Gonzalez-Crussi, from the Introduction An international bestseller, translated into eighteen languages, Paul de Kruif’s classic account of the first scientists to see and learn about the microscopic world continues to fascinate new readers. This is a timeless dramatization of the scientists, bacteriologists, doctors, and medical technicians who discovered the microbes and invented the vaccines to counter them. De Kruif writes about how seemingly simple but really fundamental discovers of science—for instance, how a microbe was first viewed in a clear drop of rain water, and when, for the first time, Louis Pasteur discovered that a simple vaccine could save a man from the ravages of rabies by attacking the microbes that cause it.

    For decades, these questions have lived exclusively in the realm of science fiction, but as Kevin Davies powerfully reveals in his new book, this is all about to change.Engrossing and page-turning, Editing Humanity takes readers inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code.Davies introduces readers to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.Though the birth of the “CRISPR babies” in China made international news, there is much more to the story of CRISPR than headlines seemingly ripped from science fiction. In Editing Humanity, Davies sheds light on the implications that this new technology can have on our everyday lives and in the lives of generations to come.

    This book was originally written by third-year medical students searching for the perfect review book--not finding it on the market, they wrote it themselves! Now in its third edition, Step-Up to Medicine boils down the full scope of tested pathology in a single ingenious tool. Each element is tailored for immediate content absorption, and an all-new, full-color interior differentiate elements for even faster, more efficient review. And, Step-Up to Medicine , third edition provides two types of self-assessment--the kinds of questions you will ask yourself as a clinician plus USMLE-style practice questions. This review book gives you just the Step-Up to the medicine clerkship, accompanying shelf exams, and USMLE Step 2 that you need! NEW Features for this blockbuster edition: Full-color, updated interior design brings the content to you in a rousing, memorable style. Full-color, updated art program illustrates concepts when a picture says it best--plenty of clinical images also supplement topics. New content on evidence-based medicine keeps you current and informed to guide your clinical decision making. Expanded content on drug dosing is added where relevant.CLASSIC Features students swear by: Complete coverage of high-yield medical topics ensures you are test ready Clinical Pearls boxes help you "file away" clinical medicine connections for handy retrieval at test time Quick Hits glimmering in the margins highlight highly testable material--just see how the sparks fly at test timeBONUS Material and study resources: eBook with the fully searchable text is available via thePoint . NEW 300 USMLE-style questions provide another means of self-assessment and practice for those exams NEW Audio clips of breath and heart sounds also available on thePoint

    Bennet Omalu, the pathologist who made one of the most significant medical discoveries of the twenty-first century, a discovery that challenges the existence of America’s favorite sport and puts Omalu in the crosshairs of football’s most powerful corporation: the NFL. Jeanne Marie Laskas first met the young forensic pathologist Dr. Bennet Omalu in 2009, while reporting a story for GQ that would go on to inspire the movie Concussion. Omalu told her about a day in September 2002, when, in a dingy morgue in downtown Pittsburgh, he picked up a scalpel and made a discovery that would rattle America in ways he’d never intended. Omalu was new to America, chasing the dream, a deeply spiritual man escaping the wounds of civil war in Nigeria. The body on the slab in front of him belonged to a fifty-year-old named Mike Webster, aka “Iron Mike,” a Hall of Fame center for the Pittsburgh Steelers, one of the greatest ever to play the game. After retiring in 1990, Webster had suffered a dizzyingly steep decline. Toward the end of his life, he was living out of his van, tasering himself to relieve his chronic pain, and fixing his rotting teeth with Super Glue. How did this happen?, Omalu asked himself. How did a young man like Mike Webster end up like this? The search for answers would change Omalu’s life forever and put him in the crosshairs of one of the most powerful corporations in America: the National Football League. What Omalu discovered in Webster’s brain—proof that Iron Mike’s mental deterioration was no accident but a disease caused by blows to the head that could affect everyone playing the game—was the one truth the NFL wanted to ignore.   Taut, gripping, and gorgeously told, Concussion is the stirring story of one unlikely man’s decision to stand up to a multibillion-dollar colossus, and to tell the world the truth.  Advance praise for Concussion “A gripping medical mystery and a dazzling portrait of the young scientist no one wanted to listen to . . . a fabulous, essential read.”—Rebecca Skloot, author of The Immortal Life of Henrietta Lacks“The story of Dr. Bennet Omalu’s battle against the NFL is classic David and Goliath stuff, and Jeanne Marie Laskas—one of my favorite writers on earth—makes it as exciting as any great courtroom or gridiron drama. A riveting, powerful human tale—and a master class on how to tell a story.”—Charles Duhigg, author of The Power of Habit   “Bennet Omalu forced football to reckon with head trauma. The NFL doesn’t want you to hear his story, but Jeanne Marie Laskas makes it unforgettable. This book is gripping, eye-opening, and full of heart.”—Emily Bazelon, author of Sticks and Stones

    We ignore this reality most of the time, but when a new threat (Ebola, SARS, Zika) seems imminent, we send our best and bravest doctors to contain it--people like Dr. Ali S. Khan.In his long career as a public health first responder—protected by a thin mask from infected patients, napping under nets to keep out scorpions, making life-and-death decisions on limited, suspect information—Khan has found that rogue microbes will always be a problem, but outbreaks are often caused by people. We make mistakes, politicize emergencies, and, too often, fail to imagine the consequences of our actions.The Next Pandemic is a firsthand account of disasters like anthrax, bird flu, and others and how we could do more to prevent their return. It's both a gripping story of our brushes with fate and an urgent lesson on how we can keep ourselves safe from the inevitable next pandemic.

