This trial serves as the backdrop for Superbugs, and the results will impact nothing less than the future of humanity.Dr. McCarthy explores the history of bacteria and antibiotics, from Alexander Fleming's discovery of penicillin, to obscure sources of innovative new medicines (often found in soil samples), to the cutting-edge DNA manipulation known as CRISPR, bringing to light how we arrived at this juncture of both incredible breakthrough and extreme vulnerability. We also meet the patients whose lives are hanging in the balance, from Remy, a teenager with a dangerous and rare infection, to Donny, a retired New York City firefighter with a compromised immune system, and many more.

    Dr. Makary, one of the nation's leading health care experts, travels across America and details why health care has become a bubble. Drawing from on-the-ground stories, his research, and his own experience, The Price We Pay paints a vivid picture of price-gouging, middlemen, and a series of elusive money games in need of a serious shake-up. Dr. Makary shows how so much of health care spending goes to things that have nothing to do with health and what you can do about it. Dr. Makary challenges the medical establishment to remember medicine's noble heritage of caring for people when they are vulnerable.The Price We Pay offers a roadmap for everyday Americans and business leaders to get a better deal on their health care, and profiles the disruptors who are innovating medical care. The movement to restore medicine to its mission, Makary argues, is alive and well--a mission that can rebuild the public trust and save our country from the crushing cost of health care.

    It turns out that the Neanderthals’ behavior was surprisingly modern: they buried the dead, cared for the sick, hunted large animals in their prime, harvested seafood, and communicated with spoken language. Meanwhile, advances in DNA technologies are compelling us to reassess the Neanderthals’ place in our own past.For hundreds of thousands of years, Neanderthals evolved in Europe parallel to Homo sapiens evolving in Africa, and, when both species made their first forays into Asia, the Neanderthals may even have had the upper hand. In this important volume, Dimitra Papagianni and Michael A. Morse compile the first full chronological narrative of the Neanderthals’ dramatic existence—from their evolution in Europe to their expansion to Siberia, their subsequent extinction, and ultimately their revival in popular novels, cartoons, cult movies, and television commercials.

    Warren Andiman, an HIV/AIDS researcher who has been on the front lines battling infectious diseases for over forty years. In Animal Viruses and Humans: A Narrow Divide, Andiman traces the history of eight zoonotic viruses —deadly microbes that have made the leap directly from animals to human populations: Middle East Respiratory Syndrome (MERS), Swine influenza, Hantavirus, Monkeypox, Severe Acute Respiratory Syndrome (SARS), Rabies, Ebola, and Henipaviruses (Nipah and Hendra). He also illustrates the labor intensive and fascinating detective work that infectious disease specialists must do to uncover the source of an outbreak.Andiman also looks to the future, envisioning the effects on zoonoses (diseases caused by zoonotic viruses) of climate change, microenvironmental damage, population shifts, and globalization. He reveals the steps that we can, and must, take to stem the spread of animal viruses, explaining, “The zoonoses I've chosen to write about . . . are meant to describe only a small sample of what is already out there but, more menacingly, what is inevitably on its way, in forms we can only imagine.” Warren Andiman, MD is professor emeritus of pediatrics and epidemiology at the Yale Schools of Medicine and Public Health.

    In The Anatomy of Violence, Raine dissects the criminal mind with a fascinating, readable, and far-reaching scientific journey into the body of evidence that reveals the brain to be a key culprit in crime causation.  Raine documents from genetic research that the seeds of sin are sown early in life, giving rise to abnormal physiological functioning that cultivates crime. Drawing on classical case studies of well-known killers in history—including Richard Speck, Ted Kaczynski, and Henry Lee Lucas—Raine illustrates how impairments to brain areas controlling our ability to experience fear, make good decisions, and feel guilt predispose us to violence. He contends that killers can actually be coldhearted: something as simple as a low resting heart rate can give rise to violence. But arguing that biology is not destiny, he also sketches out provocative new biosocial treatment approaches that can change the brain and prevent violence.  Finally, Raine tackles the thorny legal and ethical dilemmas posed by his research, visualizing a futuristic brave new world where our increasing ability to identify violent offenders early in life might shape crime-prevention policies, for good and bad. Will we sacrifice our notions of privacy and civil rights to identify children as potential killers in the hopes of helping both offenders and victims? How should we punish individuals with little to no control over their violent behavior? And should parenting require a license? The Anatomy of Violence offers a revolutionary appraisal of our understanding of criminal offending, while also raising provocative questions that challenge our core human values of free will, responsibility, and punishment.From the Hardcover edition.

