Harry. He was a Bull Terrier--the same breed as Martha's dear Minnie. Would Martha consider giving Harry a safe, loving new home?In short order, boy dog meets girl dog, the fairy tale part of this story. But there is so much more to this book. After Martha agrees to meet Harry and his owner Carol, what begins as a transaction involving a dog becomes a deep and meaningful friendship between two women with complicated lives and a love of Bull Terriers in common. Through the heartbreak and grief of Carol's illness, the bond that develops changed Martha's life, Carol's life, Minnie's life, Harry's life. As it changed Carol's death as well.In this rich and touching narrative, Martha considers the ways our stories are shaped by the people we meet, and the profound love we can find by opening our hearts to unexpected encounters.

    J. Jacobs read the entire Encyclopædia Britannica from cover to cover in a quest to learn everything in the world. In The Year of Living Biblically, he followed every single rule of the Bible -- from the Ten Commandments right on down to stoning adulterers.Now comes a collection of his most hilarious and thought-provoking experiments yet. In his role as human guinea pig, Jacobs fearlessly takes on a series of life-altering challenges that provides readers with equal parts insight and humor. (And which drives A.J.'s patient wife, Julie, to the brink of insanity.)Among the many adventures:• He outsources his life. A.J. hires a team of people in Bangalore, India, to take care of everything in his life from answering his e-mails to arguing with his spouse.• He spends a month practicing Radical Honesty -- a movement that encourages us to remove the filters between our brains and mouths. (To give you an idea of what happened, the name of the chapter is "I Think You're Fat.")• He goes to the Academy Awards disguised as a movie star to understand the strange and warping effects of fame.• He commits himself to ultimate rationality, using cutting-edge science to make the best decisions possible. It changes the way he makes choices big and small, from what to buy at the grocery store to how to talk to his kids. And his revelations will change how you make decisions, too.• He attempts to follow George Washington's rules of life, uncovering surprising truths about leadership and politics in the twenty-first century. He also spends a lot of time bowing and doffing his hat.• And then there's the month when he followed his wife's every whim -- foot massages, Kate Hudson movies, and all. Depending on your point of view, it's either the best or worst idea in the history of American marriage.A mix of Bill Bryson, George Plimpton, and Malcolm Gladwell, A.J. explores the big issues of our time -- happiness, dating, morality, marriage -- by immersing himself in eye-opening situations. You'll be entertained by these stories -- some of which are new, some of which had their start in Esquire magazine. But you'll also learn to look at life in new ways.The Guinea Pig Diaries is a book packed with both laughs and enlightenment -- and that's a promise we can make with Radical Honesty.

    The book could have been called, ‘Outrageous.’ The story Andy Slavitt tells is not just about Trump’s monumental failures but also about the deeper ones that started long before, with our health system, our politics, and more.” --Atul Gawande, author of Being Mortal The definitive, behind-the-scenes look at the U.S. Coronavirus crisis from one of themost recognizable and influential voices in healthcareFrom former Biden Senior Advisor Andy Slavitt, Preventable is the definitive inside account of the United States' failed response to the Coronavirus pandemic. Slavitt chronicles what he saw and how much could have been prevented -- an unflinching investigation of the cultural, political, and economic drivers that led to unnecessary loss of life.With unparalleled access to the key players throughout the government on both sides of the aisle, the principal public figures, as well as the people working on the frontline involved in fighting the virus, Slavitt brings you into the room as fateful decisions are made and focuses on the people at the center of the political system, health care system, patients, and caregivers. The story that emerges is one of a country in which -- despite the heroics of many -- bad leadership, political and cultural fractures, and an unwillingness to sustain sacrifice light a fuse that is difficult to extinguish. Written in the tradition of The Big Short, Preventable continues Andy Slavitt’s important work of addressing the uncomfortable realities that brought America to this place. And, he puts forth the solutions that will prevent us from being here again, ensuring a better, stronger country for everyone.

