But sometimes, when obsession gets the better of scientists, they twist a noble pursuit into something sinister. Under this spell, knowledge isn’t everything, it’s the only thing—no matter the cost. Bestselling author Sam Kean tells the true story of what happens when unfettered ambition pushes otherwise rational men and women to cross the line in the name of science, trampling ethical boundaries and often committing crimes in the process.The Icepick Surgeon masterfully guides the reader across two thousand years of history, beginning with Cleopatra’s dark deeds in ancient Egypt. The book reveals the origins of much of modern science in the transatlantic slave trade of the 1700s, as well as Thomas Edison’s mercenary support of the electric chair and the warped logic of the spies who infiltrated the Manhattan Project. But the sins of science aren’t all safely buried in the past. Many of them, Kean reminds us, still affect us today. We can draw direct lines from the medical abuses of Tuskegee and Nazi Germany to current vaccine hesitancy, and connect icepick lobotomies from the 1950s to the contemporary failings of mental-health care. Kean even takes us into the future, when advanced computers and genetic engineering could unleash whole new ways to do one another wrong.Unflinching, and exhilarating to the last page, The Icepick Surgeon fuses the drama of scientific discovery with the illicit thrill of a true-crime tale. With his trademark wit and precision, Kean shows that, while science has done more good than harm in the world, rogue scientists do exist, and when we sacrifice morals for progress, we often end up with neither.

    At the same time, he was immersed in street life. Today he is a cutting-edge neuroscientist—Columbia University's first tenured African American professor in the sciences—whose landmark, controversial research is redefining our understanding of addiction.In this provocative and eye-opening memoir, he recalls his journey of self-discovery and weaves his past and present. Hart goes beyond the hype of the antidrug movement as he examines the relationship among drugs, pleasure, choice, and motivation, both in the brain and in society. His findings shed new light on common ideas about race, poverty, and drugs, and explain why current policies are failing.Though Hart escaped neighborhoods that were dominated by entrenched poverty and the knot of problems associated with it, he has not turned his back on his roots. Determined to make a difference, he tirelessly applies his scientific research to help save real lives. But balancing his former street life with his achievements today has not been easy—a struggle he reflects on publicly for the first time.A powerful story of hope and change, of a scientist who has dedicated his life to helping others, High Price will alter the way we think about poverty, race, and addiction—and how we can effect change.

    Detroit, once the richest city in the nation, is now its poorest. Once the vanguard of America’s machine age—mass production, automobiles, and blue-collar jobs—Detroit is now America’s capital for unemployment, illiteracy, foreclosure, and dropouts. A city the size of San Francisco and Manhattan could neatly fit into Detroit’s vacant lots. In another life, Charlie LeDuff won the Pulitzer Prize reporting for The New York Times. But all that is behind him now, after returning to find his hometown in total freefall. Detroit is where his mother’s flower shop was firebombed; where his sister lost herself to drugs; where his brother works in a factory cleaning Chinese-manufactured screws so they can be repackaged as “Made in America.” With the steel-eyed reportage that has become his trademark—and the righteous indignation only a native son possesses—LeDuff sets out to uncover what destroyed his city. He embeds with a local fire brigade struggling to defend its neighborhood against systemic arson and bureaucratic corruption. He investigates state senators and career police officials, following the money to discover who benefits from Detroit’s decline. He befriends union organizers, homeless do-gooders, embattled businessmen, and struggling homeowners, all ordinary people holding the city together by sheer determination. Americans have hoped for decades that Detroit was an exception, an outlier. What LeDuff reveals is that Detroit is, once and for all, America’s city: It led us on the way up, and now it is leading us on the way down. Detroit can no longer be ignored because what happened there is happening out here. Redemption is thin on the ground in this ghost of a city, but Detroit: An American Autopsy is no hopeless parable. Instead, LeDuff shares a deeply human drama of colossal greed, ignorance, endurance, and courage. Detroit is an unbelievable story of a hard town in a rough time filled with some of the strangest and strongest people our country has to offer—and a black comic tale of the absurdity of American life in the twenty-first century.

    Together they spent a combined thirty years in prison before finally being exonerated in 2008. Meanwhile, the real killer remained free.The Cadaver King and the Country Dentist chronicles how the courts and Mississippi's death investigation system--a relic of the Jim Crow era--failed to deliver justice for its citizens and recounts the horrifying story of the two men who built successful careers on the back of this system. For nearly two decades, medical examiner Dr. Steven Hayne performed the vast majority of Mississippi's autopsies, while his friend Dr. Michael West, a local dentist, pitched himself as a forensic jack-of-all-trades. Together they became the go-to experts for prosecutors and helped put countless Mississippians in prison. But then some of those convictions began to fall apart. Radley Balko and Tucker Carrington argue that bad forensics, structural racism, and institutional failures are at fault, and raise sobering questions about our criminal justice system's ability to address them.