    But that picture is vastly incomplete. In this eye-opening book, physician Rishi Manchanda says that our health may depend even more on our social and environmental settings than it does on our most cutting-edge medical care. Manchanda argues that that the future of our health care depends on growing a new generation of health care practitioners. We need doctors who look upstream for the sources of our problems, rather than simply go for quick-hit symptomatic relief. These upstreamists, as he calls them, are doctors and nurses on the frontlines of medicine who see that health (like sickness) is more than a chemical equation that can be balanced with pills and procedures administered within clinic walls. They see that health begins in our everyday lives, in the places where we live, work, eat, and play. If our high-cost, sick-care system is to become a high-value, health care system, the upstreamists will show us the way. (Description taken from TED Library: http://www.ted.com/pages/tedbooks_lib...)

    It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds – from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes.This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history – the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to “read” and “write” the human genome – unleashing the potential to change the fates and identities of our children.Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity – and a vision of both humanity’s past and future.

    When there aren’t enough of them, or they aren’t working properly, chronic diseases can manifest and persist. From industry leaders, sport stars, and Hollywood icons to thousands of everyday, ordinary people, stem cell therapy has helped when standard medicine failed. Many of them had lost hope. These are their stories. Neil H Riordan, author of MSC: Clinical Evidence Leading Medicine’s Next Frontier, the definitive textbook on clinical stem cell therapy, brings you an easy-to-read book about how and why stem cells work, and why they’re the wave of the future. “Neil takes readers on a riveting journey through the past, present and future of stem cell therapy. His well-researched, educational and entertaining book could change your life. I highly recommend it.” Tony Robbins, NY Times #1 Bestselling Author 100 years old will soon become the new 60. Stem cells are a key therapeutic to enable this future. Dr. Riordan’s book is your guide to why this is true and how you will benefit. A must read for anyone who cares about extending their healthy lifespan.” Peter H. Diamandis, MD; Founder, XPRIZE & Singularity University; Co-Founder, Human Longevity, Inc.; Author of NY Times Best Sellers Abundance and Bold

    But was it a savage sheep killer or a shy, fussy, nocturnal feeder? And did it really drink its victims' blood? Once reviled, feared and slaughtered by government decree, the myth of the Tasmanian Tiger continues to grow. So treasured is it now, the Tasmanian Tiger has become the official logo of the island that wiped it out and a symbol of the conservation movement world-wide.A number of Australian species have miraculously reappeared after being labelled as extinct. Perhaps the Tiger is still with us. And if it's not, can it be brought back by cloning?

    After the Ice is the story of this momentous period--one in which a seemingly minor alteration in temperature could presage anything from the spread of lush woodland to the coming of apocalyptic floods--and one in which we find the origins of civilization itself.Drawing on the latest research in archaeology, human genetics, and environmental science, After the Ice takes the reader on a sweeping tour of 15,000 years of human history. Steven Mithen brings this world to life through the eyes of an imaginary modern traveler--John Lubbock, namesake of the great Victorian polymath and author of Prehistoric Times. With Lubbock, readers visit and observe communities and landscapes, experiencing prehistoric life--from aboriginal hunting parties in Tasmania, to the corralling of wild sheep in the central Sahara, to the efforts of the Guila Naquitz people in Oaxaca to combat drought with agricultural innovations.Part history, part science, part time travel, After the Ice offers an evocative and uniquely compelling portrayal of diverse cultures, lives, and landscapes that laid the foundations of the modern world.

    We see it, touch it, and live in it every day. It is a habitat for a mesmerizingly complex world of micro-organisms and physical functions that are vital to our health and our survival. It is also a waste removal plant, a warning system for underlying disease and a dynamic immune barrier to infection. One of the first things people see about us, skin is crucial to our sense of identity, providing us with social significance and psychological meaning. And yet our skin and the fascinating way it functions is largely unknown to us. In prose as lucid as his research underlying it is rigorous, blending in memorable stories from the past and from his own medical experience, Monty Lyman has written a revelatory book exploring our outer surface that will surprise and enlighten in equal measure. Through the lenses of science, sociology, and history--on topics as diverse as the mechanics and magic of touch (how much goes on in the simple act of taking keys out of a pocket and unlocking a door is astounding), the close connection between the skin and the gut, what happens instantly when one gets a paper cut, and how a midnight snack can lead to sunburn--Lyman leads us on a journey across our most underrated and unexplored organ and reveals how our skin is far stranger, more wondrous, and more complex than we have ever imagined.