    Greene, who recently launched World Science U, which offers free online science courses, explains what it is that's so "elegant" about string theory while lamenting the possible limits of what dogs (and by implication humans) can ever hope to understand about the universe. The interview was conducted by Rivka Galchen, an acclaimed fiction writer and journalist, named by The New Yorker as one of 20 Writers Under 40. Cover design by Adil Dara Kim.

    In three successive waves, from 1918 to 1919, influenza killed more than 50 million people. German soldiers termed it Blitzkatarrh, British soldiers referred to it as Flanders Grippe, but world-wide, the pandemic gained the notorious title of “Spanish Flu." Nowhere on earth escaped: the United States recorded 550,000 deaths (five times its total military fatalities in the war), while European deaths totaled more than two million.Amid the war, some governments suppressed news of the outbreak. Even as entire battalions were decimated, with both the Allies and the Germans suffering massive casualties, the details of many servicemen’s deaths were hidden to protect public morale. Meanwhile, civilian families were being struck down in their homes. Philadelphia ran out of gravediggers and coffins, and mass burial trenches had to be excavated with steam shovels. Spanish flu conjured up the specter of the Black Death of 1348 and the great plague of 1665, while the medical profession, shattered after five terrible years of conflict, lacked the resources to contain and defeat this new enemy. Through primary and archival sources, historian Catharine Arnold gives readers the first truly global account of this terrible epidemic.

    It was a sea in name only. It was actually a bone dry, ancient dusty basin pockmarked with craters and littered with rocks and boulders. Somewhere in that 500 mile diameter basin, the astronauts would attempt to make Mankind’s first landing on the Moon. Neil Armstrong would pilot the Lunar Module “Eagle” during its twelve minute descent from orbit down to a landing. Col. Edwin “Buzz” Aldrin would assist him. On the way down they would encounter a host of problems, any one of which could have potentially caused them to have to call off the landing, or, even worse, die making the attempt. The problems were all technical-communications problems, computer problems, guidance problems, sensor problems. Armstrong and Aldrin faced the very real risk of dying by the very same technical sword that they had to live by in order to accomplish the enormous task of landing on the Moon for the first time. Yet the human skills Armstrong and Aldrin employed would be more than equal to the task. Armstrong’s formidable skills as an aviator, honed from the time he was a young boy, would serve him well as he piloted Eagle down amidst a continuing series of systems problems that might have fatally distracted a lesser aviator. Armstrong’s brilliant piloting was complemented by Aldrin’s equally remarkable discipline and calmness as he stoically provided a running commentary on altitude and descent rate while handling systems problems that threatened the landing. Finally, after a harrowing twelve and a half minutes, Armstrong gently landed Eagle at “Tranquility Base”, a name he had personally chosen to denote the location of the first Moon landing. In “Landing Eagle-Inside the Cockpit During the First Moon Landing”, author Mike Engle gives a minute by minute account of the events that occurred throughout Eagle’s descent and landing on the Moon. Engle, a retired NASA engineer and Mission Control flight controller, uses NASA audio files of actual voice recordings made inside Eagle’s cockpit during landing to give the reader an “inside the cockpit” perspective on the first Moon landing. Engle’s transcripts of these recordings, along with background material on the history and technical details behind the enormous effort to accomplish the first Moon landing, give a new and fascinating insight into the events that occurred on that remarkable day fifty years ago.

    In the majority of cases individuals diagnosed as "brain dead" are the source of the organs without which transplants could not take place. In this compelling and provocative examination, Margaret Lock traces the discourse over the past thirty years that contributed to the locating of a new criterion of death in the brain, and its routinization in clinical practice in North America. She compares this situation with that in Japan where, despite the availability of the necessary technology and expertise, brain death was legally recognized only in 1997, and then under limited and contested circumstances. Twice Dead explores the cultural, historical, political, and clinical reasons for the ready acceptance of the new criterion of death in North America and its rejection, until recently, in Japan, with the result that organ transplantation has been severely restricted in that country. This incisive and timely discussion demonstrates that death is not self-evident, that the space between life and death is historically and culturally constructed, fluid, multiple, and open to dispute. In addition to an analysis of that professional literature on and popular representations of the subject, Lock draws on extensive interviews conducted over ten years with physicians working in intensive care units, transplant surgeons, organ recipients, donor families, members of the general public in both Japan and North America, and political activists in Japan opposed to the recognition of brain death. By showing that death can never be understood merely as a biological event, and that cultural, medical, legal, and political dimensions are inevitably implicated in the invention of brain death, Twice Dead confronts one of the most troubling questions of our era.

