Elizabeth A. Fenn is the first historian to reveal how deeply variola affected the outcome of the war in every colony and the lives of everyone in North America.By 1776, when military action and political ferment increased the movement of people and microbes, the epidemic worsened. Fenn's remarkable research shows us how smallpox devastated the American troops at Québec and kept them at bay during the British occupation of Boston. Soon the disease affected the war in Virginia, where it ravaged slaves who had escaped to join the British forces. During the terrible winter at Valley Forge, General Washington had to decide if and when to attempt the risky inoculation of his troops. In 1779, while Creeks and Cherokees were dying in Georgia, smallpox broke out in Mexico City, whence it followed travelers going north, striking Santa Fe and outlying pueblos in January 1781. Simultaneously it moved up the Pacific coast and east across the plains as far as Hudson's Bay.The destructive, desolating power of smallpox made for a cascade of public-health crises and heartbreaking human drama. Fenn's innovative work shows how this mega-tragedy was met and what its consequences were for America.

    One sought to discover a new planet. Another—an adventuresome female astronomer—fought to prove that science was not anathema to femininity. And a young, megalomaniacal inventor, with the tabloid press fast on his heels, sought to test his scientific bona fides and light the world through his revelations. David Baron brings to three-dimensional life these three competitors—James Craig Watson, Maria Mitchell, and Thomas Edison—and thrillingly re-creates the fierce jockeying of nineteenth-century American astronomy. With spellbinding accounts of train robberies and Indian skirmishes, the mythologized age of the last days of the Wild West comes alive as never before. A magnificent portrayal of America’s dawn as a scientific superpower, American Eclipse depicts a young nation that looked to the skies to reveal its towering ambition and expose its latent genius.

    But which one? And how?Over the past fifty years, more than three hundred infectious diseases have either newly emerged or reemerged, appearing in territories where they’ve never been seen before. Ninety percent of epidemiologists expect that one of them will cause a deadly pandemic sometime in the next two generations. It could be Ebola, avian flu, a drug-resistant superbug, or something completely new. While we can’t know which pathogen will cause the next pandemic, by unraveling the story of how pathogens have caused pandemics in the past, we can make predictions about the future. In Pandemic: Tracking Contagions, from Cholera to Ebola and Beyond, the prizewinning journalist Sonia Shah—whose book on malaria, The Fever, was called a “tour-de-force history” (The New York Times) and “revelatory” (The New Republic)—interweaves history, original reportage, and personal narrative to explore the origins of contagions, drawing parallels between cholera, one of history’s most deadly and disruptive pandemic-causing pathogens, and the new diseases that stalk humankind today.To reveal how a new pandemic might develop, Sonia Shah tracks each stage of cholera’s dramatic journey, from its emergence in the South Asian hinterlands as a harmless microbe to its rapid dispersal across the nineteenth-century world, all the way to its latest beachhead in Haiti. Along the way she reports on the pathogens now following in cholera’s footsteps, from the MRSA bacterium that besieges her own family to the never-before-seen killers coming out of China’s wet markets, the surgical wards of New Delhi, and the suburban backyards of the East Coast.By delving into the convoluted science, strange politics, and checkered history of one of the world’s deadliest diseases, Pandemic reveals what the next global contagion might look like— and what we can do to prevent it.

    Now, in The Organ Thieves, Pulitzer Prize-nominated journalist Chip Jones exposes the horrifying inequality surrounding Tucker's death and how he was used as a human guinea pig without his family's permission or knowledge. The circumstances surrounding his death reflect the long legacy of mistreating African Americans that began more than a century before with cadaver harvesting and worse. It culminated in efforts to win the heart transplant race in the late 1960s.