    Just a half century ago, this idea was revolutionary. In April 1953, James Watson and Francis Crick published in Nature their groundbreaking work revealing the double helix structure of DNA. While this discovery received wide attention from both mainstream media and the academic community, it was just one part of the bigger story in this history of molecular biology. By the mid-1950s, the scientific community confirmed that genes were indeed comprised of DNA; they just needed to crack the genetic code—and the race was on. Life’s Greatest Secret is the full and rich history of this challenge and the characters—many of whom were not biologists—whose work contributed to this grand scientific endeavor: mathematician and father of cybernetics Norbert Wiener, physicist Erwin Schrödinger, information theorist Claude Shannon, and biologists Jacques Monod and Marshall Nirenberg.In Life’s Greatest Secret, science historian and zoologist Matthew Cobb shows that the race to crack the genetic code was mostly a matter of craft—individuals or small groups struggling with ideas and concepts as much as they were with facts, trying to find the right experiment to answer the right questions, even if they didn’t know what the questions were, and finding that, even when the most definitive answer served mostly to reveal more ignorance, whether in 1953, with Watson and Crick, or in 1961, when Nirenberg and Matthaei showed how DNA codes for specific amino acids, and again and again thereafter, or in 2000, with the first publication of a human genome. Each discovery was a leap forward in our understanding of the natural world and our place within in, akin to the discoveries of Galileo and Einstein in the realm of physics, or the publication of Darwin’s On the Origin of Species. And each served to show how much bigger the problem was that anyone had previously imagined, a trend that continues, as Cobb shows, even today, whether we are discussing gene regulation, epigenetics, or GMOs.Life’s Greatest Secret is a story of ideas and of experimentation, of ingenuity, insight, and dead-ends, in the hunt to make the greatest discovery of twentieth century biology. Ultimately, though, this is a story of humans exploring what it is that makes us human.

    For the past several years, acclaimed Science reporter Jon Cohen has been following the DNA hunt, as well as eye-opening new studies in ape communication, human evolution, disease, diet, and more.In Almost Chimpanzee, Cohen invites us on a captivating scientific journey, taking us behind the scenes in cutting-edge genetics labs, rain forests in Uganda, sanctuaries in Iowa, experimental enclaves in Japan, even the Detroit Zoo. Along the way, he ferries fresh chimp sperm for a time-sensitive analysis, gets greeted by pant-hoots and chimp feces, and investigates an audacious attempt to breed a humanzee. Cohen offers a fresh and often frankly humorous insider's tour of the latest research, which promises to lead to everything from insights about the unique ways our bodies work to shedding light on stubborn human-only problems, ranging from infertility and asthma to speech disorders.And in the end, Cohen explains why it's time to move on from Jane Goodall's plea that we focus on how the two species are alike and turns to examining why our differences matter in vital ways—for understanding humans and for increasing the chances to save the endangered chimpanzee.

    Shell traces the epidemic's inception in the Ice Age, its rise during the Industrial Revolution, and its growth through the early days of medicine and into modernity. She takes readers to the front lines of the struggle to come to grips with this baffling plague — from a children's food marketing convention, to the cutthroat race to find the obese gene, to a far-flung tropical island, where a horrifying outbreak of obesity has helped unravel the disorder's genetic and evolutionary roots. Offering an unflinching insider's look into the radical and controversial surgical and pharmacological approaches used to combat what drug makers have dubbed the trillion-dollar disease, Shell takes aim at the collusion of industry and government that lies behind the crises and shows conclusively that obesity is not a matter of gluttony or weak will, but of an increasingly greedy culture preying on vulnerable human biology. Gripping and provocative, The Hungry Gene is the unsettling saga of how the world got fat — and what we can do about it.

     "The genius of Hanson's fascinating, inspiring, and entertaining book stems from the fact that it is not about how all kinds of things grow from seeds; it is about the seeds themselves." -- Mark Kurlansky, New York Times Book Review We live in a world of seeds. From our morning toast to the cotton in our clothes, they are quite literally the stuff and staff of life: supporting diets, economies, and civilizations around the globe. Just as the search for nutmeg and pepper drove the Age of Discovery, coffee beans fueled the Enlightenment and cottonseed sparked the Industrial Revolution. Seeds are fundamental objects of beauty, evolutionary wonders, and simple fascinations. Yet, despite their importance, seeds are often seen as commonplace, their extraordinary natural and human histories overlooked. Thanks to this stunning new book, they can be overlooked no more. This is a book of knowledge, adventure, and wonder, spun by an award-winning writer with both the charm of a fireside story-teller and the hard-won expertise of a field biologist. A fascinating scientific adventure, it is essential reading for anyone who loves to see a plant grow.