    Listening to his sermons, sharing coconut-flavored ices on their walks through town, roaming through the house that held together many members of a colorful extended family, Edwidge grew profoundly attached to Joseph. He was the man who “knew all the verses for love.” And so she experiences a jumble of emotions when, at twelve, she joins her parents in New York City. She is at last reunited with her two youngest brothers, and with her mother and father, whom she has struggled to remember. But she must also leave behind Joseph and the only home she’s ever known. Edwidge tells of making a new life in a new country while fearing for the safety of those still in Haiti as the political situation deteriorates. But Brother I’m Dying soon becomes a terrifying tale of good people caught up in events beyond their control. Late in 2004, his life threatened by an angry mob, forced to flee his church, the frail, eighty-one-year-old Joseph makes his way to Miami, where he thinks he will be safe. Instead, he is detained by U.S. Customs, held by the Department of Homeland Security, brutally imprisoned, and dead within days. It was a story that made headlines around the world. His brother, Mira, will soon join him in death, but not before he holds hope in his arms: Edwidge’s firstborn, who will bear his name—and the family’s stories, both joyous and tragic—into the next generation. Told with tremendous feeling, this is a true-life epic on an intimate scale: a deeply affecting story of home and family—of two men’s lives and deaths, and of a daughter’s great love for them both.

    As the pandemic unfolded, Gottlieb was in regular contact with all the key players in Congress, the Trump administration, and the drug and diagnostic industries. He provides an inside account of how level after level of American government crumbled as the COVID-19 crisis advanced.A system-wide failure across government institutions left the nation blind to the threat, and unable to mount an effective response. We’d prepared for the wrong virus. We failed to identify the contagion early enough and became overly reliant on costly and sometimes divisive tactics that couldn’t fully slow the spread. We never considered asymptomatic transmission and we assumed people would follow public health guidance. Key bureaucracies like the CDC were hidebound and outmatched. Weak political leadership aggravated these woes. We didn’t view a public health disaster as a threat to our national security.Many of the woes sprung from the CDC, which has very little real-time reporting capability to inform us of Covid’s twists and turns or assess our defenses. The agency lacked an operational capacity and mindset to mobilize the kind of national response that was needed. To guard against future pandemic risks, we must remake the CDC and properly equip it to better confront crises. We must also get our intelligence services more engaged in the global public health mission, to gather information and uncover emerging risks before they hit our shores so we can head them off. For this role, our clandestine agencies have tools and capabilities that the CDC lacks.Uncontrolled Spread argues we must fix our systems and prepare for a deadlier coronavirus variant, a flu pandemic, or whatever else nature -- or those wishing us harm -- may threaten us with. Gottlieb outlines policies and investments that are essential to prepare the United States and the world for future threats.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    Five years later, Anna packed her bags and walked out on Armand, taking the typewriter and their children. Aside from one brief encounter, the two never saw or spoke to each other again, never remarried, and never revealed what had divided them forever.A Fifty-Year Silence is the deeply involving account of Miranda Richmond Mouillot's journey to find out what happened between her grandmother, a physician, and her grandfather, an interpreter at the Nuremberg Trials, who refused to utter his wife's name aloud after she left him.  To discover the roots of their embittered and entrenched silence, Miranda abandons her plans for the future and moves to their stone house, now a crumbling ruin; immerses herself in letters, archival materials, and secondary sources; and teases stories out of her reticent, and declining, grandparents.  As she reconstructs how Anna and Armand braved overwhelming odds and how the knowledge her grandfather acquired at Nuremberg destroyed their relationship, Miranda wrestles with the legacy of trauma, the burden of history, and the complexities of memory.  She also finds herself learning how not only to survive but to thrive – making a home in the village and falling in love.With warmth, humor, and rich, evocative details that bring her grandparents' outsize characters and their daily struggles vividly to life, A Fifty-Year Silence is a heartbreaking, uplifting love story spanning two continents and three generations.

    Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.When Death Becomes Life is a thrilling look at how science advances on a grand scale to improve human lives. Mezrich examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the inspiring and heartbreaking stories of his transplant patients. Combining gentle sensitivity with scientific clarity, Mezrich reflects on his calling as a doctor and introduces the modern pioneers who made transplantation a reality—maverick surgeons whose feats of imagination, bold vision, and daring risk taking generated techniques and practices that save millions of lives around the world.Mezrich takes us inside the operating room and unlocks the wondrous process of transplant surgery, a delicate, intense ballet requiring precise timing, breathtaking skill, and at times, creative improvisation. In illuminating this work, Mezrich touches the essence of existence and what it means to be alive. Most physicians fight death, but in transplantation, doctors take from death. Mezrich shares his gratitude and awe for the privilege of being part of this transformative exchange as the dead give their last breath of life to the living. After all, the donors are his patients, too.When Death Becomes Life also engages in fascinating ethical and philosophical debates: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? What defines death, and what role did organ transplantation play in that definition? The human story behind the most exceptional medicine of our time, Mezrich’s riveting book is a beautiful, poignant reminder that a life lost can also offer the hope of a new beginning.