    Pharmaceutical breakthroughs such as anti­biotics and vaccines rank among some of the greatest advancements in human history. Yet exorbitant prices for life-saving drugs, safety recalls affecting tens of millions of Americans, and soaring rates of addiction and overdose on pre­scription opioids have caused many to lose faith in drug companies. Now, Americans are demanding a national reckoning with a monolithic industry. Pharma introduces brilliant scientists, in-corruptible government regulators, and brave whistleblowers facing off against company exec­utives often blinded by greed. A business that profits from treating ills can create far deadlier problems than it cures. Addictive products are part of the industry’s DNA, from the days when corner drugstores sold morphine, heroin, and cocaine, to the past two decades of dangerously overprescribed opioids. Pharma also uncovers the real story of the Sacklers, the family that became one of America’s wealthiest from the success of OxyContin, their blockbuster narcotic painkiller at the center of the opioid crisis. Relying on thousands of pages of government and corporate archives, dozens of hours of interviews with insiders, and previously classified FBI files, Posner exposes the secrets of the Sacklers’ rise to power—revelations that have long been buried under a byzantine web of interlocking companies with ever-changing names and hidden owners. The unexpected twists and turns of the Sackler family saga are told against the startling chronicle of a powerful industry that sits at the intersection of public health and profits. Pharma reveals how and why American drug com­panies have put earnings ahead of patients.

    secretary of stateA Fascist, observes Madeleine Albright, “is someone who claims to speak for a whole nation or group, is utterly unconcerned with the rights of others, and is willing to use violence and whatever other means are necessary to achieve the goals he or she might have.” The twentieth century was defined by the clash between democracy and Fascism, a struggle that created uncertainty about the survival of human freedom and left millions dead. Given the horrors of that experience, one might expect the world to reject the spiritual successors to Hitler and Mussolini should they arise in our era. In Fascism: A Warning, Madeleine Albright draws on her experiences as a child in war-torn Europe and her distinguished career as a diplomat to question that assumption.Fascism, as she shows, not only endured through the twentieth century but now presents a more virulent threat to peace and justice than at any time since the end of World War II.  The momentum toward democracy that swept the world when the Berlin Wall fell has gone into reverse.  The United States, which historically championed the free world, is led by a president who exacerbates division and heaps scorn on democratic institutions.  In many countries, economic, technological, and cultural factors are weakening the political center and empowering the extremes of right and left.  Contemporary leaders such as Vladimir Putin and Kim Jong-un are employing many of the tactics used by Fascists in the 1920s and 30s.Fascism: A Warning is a book for our times that is relevant to all times.  Written  by someone who has not only studied history but helped to shape it, this call to arms teaches us the lessons we must understand and the questions we must answer if we are to save ourselves from repeating the tragic errors of the past.

    The public has thus been left to wonder whether he is mad, bad, or both.In THE DANGEROUS CASE OF DONALD TRUMP, twenty-seven psychiatrists, psychologists, and other mental health experts argue that, in Mr. Trump’s case, their moral and civic “duty to warn” America supersedes professional neutrality. They then explore Trump’s symptoms and potentially relevant diagnoses to find a complex, if also dangerously mad, man.Philip Zimbardo and Rosemary Sword, for instance, explain Trump’s impulsivity in terms of “unbridled and extreme present hedonism.” Craig Malkin writes on pathological narcissism and politics as a lethal mix. Gail Sheehy, on a lack of trust that exceeds paranoia. Lance Dodes, on sociopathy. Robert Jay Lifton, on the “malignant normality” that can set in everyday life if psychiatrists do not speak up.His madness is catching, too. From the trauma people have experienced under the Trump administration to the cult-like characteristics of his followers, he has created unprecedented mental health consequences across our nation and beyond.It’s not all in our heads. It’s in his."There will not be a book published this fall more urgent, important, or controversial than The Dangerous Case of Donald Trump...profound, illuminating and discomforting" —Bill Moyers

    His murder was part of a wave of white terrorism in the wake of the 1954 Supreme Court decision that declared public school segregation unconstitutional. Only weeks later, Rosa Parks thought about young Emmett as she refused to move to the back of a city bus in Montgomery, Alabama. Five years later, Black students who called themselves “the Emmett Till generation” launched sit-in campaigns that turned the struggle for civil rights into a mass movement. Till’s lynching became the most notorious hate crime in American history.But what actually happened to Emmett Till—not the icon of injustice, but the flesh-and-blood boy? Part detective story, part political history, drawing on a wealth of new evidence, including a shocking admission of Till’s innocence from the woman in whose name he was killed. this book provides fresh insight into the way race has informed and deformed our democratic institutions.