    While the narrative predominately revolves around Meyer's story, it also includes vignettes from interviews with several other doctors, nurses, and medical assistants, to indicate the wide range of U.S. health care workers' experiences. Meyer recounts the pandemic from the period before it was identified, through its emergence in the United States, the virus's terrifying uncontrolled community spread, and concern about the long-term repercussions of COVID-19. The co-authors argue that forging personal connections is vital to practicing emergency medicine, and they impart health care providers' efforts to compensate for the myriad ways that personal connection was hampered by pandemic precautionary measures. The book isn't only a document of trauma; it also notes moments of joy, like when medical staff discovered new treatments with better patient outcomes, or when Meyer's mentor survived after contracting the virus.

    After years of failed diets Dr Nadja Hermann weighed over 23 stone at the age of 30. All her life, she had heard and read about hundreds of reasons why diets wouldn't work for her. But when her weight started to seriously affect her health, she took a hard look at the science and realised that most of what she believed about dieting was a myth. What was more, those very myths were preventing her from losing weight.Forget clean eating, paleo, or fasting — it was conquering these elements of ‘Fat Logic’ that finally led to Hermann achieving a healthy weight. One and a half years later, she weighed 10 stone, and has maintained that weight to this day. Now, using humour, the insight she’s acquired, and a dose of science, Hermann debunks widespread lies about weight loss, and shows how it is possible to attain a healthy weight.

    But while this medieval medicine now seems archaic, it also made a critical contribution to modern science.Medieval Bodies guides us on a head-to-heel journey through this era’s revolutionary advancements and disturbing convictions. We learn about the surgeons who dissected a living man’s stomach, then sewed him up again; about the geographers who delineated racial groups by skin color; and about the practice of fasting to gain spiritual renown. Encompassing medicine and mysticism, politics and art—and complete with vivid, full-color illustrations—Medieval Bodies shows us how it felt to live and die a thousand years ago.

      In 1875, tuberculosis was the deadliest disease in the world, accountable for a third of all deaths. A diagnosis of TB—often called consumption—was a death sentence. Then, in a triumph of medical science, a German doctor named Robert Koch deployed an unprecedented scientific rigor to discover the bacteria that caused TB. Koch soon embarked on a remedy—a remedy that would be his undoing.   When Koch announced his cure for consumption, Arthur Conan Doyle, then a small-town doctor in England and sometime writer, went to Berlin to cover the event. Touring the ward of reportedly cured patients, he was horrified. Koch’s "remedy" was either sloppy science or outright fraud.   But to a world desperate for relief, Koch’s remedy wasn’t so easily dismissed. As Europe’s consumptives descended upon Berlin, Koch urgently tried to prove his case. Conan Doyle, meanwhile, returned to England determined to abandon medicine in favor of writing. In particular, he turned to a character inspired by the very scientific methods that Koch had formulated: Sherlock Holmes.   Capturing the moment when mystery and magic began to yield to science, The Remedy chronicles the stunning story of how the germ theory of disease became a true fact, how two men of ambition were emboldened to reach for something more, and how scientific discoveries evolve into social truths.

    This is the story of a fateful year that prefigured the events of 1776.In The Fever of 1721, Stephen Coss brings to life an amazing cast of characters in a year that changed the course of medical history, American journalism, and colonial revolution, including Cotton Mather, the great Puritan preacher, son of the president of Harvard College; Zabdiel Boylston, a doctor whose name is on one of Boston's grand avenues; James and his younger brother Benjamin Franklin; and Elisha Cooke and his protegee; Samuel Adams.During the worst smallpox epidemic in Boston history Mather convinced Doctor Boylston to try a procedure that he believed would prevent death--by making an incision in the arm of a healthy person and implanting it with smallpox. Inoculation led to vaccination, one of the most profound medical discoveries in history. Public outrage forced Boylston into hiding, and Mather's house was firebombed.A political fever also raged. Elisha Cooke was challenging the Crown for control of the colony and finally forced Royal Governor Samuel Shute to flee Massachusetts. Samuel Adams and the Patriots would build on this to resist the British in the run-up to the American Revolution. And a bold young printer James Franklin (who was on the wrong side of the controversy on inoculation), launched America's first independent newspaper and landed in jail. His teenage brother and apprentice, Benjamin Franklin, however, learned his trade in James' shop and became a father of the Independence movement.One by one, the atmosphere in Boston in 1721 simmered and ultimately boiled over, leading to the full drama of the American Revolution.

