As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Trump is a man of great media savvy, entrepreneurial spirit, and political clout. Yet his career has been plagued by legal troubles and mounting controversy.From the origins of his family's fortune, to his own too-big-to-fail business empire; from his education and early career, to his whirlwind and ultimately successful presidential bid, The Making of Donald Trump provides the fullest picture yet of Trump's extraordinary ascendency. Love him or hate him, Trump's massive influence is undeniable, and figures as diverse as Woody Guthrie (who wrote a scathing song about Trump's father) and Red Scare prosecutor Roy Cohn, mob bosses and high rollers, as well as the average American voter, have all been pulled into his orbit.Drawing on decades of interviews, financial records, court documents, and public statements, David Cay Johnston, who has covered Trump longer and more closely than any other journalist working today, gives us the most in-depth look yet at the man who has shocked the world."Provides useful, vigorously reported overviews of Mr. Trump's life and career ... Mr. Johnston, who has followed the real estate impresario for nearly three decades, offers a searing indictment of his business practices and creative accounting."--Michiko Kakutani, The New York Times "David Cay Johnston has given us this year's must-read Trump book."--Lawrence O'Donnell, MSNBC's The Last Word "Johnston devastatingly covers ground he broke open as a reporter on the Trump beat in Philadelphia and at The New York Times...The best of investigative reporting is brought to bear on a man who could potentially lead the free world."--USA Today "Carefully fleshes out the details of Trump's known biography...with solid documentation."--Tampa Bay Times

    Haunted by the landscape of his youth, Cantú joins the Border Patrol. He and his partners are posted to remote regions crisscrossed by drug routes and smuggling corridors, where they learn to track other humans under blistering sun and through frigid nights. They haul in the dead and deliver to detention those they find alive.Cantú tries not to think where the stories go from there. Plagued by nightmares, he abandons the Patrol for civilian life. But when an immigrant friend travels to Mexico to visit his dying mother and does not return, Cantú discovers that the border has migrated with him, and now he must know the whole story. Searing and unforgettable, The Line Becomes a River makes urgent and personal the violence our border wreaks on both sides of the line.

    When death is sudden or unexplained, it falls to Shepherd to establish the cause. Each post-mortem is a detective story in its own right - and Shepherd has performed over 23,000 of them. Through his skill, dedication and insight, Dr Shepherd solves the puzzle to answer our most pressing question: how did this person die?From serial killer to natural disaster, 'perfect murder' to freak accident, Shepherd takes nothing for granted in pursuit of truth. And while he's been involved in some of the most high-profile cases of recent times, it's often the less well known encounters that prove the most perplexing, intriguing and even bizarre. In or out of the public eye, his evidence has put killers behind bars, freed the innocent and turned open-and-shut cases on their heads.But a life in death, bearing witness to some of humanity's darkest corners, exacts a price and Shepherd doesn't flinch from counting the cost to him and his family.

    Through a series of disastrous decisions, the state government had switched the city’s water to a source that corroded Flint’s aging lead pipes. Complaints about the foul-smelling water were dismissed: the residents of Flint—a largely poor African American city of about 100,000 people—were not seen as credible, even in matters of their own lives.It took 18 months of activism and a band of dogged outsiders to force the state to admit that the water was poisonous. But this was only after 12 people died and Flint's children suffered irreparable harm. The long battle for accountability and a humane response to this man-made disaster have only just begun.In the first full-length account of this epic failure, The Poisoned City recounts the gripping story of Flint’s poisoned water through the people who caused it, suffered from it, and exposed it. It is a chronicle of one town, but could also be about any American city, all made precarious by the neglect of infrastructure and the erosion of democratic decision-making. Cities like Flint are set up to fail—and for the people who live and work in them, the consequences may be mortal.A 2019 Library of Michigan Notable Books

    Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    No one in this radical splinter sect of the Mormon Church was more powerful or terrifying than its leader Warren Jeffs—Rachel’s father.Living outside mainstream Mormonism and federal law, Jeffs arranged marriages between under-age girls and middle-aged and elderly members of his congregation. In 2006, he gained international notoriety when the FBI placed him on its Ten Most Wanted List. Though he is serving a life sentence for child sexual assault, Jeffs’ iron grip on the church remains firm, and his edicts to his followers increasingly restrictive and bizarre.In Breaking Free, Rachel blows the lid off this taciturn community made famous by John Krakauer’s bestselling Under the Banner of Heaven to offer a harrowing look at her life with Warren Jeffs, and the years of physical and emotional abuse she suffered. Sexually assaulted, compelled into an arranged polygamous marriage, locked away in "houses of hiding" as punishment for perceived transgressions, and physically separated from her children, Rachel, Jeffs’ first plural daughter by his second of more than fifty wives, eventually found the courage to leave the church in 2015. But Breaking Free is not only her story—Rachel’s experiences illuminate those of her family and the countless others who remain trapped in the strange world she left behind.A shocking and mesmerizing memoir of faith, abuse, courage, and freedom, Breaking Free is an expose of religious extremism and a beacon of hope for anyone trying to overcome personal obstacles.