    . . If what we want in this moment is insight from this brilliant doctor about pandemics, he wants us to see that they do not occur in isolation. --Carolyn Kellogg, The Boston GlobeIn 2014, Sierra Leone, Liberia, and Guinea suffered the worst epidemic of Ebola in history. The brutal virus spread rapidly through a clinical desert where basic health-care facilities were few and far between. Causing severe loss of life and economic disruption, the Ebola crisis was a major tragedy of modern medicine. But why did it happen, and what can we learn from it?Paul Farmer, the internationally renowned doctor and anthropologist, experienced the Ebola outbreak firsthand--Partners in Health, the organization he founded, was among the international responders. In Fevers, Feuds, and Diamonds, he offers the first substantive account of this frightening, fast-moving episode and its implications. In vibrant prose, Farmer tells the harrowing stories of Ebola victims while showing why the medical response was slow and insufficient. Rebutting misleading claims about the origins of Ebola and why it spread so rapidly, he traces West Africa's chronic health failures back to centuries of exploitation and injustice. Under formal colonial rule, disease containment was a priority but care was not - and the region's health care woes worsened, with devastating consequences that Farmer traces up to the present.This thorough and hopeful narrative is a definitive work of reportage, history, and advocacy, and a crucial intervention in public-health discussions around the world.

    The book includes charts with the recipes, instructions on keeping diets simple and balanced, guidelines on preparation, suggestions for finding ingredients, and how much to feed a dog by body weight. There are recipes for healthy adult dogs, as well as guidelines for puppies, senior dogs, and dogs with health conditions including pancreatitis, renal problems, gastric issues, allergies, heart disease, liver disease, and cancer.Tracing the history of feeding dogs, the author shows when commercial dog food rose and took hold of the market. She discusses canine nutritional needs and provides research on how home-prepared foods can meet pets' needs better than commercial, processed dog food. Written with thorough information for the seasoned raw feeder, this guide can also be easily followed by any newcomer to home-feeding.This revised edition includes new information on special care and feeding of pregnant, newborn, performance, and toy breed dogs as well as senior dog considerations and the safety of the raw food diet for dogs.From the Trade Paperback edition.

    For most of that time, she didn't know why. All of her trips to the ER and her daily anguish, pain, and lethargy only ever resulted in one question: How could any one person be this sick? Several drug addictions, three major hospitalizations, and over $100,000 later, she finally had a diagnosis: late-stage Lyme disease. Sick is Khakpour's arduous, emotional journey—as a woman, a writer, and a lifelong sufferer of undiagnosed health problems—through the chronic illness that perpetually left her a victim of anxiety, living a life stymied by an unknown condition.Divided by settings, Khakpour guides the reader through her illness by way of the locations that changed her course—New York, LA, New Mexico, and Germany—as she meditates on both the physical and psychological impacts of uncertainty, and the eventual challenge of accepting the diagnosis she had searched for over the course of her adult life. With candor and grace, she examines her subsequent struggles with mental illness, her addiction to the benzodiazepines prescribed by her psychiatrists, and her ever-deteriorating physical health. A story about survival, pain, and transformation, Sick is a candid, illuminating narrative of hope and uncertainty, boldly examining the deep impact of illness on one woman's life.

    Award-winning author Jonathan Edlow, M.D., shows the doctor as detective and the epidemiologist as elite sleuth in stories that are as gripping as the best thrillers.In these stories a notorious stomach bug turns a suburban dinner party into a disaster that almost claims its host; a diminutive woman routinely eats more than her football-playing boyfriend but continually loses weight; a young executive is diagnosed with lung cancer, yet the tumors seem to wax and wane inexplicably. Written for the lay person who wishes to better grasp how doctors decipher the myriad clues and puzzling symptoms they often encounter, each story presents a very different case where doctors must work to find the accurate diagnosis before it is too late. Edlow uses his unique ability to relate complex medical concepts in a writing style that is clear, engaging and easily understandable. The resulting stories both entertain us and teach us much about medicine, its history and the subtle interactions among pathogens, humans, and the environment.

    Prepare. Trip. Transform!With so much misinformation surrounding magic mushrooms out there, it can be hard to separate fact from fiction. This is where Your Psilocybin Mushroom Companion comes in to help. In this book, you’ll find a comprehensive yet friendly guide to everything there is to know about magic mushrooms.Learn how to plan safe, effective trips with easy-to-follow step-by-step advice. Discover how to train a guide to take care of those on psychedelic voyages, as well as how to access the transformative nature of these experiences. Even learn how microdosing can improve your mood, cognitive functioning, creativity, physical stamina, and more.With the most up-to-date research, Your Psilocybin Mushroom Companion will put magic mushrooms into perspective, dispel myths and urban legends, and open your mind to the benefits of psychedelic tripping.

    In superb graphic detail, with hundreds of plans, illustrations, and diagrams, this comprehensive resource presents and entire library's worth of essential design data for residential development.