    Contrary to what the glossy magazines would have us believe, we do not enjoy potato chips because they crunch just like the insects our forebears snacked on. As Zuk argues, such beliefs incorrectly assume that we’re stuck—finished evolving—and have been for tens of thousands of years. She draws on fascinating evidence that examines everything from adults’ ability to drink milk to the texture of our ear wax to show that we’ve actually never stopped evolving. Our nostalgic visions of an ideal evolutionary past in which we ate, lived, and reproduced as we were “meant to” fail to recognize that we were never perfectly suited to our environment. Evolution is about change, and every organism is full of trade-offs.From debunking the caveman diet to unraveling gender stereotypes, Zuk gives an analysis of widespread paleofantasies and the scientific evidence that undermines them, all the while broadening our understanding of our origins and what they can really tell us about our present and our future.

    In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future

    It is too bad, write scientist-historian couple Robert and Michèle Root-Bernstein, who deplore the loss of proven methods developed without the blessing of the academy, noting that "formal academic systems are only one of many ways in which knowledge is discovered, accumulated, and transmitted." Many scientists are now coming to agree with this view, they write in this fascinating collection of case studies. Researchers have showed that black tea, for instance, has powerful antibiotic properties and that maggots do an extraordinary job of cleaning wounds--as traditional healers have known all along.

    At the end of the nineteenth century, serial murderer Joseph Vacher, known and feared as "The Killer of Little Shepherds," terrorized the French countryside. He eluded authorities for years--until he ran up against prosecutor Emile Fourquet and Dr. Alexandre Lacassagne, the era's most renowned criminologist. The two men--intelligent and bold--typified the Belle Epoque, a period of immense scientific achievement and fascination with science's promise to reveal the secrets of the human condition. With high drama and stunning detail, Douglas Starr revisits Vacher's infamous crime wave, interweaving the story of how Lacassagne and his colleagues were developing forensic science as we know it. We see one of the earliest uses of criminal profiling, as Fourquet painstakingly collects eyewitness accounts and constructs a map of Vacher's crimes. We follow the tense and exciting events leading to the murderer's arrest. And we witness the twists and turns of the trial, celebrated in its day. In an attempt to disprove Vacher's defense by reason of insanity, Fourquet recruits Lacassagne, who in the previous decades had revolutionized criminal science by refining the use of blood-spatter evidence, systematizing the autopsy, and doing groundbreaking research in psychology. Lacassagne's efforts lead to a gripping courtroom denouement. "The Killer of Little Shepherds" is an important contribution to the history of criminal justice, impressively researched and thrillingly told.

    Between 1900 and 1907, she infected twenty-two New Yorkers with typhoid fever through her puddings and cakes; one of them died. Tracked down through epidemiological detective work, she was finally apprehended as she hid behind a barricade of trashcans. To protect the public's health, authorities isolated her on Manhattan's North Brother Island, where she died some thirty years later.This book tells the remarkable story of Mary Mallon--the real Typhoid Mary. Combining social history with biography, historian Judith Leavitt re-creates early-twentieth-century New York City, a world of strict class divisions and prejudice against immigrants and women. Leavitt engages the reader with the excitement of the early days of microbiology and brings to life the conflicting perspectives of journalists, public health officials, the law, and Mary Mallon herself.Leavitt's readable account illuminates dilemmas that continue to haunt us. To what degree are we willing to sacrifice individual liberty to protect the public's health? How far should we go in the age of AIDS, drug-resistant tuberculosis, and other diseases? For anyone who is concerned about the threats and quandaries posed by new epidemics, Typhoid Mary is a vivid reminder of the human side of disease and disease control.

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.