    Eilene Zimmerman noticed that her ex-husband looked thin, seemed distracted, and was frequently absent from activities with their children. She thought he looked sick and needed to see a doctor, and indeed, he told her he had been diagnosed with an autoimmune disorder. Yet in many ways, Peter also seemed to have it all: a beautiful house by the beach purchased after their divorce, expensive cars, and other luxuries that came with an affluent life. Eilene assumed his odd behavior was due to stress and overwork--he was a senior partner at a prominent law firm and had been working more than 60 hours a week for the last 20 years.Although they were divorced, Eilene and Peter had been partners and friends for decades, so, when her calls to Peter were not returned for several days, Eilene went to his house to see if he was OK.So begins Smacked, a brilliant, moving memoir of Eilene's shocking discovery, one that sets her on a journey to find out how a man she knew for nearly 30 years became a drug addict, and hid it so well that neither she nor anyone else in his life suspected what was happening. Eilene discovers that Peter led a secret life, one that started with pills and ended with opioids, cocaine and methamphetamine. Peter was also addicted to work; the last call he ever made was to dial into a conference call.Eilene is determined to learn all she can about Peter's hidden life, and also about drug addiction among ambitious and high achieving professionals like him. Through extensive research and interviews, she presents a picture of drug dependence today in that moneyed, upwardly mobile world. She also embarks on a journey to recreate her life in the wake of loss, both of the person--and the relationship--that profoundly defined the woman she had become.Smacked takes readers on an intimate journey into a little-known part of the drug epidemic, through the story of one man, one woman and one family.

    But Charlie wasn't lighting fires alone: he had an accomplice, his girlfriend Tonya Bundick. Through her depiction of the dangerous shift that happened in their passionate relationship, Hesse brilliantly brings to life the once-thriving coastal community and its distressed inhabitants, who had already been decimated by a punishing economy before they were terrified by a string of fires they could not explain. Incorporating this drama into the long-overlooked history of arson in the United States, American Fire re-creates the anguished nights that this quiet county spent lit up in flames, mesmerizingly evoking a microcosm of rural America - a land half gutted before the fires even began.

    In the era of Donald Trump, many lower- and middle-class white Americans are drawn to politicians who pledge to make their lives great again. But as Dying of Whiteness shows, the policies that result actually place white Americans at ever-greater risk of sickness and death.Physician Jonathan M. Metzl's quest to understand the health implications of "backlash governance" leads him across America's heartland. Interviewing a range of everyday Americans, he examines how racial resentment has fueled pro-gun laws in Missouri, resistance to the Affordable Care Act in Tennessee, and cuts to schools and social services in Kansas. And he shows these policies' costs: increasing deaths by gun suicide, rising dropout rates, and falling life expectancies. White Americans, Metzl argues, must reject the racial hierarchies that promise to aid them but in fact lead our nation to demise.

    One man dared to challenge their effort and thwart attempts to take over the city, Police Detective Ron Stallworth. He launched an undercover investigation into the Klan, gained membership into the organization, briefly served as Duke's bodyguard, and was eventually asked to be the leader of the Colorado Springs chapter. The irony of this investigation was that Stallworth is… A Black man. In the process he battled internal departmental politics to successfully pull off this "sting." Black Klansman explains how he overcame these obstacles and accomplished this almost unbelievable unique achievement.

    What was really going on around the president, as the government failed to contain the coronavirus and over half a million Americans perished? Who was influencing Trump after he refused to concede an election he had clearly lost and spread lies about election fraud? To answer these questions, Philip Rucker and Carol Leonnig reveal a dysfunctional and bumbling presidency’s inner workings in unprecedented, stunning detail. Focused on Trump and the key players around him—the doctors, generals, senior advisers, and Trump family members— Rucker and Leonnig provide a forensic account of the most devastating year in a presidency like no other. Their sources were in the room as time and time again Trump put his personal gain ahead of the good of the country. These witnesses to history tell the story of him longing to deploy the military to the streets of American cities to crush the protest movement in the wake of the killing of George Floyd, all to bolster his image of strength ahead of the election. These sources saw firsthand his refusal to take the threat of the coronavirus seriously—even to the point of allowing himself and those around him to be infected. This is a story of a nation sabotaged—economically, medically, and politically—by its own leader, culminating with a groundbreaking, minute-by-minute account of exactly what went on in the Capitol building on January 6, as Trump’s supporters so easily breached the most sacred halls of American democracy, and how the president reacted. With unparalleled access, Rucker and Leonnig explain and expose exactly who enabled—and who foiled—Trump as he sought desperately to cling to power. A classic and heart-racing work of investigative reporting, this book is destined to be read and studied by citizens and historians alike for decades to come.

    It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

    This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.