     Elinor Cleghorn became an unwell woman ten years ago. She was diagnosed with an autoimmune disease after a long period of being told her symptoms were anything from psychosomatic to a possible pregnancy. As Elinor learned to live with her unpredictable disease she turned to history for answers, and found an enraging legacy of suffering, mystification, and misdiagnosis.In Unwell Women, Elinor Cleghorn traces the almost unbelievable history of how medicine has failed women by treating their bodies as alien and other, often to perilous effect. The result is an authoritative and groundbreaking exploration of the relationship between women and medical practice, from the wandering womb of Ancient Greece to the rise of witch trials across Europe, and from the dawn of hysteria as a catchall for difficult-to-diagnose disorders to the first forays into autoimmunity and the shifting understanding of hormones, menstruation, menopause, and conditions like endometriosis.Packed with character studies and case histories of women who have suffered, challenged, and rewritten medical orthodoxy--and the men who controlled their fate--this is a revolutionary examination of the relationship between women, illness, and medicine. With these case histories, Elinor pays homage to the women who suffered so strides could be made, and shows how being unwell has become normalized in society and culture, where women have long been distrusted as reliable narrators of their own bodies and pain. But the time for real change is long overdue: answers reside in the body, in the testimonies of unwell women--and their lives depend on medicine learning to listen.

    The paint is the blood that splatters on the walls and floors. In the course of nearly five years of recorded interviews Frank Sheeran confessed to Charles Brandt that he handled more than twenty-five hits for the mob, and for his friend Hoffa. Sheeran learned to kill in the U.S. Army, where he saw an astonishing 411 days of active combat duty in Italy during World War II. After returning home he became a hustler and hit man, working for legendary crime boss Russell Bufalino. Eventually he would rise to a position of such prominence that in a RICO suit then-U.S. Attorney Rudy Giuliani would name him as one of only two non-Italians on a list of 26 top mob figures. When Bufalino ordered Sheeran to kill Hoffa, he did the deed, knowing that if he had refused he would have been killed himself. Sheeran's important and fascinating story includes new information on other famous murders, and provides rare insight to a chapter in American history. Charles Brandt has written a page-turner that is destined to become a true crime classic.

    In the early 1800s, women were dying in large numbers from treatable diseases because they avoided receiving medical care. Examinations performed by male doctors were often demeaning and even painful. In addition, women faced stigma from illness—a diagnosis could greatly limit their ability to find husbands, jobs or be received in polite society.Motivated by personal loss and frustration over inadequate medical care, Elizabeth Blackwell, Elizabeth Garrett Anderson and Sophia Jex-Blake fought for a woman’s place in the male-dominated medical field. For the first time ever, Women in White Coats tells the complete history of these three pioneering women who, despite countless obstacles, earned medical degrees and paved the way for other women to do the same. Though very different in personality and circumstance, together these women built women-run hospitals and teaching colleges—creating for the first time medical care for women by women.With gripping storytelling based on extensive research and access to archival documents, Women in White Coats tells the courageous history these women made by becoming doctors, detailing the boundaries they broke of gender and science to reshape how we receive medical care today.

    America was founded by wishful dreamers, magical thinkers, and true believers, by hucksters and their suckers. Fantasy is deeply embedded in our DNA.Over the course of five centuries--from the Salem witch trials to Scientology to the Satanic Panic of the 1980s, from P. T. Barnum to Hollywood and the anything-goes, wild-and-crazy sixties, from conspiracy theories to our fetish for guns and obsession with extraterrestrials--our love of the fantastic has made America exceptional in a way that we've never fully acknowledged. From the start, our ultra-individualism was attached to epic dreams and epic fantasies--every citizen was free to believe absolutely anything, or to pretend to be absolutely anybody. With the gleeful erudition and tell-it-like-it-is ferocity of a Christopher Hitchens, Andersen explores whether the great American experiment in liberty has gone off the rails.

    When he learned how to see again, he didn't want anyone's pity. People shouldn't feel sorry for him, he decided, and they shouldn't feel sorry for themselves either. Most people's everyday challenges aren't as extreme as surviving combat or working to regain their sight, but that's just Crenshaw's point: If we can meet life's toughest challenges without resenting our luck or complaining, minor daily obstacles aren't worth our outrage. "Microaggressions" and "triggers" from mere words mean little to someone who's had bullets fly by their head. That's Crenshaw's simple lesson in FORTITUDE: Lighten up, toughen up, and get to work on what's important (hint: it's not giving into a culture of outrage, playing the victim, and seeking an apology).FORTITUDE is a no-nonsense advice book for a society desperately in need of tough love. With meditations on perseverance, failure, and finding much-needed heroes, the book is the antidote for a prevailing "safety culture" of trigger warnings and safe spaces. Interspersed with lessons and advice is Crenshaw's own story of how an average American kid from the Houston suburbs has faced all sorts of unexpected situations -- from war zones to the halls of Congress -- and managed to navigate them all with a few simple tricks: a sense of humor and an even greater sense that, no matter what anyone else around us says or does, we are in control of our own destiny.

    These invisible casualties of the Great Recession have taken to the road by the tens of thousands in RVs and modified vans, forming a growing community of nomads.Nomadland tells a revelatory tale of the dark underbelly of the American economy—one which foreshadows the precarious future that may await many more of us. At the same time, it celebrates the exceptional resilience and creativity of these Americans who have given up ordinary rootedness to survive, but have not given up hope.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Gang Leader for a Day is the fascinating full story of how Sudhir Venkatesh managed to gain entrée into the gang, what he learned, and how his method revolutionized the academic establishment. When Venkatesh walked into an abandoned building in one of Chicago's most notorious housing projects, he was looking for people to take a multiple-choice survey on urban poverty. A first-year grad student, he would befriend a gang leader named JT and spend the better part of the next decade inside the projects under JT's protection, documenting what he saw there. Over the next seven years, Venkatesh observed JT and the rest of the gang as they operated their crack selling business, conducted PR within their community, and rose up or fell within the ranks of the gang's complex organizational structure. Gang Leader for a Day is an inside view into the morally ambiguous, highly intricate, often corrupt struggle to survive in an urban war zone. It is also the story of a complicated friendship between two young and ambitious men, a universe apart.